Clinical trials: sponsored by NYU Langone Health
Pain
MBCT-T for Preoperative Pain Catastrophizing and Pain Outcomes After Spine Surgery
This is a two phase study. In phase 1, a focus group (N=5) will be conducted to adapt MBCT-T for use in the study population. In phase 2, a single-arm trial will be conducted examining four, weekly sessions of preoperative MBCT-T…
- Trial name
- NCT05888025
- Testing
- Telephone-Delivered Mindfulness-based Cognitive Therapy (MBCT-T)
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Oropharyngeal Carcinoma, HPV Positive Oropharyngeal Squamous Cell Carcinoma
Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma
This is a phase II clinical trial. The purpose of this study is to determine the feasibility of deescalating chemoradiation treatment based on mid-treatment tumor response determined by rapid nodal shrinkage and clearance of…
- Trial name
- NCT03215719
- Testing
- Standard Radiation Treatment, Dose-Deescalated Treatment, Cisplatinum
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Fracture Healing
Does Weightbearing Crutch Technology Impact Patient Compliance?
The goal of this study is to determine if weight-bearing crutch technology that delivers active feedback to patients during their treatment will impact patient compliance with physician instructions.
- Trial name
- NCT05825079
- Testing
- Weight-Bearing Feedback, Smart Crutch Tip
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
High-Grade Glioma
Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas
This is an open-label, dose-finding study of XRD-0394 in subjects with newly diagnosed and recurrent high grade gliomas receiving radiation therapy, with and without concurrent temozolomide based on O6-Methylguanine-DNA…
- Trial name
- NCT06829173
- Testing
- XRD-0394, Radiation Therapy, Surgical Resection
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- NYU Langone Health
Acute Respiratory Infection
Decreasing Antibiotic Prescribing in Acute Respiratory Infections Through Nurse Driven Clinical Decision Support
This study evaluates the effects of a novel integrated clinical prediction tool on antibiotic prescription patterns of nurses for acute respiratory infections (ARIs).
- Trial name
- NCT04255303
- Testing
- Integrated clinical prediction rule (iCPR) system (iCPR)
- Where
- 3 sites in United States
- Volunteers
- 347 people
- Sponsor
- NYU Langone Health
SARS-CoV-2 Infection
Understanding the Long-term Impact of COVID on Children and Families
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals age 0-25 years who will enter the cohort with and without SARS-CoV-2 infection at varying stages before and after infection.
- Trial name
- NCT05172011
- Where
- 65 sites in United States
- Volunteers
- 15,028 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Takotsubo Cardiomyopathy, Broken Heart Syndrome
Registry of Patients With Takotsubo Syndrome
Takotsubo syndrome is a condition which mimics acute myocardial infarction, and is diagnosed in 1.5% to 2.2% of patients referred to hospital with suspected acute coronary syndrome.
- Conditions
- Takotsubo Cardiomyopathy, Broken Heart Syndrome, Tako-tsubo Cardiomyopathy
- Trial name
- NCT03663348
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Breast Cancer
Prone Partial Breast Irradiation (PBI): a Prospective Randomized Trial
The purpose of this study is to test whether a radiotherapy regimen of 8 GY x 3 days over 5 days (every other day) is as safe (well-tolerated) and effective as 6 Gy x 5 over five consecutive days
- Trial name
- NCT02276885
- Testing
- PBI Radiotherapy 6 Gy, PBI Radiotherapy 8 Gy
- Where
- United States
- Volunteers
- 284 people
- Sponsor
- NYU Langone Health
Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation
Ladarixin With Sotorasib in Advanced NSCLC
This is a phase I/II, open-label, study of twice-daily oral ladarixin with sotorasib in participants with advanced KRASG12C mutant non-small cell lung cancer (NSCLC).
- Trial name
- NCT05815173
- Testing
- Sotorasib, Ladarixin
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Type2 Diabetes Mellitus
INcreasing the Uptake of DSMES Program and Addressing Social Needs in Low-Income VulneRablE Immigrants
The purpose of this study is to evaluate a multi-level approach to improve diabetes control via access to social service supports and online, culturally-tailored diabetes self-management education and support (DSMES) videos among…
- Trial name
- INSPIRE (NCT07296211)
- Testing
- CHW-enabled CCL, Mobile health (mHealth) diabetes self-management education and support (DSMES) videos
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- NYU Langone Health
Stuttering
Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter
This Phase 2a clinical trial is an open-label, single-group, within-subjects pilot study designed to evaluate the safety, feasibility, and preliminary efficacy of psilocybin as a therapeutic intervention for adults with…
- Trial name
- NCT07296328
- Testing
- Psilocybin, Speech therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Colon Cancer
Use of Text Messaging Reminders to Increase FIT Completion Among Patients at the NYU FHCs
The research team will compare the efficacy of targeted text message reminders against currently used phone call reminders at increasing patient completion of fecal immunochemical test (FIT) for colon cancer screening.
- Trial name
- NCT06632054
- Testing
- Text Message Reminders
- Where
- United States
- Volunteers
- 1,283 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Cancer Screening
NYC Cancer Outreach Network in Neighborhoods for Equity and Community Translation
NYC CONNECT will carry out a randomized controlled trial (RCT) which will assess the relative effectiveness of two evidence-based strategies to increase cancer screening rates for breast, cervical, and colorectal cancer.
- Trial name
- NYC CONNECT (NCT05742178)
- Testing
- Patient Navigation (PN) - More Intensive, Educational Materials, Patient Navigation (PN) - Less Intensive
- Where
- 2 sites in United States
- Volunteers
- 2,160 people
- Sponsor
- NYU Langone Health
Chronic Kidney Diseases, Fatigue
Fatigue Reduction in Chronic Kidney Disease (CKD)
In this pilot trial, investigators will pilot test a cognitive behavioral intervention for acceptability and proof of concept for a larger future trial to be submitted for federal funding.
- Trial name
- NCT06768983
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- NYU Langone Health
Hearing Impairment
Evaluating a Noise Reduction Algorithm With Cochlear Implant Users
In this study, a noise reduction algorithm will be implemented in various listening situations to evaluate its effectiveness in improving speech understanding for cochlear implant users ages 12 and older.
- Trial name
- NCT05805384
- Testing
- SEDA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Chronic Pancreatitis
Predictive Biomarker for Endoscopic Therapy in Chronic Pancreatitis
This is an observational prospective study to develop predictive biomarkers for pain response in participants with chronic pancreatitis scheduled for endoscopic therapy.
- Trial name
- NCT06267365
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Pupillary Response
taVNS on Pupillary Response and Perceptual Learning
This study has two parts. The study team will evaluate transcutaneous auricular vagal nerve stimulation (taVNS) and two sham settings during a passive task while measuring pupillary response.
- Trial name
- NCT05386563
- Testing
- Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation
Subspecialty Ambulatory Quality Cardiology Program
Investigators will evaluate the effectiveness of an audit and feedback performance improvement strategy in which cardiology providers receive quarterly emails on ambulatory quality improvement goals.
- Trial name
- NCT07283666
- Where
- United States
- Volunteers
- 7,000 people
- Sponsor
- NYU Langone Health
SARS-CoV2 Infection
Understanding the Long-term Impact of COVID-19 in Adults (RECOVER)
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals who will enter the cohort with and without SARS-CoV-2 infection and at varying stages before and after infection.
- Trial name
- NCT05172024
- Where
- 86 sites in United States, Puerto Rico
- Volunteers
- 15,172 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Heart Transplantation
Belatacept in De Novo Heart Transplantation
The purpose of this study is to determine if Belatacept is safe to give to adult heart transplant recipients. Belatacept (NULOJIX) is an anti-rejection medication that is available through a prescription from a doctor.
- Trial name
- NCT04477629
- Testing
- Belatacept, Tacrolimus, Mycophenolate Mofetil
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- NYU Langone Health
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