Clinical trials: sponsored by Northwell Health
Ischemic Stroke
Connectomic Alterations Following Acute Ischemic Stroke in the MCA Territory
This study seeks to use safe, powerful, non-invasive computing tools, including machine learning and advanced neuroimaging analysis, to better understand how stroke affects the brain's network of connections.
- Trial name
- NCT07584681
- Testing
- MRI with connectomic sequencing
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Facet Joint Arthropathy, Pain
Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy
This single-site, single-arm study evaluates the feasibility, safety, tolerability, and efficacy of trans-arterial embolization (TAE) using Embozene microparticles for treating facetogenic pain due to facet arthropathy…
- Conditions
- Facet Joint Arthropathy, Pain, Osteoarthritis
- Trial name
- NCT06965452
- Testing
- Spinal angiography and embolization/ Embozene Microspheres
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Pancreatic Cancer
Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Pancreatic Cancer
Predicting drug response offers an opportunity to improve cancer treatment delivery. Recently, microdevices were invented to ascertain in vivo drug response but have not yet been evaluated for pancreatic cancer.
- Trial name
- NCT07254091
- Testing
- Device Arm with Therapeutic Agents
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Neuromodulation
Non-invasive Vagus Nerve Stimulation in Patients Undergoing Electrophysiological Study
The Non-invasive Vagus Nerve Stimulation in Patients Undergoing Electrophysiological Study is a single center, pilot, prospective study that aims at evaluating the effects of auricular vagus nerve stimulation (aVNS) on the human…
- Trial name
- VNS-EPS (NCT05350150)
- Testing
- Auricular Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Cardiac Arrest
Accuracy of Doppler Ultrasound Versus Manual Palpation of Pulse in Cardiac Arrest
The FloPatch FP120 device is indicated for use for the noninvasive assessment of blood flow in the carotid artery. The FloPatch FP120 device uses ultrasound and the Doppler effect to non-invasively assess the flow of flood.
- Trial name
- NCT05558228
- Testing
- FloPatch FP120
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Northwell Health
Schizophrenia, Cerebellar Function
Impact of Cerebellar TMS on Brain and Cognitive Functions in Schizophrenia: a Pilot Study
This is a single-site, sham-controlled, randomized trial in a total of 40 subjects between ages 18 and 60 years with schizophrenia.
- Conditions
- Schizophrenia, Cerebellar Function, Condition
- Trial name
- NCT05389787
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Atrial Fibrillation (AF), Pulmonary Embolism (PE)
Exclusion of Left Atrial Appendage Thrombus in Emergency Department Patients With Atrial Fibrillation Undergoing CT to Assess for Pulmonary Embolus: A Feasibility Study
This study aims to investigate whether a quick, additional CT scan of the heart, performed immediately after a standard CT scan for pulmonary embolism, can effectively detect blood clots in the left atrial appendage (LAA) in…
- Conditions
- Atrial Fibrillation (AF), Pulmonary Embolism (PE), Left Atrial Appendage Thrombosis
- Trial name
- ELATE-AF (NCT07647939)
- Testing
- Delayed Un-gated CT Scan for Left Atrial Appendage Thrombus, Delayed Gated CT Scan for Left Atrial Appendage Thrombus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Epilepsy
An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy
The overall goal of this project is to better understand the micro-physiology of human epilepsy and cognition using the intracranial electroencephalogram (iEEG), electrical brain stimulation, functional magnetic resonance imaging…
- Trial name
- NCT00859794
- Testing
- fMRI, Neuropsychological Testing, Additional electrode implantation
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Northwell Health
Graves Disease, Graves' Disease
Impact of Vitamin D Therapy on Thyroid Function and Antibody Levels in Pediatric Graves' Disease
The goal of this randomized pilot feasibility clinical trial is to determine the feasibility of implementing a protocol for a larger trial to assess the effects of high-dose vitamin D supplementation in pediatric patients (9-17…
- Conditions
- Graves Disease, Graves' Disease, Hyperthyroidism
- Trial name
- NCT07369063
- Testing
- Ergocalciferol 50,000 IU, Methimazole
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Intellectual Disability
Future Planning and Well-Being for Individuals With Intellectual Disabilities and Family Caregivers
This study will compare the effectiveness of a web-based long-term care planning tool (Map Our Life) partnered with traditional case management services to traditional case management services partnered with an attention-control…
- Trial name
- NCT06065527
- Testing
- Map Our Life, Attention Control
- Where
- United States
- Volunteers
- 1,050 people
- Sponsor
- Northwell Health
Vasodilatory Shock
Synthetic Angiotensin II/Giapreza in Pediatric Patients With Refractory Hypotension
The goal of this clinical trial is to determine the safety and efficacy of Angiotensin-II in the treatment of pediatric patients in fluid refractory vasodilatory shock.
- Trial name
- NCT07212686
- Testing
- Angiotensin-II
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Pain
This Study is Comparing Pain Outcomes After Urethral Bulking When Participants Are Randomized to Two Different Pain Medication Regimens.
We are doing this study to find the best way to manage pain during a procedure called urethral bulking. This procedure treats urine leakage that happens with coughing, laughing, sneezing, or physical activity.
- Trial name
- NCT07889687
- Testing
- Lidocaine injection, Gyldo, Saline
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Northwell Health
Growth Disorders, Growth Failure
Randomized Clinical Trial of Two Different Initial Growth Hormone Doses in Children
A prospective, randomized, open-label single-blinded study of 50 subjects with growth hormone deficiency, ages 5 to 15 years in which 25 subjects will initiate rhGH therapy at 0.3mg/kg/week and the remaining 25 subjects will…
- Conditions
- Growth Disorders, Growth Failure, Growth Hormone Treatment, Growth
- Trial name
- NCT06103513
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Acute Kidney Injury, Acute Kidney Injury (AKI)
COordiNated CommuNication, Education, and Care Transitions After Acute Kidney Injury (CONNECT-AKI)
The goal of this clinical trial is to learn whether different ways of providing information and follow-up support after acute kidney injury, also called AKI, can improve care transitions for adults being discharged from the…
- Trial name
- CONNECT-AKI (NCT07626268)
- Testing
- AKI Discharge Summary Template, Chat-Based Educational Messaging Program
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Northwell Health
PreDiabetes, Adolescent Obesity
SMART GOALS for Youth With Prediabetes
The goal of this study is to compare the impact of a SMART ((specific, measurable, attainable, realistic, or timely) Goal setting protocol on body weight, metabolic parameters (Hemoglobin A1c, lipids), diet quality and physical…
- Conditions
- PreDiabetes, Adolescent Obesity, Behavior, Health, Nutritional and Metabolic Diseases
- Trial name
- NCT06067451
- Testing
- SMART GOALS Setting Tool/ Protocol
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Northwell Health
Cardiovascular Risk Factor
Primary Prevention of Cardiovascular Disease Among Female Hospital Employees: The Heart Smart for Women Intervention
This study aims to show that a 6-week program designed specifically for women can lead to sustainable behavior change and improvement in heart disease risk factors over one year among a cohort of 46 female employees recruited…
- Trial name
- Heart Smart (NCT04166097)
- Testing
- Heart Smart Interventional Program
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Northwell Health
Diverticulitis
Developing a Decision Tool for Diverticulitis in the Emergency Department Using Ultrasound
The purpose of this study is to create a decision tool using ultrasound, patient history, and laboratory values to predict a diagnosis of complicated diverticulitis and whether the patient requires further imaging.
- Trial name
- NCT05832242
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 1,125 people
- Sponsor
- Northwell Health
Dystonia Disorder
Impact of rTMS on Abnormal Cortical fMRI in Patients With Dystonia
By tracking resting-state fMRI scans, we aim to discover how repetitive transcranial magnetic stimulation (rTMS) changes brain connectivity in individuals with dystonia.
- Trial name
- NCT07626216
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Atrial Fibrillation (AF)
Prospective Remapping With Concomitant Left Atrial Appendage Occlusion to Ensure Durable Electroporation Study
This is a single-arm, open label, clinical outcome study to research the durability (success) of receiving a pulsed field ablation (PFA) per standard of care for treatment of atrial fibrillation during a subsequent procedure for…
- Trial name
- PRECLUDE (NCT07620262)
- Testing
- Remapping Procedure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Nasal Obstruction, Septal Defect
Does Batten Grafting Improve Nasal Outcomes in Septoplasty and Turbinate Reduction?
The objective of this study is to compare the effectiveness of batten grafts plus septoplasty and turbinate reduction (intervention arm) compared to septoplasty and turbinate reduction alone (control arm), both in terms of…
- Conditions
- Nasal Obstruction, Septal Defect, Allergic Rhinitis, Nasal Polyps
- Trial name
- NCT05287841
- Testing
- Batten batten graft, Septoplasty, Inferior Turbinate Reduction
- Where
- 3 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Northwell Health