Clinical trials: sponsored by Northwell Health
Obstetric Complication
Maternal Positioning to Correct Fetal Occiput Posterior
In evaluating a patient's ability to have a normal vaginal delivery, a practitioner must consider three factors. Commonly referred to as the three P's, these include Power (contractions), Passage (pelvis and soft tissue) and…
- Trial name
- NCT05307393
- Testing
- Positioning
- Where
- United States
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pneumoperitoneum
Warm and Humidified vs Cold and Dry Carbon Dioxide (CO2) Pneumoperitoneum
Laparoscopic surgery (surgery with the use of a camera and small instruments) uses insufflation, which is the standard medical practice where CO2 (carbon dioxide) gas is blown into the abdomen to create space for surgical…
- Trial name
- NCT03330067
- Testing
- Cold and dry CO2 pneumoperitoneum, Warm and humidified CO2 pneumoperitoneum
- Where
- United States
- Sponsor
- Northwell Health
Systemic Lupus Erythematosus
Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus
Cognitive impairment occurs in as many as 80% of lupus patients and affective disorders, depression and anxiety, are also common. Both of these problems contribute significantly to disease burden and disability.
- Trial name
- NCT02456168
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Surgical Blood Loss
To Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer in Primary Unilateral Total Knee Arthroplasty
The purpose of this study is to investigate whether the saline-coupled bipolar sealer compared to the unipolar electrocautery provides superior hemostasis in patients undergoing primary unilateral total knee arthroplasty.
- Trial name
- NCT03952546
- Testing
- Saline-coupled Bipolar Sealer, Unipolar electrocautery
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Focal Epilepsy, Intractable Epilepsy
Long-term Cardiac Monitoring in Epilepsy
The purpose of this research study to investigate, classify, and quantify chronic cardiac rhythm disorders in three groups of patients with epilepsy (intractable focal epilepsy, controlled focal epilepsy and symptomatic…
- Conditions
- Focal Epilepsy, Intractable Epilepsy, Epileptic Encephalopathy, Lennox Gastaut Syndrome
- Trial name
- LOOP (NCT03955432)
- Testing
- Reveal LINQ ICM System
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Northwell Health
Fatigue
Feasibility of Light Therapy for Fatigue N-of-1 Trials
This Personalized Trial will test the feasibility and effectiveness of employing technology to facilitate remote N-of-1 interventions to research participants with self-identified fatigue.
- Trial name
- NCT04707846
- Testing
- Bright Blue Light Commercial AYO Light Therapy Device, Dim Blue Light Commercial AYO Light Therapy Device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Covid19
Workforce Serosurveillance to Track Long-term Modifications to COVID-19 Exposure Due to Factors in the Built Environment
The goal, with this study, is to leverage Northwell Health System's diverse workforce and robust testing structures, to contribute data-driven, evidence-based strategies to better understand the sustained prevalence of antibodies…
- Trial name
- NCT04542200
- Testing
- Antibody testing
- Where
- United States
- Volunteers
- 40,132 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Radiation Exposure
Comparison Of Effective Radiation Shielding Between Rampart IC, M1128 Shield vs Conventional Apron And Shields In Clinical Interventional Procedures
Previous studies have documented that orthopedic injuries and musculoskeletal pain are a likely result of wearing heavy leaded aprons.
- Trial name
- RAMPART (NCT05347290)
- Testing
- Rampart IC, M1128, Lead Apron and Ancillary Shield, Rampart IC, M1128 and Lead Apron
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Stress Urinary Incontinence, Patient Satisfaction
Postoperative Activity Restrictions After Slings
Postoperative restrictions are often based on expert opinion and "common sense". There is a wide variety in the recommended activity limitation amongst pelvic floor surgeons.
- Conditions
- Stress Urinary Incontinence, Patient Satisfaction, Surgery
- Trial name
- PARS (NCT04552457)
- Testing
- No activity restrictions, Activity restrictions
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Sedentary Behavior
Behavior Change Techniques (BCTs) to Improve Low Intensity Physical Activity in Older Adults
The purpose of this pilot study is to determine the feasibility of using personalized trial methods in a virtual research study with Northwell employees aged 45-75 years old to increase low-intensity walking by 2,000 steps per…
- Trial name
- NCT04967313
- Testing
- Behavioral Change Techniques
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Knee Osteoarthritis, CBD
The Use of Cannabinoid Patch for Knee Osteoarthritis
This randomized, double-blind 2-arm parallel group study to determine the efficacy of a cannabinoid (CBD) patch on reducing pain in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, CBD, Osteoarthritis
- Trial name
- NCT04412837
- Testing
- Topical CBD Patch
- Where
- United States
- Sponsor
- Northwell Health
Alzheimer's Disease and Related Dementias
Reducing Behavioral and Psychological Symptoms of Dementia: Family Caregivers (Aim 1)
Persons with Alzheimer's Disease and Related Dementias (ADRD) account for 3.2 million hospital admissions per year and have over three times more hospitalizations than those without cognitive impairment, yet hospital caregivers…
- Trial name
- NCT04481568
- Testing
- PES-4-BPSD Model, The attention control condition
- Where
- 2 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Respiratory Failure, Shock
Comparing Post Cardiac Surgery Outcomes in ESRD Patient's With Early Dialysis Versus Standard Care
End-stage renal disease (ESRD) is an important risk factor for coronary and valvular cardiac disease leading to cardiac surgery.
- Conditions
- Respiratory Failure, Shock, Coagulopathy
- Trial name
- NCT04705701
- Testing
- Hemodialysis
- Sponsor
- Northwell Health
Vagus Nerve Stimulation
Effect of Transcutaneous Electrical Auricular Stimulation of the Vagus Nerve in Kidney Transplant Recipients
Kidney transplantation entails the implantation of a live or deceased organ into a recipient. As a result of this event, there is an inflammatory response in the recipient elicited by the transplanted organ.
- Trial name
- VNS-KTx (NCT04256837)
- Testing
- Transcutaneous electrical auricular vagus nerve stimulation (VNS)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Northwell Health
COVID -19, Respiratory Failure
Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.
To determine whether the use of oxygen hoods as compared to conventional high-flow oxygen delivery systems, and the effects on oxygenation, mechanical ventilation and mortality rates in hypoxic patients with COVID-19.
- Conditions
- COVID -19, Respiratory Failure, Hypoxia
- Trial name
- NCT04407260
- Testing
- Oxygen Hood
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Northwell Health
Diamond Blackfan Anemia, Blackfan Diamond Syndrome
Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia
This study will determine the safety and possibility of giving the amino acid, leucine, in patients with Diamond Blackfan anemia(DBA)who are on dependent on red blood cell transfusions.
- Conditions
- Diamond Blackfan Anemia, Blackfan Diamond Syndrome, DBA, Congenital Hypoplastic Anemia
- Trial name
- LeucineDBA (NCT01362595)
- Testing
- leucine
- Where
- 11 sites in United States
- Volunteers
- 55 people
- Sponsor
- Northwell Health
Sedentary Behavior, Aging
A Trial of Habit Formation Theory for Exercise in Older Adults
This personalized trial will evaluate the effects of five behavioral change techniques (BCTs) described in Habit Formation Theory (Goal setting, Action Planning, Self-Monitoring, Behavioral Practice/Rehearsal and Habit Formation)…
- Conditions
- Sedentary Behavior, Aging, Activity, Motor, Behavior, Health
- Trial name
- NCT04869644
- Testing
- Goal setting, Action Planning, Self-monitoring of behavior
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Postoperative Pain, IVF
Oral Versus Intravenous Acetaminophen for Postoperative Pain Control
The investigators are going to study the difference in postoperative pain control after administration of oral versus intravenous formulation of acetaminophen
- Trial name
- NCT04662567
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Northwell Health
Pilonidal Disease, Pilonidal Cyst/Fistula
MIPE for Pilonidal Disease
Pilonidal disease often presents as a chronic, relapsing condition. A variety of procedures are used in the management of pilonidal disease, with varying degrees of morbidity, disease-free interval, and long-term success.
- Conditions
- Pilonidal Disease, Pilonidal Cyst/Fistula, Pilonidal Sinus Without Abscess, Pilonidal Cyst Without Abscess
- Trial name
- NCT03772873
- Testing
- minimally invasive pilonidal excision
- Where
- 10 sites in United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Total Knee Replacement
Use of the DJO Brace With the Motion Intelligence Platform in the Postoperative Total Knee Arthroplasty Patient
This is a single center, investigator initiated clinical trial using a FDA approved, marketed brace called DJO X4. This phase 4, prospective, randomized clinical trial is being conducted to evaluate the use of the X4 knee brace…
- Trial name
- NCT04655703
- Testing
- DJO X4 brace with Motion Intelligence Platform
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwell Health