Clinical trials: sponsored by Odense University Hospital
Colon Cancer
CME Versus Standard Right Hemicolectomy for Right Sided Cancers
Our aim of this study is to compare the difference in lymph node yield in CME specimens versus those patients having a standard right hemicolectomy for right sided cancer .The secondary aim of this study was to investigate…
- Trial name
- NCT05230329
- Testing
- right sided hemicolectomy, laparoscopy
- Where
- Denmark
- Volunteers
- 330 people
- Sponsor
- Odense University Hospital
Polycystic Ovary Syndrome, Gestational Diabetes Mellitus
Screening for GDM in Women With PCOS and Controls
Women with polycystic ovary syndrome (PCOS) are often insulin resistant. During pregnancy, insulin sensitivity decreases. The investigators examine glucose metabolism during oral glucose tolerance test and the incidense of…
- Trial name
- NCT02183558
- Testing
- OGTT by randomization, OGTT by indication
- Where
- Denmark
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Endoscopy, Simulation
Using Simulation to Ensure Basic Competence in Gastroscopy
The main purpose of this study is to develop and gather validity evidence for a simulation-based test to ensure learning basic competence in gastroscopy.
- Conditions
- Endoscopy, Simulation, Education, Gastroscopy
- Trial name
- NCT04150237
- Testing
- Simulation training in gastroscopy
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Odense University Hospital
Polydactyly Toe, Thumb Hypoplasia
Clonidine for Tourniquet-related Pain in Children
This study is designed as a randomized, placebo-controlled, double-blinded, clinical trial with two parallel groups. This study investigates the association between a single dose of the drug, Clonidine, and the total amount of…
- Conditions
- Polydactyly Toe, Thumb Hypoplasia, Trigger Finger, Polydactyly; Fingers
- Trial name
- CLOTCH (NCT04564430)
- Testing
- Catapresan, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Incomplete Colonoscopy, CT Colonography
Patients With Incomplete Colonoscopy a Comparison of Colon Capsule Endoscopy and CT Colonography
A total of 8000 colonoscopies are performed on a yearly basis on the Funen Island. Between 5% and 10% of those are incomplete due to excessive pain, fixed colon loops, and other reasons.
- Conditions
- Incomplete Colonoscopy, CT Colonography, Camera Capsule Endoscopy
- Trial name
- CfC100 (NCT02826993)
- Testing
- CCE in incomplete Colonoscopies
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Disorder Related to Renal Transplantation
The Effects of Spironolactone on Calcineurin Inhibitor Induced Nephrotoxicity
The purpose of this study is to assess whether the diuretic drug spironolactone can prevent chronic damage to transplanted kidneys caused by the medication that prevents rejection.
- Trial name
- SPIREN (NCT01602861)
- Testing
- Spironolactone
- Where
- Denmark
- Volunteers
- 188 people
- Sponsor
- Odense University Hospital
Aortic Valve Stenosis, Valvular Stenosis
Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis
When aortic valve-area is <1.0cm2 and transvalvular mean-gradient is >40mmHg, the diagnosis of severe aortic stenosis (AS) is straightforward.
- Conditions
- Aortic Valve Stenosis, Valvular Stenosis, Valvular Heart Disease
- Trial name
- DALLAS (NCT05015829)
- Testing
- Dobutamine Stress Echocardiography
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Odense University Hospital
Chronic Heart Failure
Are Carvedilol and Metoprolol Succinate Comparable Treatments in Heart Failure Patients With Reduced Ejection Fraction
The objective of CROWD-COMPARE is to compare the efficacy of carvedilol and metoprolol succinate on all-cause mortality or first hospitalization for worsening heart failure in patients with heart failure with reduced ejection…
- Trial name
- CROWD-COMPARE (NCT04996550)
- Testing
- Carvedilol, Metoprolol Succinate
- Where
- Denmark
- Volunteers
- 5,600 people
- Sponsor
- Odense University Hospital
Rectal Cancer
Robotic vs. TaTME Rectal Surgery (ROTA STUDY)
Background Recent novel surgical techniques for resection of low rectal cancer have been introduced and these approaches have the potential to overcome anatomical limitations like obesity, narrow male pelvis and bulky and low…
- Trial name
- ROTA (NCT04200027)
- Testing
- total mesorectal excision
- Where
- 2 sites in Denmark, United Kingdom
- Volunteers
- 330 people
- Sponsor
- Odense University Hospital
Cancer
COVID-19 Pandemic Impact on Patients With Cancer - a Danish Survey
The outbreak of coronavirus was categorized as a global pandemic in March 2020. The Danish government recommends social distancing during the COVID-19 pandemic.
- Trial name
- COPICADS (NCT04389996)
- Testing
- No intervention
- Where
- 2 sites in Denmark
- Volunteers
- 6,810 people
- Sponsor
- Odense University Hospital
Cardiac Arrest With Successful Resuscitation
Rehabilitation for Survivors of Cardiac Arrest Focused on Fatigue
More people are surviving a cardiac arrest due to improvements in bystander resuscitation and acute hospital care. However, many survivors of cardiac arrest are left with physical, mental and social problems impacting negatively…
- Trial name
- SCARF (NCT04114773)
- Testing
- SCARF (Survivors of Cardiac Arrest Rehabilitation focused on Fatigue)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital
Thromboembolism, Lung Cancer
Coagulation System In STereotactic Radiotherapy Of NSCLC
The risk of thromboembolism is elevated in lung cancer patients. The present project investigates whether stereotactic body radiation therapy (SBRT) further increases the risk of thromboembolic disease in lung cancer patients.
- Conditions
- Thromboembolism, Lung Cancer, NSCLC, Radiotherapy; Complications
- Trial name
- CISTRON (NCT03893461)
- Testing
- x
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Odense University Hospital
Type2 Diabetes, Nonalcoholic Steatohepatitis
A Reduced-carbohydrate Diet High in Monounsaturated Fats in Type 2 Diabetes
Further studies are needed to establish the optimal diet for treating T2D. The investigators wishes to investigate whether a low carbohydrate diet, high in monounsaturated fats (LCD) will affect cardiovascular function…
- Conditions
- Type2 Diabetes, Nonalcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease, Atherosclerosis
- Trial name
- ReDuCtion (NCT03068078)
- Testing
- Low carbohydrate diet high in monounsaturated fats
- Where
- Denmark
- Volunteers
- 185 people
- Sponsor
- Odense University Hospital
Seroma, Surgical Site Infection
Prevention of Seroma Following Inguinal Lymph Node Dissection With Prophylactic Incisional Negative Pressure Wound Therapy
Inguinal lymph node dissection (ILND) is indicated following metastatic malignant melanoma, and is associated with a high-complication rate, of which many begin with the formation of seroma and ends in complicated wound healing…
- Conditions
- Seroma, Surgical Site Infection, Lymphedema, Quality of Life
- Trial name
- NCT03433937
- Testing
- Negative pressure wound therapy, Micropore tape
- Where
- 4 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Lymphedema
Treatment of Breast Cancer-related Lymphedema With Stem Cells and Fat Grafting
Breast cancer-related lymphedema is one of the most common and feared consequences of breast cancer treatment. Currently, lymphedema is primarily addressed conservatively with compression garments.
- Trial name
- NCT03776721
- Testing
- Liposuction, Fat graft, Stem cell injection
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Odense University Hospital
Lymphedema
Prevention of Breast Cancer-related Lymphedma With Tacrolimus
Breast cancer-related lymphedema is one of the most common and feared consequences of breast cancer treatment. Tacrolimus ointment may prevent lymphedema by inhibition of CD4+T cells.
- Trial name
- BCRL-TACRO (NCT04390685)
- Testing
- Tacrolimus ointment
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Laparoscopic Ultrasound
Laparoscopic Ultrasound Guided Minimal Invasive Excision of Intra-/Retroperitoneal Tumors
Patients included in the study went through standard preoperative preparation and were informed about potential conversion to open surgery.
- Trial name
- NCT04911634
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Metastatic Breast Cancer, Molecular Imaging
Molecular Evaluation in Metastatic Breast Cancer
Background: Despite that up 90% of patients with early-stage breast cancer receives adjuvant treatment, there are still about 300 patients diagnosed with primary metastatic breast cancer (MBC) and about 1,200 patients who develop…
- Trial name
- MESTAR (NCT03358589)
- Testing
- FDG-PET/CT
- Where
- Denmark
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Thoracic Cancer
Changes in Pleural Cavity Volume and Surgical Exposure
The investigators want to investigate if a diaphragmatic traction-suture affects the pleural cavity volume, as well as improves visual overview of a surgical field during minimally invasive thoracic surgery.
- Trial name
- NCT04837950
- Testing
- Diaphragmatic traction-suture
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital
Non-celiac Gluten Sensitivity; Adolescents
Non Celiac Gluten Sensitivity, DBPCFC in Adolescents
In a population based on healthy adolescents we will conduct a double blind placebo controlled food challenge (DBPCFC) with cross-over to identify patients with NCGS as recommended by the socalled Salerno criteria.
- Trial name
- NCT04639921
- Testing
- positive test followed by gluten-free diet
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital