Clinical trials: sponsored by Memorial Sloan Kettering Cancer Center
Healthy
Development and Evaluation of Magnetic Resonance Imaging Acquisition and Analysis Methods
Magnetic resonance imaging (MRI) is a diagnostic imaging method with constant progress and improvement in the way the MRI images are obtained. Many of these advances involve changes to MRI software and hardware.
- Trial name
- NCT02091518
- Testing
- MR Screening Questionnaire, Magnetic Resonance Imaging Acquisition and Analysis
- Where
- United States
- Volunteers
- 682 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Small Cell Lung Cancer, Small Cell Lung Carcinoma
PET/CT Imaging of Small Cell Lung Cancer Using 89Zr-DFO-SC16.56
The purpose of this study is to look at how safe 89Zr-DFO-SC16.56 is, and how it is processed by the body in people with small cell lung cancer.
- Trial name
- NCT04199741
- Testing
- 89Zr-DFO-SC16.56, SC16.56, Phase I, Cohort 2, SC16.56, Phase I, Cohort 3
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Solid Tumor Cancer
A Study of a Distress Screening and Referral Program in People With Recently Diagnosed Cancer
It is recommended that cancer centers screen patients for distress and refer them to mental health services when their distress levels reach a certain level.
- Trial name
- NCT07117461
- Testing
- NCCN Distress Thermometer
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sharps Injuries
A Study of VAX-ID® 2200, a New Device for Intradermal Injections
The researchers are doing this study to find out whether the VAX-ID® 2200 device is safe and easy to use for healthcare professionals who give intradermal injections.
- Trial name
- NCT07898111
- Testing
- VAX-ID® 2200
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreatic Cancer, Skin Toxicities
A Study of Standard of Care Drugs With or Without Ivermectin for Daraxonrasib-Induced Skin Toxicity in People With Pancreatic Cancer
The researchers are doing this study to find out whether the combination of ivermectin and standard of care prophylaxis (SOCP; drugs given to prevent the development of a disease or condition) is an effective treatment approach…
- Trial name
- NCT07895498
- Testing
- Minocycline, Hypochlorous Acid, Hydrocortison cream
- Where
- 7 sites in United States
- Volunteers
- 122 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
HER2-positive Breast Cancer, Breast Cancer
A Study of Skipping Radiation Therapy in People With Breast Cancer
The purpose of this study is to find out whether it is safe to skip (omit) radiation therapy to the breast after lumpectomy in people with low-risk HER2-positive breast cancer who are receiving HER2-targeted therapy.
- Trial name
- SuperHERO (NCT07895511)
- Testing
- HER2-targeted therapy, Tamoxifen, No Radiation Therapy
- Where
- 7 sites in United States
- Volunteers
- 136 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cushing's Disease, Cushing Syndrome
Collecting Information About Treatment Results for Patients With Cushing's Syndrome
The purpose of this study is to follow participants with Cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.
- Conditions
- Cushing's Disease, Cushing Syndrome, Cushing Disease
- Trial name
- NCT03364803
- Testing
- Cushing's QoL (Quality of Life Questionnaire), Nottingham Health Profile (NHP), Hospital Anxiety and Depression Scale (HADS)
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Follicular Lymphoma, Marginal Zone Lymphoma
A Study of Reduced Dose Radiation Therapy for People With B-Cell Lymphomas
The researchers are doing this study to find out whether a very low dose of radiation therapy (VLDRT) is an effective treatment for people with follicular lymphoma (FL) or marginal zone lymphoma (MZL) and works as well as the…
- Trial name
- NCT07029217
- Testing
- Radiation (Standard), Radiation (Very low dose)
- Where
- 7 sites in United States
- Volunteers
- 375 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Primary Extra-cranial Solid Tumor, Recurrent or Refractory Glypican 3 (GPC3)
A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After Treatment
The purpose of this study to find out whether codrituzumab is a safe treatment that causes few or mild side effects in children and young adults who have solid tumors that express the protein GPC3.
- Trial name
- NCT04928677
- Testing
- Codrituzumab
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bladder Cancer, Metastatic Bladder Cancer
A Phase II Study of Atezolizumab in Combination With Cisplatin + Gemcitabine Before Surgery to Remove the Bladder Cancer
The purpose of this study is to test the safety of the study drug, atezolizumab, when combined with the standard chemotherapy drugs, gemcitabine and cisplatin (or GC).
- Conditions
- Bladder Cancer, Metastatic Bladder Cancer, Urothelial Carcinoma
- Trial name
- NCT02989584
- Testing
- Atezolizumab, Gemcitabine, Cisplatin
- Where
- 9 sites in United States
- Volunteers
- 54 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Pain, Musculoskeletal Pain
PEACE: Comparing Chronic Pain Treatment Options
The purpose of this study is to compare two types of acupuncture with usual care on treating chronic pain. This study has three groups. Two groups will received acupuncture.
- Conditions
- Chronic Pain, Musculoskeletal Pain, Fibromyalgia, Pain Management
- Trial name
- PEACE (NCT02979574)
- Testing
- Electro-Acupuncture (EA), Battle Field Acupuncture (BFA), Wait List Control (WLC)
- Where
- 7 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer Patients, Care Givers
A Study of an Anxiety Intervention for Latino/Latina/Hispanic Older Adults With Cancer and Their Caregivers
The purpose of this study is to find out if an anxiety treatment program is practical and effective for Latino older adults with cancer (OACs) and their caregivers.
- Trial name
- NCT06305741
- Testing
- Managing Anxiety from Cancer (MAC)
- Where
- 7 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Low-Grade Serous Ovarian Cancer
A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer
The researchers are doing this study to find out whether the combination of avutometinib, defactinib, and letrozole is an effective treatment for people with low-grade serous ovarian cancer (LGSOC).
- Trial name
- CHAMELEON (NCT06394804)
- Testing
- Avutometinib, Defactinib, Letrozole
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Multiple Ground Glass Opacities (GGOs)
A Registry for Patients With Multifocal Ground Glass Opacities (GGOs)
The purpose of this registry study is to actively monitor people with GGOs and collect information about them, so that investigators can learn more about these lesions and about the risk of developing lung cancer in study…
- Trial name
- NCT03802981
- Where
- 32 sites in United States, Canada
- Volunteers
- 338 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hodgkin Lymphoma, Relapsed or Refractory Hodgkin Lymphoma
Phase II Study of Second- Line Pembrolizumab Plus GVD for Relapsed or Refractory Hodgkin Lymphoma
The purpose of this study is to test any good and bad effects of the study drug, pembrolizumab, in combination with GVD in the treatment of Hodgkin lymphoma.
- Trial name
- NCT03618550
- Testing
- pembrolizumab, gemcitabine, vinorelbine
- Where
- 10 sites in United States
- Volunteers
- 257 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Operator Radiation Exposure
Operator Radiation Exposure During Image-Guided Robotic-Assisted Bronchoscopy: A Multicenter Prospective Cohort Study
This is a multicenter, single-arm, prospective, observational study designed to evaluate bronchoscopist radiation exposure during standard-of-care image-guided robotic-assisted bronchoscopy (RAB) for sampling of a single…
- Trial name
- NCT07318402
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hematologic Malignancies
Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell Transplantation
The purpose of this study is to see if a condensed version of the chemotherapy regimen busulfan, melphalan, fludarabine (bu/mel/flu) and the drug antithymocyte globulin (ATG-also referred to as rATG or thymoglobulin) can have the…
- Trial name
- NCT04098393
- Testing
- Busulfan 3.2 mg/kg/day, Fludarabine, Melphalan
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Wilms Tumor, Rhabdoid Tumor
A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors
The purpose of this study is to find out whether selinexor is an effective treatment for people who have a relapsed/refractory Wilms tumor, rhabdoid tumor, MPNST, BCOR-driven sarcoma, or another solid tumor that makes a higher…
- Conditions
- Wilms Tumor, Rhabdoid Tumor, Malignant Peripheral Nerve Sheath Tumors, MPNST
- Trial name
- NCT05985161
- Testing
- Selinexor
- Where
- 16 sites in United States
- Volunteers
- 45 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Rectal Adenocarcinoma, Clinical Stage: Stage II (T3-4, N-)
Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
The purpose of this study is to find out whether the study drug, TSR-042, followed by standard chemoradiotherapy (the chemotherapy drug capecitabine + radiation therapy) and standard surgery is an effective treatment for advanced…
- Conditions
- Rectal Adenocarcinoma, Clinical Stage: Stage II (T3-4, N-), Stage III (Any T, N+), Solid Tumor
- Trial name
- NCT04165772
- Testing
- TSR-042 or Dostarlimab, capecitabine or 5-FU, Intensity Modulated Radiation Therapy (IMRT)
- Where
- 10 sites in United States
- Volunteers
- 212 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Myelogenous Leukemia (AML), Acute Lymphoblastic Leukemia (ALL)
Cord Blood Transplant in Adults With Blood Cancers
Cord blood transplants (CBT) are a standard treatment for adults with blood cancers. MSK has developed a standard ("optimized") practice for cord blood transplant (CBT).
- Conditions
- Acute Myelogenous Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Chronic Myelogenous Leukemia (CML), Myelodysplastic Syndromes (MDS)
- Trial name
- NCT05884333
- Testing
- Conditioning Chemotherapy, Cord blood graft
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
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