Clinical trials: sponsored by Ohio State University
Leukemia
Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01005758
- Testing
- cyclophosphamide, cytarabine, dexamethasone
- Volunteers
- 180 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anesthetic Effectiveness
Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to the tooth as a supplemental injection, works very well following a…
- Trial name
- NCT01567839
- Testing
- Mandibular buccal Infiltration injection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Bacterial Vaginosis
Vitamin D and Sexual Health
Bacterial vaginosis (BV) develops when the concentration of healthy Lactobacillus species in the vagina declines and is replaced by other bacterial species.
- Trial name
- DASH (NCT01450462)
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cystic Fibrosis, Bronchospasm
Exercise-Induced Bronchospasm in Cystic Fibrosis
Exercise is an important clinical feature in cystic fibrosis. Better exercise capacity has been associated with better patient outcomes and quality of life.
- Trial name
- NCT00806455
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Ohio State University
Malignant Neoplasm
Ondansetron Versus Palonosetron Antiemetic Regimen Prior to Highly Emetogenic Chemotherapy(HEC)
Palonosetron is different from ondansetron because it stays in the body longer and may prevent nausea and vomiting for a longer period of time than ondansetron.
- Trial name
- NCT01640340
- Testing
- aprepitant, palonosetron hydrochloride, ondansetron
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Obesity, Respiratory Insufficiency
Effects of Obesity on Care and Outcomes in Mechanically Ventilated Individuals in the Intensive Care Unit
Obesity is a significant health care issue in the United States, particularly among the critically ill. Preliminary research has shown that differences in ventilator management exist among obese and non-obese individuals.
- Trial name
- NCT00296088
- Where
- United States
- Volunteers
- 582 people
- Sponsor
- Ohio State University
Sepsis
Infected Elders in the Emergency Department: Outcomes and Processes of Care
The purpose of this study is to determine factors which predict a complicated hospital course and then to develop from these findings an Emergency Department guideline to assist in knowing who is at highest risk of elderly…
- Trial name
- NCT00591955
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Ohio State University
Renal Cancer
Interferon Alpha-2b (Intron A) for Metastatic or Unresectable Clear Cell Renal Carcinoma
This study will determine the response rate of daily low dose interferon-alpha-2b in patients with metastatic or unresectable clear cell renal cell carcinoma.
- Trial name
- NCT00293527
- Testing
- Interferon Alpha-2b
- Sponsor
- Ohio State University Comprehensive Cancer Center
Osteoporosis
Calcium and Bone Mass in Young Females
We originally suggested that calcium in the diet is important in determining the amount of bone (bone mass) that builds up in young adults. We are testing the effect of calcium on bone mass in 354 Caucasian (white) girls.
- Trial name
- NCT00000402
- Testing
- Calcium
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Unspecified Adult Solid Tumor, Protocol Specific
Combination Chemotherapy in Treating Patients With Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00009932
- Testing
- cisplatin, fenretinide, paclitaxel
- Where
- United States
- Sponsor
- Ohio State University Comprehensive Cancer Center
Unspecified Adult Solid Tumor, Protocol Specific
Oxaliplatin and Paclitaxel in Treating Patients With Metastatic or Unresectable Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00004173
- Testing
- oxaliplatin, paclitaxel
- Where
- United States
- Sponsor
- Ohio State University Comprehensive Cancer Center
Leukemia
Combination Chemotherapy and Tipifarnib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy, such as cytarabine, daunorubicin, and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00124644
- Testing
- cytarabine, daunorubicin hydrochloride, etoposide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Substance Abuse
Evaluation of Treatments for Homeless Youths
Youth who leave home for the streets are at significantly more risk for a multitude of problems, yet little research is available to guide treatment intervention efforts with this population.
- Trial name
- NCT01143792
- Testing
- Community Reinforcement Approach (CRA) + HIV prevention, Case Management + HIV Prevention, Motivational Enhancement Therapy (MET) + HIV prevention
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Ohio State University
Substance Abuse
Stage 1 Treatment Development With Homeless Mothers
Aim 1. Identify specific targets and processes of intervention among homeless substance abusing mothers with children between the ages of 2 and 6 years from information collected in focus groups and assessment interviews.
- Trial name
- NCT01193114
- Testing
- Ecologically Based Treatment (EBT), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Colorectal Cancer
Chloroquinoxaline Sulfonamide in Treating Patients With Stage IV Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of chloroquinoxaline sulfonamide in treating patients who…
- Trial name
- NCT00005864
- Testing
- chloroquinoxaline sulfonamide
- Where
- 4 sites in United States
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer
Pyrazoloacridine in Treating Women With Refractory Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of pyrazoloacridine in treating women who have refractory…
- Trial name
- NCT00003041
- Testing
- pyrazoloacridine
- Where
- 5 sites in United States
- Sponsor
- Ohio State University Comprehensive Cancer Center
Head and Neck Cancer
Oxaliplatin in Treating Patients With Advanced Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of oxaliplatin in treating patients who have advanced head…
- Trial name
- NCT00005035
- Testing
- oxaliplatin
- Where
- 11 sites in United States
- Sponsor
- Ohio State University Comprehensive Cancer Center
Gastrointestinal Carcinoid Tumor, Islet Cell Tumor
PS-341 in Treating Patients With Metastatic Neuroendocrine Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of PS-341 in treating patients who have metastatic…
- Trial name
- NCT00017199
- Testing
- bortezomib
- Where
- 2 sites in United States
- Sponsor
- Ohio State University Comprehensive Cancer Center
Leukemia, Lymphoma
FR901228 in Treating Patients With Hematologic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of FR901228 in treating patients who have hematologic…
- Trial name
- NCT00024180
- Testing
- romidepsin
- Where
- United States
- Sponsor
- Ohio State University Comprehensive Cancer Center
Unspecified Adult Solid Tumor, Protocol Specific
SU5416, Irinotecan, and Cisplatin in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. SU5416 may stop the growth of solid tumors by stopping blood flow to the tumor.
- Trial name
- NCT00006000
- Testing
- cisplatin, irinotecan hydrochloride, semaxanib
- Where
- United States
- Sponsor
- Ohio State University Comprehensive Cancer Center