Clinical trials: sponsored by NYU Langone Health
Metastatic Clear Cell Renal Cell Carcinoma
Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)
The purpose of this study is to identify changes in Carbonic Anhydrase IX (CAIX) expression induced by hypoxia-inducible factor 2 alpha (HIF-2α) inhibition by initiating belzutifan single agent therapy and imaging CAIX expression…
- Trial name
- NCT07179770
- Testing
- Belzutifan, 89Zr-DFO-girentuximab, 89Zr-DFO-girentuximab PET
- Where
- United States
- Sponsor
- NYU Langone Health
Prostate Adenocarcinoma
SURPASS: Stereotactic Ultra-hypofractionated Radiotherapy for Post-prostatectomy Patients: Adaptive Salvage SBRT
The purpose of the study is to evaluate the safety and feasibility of daily-adaptive post-prostatectomy stereotactic body radiotherapy (SBRT) to the prostate fossa in men undergoing salvage radiotherapy after radical…
- Trial name
- NCT07888283
- Testing
- Adaptive stereotactic body radiotherapy (SBRT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Biliary Track Cancer
Histotripsy in Biliary Tract Cancer
The purpose of this pilot study is to examine the safety and feasibility of histotripsy in two cohorts of 12 patients each with Biliary Track Cancer (BTC), with a plan to expand to a larger multi-center study if both safety and…
- Trial name
- NCT07853690
- Testing
- Gemcitabine, Cisplatin, Durvalumab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NYU Langone Health
Tracheomalacia
Dynamic Airway CT is Diagnostic for Tracheomalacia in Children
The purpose of this pilot interventional study is to evaluate the use of Dynamic Airway Computed Tomography (DA-CT) for diagnosis of tracheomalacia in children 0-18 years for whom flexible bronchoscopy has been performed.
- Trial name
- NCT06028646
- Testing
- Dynamic Airway CT scan (DA-CT)
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Heart Failure, Heart Failure New York Heart Association Class III
Inspiratory Muscle Training in Hospitalized Patients With Heart Failure Awaiting Advanced Therapies
The primary objective of this study is to evaluate the feasibility and safety of inspiratory muscle training (IMT) when implemented as part of routine inpatient physical therapy care in patients undergoing evaluation for advanced…
- Conditions
- Heart Failure, Heart Failure New York Heart Association Class III, Heart Failure New York Heart Association Class IV
- Trial name
- NCT07862738
- Testing
- POWERbreathe KH2, Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor
Osimertinib and Cyclosporine A to Enhance Antitumor Efficacy in NSCLC
This single-site, biomarker-enriched, randomized Phase II study will evaluate osimertinib with or without cyclosporine A (CsA) in metastatic epidermal growth factor receptor (EGFR )-mutant non-small cell lung cancer (NSCLC) [exon…
- Trial name
- OCEAN (NCT07874490)
- Testing
- Osimertinib, Cyclosporine A (CsA), ctDNA Biopsy Panel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Advanced Cancer
Psilocybin Therapy in Advanced Cancer
The purpose of this research is to study the safety and effects of single-dose psilocybin 25mg versus an active placebo (single dose niacin 100mg) in the treatment of anxiety, depression, and existential distress (i.e., loss of…
- Trial name
- NCT05398484
- Testing
- Psilocybin 25 mgs, Niacin 100mg, Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Adenotonsillectomy, Postoperative Pain
Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric Adenotonsillectomy
This is an open-label randomized study of approximately 500 pediatric patients (2-18 years of age, weighing more than 10 kg) undergoing adenotonsillectomy.
- Trial name
- NCT07870447
- Testing
- Celecoxib, Acetaminophen, Dexamethasone
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Metabolic Testing
The Metabolic Response of Unweighted Treadmill Walking
This study will use an experimental quantitative research design. Participants will serve as their own control with a metabolic assessment by open circuit spirometry when walking on the Alter G treadmill for less than ten minutes…
- Trial name
- NCT07870434
- Testing
- AlterG Treadmill, Metabolic Assessment
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pre Diabetes, Weight Loss
Integrated Community-Clinical Linkage Model to Promote Weight Loss Among South Asians With Pre-Diabetes
The study "Integrated Community-Clinical Linkage Model to Promote Weight Loss among South Asians with Pre-Diabetes" is a two-arm randomized control trial that analyzes the implementation and effectiveness of a multi-component…
- Trial name
- NCT03188094
- Testing
- CHW-Led Health Coaching, EHR Alerts
- Where
- United States
- Volunteers
- 974 people
- Sponsor
- NYU Langone Health
Migraine
RELAXaHEAD for Headache Patients (Phase III)
This study is a fully powered, remote randomized control trial to evaluate RELAXaHEAD in people with migraine.
- Trial name
- NCT06077838
- Testing
- RELAXaHEAD Smartphone App Version 1, RELAXaHEAD Smartphone App Version 2
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health
Deafness
Hearing Program in Primary Care
During a primary care visit, investigators will screen and identify participants with hearing loss and then randomize to a) counseling on accessible assistive listening devices or b) referral to traditional audiology care pathway…
- Trial name
- NCT05943509
- Testing
- Alternative rehabilitation strategies, Usual Care
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Food Selection, Food Choices
Influence of Social Media Ads on Food Choice - Master Protocol
This is a Master ClinicalTrials.gov Protocol for study 20-01796: Aim 1: Examining Influence of Social Media Ads on Black and White Adolescents' Food Choices - Study 1 (NCT05380505) Aim 2: A Randomized Trial to Examine the…
- Conditions
- Food Selection, Food Choices, Calorie Consumption
- Trial name
- NCT07249398
- Testing
- Racially Congruent Ads, Racially Incongruent Ads, Black Ads
- Where
- United States
- Volunteers
- 3,650 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Opioid Use Disorder (OUD)
Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)
This is a two phase study investigating combinations of pharmacological and behavioral interventions to optimize the treatment of Opioid Use Disorder (OUD).
- Trial name
- NCT04464980
- Testing
- SL-BUP, XR-BUP, XR-NTX
- Where
- 21 sites in United States
- Volunteers
- 1,516 people
- Sponsor
- NYU Langone Health
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Diabetes Mellitus Type II, Hypertension
Scaling Telehealth Models to Improve Co-morbid Diabetes and Hypertension (Phase II)
The purpose of this study is to test the effectiveness and implementation process of a culturally and contextually tailored telehealth-based community health worker (CHW) led coaching intervention for hypertension control among…
- Trial name
- NCT06542939
- Testing
- Integrated CHW Intervention, CHW Session 1 Only
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health
Lewy Body Disease, Lewy Body Dementia
Visual Hallucinations in Lewy Body Diseases
The goal of this basic experimental study involving humans (BESH) protocol is to improve the understanding of neural mechanisms underlying visual hallucinations in Lewy Body diseases to inform future treatment developments.
- Conditions
- Lewy Body Disease, Lewy Body Dementia, Parkinson Disease, Parkinson Disease Dementia
- Trial name
- NCT07849413
- Testing
- Behavioral Tasks, MRI/MEG Scans
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Muscle-invasive Urothelial Cancer of the Bladder
Pembrolizumab (MK3475), Gemcitabine, and Concurrent Hypofractionated Radiation Therapy for Muscle-Invasive Urothelial Cancer of the Bladder
This trial is to assess the efficacy of pembrolizumab (MK3475) added to concurrent radiation and gemcitabine in the management of patients with muscle-invasive urothelial cancer who are not candidates for or decline radical…
- Trial name
- NCT02621151
- Testing
- Pembrolizumab, Transurethral Resection of Bladder Tumor, Gemcitabine
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI
The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2.
- Trial name
- NCT05615415
- Testing
- PET Tracer, MRI Tracer, 3T PET/MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Glioma
Residual IDH1-Mutant Tumor Cell Quantification Study
This is a single-site, single-arm, prospective, interventional cohort study using intraoperative ultra-rapid droplet digital polymerase chain reaction (UR- ddPCR) to assess residual IDH1-mutant tumor at the end of surgical…
- Trial name
- NCT07219199
- Testing
- UR-ddPCR
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- NYU Langone Health