Clinical trials: sponsored by McMaster University
Breast Cancer Invasive Nos, Stage 0 Breast Carcinoma
Trial Comparing Radioactive Seed Localization to Standard Procedure for Non-palpable Breast Cancers
The purpose of this study is to determine whether a new surgical technique (radioguided seed localization) for localizing nonpalpable breast tumours is better than the standard technique (needle localization).
- Trial name
- NCT00225927
- Testing
- radioguided seed localization for nonpalpable breast cancers
- Where
- 3 sites in Canada
- Volunteers
- 333 people
- Sponsor
- McMaster University
Asthma, COPD
Causes, Characteristics and Mechanisms of Infective Exacerbations in Subjects With Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Diseases of the airways (bronchi) of the lungs include asthma and chronic obstructive pulmonary disease (COPD), which are leading causes of reduced quality of life, loss of work, hospital admissions and deaths and result in a…
- Trial name
- NCT00512954
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Critical Illness, Deep Venous Thrombosis
PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT)
The purpose of this study is to evaluate the effect of Low Molecular Weight Heparin (LMWH) (Fragmin, dalteparin) versus Unfractionated Heparin (UFH) on the primary outcome of proximal leg Deep Vein Thrombosis (DVT) diagnosed by…
- Trial name
- NCT00182143
- Testing
- LMWH (Fragmin, dalteparin), Unfractionated Heparin
- Where
- 67 sites in United States, Australia and 4 more
- Volunteers
- 3,659 people
- Sponsor
- McMaster University
Psychological Phenomena: Central Fatigue
Impact of Varying Doses of Amino Acids on Exercise, Muscular and Mental Performance
A number of studies have shown that ingestion of crystalline amino acids, in particular branched chain amino acids (BCAA) can affect endurance performance, markers of muscle damage, and possibly mental focus.
- Trial name
- NCT01215396
- Testing
- AminoVital Amino Acid formulation, Amino Vital Amino Acid formulation
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hematologic Malignancies
Thymoglobulin in Unrelated Hematopoietic Progenitor Cell Transplantation
This is a randomized trial for patients undergoing hematopoietic progenitor cell transplantation (HPCT) from an unrelated donor.
- Trial name
- NCT01217723
- Testing
- Anti-Thymocyte Globulin (Rabbit), Patients will receive a standard preparative regimen (i.e. one that does not contain Thymoglobulin)
- Where
- 10 sites in Canada
- Volunteers
- 198 people
- Sponsor
- McMaster University
Diabetes Mellitus, Type 2
Diabetes IN-CHARGE: Trial of Diabetes Intervention in the Community to Help Achieve Reduced Glucose Elevation
The purpose of this study is to test whether providing personalized diabetes self-management recommendations and feedback improves blood sugar control more than providing generalized diabetes educational material alone.
- Trial name
- NCT00182026
- Testing
- personal feedback report
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- McMaster University
Knee Osteoarthritis
Effects of Ultrasound Therapy on Cartilage Healing in Patients With Knee Osteoarthritis
The purpose of this study is to determine the effects of low intensity ultrasound therapy over the cartilage morphology (thickness and volume) of patients with mild or moderate knee osteoarthritis.
- Trial name
- NCT00931749
- Testing
- Low intensity pulsed ultrasound therapy
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- McMaster University
Cardiovascular Disease
PeriOperative ISchemic Evaluation-2 Pilot
Major non-cardiac surgeries are common and major heart problems during or after such surgeries represent a large population health problem. Few treatments to prevent heart problems around the time of surgery have been tested.
- Trial name
- POISE2-pilot (NCT00860925)
- Testing
- active clonidine, active ASA
- Where
- 4 sites in Canada, China
- Volunteers
- 90 people
- Sponsor
- McMaster University
Breast Cancer, Magnetic Resonance Imaging
Pre-operative Magnetic Resonance Imaging (MRI) in Young Breast Cancer Patients
Young women with breast cancer have an increased breast tissue density and conventional imaging tests such as mammography and breast ultrasound are less sensitive and specific for detecting breast cancer than in older breast…
- Conditions
- Breast Cancer, Magnetic Resonance Imaging, Preoperative MRI
- Trial name
- NCT00801476
- Testing
- Pre-operative bilateral breast MRI
- Where
- 2 sites in Canada
- Volunteers
- 44 people
- Sponsor
- McMaster University
Delivery of Health Care, Smoking Cessation
Increasing Smoking Cessation Counselling in Primary Care Using a Chronic Disease Management System
This pilot study will determine the feasibility of studying a new smoking cessation management module in an existing chronic disease management system.
- Trial name
- NCT01004276
- Testing
- New, improved smoking cessation management module
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
COPD
Study to Evaluate the Effects of Tiotropium Bromide on Chronic Obstructive Pulmonary Disease (COPD) During Exercise
The purpose of this study is to determine the effect of treatment with tiotropium bromide on efficiency of gas exchange and exercise performance in COPD subjects during exercise.
- Trial name
- NCT00412204
- Testing
- tiotropium bromide
- Volunteers
- 20 people
- Sponsor
- McMaster University
Intimate Partner Violence Against Women
Does Routine Screening for Intimate Partner Violence Against Women in Health Care Settings do More Good Than Harm?
The purpose of the research is to evaluate whether routine screening for woman abuse in health care settings, as compared to no screening, does more good than harm.
- Trial name
- NCT00182468
- Testing
- Screening for intimate partner violence
- Where
- 28 sites in Canada
- Volunteers
- 5,681 people, healthy volunteers welcome
- Sponsor
- McMaster University
Pregnancy
Innovation to Providing Interprofessional Maternity Care
The aim of this pilot project is to determine if there are differences in patient outcomes and healthcare utilization between patients randomly assigned to usual care (a collaborative model of maternity care with co-located…
- Trial name
- NCT00961987
- Testing
- Collaborative model, Usual care
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- McMaster University
Continuity of Care, Quality of Life
SONICS - Effectiveness of Specialist Oncology Nursing
This research project will address the issue of gaps in continuity of supportive care for cancer patients during the early phases of the disease trajectory that result in unmet needs and unnecessary morbidity.
- Trial name
- NCT00182234
- Testing
- Community Interlink Program
- Volunteers
- 183 people
- Sponsor
- McMaster University
Irritable Bowel Syndrome
Chronic Gastrointestinal Sequelae of an Acute Outbreak of Bacterial Gastroenteritis in Walkerton Ontario
Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood.
- Trial name
- NCT00235326
- Where
- Canada
- Volunteers
- 4,561 people, healthy volunteers welcome
- Sponsor
- McMaster University
Alzheimer's Disease
A Pilot Study of Inflammatory Markers in Alzheimer's Disease
The purpose of this study is to examine the cerebrospinal fluid (CSF) of patients with Alzheimer's disease for biomarkers of inflammation and their response to the antibiotics doxycycline and rifampin.
- Trial name
- NCT00715858
- Testing
- doxycycline, rifampin
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetes
A Randomized Trial of Electronic Integration of Care for Better Diabetes Outcomes; The COMPETE II Study
This study will evaluate whether the use of an electronic diabetes tracker by both patients and family physicians in Ontario improves diabetes outcomes, satisfaction with care and with technology and health data privacy issues.
- Trial name
- COMPETEII (NCT00813085)
- Testing
- Electronic disease management decision support
- Where
- Canada
- Volunteers
- 511 people
- Sponsor
- McMaster University
Frailty
Preventive Primary Care Outreach for High Risk Older Persons
It is recognized that a significant proportion of seniors over 75 years of age are at risk of functional decline, and thus of institutionalization and death.
- Trial name
- PPCO (NCT00134836)
- Testing
- Preventive Primary Care Outreach
- Where
- Canada
- Volunteers
- 719 people
- Sponsor
- McMaster University
Antibiotic-Associated Diarrhea
Comparison of Two Formulations of Bio-K
Main research Question: The investigators would like to find out if both the Bio-K (lactobacillus acidophilus and lactobacillus casei) drink and capsule are equally effective in the prevention of diarrhea associated with…
- Trial name
- NCT00792844
- Testing
- Bio-K capsule formulation, Bio-K drink
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- McMaster University
Cystic Fibrosis, Osteoporosis
Study of Alendronate to Prevent and Treat Osteoporosis in Cystic Fibrosis Patients
The primary objective of this study is to determine efficacy of 70 mg alendronate once weekly compared to placebo. This will be measured by percent changes in lumbar spine(LS) bone mineral density(BMD) in adult cystic…
- Conditions
- Cystic Fibrosis, Osteoporosis, Bone Diseases, Metabolic
- Trial name
- NCT00157690
- Testing
- Alendronate
- Where
- 6 sites in Canada
- Volunteers
- 56 people
- Sponsor
- McMaster University