Clinical trials: sponsored by Northwell Health
Obsessive-Compulsive Disorder (OCD)
DBS for Obsessive-Compulsive Disorder
There are two primary approaches to the treatment of OCD, pharmacotherapy and cognitive behavior therapy (CBT). Lack of therapeutic success with one approach leads to trials of the alternative approach or a combination of the…
- Trial name
- DBS (NCT02773082)
- Testing
- Reclaim™ DBS Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Colon Resection
Regular Diet Versus Extended Low Residue After Colon Surgery
The goal of this clinical trial is to learn if a 10 day low-residue diet restriction is better for bowel function and quality of life without increasing complications compared to a 6 week low-residue diet restriction after…
- Trial name
- NCT07083076
- Testing
- Short term (10 day) low residue diet restriction, 6 week low residue diet restriction
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- Northwell Health
Urinary Tract Infection(UTI), Recurrent Urinary Tract Infections
Emotional Urinary Tract Infection
This project proposes a rigorous investigation into the psychological impact of positive urine culture results and recurrent urinary tract infections (UTIs) in women, with a particular focus on Interstitial Cystitis and Bladder…
- Trial name
- UTI (NCT07191041)
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Northwell Health
Thyroid Nodule
Radiofrequency Ablation Study in LatinX Patients
Benign thyroid nodules can still create cosmetic, compressive, or hormonal issues for patients. In the past, surgery was typically used to treat thyroid nodules causing the above issues through partial or complete thyroidectomy.
- Trial name
- NCT05903196
- Testing
- Mygen V-1000 RF system
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Northwell Health
Cervical Dysplasia, Cervical Cancer
Circulating Human Papilloma Virus (HPV) DNA for the Screening and Surveillance of Gynecologic Cancers
Human papilloma virus-related gynecologic malignancies affect over 20,000 women in the United States, and over half a million women globally each year.
- Trial name
- NCT05606133
- Testing
- NavDx(R)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwell Health
Systemic Lupus Erythematosus
Centrally Acting ACE Inhibition in SLE
SLE is a chronic autoimmune disease that often involves multiple systems and organs of the body. An autoimmune disease is one which your immune system attacks the cells and tissues in different parts of the body.
- Trial name
- NCT04486118
- Testing
- Lisinopril Pills, Benazepril Pill
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Northwell Health
Atrial Fibrillation, Supraventricular Arrhythmia
Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors
This study will enroll patients initiating Bruton Tyrosine Kinase (BTK) inhibitors without history of documented arrhythmia while on therapy using the Medtronic LINQ-2 insertable cardiac monitor (ILR).
- Conditions
- Atrial Fibrillation, Supraventricular Arrhythmia, Ventricular Arrhythmias and Cardiac Arrest, Chronic Lymphocytic Leukemia
- Trial name
- NCT05643235
- Testing
- Medtronic LINQ-2 Insertable Cardiac Monitor (ILR)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Endometrial Cancer, Papillary Serous Endometrial Carcinoma
Trial of Maintenance With Niraparib- Uterine Serous Carcinoma
Uterine serous carcinoma (USC) accounts for up to 40% of endometrial cancer-related deaths. Patients with USC share many genomic and clinical characteristics with patients who has serous ovarian cancer.
- Conditions
- Endometrial Cancer, Papillary Serous Endometrial Carcinoma, Uterine Serous Carcinoma, Endometrial Carcinoma
- Trial name
- NCT04080284
- Testing
- Niraparib
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Northwell Health
Normal Tension Glaucoma, Obstructive Sleep Apnea
Obstructive Sleep Apnea as a Risk Factor for Normal Tension Glaucoma and a Crucial Step in Preventing Blindness
The purpose of this research study is to learn more about the relationship between Obstructive Sleep Apnea (OSA) and Normal Tension Glaucoma (NTG).
- Trial name
- NCT06023927
- Testing
- Clinical observation, diagnostic testing
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Northwell Health
Joint Infection
Rate of Total Joint Infection 90-day After Surgery Following Irrigation With Next Science No-Rinse Solution vs SOC Alone
A prospective, single-site, double-arm, parallel, interventional, randomized, controlled clinical trial to assess 90-day rate of joint infections in subjects undergoing primary hip replacements after administration of Next…
- Trial name
- NCT05519007
- Testing
- No-Rinse Solution (NS), Saline irrigation
- Where
- 3 sites in United States
- Volunteers
- 936 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Total Hip Arthroplasty, Total Knee Arthroplasty
Clinical Evaluation of the Next Science SurgX Antimicrobial Wound Gel Impact on Surgical Site Complications
This is a single-site, prospective, clinical study of subjects that are scheduled to undergo either total hip or total knee arthroplasties.
- Trial name
- NCT05517278
- Testing
- SurgX Antimicrobial Wound Gel, Standard of Care
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
ADHD
Cognitive-Behavioral Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in College Students - Study 1
College students with ADHD have significant difficulty effectively managing their time, organizing, planning, and completing their academic work.
- Trial name
- ADHD (NCT05588505)
- Testing
- Cognitive-Behavioral Therapy Targeting Executive Dysfunction in College Students with ADHD
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Northwell Health
Benign Prostatic Hyperplasia
Catheterless Water Vapor Therapy for the Treatment of BPH
The Rezum system is an ablative procedure for patients with benign prostatic hyperplasia (BPH). One of the limitations of the technology is the need for post-operative catheterization up to 5 days.
- Trial name
- NCT04997369
- Testing
- Rezum
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwell Health
Rotator Cuff Tears, Rotator Cuff Tendinitis
Use of Extended Release Triamcinolone in the Treatment of Rotator Cuff Disease
The primary objective of this study is to assess the overall safety and general tolerability of extended release triamcinolone acetate (TA-ER/FX006) in patient with rotator cuff disease.
- Conditions
- Rotator Cuff Tears, Rotator Cuff Tendinitis, Rotator Cuff Impingement, Injections
- Trial name
- NCT04094298
- Testing
- FX006 Injection
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Northwell Health
Constipation, Post-Op Complication
Does a Preoperative Bowel Regimen Change Time to First Bowel Movement After Robotic Sacral Colpopexy
The hypothesis is that starting a bowel regimen with Polyethylene Glycol prior to robotic assisted sacrocolpopexy will decrease time to first bowel movement after surgery.
- Trial name
- NCT04197869
- Testing
- Polyethylene Glycol Powder
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Mitral Valve Prolapse
Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse
This is a qualitative and quantitative study that seeks to obtain information from patients with degenerative mitral valve prolapse and providers regarding factors important in deciding between surgical mitral valve repair (MVR)…
- Trial name
- PRIMARY SDM (NCT06738537)
- Testing
- Focus Groups/Quantitative Survey for Patients, Focus Group/Quantitative Survey for HCPs, Qualitative Focus Group
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Northwell Health
Pain, Postoperative
Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy
Obtaining Likest-pain scale score on postoperative day one after injection of local anesthetic into incision sites of a laparoscopic/robotic-assisted sacrocolpopexy
- Trial name
- CLAPPS (NCT04996251)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Laboring Women
The Effect of the Use of Peanut Ball on Labor Time in Nulliparous Women
Peanut ball use has become popular with midwives and nurses because it is an inexpensive, nonpharmacological intervention that can help with positioning the patient to decrease labor time.
- Trial name
- NCT04998149
- Testing
- Peanut Ball positioning device
- Where
- 4 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Medication Adherence
A BCT Intervention for Medication Adherence Among Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of medication adherence among participants on primary prevention statin…
- Trial name
- NCT05273736
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pulmonary Embolism, Pulmonary Hypertension
Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE
To determine whether peripheral low dose systemic thrombolysis (PLST) is non-inferior to catheter directed acoustic pulse thrombolysis (ACDT) in improving RV function and reducing pulmonary artery pressures in submassive…
- Conditions
- Pulmonary Embolism, Pulmonary Hypertension, Thromboembolism, Right Ventricular Dysfunction
- Trial name
- NCT03581877
- Testing
- Alteplase, EKOS
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health