Clinical trials: sponsored by Oregon Health and Science University
Heavy Menstrual Bleeding, Bleeding Disorder
Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study
The goal of this multicenter prospective observational study and registry of U.S. adolescents and young adults with heritable bleeding disorders is to determine the bleeding outcomes, satisfaction, hemostatic parameter changes…
- Conditions
- Heavy Menstrual Bleeding, Bleeding Disorder, Von Willebrand Diseases
- Trial name
- HMB-BD (NCT05916469)
- Testing
- Levonorgestrel Intrauterine System, Norethindrone Acetate
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Urinary Tract Infections, Recurrent Urinary Tract Infection
Chlorhexidine Lavage for Recurrent Urinary Tract Infection
A two-arm randomized control trial evaluating rates of urinary tract infection in post-menopausal women on vaginal estrogen with recurrent urinary tract infections.
- Trial name
- NCT06598514
- Testing
- Chlorhexidine, Sterile Water
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Oregon Health and Science University
Pregnancy Related
Assessing the Use of Wearable Activity Trackers in a Pregnancy Cohort
This is a randomized controlled pilot study to evaluate the utility of the Garmin Vivosmart 5 wearable activity tracker in pregnancy.
- Trial name
- NCT07331909
- Testing
- Wearable Activity Tracker
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Oregon Health and Science University
Idiopathic Generalized Epilepsy
High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years
The purpose of this study is to find out if magnetic resonance (MRI)-guided high-intensity focused ultrasound (HIFU) is safe and effective for treating medically refractory generalized epilepsy.
- Trial name
- HIFU for MRGE (NCT07803692)
- Testing
- Intervention 1, Intervention 2
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Obesity
Evaluation of Safety and Health Involvement For Truck Drivers
The current project is a randomized, controlled evaluation of a new weight loss and health promotion intervention for truck drivers.
- Trial name
- SHIFT (NCT02105571)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Nonspecific Chronic Low Back Pain
Body and the Brain: Cortical Reactivity and Cognitive-Affective Regulation to Experimental Pain.
The purpose of this cross-sectional study is to compare cortical reactivity and cognitive-affective regulation in response to experimental pain between healthy controls and individuals with non-specific chronic low back pain.
- Trial name
- NCT07896785
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pain Catastrophizing, Pain, Chronic
Efficacy of a Chronic Pain Treatment Prior to Gender-affirming Surgery
The primary objective of this study is to examine a single-session, 2-hour group intervention provided to a population of transgender or gender-diverse patients with chronic pain prior to gender-affirming surgery, to determine if…
- Conditions
- Pain Catastrophizing, Pain, Chronic, Gender Identity
- Trial name
- NCT06443164
- Testing
- Empowered Relief, Standard of Care
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Provoked Localized Vulvodynia
Remote Mindfulness Education PLV
This is a study designed to learn more about the use of an online remote education and mindfulness practice program for the pain and anxiety associated with provoked localized vulvodynia.
- Trial name
- NCT03541512
- Testing
- Mindfulness + Education, Education
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Oregon Health and Science University
Inflammation, Depression Disorder
Inflammatory Pathways Modulated by Prenatal Mindfulness: A Route to Improve Maternal Child Emotional Well Being and Whole Person Health
The goal of this study is to investigate inflammation as the biological mechanism by which mindfulness based cognitive therapy for perinatal depression (MBCT-PD) administered during pregnancy improves women's emotional well-being…
- Conditions
- Inflammation, Depression Disorder, Mindfulness, Emotional Well-being
- Trial name
- NCT07892326
- Testing
- Mindfulness-based cognitive therapy for perinatal depression, Pregnancy Health Group
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Vulvar Pain, Vulvodynia
Vestibulectomy Surgical Techniques Comparison Study
Vestibulectomy Surgical Techniques Comparison Study
- Trial name
- NCT05343182
- Testing
- Modified Technique, Traditional Technique
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Oregon Health and Science University
Methamphetamine Use, Heart Failure
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
The goal of PEER-Heart is to implement and assess feasibility and preliminary effectiveness of a community peer-facilitated screening for methamphetamine-associated heart failure (MAHF) and linkage to evidence-based cardiology…
- Trial name
- PEER-Heart (NCT06461962)
- Testing
- Treatment as Usual, Telehealth-Cardiology
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Opioid Dependence, Substance Abuse Disorders
The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care
The goal of this pilot clinical trial is to learn if a community informed designed program of addiction counseling with coordinated community peer navigator for people with Opioid Use Disorder (OUD) and other medical conditions…
- Conditions
- Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
- Trial name
- MOUD+ (NCT06837662)
- Testing
- MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Oregon Health and Science University
Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterium Infection
Hypertonic Saline for MAC
The MAC-HS study is a testing whether hypertonic saline helps improve symptoms and clearance of mycobacteria in patients with M. avium complex lung infections.
- Trial name
- NCT04921943
- Testing
- Hypertonic saline, Azithromycin, Ethambutol
- Where
- 3 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Distress, Emotional, Internalizing Mental Health Symptoms
Piloting a School-Based Distress Tolerance Skills Program for Adolescents
Research suggests that an individual's perceived ability to withstand distressing or upsetting emotions (i.e., distress tolerance; DT) is a common risk factor across several mental health conditions that commonly emerge during…
- Trial name
- STRIDE (NCT06638853)
- Testing
- Distress Tolerance Skills Training
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Palsy Supranuclear, Supranuclear Palsy, Progressive
Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy
The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP).
- Trial name
- NCT04468932
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Sleep
Cannabis Association With Sleep Study
The purpose of this study is to learn more about cannabis use, sleep, and stress, and whether there is any relationship between the three.
- Trial name
- CaSS (NCT06982950)
- Testing
- Manipulation of Sleep Duration
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Compartment Syndrome Traumatic Lower Extremity
BM-MNCs for Lower Extremity Compartment Syndrome Injury
This is a phase 1 study to assess safety and tolerability of intramuscular administration of two different doses of autologous bone marrow mononuclear cells (BM-MNCs) for treatment of lower extremity injury complicated by…
- Trial name
- NCT03880656
- Testing
- Intramuscular administration of autologous BM-MNCs
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Oregon Health and Science University
Suicide, Adolescent Behavior
Wearable Suicidal Early Warning System for Adolescents
This study is prospectively enrolling a cohort of adolescent patients who present to the Emergency Department and an inpatient psychiatric adolescent unit with acute suicidality.
- Trial name
- NCT03030924
- Testing
- Solace
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Oregon Health and Science University
Suicide, Mental Health Issue
Proximal Risk for Suicide in Adolescents
The central hypothesis is that biometric data can continuously monitor and allow for early identification/intervention of escalating suicidal symptoms.
- Trial name
- NCT06400810
- Testing
- Analog Devices Inc.
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Oregon Health and Science University
Atrial Fibrillation
Optimizing Stroke Prophylaxis of Acute Atrial Fibrillation With an Electronic Clinical Decision Support Tool
Atrial fibrillation (AF) is the most common arrhythmia in the world, with significant morbidity and mortality. With appropriate oral anticoagulation, the risk of stroke due to atrial fibrillation decreases by 64%.
- Trial name
- AF SWCRT-CDS (NCT05341986)
- Testing
- Clinical Decision Support (CDS) tool
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Oregon Health and Science University