Clinical trials: sponsored by Odense University Hospital
Lupus Erythematosus, Systemic, Pulmonary Disease
Pulmonary Disease Among Patients With Systemic Lupus Erythematosus
Pulmonary diseases are common among patients with Systemic Lupus Erythematosus (SLE) and associated with a significantly increased morbidity, mortality, and lower self-reported health related quality of life.
- Trial name
- NCT06087523
- Testing
- Multidisciplinary discussion
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease, Stable Angina
Optimal Predilatation Treatment Before Implantation of a Magmaris Bioresorbable Scaffold in Coronary Artery Stenosis
The aim of the study is to investigate if lesion preparation with a ScoreFlex balloon compared to a standard non-compliant balloon improve vascular healing and minimize lumen reduction after implantation of a Magmaris…
- Conditions
- Coronary Artery Disease, Stable Angina, Coronary Artery Stenosis, Myocardial Infarction
- Trial name
- OPTIMIS (NCT04666584)
- Testing
- ScoreFlex balloon, Device: standard non-compliant balloon
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Odense University Hospital
Diverticulitis, Colonic
Colon Capsule Endoscopy in Patients With Colonic Diverticulitis
Introduction: Follow-up after colonic diverticulitis is a common indication for colonoscopy, even though studies have shown a low risk of positive findings in this population.
- Trial name
- CACODI (NCT05700981)
- Testing
- colon capsule endoscopy
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Odense University Hospital
Colitis
Efficacy and Safety of Infliximab for Immune Checkpoint Inhibitor Induced Colitis
The goal of this clinical trial is to assess whether the early introduction of biological treatment with a TNF-alpha inhibitor (infliximab) in addition to corticosteroids for severe ir-colitis/diarrhoea will reduce the time to…
- Trial name
- iCaD (NCT05947669)
- Testing
- Infliximab, Methylprednisolone, Prednisolone
- Where
- 3 sites in Denmark, United Kingdom
- Volunteers
- 195 people
- Sponsor
- Odense University Hospital
Lung Neoplasms, Pain
Supplementary Epidural Analgesia in Video-Assisted Thoracic Surgery (VATS) - The SEAVATS Study
Whereas it, in the case of conventional thoracotomy, has been demonstrated that thoracic epidural analgesia is more effective than systemic opioids in terms of pain relief and preservation of postoperative pulmonary function, the…
- Conditions
- Lung Neoplasms, Pain, Immune Suppression
- Trial name
- SEAVATS (NCT02359175)
- Testing
- Bupivacaine in epidural catheter, Fentanyl in epidural catheter, Oral Paracetamol
- Where
- Denmark
- Volunteers
- 161 people
- Sponsor
- Odense University Hospital
Non-small Cell Lung Cancer, Stereotactic Body Radiotherapy
LIVELUNG - Impact of CGA in Patients Diagnosed With Localized NSCLC Treated With SBRT
Older patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT) often die from other causes than lung cancer due to age-related comorbidities.
- Conditions
- Non-small Cell Lung Cancer, Stereotactic Body Radiotherapy, Comprehensive Geriatric Assessment
- Trial name
- LIVELUNG (NCT05919641)
- Testing
- Comprehensive Geriatric Assessment
- Where
- 4 sites in Denmark
- Volunteers
- 130 people
- Sponsor
- Odense University Hospital
Intracranial Pressure
Estimation of Intracranial Pressure Using Non-invasive Fundus Videos
The purpose of this pilot study is to assess whether the intracranial pressure (ICP) can be detected by using a non-invasive retinal fundus scanner, recording the vessels of the eye entering from the optic disc.
- Trial name
- NCT03382860
- Testing
- Fundus videos
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Odense University Hospital
Polycystic Ovary Syndrome
The Effect of Escitalopram in PCOS
In a randomized study the investigators aim to characterize the effect of antidepressive medicine on quality of life, body composition, adrenal activity and glucose metabolism in PCOS.
- Trial name
- NCT05840692
- Testing
- Escitalopram 20 mg
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Polycystic Ovary Syndrome
Characterization of a Prospective Cohort of Women With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women. PCOS is characterized by increase levels of testosterone, unwanted hair growth, adiposity, irregular menstrual cycle, and infertility.
- Trial name
- NCT02010814
- Where
- Denmark
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Ovarian Cancer, Frailty
FRAGINOC Study: Screening and Geriatric Assessment and Intervention in Older Patients With Epithelial Ovarian Cancer
Ovarian cancer (OC) is the fifth most common cause of cancer death. More than 40% are older than 70 years. The standard treatment is radical surgery combined with chemotherapy.
- Trial name
- FRAGINOC (NCT05810701)
- Testing
- Comprehensive geriatric assessment and individualised physical training
- Where
- 5 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Odense University Hospital
Transplantation Infection, Kidney Diseases
Molecular Biological and Moleculargenetic Monitoring of Therapy After Kidney Transplantation
Molecular monitoring is conducted in blood cells, plasma samples, urine samples and/or tissue from patients after kidney transplantation.
- Trial name
- MoMoTxRes (NCT01515605)
- Where
- Denmark
- Volunteers
- 1,500 people
- Sponsor
- Odense University Hospital
Postherpetic Neuralgia, Shingles
Treatment of Chronic Postherpetic Pain With Autologous Fat Grafting - A RCT
This randomized clinical trial investigates the possible beneficial effect of autologous fat grafting on postherpetic neuralgia.
- Conditions
- Postherpetic Neuralgia, Shingles, Varicella Zoster, Herpes Zoster
- Trial name
- NCT04099706
- Testing
- Autologous Fat Grafting / Fat Transplant
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Odense University Hospital
Postoperative Air Leak
Prolonged Air Leakage After Major Lung Resection
The goal of this prospective randomized controlled trial is to investigate the clinical effects of autologous blood pleurodesis in the treatment of pulmonary air leaks on the first postoperative day following VATS pulmonary…
- Trial name
- PRAL (NCT05638113)
- Testing
- Pleural injection of autologous blood
- Where
- Denmark
- Volunteers
- 182 people
- Sponsor
- Odense University Hospital
Breast Cancer
Health Technologies Readiness in Breast Cancer Patients
This study aims to investigate the degree of Health Technologies Readiness amongst patients with suspected breast cancer using the READHY-tool.
- Trial name
- NCT04745117
- Testing
- READHY - questionnaire
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Infertility, IVF
Quality of Human Embryos in IVF, Culturing in Differentiated Oxygen
The goal of this clinical trial is to evaluate the importance of differential O2 tension to the developing embryos. As a secondary aim, we investigate the levels of reactive oxygen species (ROS) in spent media from the developing…
- Conditions
- Infertility, IVF, Embryo
- Trial name
- NCT05737381
- Testing
- Differential oxygen tension
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Adverse Effects
The Use of PatientReportedOutcomes (PRO)- CTCAE by Melanoma Patients Receiving Immunotherapy
This study evaluates if melanoma patients who report their side effects to immunotherapy weekly by the use of ePRO-CTCAE will experience an overall reduction of grade 3 and 4 events with 50% compared to routine monitoring carried…
- Trial name
- NCT03073031
- Testing
- Tablet: Samsung Galaxy Tab A
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Odense University Hospital
Fibromyalgia
Fibromyalgia and Naltrexone: The FINAL Study
This study evaluates the effect of low dose naltrexone (LDN) on pain in women with fibromyalgia (FM). The study is designed as a parallel randomized (1:1) double blind, placebo-controlled superiority trial.
- Trial name
- FINAL (NCT04270877)
- Testing
- Naltrexone Pill
- Where
- Denmark
- Volunteers
- 99 people
- Sponsor
- Odense University Hospital
Anastomotic Leak
Quantification of Anastomostic Blood Flow With Fluorescence Imaging in Low Anterior Resection for Rectal Cancer
A serious and life-threatening complication to rectal surgery is anastomotic leakage, AL. In Denmark, approximately 800 patients every year, are operated for rectal cancer, 50% of these with resection and anastomosis.
- Trial name
- FILAR (NCT05627934)
- Testing
- qICG
- Where
- Denmark
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Chronic Kidney Disease Requiring Chronic Dialysis
Activation of the Contact System and the Immune System in Patients With Chronic Kidney Disease.
Patients with end-stage renal disease undergoing hemodialysis (HD) are burdened with extremely high mortality rates (15% per year) and during the early stage (≤120days) the mortality rate is even higher (27% per year).
- Trial name
- AKIM-CKD (NCT05266092)
- Testing
- Observational study
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Extended Cross-sectoral Nurse Follow-up After Discharge From a Geriatric Ward
Extended Cross-sectoral Nurse Follow-up After Discharge From a Geriatric Ward - Benefits and Challenges. A Mixed-method Study
Purpose By using both quantitative and qualitative research methods to examine the impact of a coordinated home visit by a geriatric nurse and a community (home care) nurse to vulnerable older patients recently discharged from a…
- Trial name
- NCT05139823
- Testing
- geriatric follow-up home visit after discharge
- Volunteers
- 1,514 people
- Sponsor
- Odense University Hospital