Clinical trials: open to volunteers, sponsored by Northwestern University
Inguinal Hernia
Permanent Versus Slowly Dissolving Stitches for Non-Mesh (Shouldice) Groin Hernia Repair
The goal of this clinical trial is to learn whether slowly dissolving stitches work as well as permanent stitches for repairing a groin (inguinal) hernia in adults using the Shouldice technique, a hernia repair that does not use…
- Trial name
- NCT07883122
- Testing
- Polypropylene suture (Prolene), Polydioxanone suture (PDS)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Umbilical Hernia, Ventral Hernia
Duramesh Versus Minimally Invasive IPOM for High-Risk Umbilical Hernia Repairs
Umbilical hernias are common, and repair with mesh lowers the risk of the hernia coming back compared with stitches alone. Most evidence comes from lower-risk patients.
- Trial name
- NCT07881354
- Testing
- Duramesh, Mesh
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Northwestern University
Hypertension
A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure Control
Exercise is known to prevent nearly one in three cases of hypertension and slow its progression in young adults, but we do not know which specific exercise types are most effective.
- Trial name
- MOVE-BP (NCT07915752)
- Testing
- Core intervention (Fitbit tracking and BP health education), Aerobic training (AT), Dynamic resistance training (DRT)
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- Northwestern University
Inguinal Hernia Bilateral, Inguinal Hernia Unilateral
Watchful Waiting Versus Immediate Repair for Occult Contralateral Inguinal Hernias.
This study will compare two ways of managing a small, hidden hernia that can sometimes be found during minimally invasive surgery to repair a hernia on one side of the groin.
- Trial name
- WATCH IT (NCT07461558)
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, Watchful waiting with supportive care
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Northwestern University
Obesity, Smoking Cessation
Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors
The goal of this clinical trial is to improve cancer patient's health, survival, and quality of life by dispelling risk behaviors for Northwestern Memorial Health Care (NMHC) patients who are cancer survivors.
- Conditions
- Obesity, Smoking Cessation, Physical Inactivity
- Trial name
- STELLAR (NCT05687604)
- Testing
- multiple behavior change therapy
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Northwestern University
Familial Hypercholesterolemia
Penn Family Screening for Familial Hypercholesterolemia (NHLBI R33) Trial 3
The goal of this clinical trial is to test two implementation strategies (digital strategy vs. care navigator strategy) to promote family cascade screening for familial hypercholesterolemia (FH) in Penn Medicine patients…
- Trial name
- NCT07919353
- Testing
- Cascade Screening
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Northwestern University
Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury
Valproic AcId for Traumatic BRAin INjury Trial
The long-term goal of the clinical trial is to develop effective, safe, and easily administered life-saving treatments for patients with moderate to severe traumatic brain injury (TBI).
- Trial name
- VIBRANT (NCT07166393)
- Testing
- Valproic Acid (VPA), Standard of care treatment + normal saline
- Where
- 9 sites in United States
- Volunteers
- 432 people
- Sponsor
- Northwestern University
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants
This is a phase 1 trial, 36 month duration for subjects with end-stage renal disease (ESRD). The objectives of the trail are1) Determine the safety of ECP-DL cell infusion in living donor renal transplant recipients.
- Trial name
- ECP (NCT07083830)
- Testing
- ECP-DL treated mononuclear cell infusion
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Acute Lymphobkastic Leukemia, Medication Adherence
The AYA Oncology Self-care Movement
This trial will test the impact of a social media intervention for improving oral chemotherapy adherence among adolescents and young adults (AYAs) with acute lymphoblastic leukemia.
- Trial name
- #AYAOSM (NCT07724652)
- Testing
- Educational Website, #AYAOSM
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Hematologic Malignancy, Stem Cell Transplant
Mosaic Trial for Stem Cell Transplant Recipients
The goal of this clinical trial is to learn if using an intervention website (Mosaic) improves selected patient-reported outcomes in adult blood cancer patients undergoing allogeneic or autologous stem cell transplant, compared…
- Conditions
- Hematologic Malignancy, Stem Cell Transplant, Bone Marrow Transplant, Leukemia
- Trial name
- Mosaic (NCT06960993)
- Testing
- Intervention website, Enhanced Usual Care (Control) Website
- Where
- 3 sites in United States
- Volunteers
- 356 people
- Sponsor
- Northwestern University
Cutaneous T Cell Lymphoma
Characterization of the Microbiome in Cutaneous T Cell Lymphoma
Investigators plan to perform a pilot study that aims to characterize the microbiome of human cutaneous T cell lymphoma patients and compare this to the microbiome of age and sex matched controls.
- Trial name
- NCT03932279
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma
SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial
This phase II trial tests the impact of using SMAD4-mutant status to personalize chemotherapy in treating patients with pancreatic ductal adenocarcinoma (PDAC) that can be removed by surgery (resectable) or that may be between…
- Trial name
- NCT07748611
- Testing
- Biospecimen Collection, Computed Tomography, Electronic Health Record Review
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Northwestern University
Pain, Chronic
VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain
This study will examine the impact of virtual reality used in conjunction with sedation compared to sedation alone in patients undergoing watervcooled genicular nerve ablations for chronic knee pain.
- Trial name
- NCT06336447
- Testing
- Experimental: Group #1: Virtual Reality Headset, Group 2 No Virtual Reality Headset
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Northwestern University
Anxiety
Impact of Virtual Reality on Anxiety in Patients Undergoing Interventional Procedures
Periprocedural anxiety is a common problem for patients who undergo interventional pain procedures. Virtual Reality (VR) is an immersive experience that has gained acceptance in the medical field as a tool for reducing anxiety…
- Trial name
- NCT05744336
- Testing
- Group 1 Immersive Virtual Reality (VR), Group 2 Control Group
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Northwestern University
Alzheimer's Disease (AD), Dementia
Negotiation Training for Family Caregivers of People With Alzheimer's Disease
Family caregivers of people living with Alzheimer's disease and related dementias often experience conflicts and communication challenges when coordinating care, making decisions, and interacting with family members and…
- Conditions
- Alzheimer's Disease (AD), Dementia, Cognitive Impairment
- Trial name
- NCT07859540
- Testing
- NegotiAge, PlanYourLifespan
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Healthy Adult, Flushing
ALDH2 Genetic Testing in East Asian Community
The goal of this clinical trial is to learn whether education plus genetic testing for ALDH2*2 and ADH1B*2 is feasible and acceptable and whether it influences modifiable health behaviors in East Asian American adults who…
- Trial name
- NCT07392775
- Testing
- Genetic Test Results Return, Alcohol Flushing Education
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Lung Carcinoma, Lung Non-Small Cell Carcinoma
Using an Artificial Intelligence Software Tool (iSeg) During Radiation Treatment Planning for Patients With Lung Tumors
This clinical trial studies whether an artificial intelligence (AI) software tool called iSeg can be safely and effectively used during routine radiation treatment planning for patients with lung tumors.
- Conditions
- Lung Carcinoma, Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Lung
- Trial name
- NCT07898241
- Testing
- Artificial Intelligence-based Intervention, Best Practice, Computed Tomography
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Northwestern University
Ulcerative Colitis
Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)
Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue…
- Trial name
- HBOT-UC (NCT05987852)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 13 sites in United States
- Volunteers
- 126 people
- Sponsor
- Northwestern University
Perinatal Mental Health, Fathers
Fathers and Babies (FAB) Research Study
The purpose of this study is to examine the effectiveness of the Fathers and Babies intervention (FAB). FAB aims to improve the mental health of fathers and provide strategies that help fathers support the mental health of their…
- Conditions
- Perinatal Mental Health, Fathers, Stress Management
- Trial name
- NCT07893210
- Testing
- Fathers and Babies Program, Mothers and Babies Program
- Where
- United States
- Volunteers
- 624 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Developmental Delays
Empower EI: Comparing Early Intervention Approaches to Improve Communication in Toddlers With Developmental Delays
This study is testing three ways to deliver Early Intervention (EI) services for toddlers with developmental disabilities (DD). Children enrolled in EI speech therapy will receive one of three approaches: 1.
- Trial name
- NCT07227974
- Testing
- Therapist-Delivered Early Intervention Approach, Caregiver Coaching Early Intervention Approach, Parents Taking Action
- Where
- United States
- Volunteers
- 1,269 people
- Sponsor
- Northwestern University