Clinical trials: open to volunteers, sponsored by Menoufia University
Edentulism Complete
Accuracy of Complete-Arch Implant Scans Using Non Calibrated Splinting Scanbodies
This randomized crossover clinical study will evaluate and compare the accuracy and chairside time of two non-calibrated splinting systems, IoConnect and Scan Pro, for obtaining complete-arch implant digital scans.
- Trial name
- NCT07862218
- Testing
- Scan Pro, IoConnect
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Menoufia University
Edentulism in Lower Jaw
Accuracy of Immediate Implant Placement
This randomized clinical study will compare the accuracy of immediate implant placement performed using three different surgical approaches: freehand surgery, conventional tooth-supported static computer-guided surgery, and a…
- Trial name
- NCT07863700
- Testing
- Freehand Immediate Implant Placement, Tooth-Supported Static Computer-Guided Implant Placement, Tooth- and Socket-Supported Static Guided Implant Placement
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Bilateral Inguinal Hernia Repair, Open Upper Abdominal Surgeries
Ultrasound-guided Quadratus Lumborum Block Versus Erector Spinae Plane Block for Postoperative Analgesia in Children Undergoing Elective Open Lower Abdominal Surgeries
To compare the postoperative analgesic efficacy of ultrasound-guided Quadratus Lumborum Block (anterior approach) versus Erector Spinae Plane Block (T10-T12 level), both performed bilaterally with 0.25% bupivacaine (0.5 mL/kg per…
- Trial name
- NCT07853586
- Testing
- ultrasound guided anterior oudratus lumborum block, Ultrasound guided erector spinae plane block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Autoimmune Encephalitis (AE)
Plasma Exchange in Pediatric Autoimmune Encephalitis
The aim of the study will be to compare the efficacy of daily plasma exchange (PLEX) versus alternate-day PLEX in achieving a favorable functional outcome in children with autoimmune encephalitis.
- Trial name
- PE/AIE (NCT07707739)
- Testing
- Plasma exchange (PE)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Menoufia University
Prophylactic, Anticoagulation
Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children
This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026…
- Trial name
- NCT07710482
- Testing
- Enoxaparin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Severe Sepsis
Plasma Exchange in Children With Severe Sepsis and Septic Shock
The aim of the study will be to to evaluate whether therapeutic plasma exchange (TPE) reduces mortality in critically ill children with severe sepsis or septic shock compared to the standard care of sepsis alone.
- Trial name
- PE/Sepsis (NCT07706413)
- Testing
- Plasma exchange (PE)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Menoufia University
Sepsis and Septic Shock
Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock
This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using…
- Trial name
- NCT07516236
- Testing
- Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Menoufia University
Liver Resection, Upper Abdominal Surgeries
Comparative Effects of ESP Block and EOIP Block on Postoperative Respiratory Recovery Following Liver Resection
This study evaluates respiratory recovery as a multidimensional construct using clinically relevant and measurable parameters, including LUS, diaphragmatic excursion, oxygen requirement, and PPCs.
- Trial name
- NCT07740382
- Testing
- Ultrasound-guided bilateral external oblique intercostal plane (EOIP) block, Ultrasound-guided bilateral erector spinae plane (ESP) block
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Menoufia University
Thyroid Surgeries
Comparative Study of Ultrasound Guided Superficial vs Intermediate Cervical Plexus Block for Perioperative Analgesia in Thyroid Surgeries.
The investigator compare the analgesic efficacy of ultrasound-guided subcutaneous cervical plexus block vs ultrasound-guided intermediate cervical plexus block pre-intra and postoperative thyroid surgery
- Trial name
- NCT07843589
- Testing
- Ultrasound guided superficial cervical plexus block, ultrasound guided intermediate cervical plexus block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Menoufia University
Cervical, Erector Spinae Plane Block
Cervical Erector Spinae Plane Block in Proximal Humeral Fracture Surgery, A Motor-Sparing Block
This study aims to evaluate the efficacy of cervical erector spinae plane block (ESPB) in managing postoperative pain following proximal humerus fracture repair in patients receiving general anesthesia.
- Conditions
- Cervical, Erector Spinae Plane Block, Proximal Humeral Fracture Surgery
- Trial name
- NCT07824466
- Testing
- Cervical erector spinae plane block, General anesthesia
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Menoufia University
Obese Patients
External Oblique Intercostal Block With or Without Intravenous Lidocaine Infusion for Analgesia in Patients Undergoing Gastric Bypass Surgery
Adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption (ANI guided rescue) compared to placebo, without increasing…
- Trial name
- NCT07809425
- Testing
- Investigatore hypothesize that adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption., Bilateral EOIB + fentanyl 1 μg/kg loading + normal saline loading (equivalent volume) + normal saline infusion (equivalent rate).
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Critically Ill Intensive Care Unit Patients
Diagnostic Accuracy of Hepatic Vein SFF Compared With TAPSE for Assessment of RV Systolic Function in Mechanically Ventilated Patients
This prospective observational diagnostic accuracy study investigates the efficacy of the hepatic vein systolic filling fraction (SFF) as a real-time, non-invasive indicator of right ventricular (RV) systolic function in…
- Trial name
- NCT07732114
- Testing
- Diagnostic accuracy of hepatic vein systolic filling fraction compared with TAPSE for assessment of right ventricular systolic function in mechanically ventilated critically ill patients
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Menoufia University
Edentulism, Edentulism Complete
Comparison of Non-Calibrated Splinting Bodies and T-Marker for Complete-Arch Implant Scanning
This randomized crossover clinical trial aims to compare the accuracy and scanning efficiency of two digital techniques for recording implant positions in completely edentulous patients receiving implant-supported full-arch…
- Trial name
- NCT07723404
- Testing
- Non-Calibrated Splinting Scan Body System (IoConnect), Mobile Phone-Based Photogrammetry System (T-Marker)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Total Dose of Bupivacaine Administered During Labor
Dexmedetomidine as an Adjuvant During Dural Puncture Epidural
The study aimed to determine the effects of using varied doses of DEX on the concentration of bupivacaine injected for epidural labor analgesia, and to assess the benefits of the dural puncture epidural.
- Trial name
- NCT07506044
- Testing
- Epidural Catheter with bupivacaine, Epidural with dural puncture, Dexmedetomidine 0.4 added
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Menoufia University
Change in Serum Levels of the Estimated Inflammatory Cytokines, Total Dose of IO Fentanyl
Deep Versus Moderate Neuromuscular Blocking
This study aimed for Determination of the impacts of deep neuromuscular blockade (DNMB) on surgical outcomes, consumption of perioperative opioid analgesia, and serum levels of inflammatory cytokines in comparison to moderate NMB…
- Conditions
- Change in Serum Levels of the Estimated Inflammatory Cytokines, Total Dose of IO Fentanyl, PO Morphine, Surgeons' Rating
- Trial name
- NCT07485517
- Testing
- Moderate Neuromuscular Blockade, Deep neuromuscular block
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Menoufia University
Initial Caries
Early Detection of Initial Caries Using Fluorescent Starch Nano-particles Compared With Salivary Biomarkers
Dental caries is one of the most prevalent chronic oral diseases worldwide and remains a major public health concern. The disease begins with microscopic demineralization of enamel, which is reversible if diagnosed at an early…
- Trial name
- NCT07732127
- Testing
- Fluorescent Starch Nano-particles
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Hip Osteoarthritis, Hip Arthroplasty Replacement
Virtual Reality for Intraoperative Anxiolysis and Postoperative Agitation in Elderely Hip Arthroplasty Patients
This study evaluates the effectiveness of Virtual Reality (VR) as a non-pharmacological intervention to reduce intraoperative anxiety and postoperative agitation in elderly patients undergoing elective hip arthroplasty under…
- Conditions
- Hip Osteoarthritis, Hip Arthroplasty Replacement, Emergence Delirium, Anesthesia, Emergence Agitation
- Trial name
- VR (NCT07705451)
- Testing
- immersive virtual reality, standard sedation
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Denture, CAD/CAM
Effect of Certain Denture Disinfectants on Surface Topography, Microhardness and Dimensional Stability of CAD/CAM Milled Polymethyl Methacrylate and Polyether Ether Ketone Denture Base Materials
This study aims to evaluate and compare the influence of different denture cleansing methods using 1% sodium hypochlorite solution, 0.2% chlorhexidine solution and effervescent alkaline peroxide tablet solution -according to…
- Conditions
- Denture, CAD/CAM, Stability, PEEK
- Trial name
- NCT07672847
- Testing
- M0 group, M1 group : PMMA+ Sodium hypochlorite, M2 group: PMMA+ Chlorhexidine
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Menoufia University
Hemidiaphragmatic Paralysis, Postoperative Pain
Comparative Evaluation of Diaphragmatic Function Following Interscalene, Anterior Suprascapular, and Costoclavicular Nerve Blocks in Shoulder Surgery
Shoulder surgery causes significant postoperative pain, and ultrasound-guided regional anesthesia is central to its management. The interscalene block (ISB) is the gold standard but frequently causes phrenic nerve paralysis and…
- Conditions
- Hemidiaphragmatic Paralysis, Postoperative Pain, Shoulder Surgery, Brachial Plexus Block
- Trial name
- NCT07671352
- Testing
- Ultrasound-guided interscalene brachial plexus block, Ultrasound-guided suprascapular nerve block, Ultrasound-guided costoclavicular brachial plexus block
- Volunteers
- 75 people
- Sponsor
- Menoufia University
Prosthesis User
Clinical Performance of 3D-Printed Resin and Zirconia Implant Restorations
This randomized controlled clinical trial evaluates the clinical performance of 3D-printed resin restorations compared with milled monolithic zirconia in implant-supported single crowns and short-span fixed partial dentures…
- Trial name
- NCT07522671
- Testing
- 3D-Printed Resin Restoration (CROWNTEC)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University