Clinical trials: sponsored by Montefiore Medical Center
Radiculopathy, Lumbosacral Region, Back Pain With Radiation
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by…
- Conditions
- Radiculopathy, Lumbosacral Region, Back Pain With Radiation, Low Back Pain
- Trial name
- NCT05721027
- Testing
- Ibuprofen 400 mg, Dexamethasone Oral, Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Digestive System Carcinoma, Head and Neck Carcinoma
Continuous Activity Monitoring During Fractionated Radiotherapy in Patients With Head and Neck, Lung, or Gastrointestinal Cancer
This pilot research trial studies continuous activity monitoring during fractionated radiotherapy in patients with head and neck, lung, or gastrointestinal cancer.
- Conditions
- Digestive System Carcinoma, Head and Neck Carcinoma, Lung Carcinoma
- Trial name
- NCT02649569
- Testing
- Monitoring Device, Quality-of-Life Assessment
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Montefiore Medical Center
Cancer of the Head and Neck, Cancer of Lung
Real-time Activity Monitoring to Prevent Admissions During RadioTherapy
This study will aim to demonstrate that implementation of a rapid, multidisciplinary supportive care program for patients receiving chemoradiotherapy who are deemed to be at high risk for hospitalization based on real-time…
- Conditions
- Cancer of the Head and Neck, Cancer of Lung, Cancer of Esophagus, Cancer of Stomach
- Trial name
- RAMPART (NCT03102229)
- Testing
- Enhanced Supportive Care - Status Checks, Enhanced Supportive Care - Referrals
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Montefiore Medical Center
Brain Cancer, Head and Neck Cancer
A Simple Walking Program to Enhance Concurrent Chemoradiotherapy Delivery
By utilizing fitness trackers, this study aims to demonstrate that a simple walking program improves patients' ability to tolerate curative concurrent chemoradiotherapy without treatment interruption.
- Conditions
- Brain Cancer, Head and Neck Cancer, Lung Cancer, Gastrointestinal Cancer
- Trial name
- NCT03115398
- Testing
- Pedometer-based Walking Program
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Montefiore Medical Center
Parenting, Family Relations
Supporting Healthy Relationships Program for FRAMEWorks (SHR FRAMEWorks)
The overarching objective for the Supporting Health Relationships (SHR) program is to create and sustain families in the Bronx by improving relationship skills, improving parenting skills, and improving parental financial support…
- Conditions
- Parenting, Family Relations, Relationship, Family
- Trial name
- FRAMEWorks (NCT05367102)
- Testing
- Supporting Healthy Relationships program
- Where
- United States
- Volunteers
- 1,022 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pancreatic Cancer, Cancer
Carbon Ion Radiation Therapy for Locally Advanced Pancreatic Cancer
This is a phase I trial to determine the maximum tolerated dose of carbon ion radiotherapy for the treatment of locally advanced, unresectable, pancreatic cancer.
- Trial name
- NCT03403049
- Testing
- Carbon Ion, Gemcitabine + Cisplatin, Gemcitabine + Capecitabine
- Where
- 2 sites in United States, China
- Volunteers
- 14 people
- Sponsor
- Montefiore Medical Center
Non-small Cell Lung Cancer, NSCLC
The Selective Personalized Radio-Immunotherapy for Locally Advanced NSCLC Trial
The goal of this study is to explore if, for locally advanced non-small cell lung cancer patients whose tumors have high levels of PD-L1 (a marker associated with benefits from immunotherapy), a combination of immunotherapy and a…
- Trial name
- SPRINT (NCT03523702)
- Testing
- PembroRT
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Montefiore Medical Center
Head and Neck Neoplasms
Molecular and Genomic Profiling of Head and Neck Tumors
The purpose of this study is to study the genetic profile of head and neck tumors and their relationship to treatment response and outcome
- Trial name
- NCT00200486
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Montefiore Medical Center
Substance Use, Child Abuse
A Regional Partnership to Improve Outcomes Through Fatherhood Engagement
Montefiore will engage fathers in families at risk of substance misuse in the Bronx and neighboring communities. Families will be referred from Bronx and neighboring community-based child welfare systems, substance use disorder…
- Conditions
- Substance Use, Child Abuse, Child Neglect, Fathers
- Trial name
- NCT05562557
- Testing
- Motivational Enhancement, HERO Dads Fatherhood Program, Contingency Management
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Osteosarcoma
Upfront Surgical Resection for Osteosarcoma
The goal of this pilot study is to learn about patients with newly diagnosed osteosarcoma of an extremity, and whether surgically removing the tumor prior to the administration of any chemotherapy will improve functional…
- Trial name
- UFSR for OS (NCT06384404)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Montefiore Medical Center
Acute Myeloid Leukemia, Myelodysplastic Syndrome
FHD-286 With Low-Dose Weekly Decitabine/Venetoclax in Patients With Acute Myeloid Leukemia
This is a Phase 1, uncontrolled, single-arm, open-label, nonrandomized, dose escalation, study of Decitabine (DAC)+Venetoclax (VEN)+FHD-286 in participants with newly diagnosed Acute Myeloid Leukemia (AML) classified as adverse…
- Trial name
- FHD-286 (NCT07283094)
- Testing
- Decitabine, Venetoclax, FHD-286
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Montefiore Medical Center
Chronic Pain, Opioid Use Disorder
Assessing the Efficacy of Self-Driven Repetitive Artmaking Practice
The primary purpose of this study is to assess the acceptability of self-directed art making for people with chronic pain and OUD/opioid misuse, or to state it another way, whether people with chronic pain and OUD/opioid misuse…
- Conditions
- Chronic Pain, Opioid Use Disorder, Opioid Misuse, Opioid-Related Disorders
- Trial name
- NCT06554431
- Testing
- Self-Driven Repetitive Artmaking
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Montefiore Medical Center
Pain, Procedural
Virtual Reality Goggle Utilization for Venipuncture Distraction
This is a randomized non-blinded trial evaluating the effect of virtual reality goggles on perceived pain and anxiety scores during venipuncture on hospitalized children ages 5-21.
- Trial name
- NCT04479735
- Testing
- Virtual Reality Goggles
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Adolescent Idiopathic Scoliosis (AIS), Mental Health
Psychological Assessment of Scoliosis Patients Undergoing Surgical Management
Working in partnership with Montefiore-Einstein's Department of Translational Psychiatry, the investigators have designed a prospective randomized clinical trial (2:1) study for 45 Adolescent Idiopathic Scoliosis (AIS) patients…
- Trial name
- PASS (NCT05774002)
- Testing
- Aims to Decrease Anxiety and Pain Treatment (ADAPT)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Montefiore Medical Center
Breast Cancer
Stereotactic Guided Biopsy and Cryoablation
The purpose of this study is to evaluate a new strategy to treat small breast cancer called cryoablation, or cryosurgery, in combination with biopsy methods which are guided by certain imaging like mammography.
- Trial name
- NCT07439432
- Testing
- Stereotactic Guided Biopsy and Cryoablation
- Sponsor
- Montefiore Medical Center
Mobile Applications, Cancer Patients
Use of a Comprehensive, Mobile Application to Assist Cancer Patients With Diet, Nutrition and Activity
The overarching purpose of this study is to assess whether patients will use the app throughout treatment on a regular basis, as the ultimate goal is to provide an educational platform that can impact patient behaviors and…
- Trial name
- NCT06860425
- Testing
- RestoreMe
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Montefiore Medical Center
Adrenal Insufficiency
Updated Diagnostic Cortisol Values for Adrenal Insufficiency
The purpose of this study is to determine the cortisol levels that most accurately diagnose a patient with adrenal insufficiency, a condition in which cortisol levels are too low for daily living.
- Trial name
- NCT05149638
- Testing
- Cosyntropin stimulation test
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Scarring Due to Treatment
Silicone Gel for Postsurgical Scars of the Eyelid
To determine whether silicone gel is effective at preventing or minimizing scar formation after eyelid surgery.
- Trial name
- NCT03601247
- Testing
- silicone gel
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Non-obstructive Hypertrophic Cardiomyopathy, Hypertrophic Cardiomyopathy
Effect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyopathy
This will be a two-arm investigator-initiated randomized controlled study of patients with nHCM and LV ejection fraction ≥50% and NYHA II-III symptoms, normal intrinsic conduction system and pre-existing suitable dual-chamber…
- Trial name
- PACE-nHCM (NCT06775886)
- Testing
- myPACE+ algorithm
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Montefiore Medical Center
Terminal Illness, Critical Illness
Targeting Bias to Reduce Disparities in End of Life Care
This study aims to determine the ways in which clinician implicit racial biases affect clinician communication with family members of patients near the end of life and to test a novel physician training intervention to reduce the…
- Trial name
- BRiDgE-Sim (NCT05165888)
- Testing
- Communication and Bias Mitigation Training, Communication skills training
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center