Clinical trials: sponsored by Northwell Health
Postoperative Nausea
Aprepitant for Post-operative Nausea
Anesthesia, especially for laparoscopic surgery, can cause post-operative nausea and vomiting. Most patients are given two drugs, decadron and ondansetron, to try to minimize this.
- Trial name
- NCT01020903
- Testing
- Aprepitant
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Northwell Health
Total Knee Replacement
Bone Wax Use for Hemostasis During Primary Unilateral Total Knee Arthroplasty
The purpose of this study is to assess whether the application of bone wax to exposed cancellous bone, after the cemented implants are in place, will provide superior hemostasis in total knee arthroplasty (TKA) patients compared…
- Trial name
- NCT04992052
- Testing
- Bone wax
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Northwell Health
Attenuated Psychosis Syndrome
Fluoxetine vs Aripiprazole Comparative Trial (FACT)
We are conducting a randomized, 24-week, double-blind study, comparing fluoxetine with aripiprazole in 48 patients with attenuated positive symptoms at a level of at least moderate severity.
- Trial name
- FACT (NCT02357849)
- Testing
- Aripiprazole, Fluoxetine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwell Health
Schizophrenia, First Episode Psychosis
Using Digital Media Advertising to Reduce the Duration of Untreated Psychosis
There is compelling evidence that longer duration of untreated psychosis independently predicts negative outcomes. The proposal aims to explore whether targeted and proactive online outreach through search engine advertisements…
- Trial name
- NCT03975400
- Testing
- search engine advertisement campaign
- Where
- 2 sites in United States
- Volunteers
- 698 people
- Sponsor
- Northwell Health
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
The Young Heart Study
The purpose of our project is to better understand the characteristics of the young patients with coronary artery disease presenting for cardiac catheterization at our institution and to put forth a program to optimize their risk…
- Trial name
- NCT04462159
- Testing
- Risk Reduction Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Hypercapnic Respiratory Failure
NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
The goal of this study is to compare two different modes of noninvasive ventilation in hypercapnic respiratory failure. The investigators will compare AVAPS and BIPAP S/T and hypothesize that AVAPS will result in a decreased…
- Trial name
- NCT06047405
- Testing
- Average Volume-Assured Pressure Support (AVAPS), Bilevel Positive Airway Pressure Spontaneous Timed (BIPAP S/T)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwell Health
Alcohol-Related Disorders, Alcohol Drinking
Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home
The purpose of this research study is to develop and test a care model to treat excessive drinking and alcohol use disorders in the primary care setting.
- Conditions
- Alcohol-Related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
- Trial name
- NCT02885311
- Testing
- Motivation Enhancement Therapy, Modified Behavioral Self-Control Therapy, Naltrexone
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Distal Radius Fracture
Randomized Controlled Trial Assessing the Effect of Dexamethasone on Postoperative Function After Distal Radius Fixation
The study is designed to assess the use of intraoperative dexamethasone on postoperative analgesia and stiffness after open reduction and internal fixation of distal radius fractures.
- Trial name
- NCT04889547
- Testing
- Dexamethasone, No dexamethasone
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Northwell Health
ACL Injury
Continuous Vs Single Shot Block After ACL
The investigators will be randomizing patients to either receive an adductor canal block in the operating room postoperatively as single shot of 20-30cc bupivacaine or to have a catheter inserted into the adductor canal which…
- Trial name
- NCT04101682
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Erectile Dysfunction
Changes in Penile Firmness With Low-Intensity Shockwave Therapy (LiST)
Patients presenting with erectile dysfunction are often found to have increased corporal firmness on elastography. We hypothesize that this corporal firmness reflects reversable changes that can be altered by Low-Intensity…
- Trial name
- NCT05756803
- Testing
- Low-intensity acoustic shockwave therapy
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Rhytides
Effective OnabotulinumtoxinA Dose Response Study for Upper Facial Wrinkles
This research is being done to determine if lower doses of botox than what is currently recommended can give similar results to patients, at lower cost and lower risk to them.
- Trial name
- NCT04994990
- Testing
- OnabotulinumtoxinA Standard Dose, OnabotulinumtoxinA Half Standard Dose
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Type 2 Diabetes Mellitus, Type 2 Diabetes
Diabetes Management Program for Hispanic/Latino
To compare Diabetes Telemonitoring to comprehensive outpatient management (COM) on critical patient-centered outcomes, including HbA1c.
- Trial name
- NCT03960424
- Testing
- Comprehensive Outpatient Management, Diabetes Telemonitoring
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Northwell Health
Infertility, Diminished Ovarian Reserve
The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol
Ovarian reserve defines the quantity and quality of the ovarian primordial follicular pool. Diminished ovarian reserve (DOR) indicates a reduction in the quantity of ovarian follicular pool to less than expected for age.
- Conditions
- Infertility, Diminished Ovarian Reserve, IVF
- Trial name
- NCT04447872
- Testing
- Timing of injectable gonadotropins
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Northwell Health
Healthy Volunteers, Spinal Cord Injury Cervical
Evaluating Neuromuscular Stimulation for Restoring Hand Movements
The specific aim of this study is to evoke functional movement in the hand of both healthy individuals and individuals diagnosed with a stable cervical spinal cord injury with non-functional movement of the fingers.
- Conditions
- Healthy Volunteers, Spinal Cord Injury Cervical, Physical and Rehabilitation Medicine
- Trial name
- NCT03385005
- Testing
- Participants will receive neuromuscular electrical stimulation via an investigational (not FDA approved) neuromuscular stimulator.
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
HIV Infection Primary
Assessing Differential Adherence to Medications and Quality of Life Among People Living With HIV and Comorbidities
The investigators propose to utilize quantitative and qualitative methodology to better understand the impact of multiple drug use (polypharmacy) on medication adherence as well as the driving forces behind differential adherence…
- Trial name
- TEAMH (NCT03387397)
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Schizophrenia, Schizo Affective Disorder
Financial Incentives to Improve Medication Adherence
Medication adherence is a challenge in all of medicine and is associated with multiple negative outcomes. Strategies to better measure and enhance adherence to medication are urgent and necessary to minimize unwanted health…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Bipolar Disorder, Depression
- Trial name
- NCT04191876
- Testing
- Wellth - Financial Incentives
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Respiratory Insufficiency
Music Therapy During Pediatric Extubation Readiness Trials
This study seeks to research the effects of music therapy during pediatric extubation readiness trials. Amount of sedation, physiological measures, and parent/staff satisfaction surveys will be measured.
- Trial name
- MTPERT (NCT02845947)
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwell Health
Kidney Stones
Trial of Randomized Antibiotic Administration in Percutaneous Nephrolithotomy
The Investigators objective is to compare the clinical efficacy of a single-day protocol with a short-course protocol for PCNL. The investigator hope is to reduce the use of possibly unnecessary prolonged antibiotic use, reduce…
- Trial name
- NCT02579161
- Testing
- cephalosporins, Fluoroquinolones, Clindamycin
- Where
- 2 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Covid19
Randomized Open Investigation Determining Steroid Dose
Dexamethasone has been approved for the treatment of severe COVID-19, but higher doses of steroids may be more effective. The purpose of this research study is to compare the current standard dose of dexamethasone 6 mg to a…
- Trial name
- ROIDS-Dose (NCT04834375)
- Testing
- Weight-based dexamethasone dose
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Northwell Health
Pregnancy Complications, Ultrasound Therapy; Complications
Lung Ultrasound Patterns Preeclampsia
Evaluation of lung ultrasound as a diagnostic tool in pregnant patients.
- Conditions
- Pregnancy Complications, Ultrasound Therapy; Complications, Pulmonary Disease, Pulmonary Edema
- Trial name
- NCT03576092
- Testing
- Lung Ultrasound
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Northwell Health