Clinical trials: sponsored by Montefiore Medical Center
Hepatitis C, Substance Use Disorders
HCV Group Evaluation and Treatment Uptake (HCV GET-UP) Intervention
People who inject drugs (PWID) represent the overwhelming majority of both HCV and HIV/HCV infected people in the United States.
- Trial name
- NCT03242655
- Testing
- HCV GET-Up (Group Evaluation and Treatment Uptake)
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Firearm Safety
Pediatric Inpatient Firearm Safety Study
There is currently no available data regarding using the inpatient setting as an opportunity to talk to parents/guardians about firearm safety.
- Trial name
- IF (NCT03077646)
- Testing
- Be SMART, Control: TSE, Be SMART + MD review
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Montefiore Medical Center
Prostate Cancer
Beta Adrenergic Receptor Blockade as a Novel Therapy for Patients With Adenocarcinoma of the Prostate
This will be a single arm, window of opportunity study in men with treatment-naïve prostate cancer who will proceed to prostatectomy. Men will be treated with carvedilol prior to undergoing prostatectomy.
- Trial name
- NCT02944201
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Montefiore Medical Center
Intrauterine Fetal Demise, Fetal Death
Mifepristone Induction for Fetal Demise
Methods: Double blinded, randomized controlled trial with 1:1 allocation of mifepristone or placebo at initiation of induction of labor for fetal demise 20 weeks estimated gestational age or greater.
- Trial name
- MIFD (NCT02620904)
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Full Term Infants, Environmental Exposures
Epigenetic and Developmental Effects of In Utero Exposure to Environmental Toxicants
Metabolic diseases such as obesity and diabetes are modern day epidemics. Early life exposure to an adverse developmental environment, including environmental toxins, are linked to increased susceptibility to obesity, metabolic…
- Conditions
- Full Term Infants, Environmental Exposures, Adiposity
- Trial name
- NCT01815385
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pediatric Hypertension
Boosting Primary Care Awareness and Treatment of Childhood Hypertension
The proposed research, building on an ongoing AHRQ-funded research project to prevent pediatric diagnostic errors in primary care (R01HS023608) and using a prospective, cluster-randomized, stepped wedge design, will investigate…
- Trial name
- BP-CATCH (NCT03783650)
- Testing
- Control condition, QIC with PCP and without subspecialist, QIC with Subspecialist
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain
Study of TAP and Laparoscopic and Robotic Gynecologic Procedures and Obese Women
Study the effect of the Transversis Abdominis Plane (TAP) block on pain after surgery for obese women undergoing laparoscopic or robotic gynecologic procedures.
- Trial name
- NCT01866917
- Testing
- Ropivacaine 0.5% 20cc injectate bilaterally
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Asthma
Azithromycin for Children Hospitalized With Asthma
Asthma is a chronic lung condition in children, and often requires hospitalization for acute exacerbations. Azithromycin has been used successfully in other chronic lung diseases, including cystic fibrosis.
- Trial name
- NCT02003911
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Montefiore Medical Center
Uterine Cancer
A Study of Radiation Therapy and Paclitaxel and Carboplatin in Patients With Uterine Papillary Serous Carcinoma
Combination chemo/radiotherapy trials in advanced/recurrent endometrial cancer are ongoing. The optimal radiation modality, chemotherapeutic agents, and sequence of these regimens for the treatment of UPSC are yet to be…
- Trial name
- NCT00231868
- Testing
- Carboplatin and Paclitaxel and Pelvic Radiation Therapy, Carboplatin and Paclitaxel and Radiation Therapy
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Montefiore Medical Center
Low Back Pain
Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain
This is a randomized study, based in emergency departments, in which the investigators determine the utility of adding various skeletal muscle relaxants to standard therapy, which consists of ibuprofen and an educational session.
- Trial name
- NCT03068897
- Testing
- Metaxalone, Tizanidine, Baclofen
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Montefiore Medical Center
Migraine
Greater Occipital Nerve Block With Bupivacaine for Acute Migraine
This is a randomized, sham-controlled study of greater occipital nerve block (GONB) using bupivacaine 0.5% for emergency department patients with acute migraine.
- Trial name
- NCT02665273
- Testing
- Greater occipital nerve block, Bupivacaine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Montefiore Medical Center
Abdominal Pain
Intravenous Lidocaine Randomized Comparative Effectiveness Trial
This is a randomized, double-blind, emergency department based, comparative effectiveness study of two medication for acute abdominal pain: intravenous lidocaine and intravenous hydromorphone.
- Trial name
- NCT03300674
- Testing
- Hydromorphone, Lidocaine
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Montefiore Medical Center
Shock
Variation in Fluids Administered in Shock
To conduct a multicenter observational cohort study to determine the variability in fluid resuscitation in shock in a broad range of areas in hospitals and treatment areas.
- Trial name
- VOLUME (NCT03190408)
- Testing
- Fluids
- Where
- United States
- Volunteers
- 1,639 people
- Sponsor
- Montefiore Medical Center
Opioid Use, Unspecified
the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block
The purpose of the study is to determine if perineural dexmedetomidine can provide increased prolongation of analgesia when compared to perineural dexamethasone in patients receiving regional block for shoulder surgery.
- Trial name
- NCT02653144
- Testing
- Ropivacaine, Dexmedetomidine, Dexamethasone
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Montefiore Medical Center
Cesarean Section Complications
RCT Investigating Pre-cesarean Vaginal Wash of Chlorhexidine vs Povidone-iodine for Patient With Ruptured Amniotic Membrane.
The objective of this study is to investigate if the rate of infectious morbidity is decreased with the use of chlorhexidine or povidone-iodine vaginal scrub before cesarean section after ruptured membranes.
- Trial name
- VAP (NCT03925155)
- Testing
- EZ scrub vaginal chlorhexidine 4% solution, 10% provodine-iodine vaginal preparation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Bleeding
Efficacy of Tranexamic Acid and Epsilon-aminocaproic Acid in Reducing Bleeding and Transfusions in Cardiac Surgery
The investigators primary objective is to compare the effectiveness of epsilon-aminocaproic acid (EACA) and tranexamic acid (TA) in reducing bleeding and transfusion in cardiac surgery, with the hypothesis that TA is more…
- Trial name
- NCT02655653
- Testing
- Epsilon-aminocaproic acid administered, Tranexamic Acid administered
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
COVID, Coronavirus
Hydroxychloroquine Treatment of Healthcare Workers With COVID19 Illness at Montefiore
Given the high prevalence of COVID19 illness (both SARS-CoV-2 RT-PCR confirmed and highly suspect cases) among healthcare workers (HCW) within the Montefiore Health System (MHS), hydroxychloroquine (HCQ) will be prescribed to…
- Conditions
- COVID, Coronavirus, COVID-19
- Trial name
- NCT04350450
- Testing
- Hydroxychloroquine
- Where
- United States
- Sponsor
- Montefiore Medical Center
Anesthesia
A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation
Hypothesis: A combination of midazolam with dexmedetomidine for sedation during third molar surgery will provide 1) superior patient satisfaction, 2) superior operator satisfaction and 3) no significant hemodynamic or respiratory…
- Trial name
- NCT03255824
- Testing
- Dexmedetomidine and Midazolam, Propofol, Midazolam, and Fentanyl
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Anesthesia
0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka
Total knee and hip replacements are some of the most common orthopedic procedures that require aggressive postoperative pain management.
- Trial name
- NCT03303794
- Testing
- Exparel, 0.25% bupivacaine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Montefiore Medical Center