Clinical trials: sponsored by Oregon Health and Science University
Urea Cycle Disorder, Propionic Aciduria
MyRareDiet A Novel Diet Tracking Tool
The investigators propose to develop and validate MyRareDiet® (MRD) to address an unmet need in the inborn errors of metabolism (IEM) population to assist with dietary management designed to increase adherence and compliance to…
- Conditions
- Urea Cycle Disorder, Propionic Aciduria, Maple Syrup Urine Disease, Methylmalonic Acidemia
- Trial name
- MRD (NCT06664840)
- Testing
- MDR diet assessment, 24 hour recall
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Parkinson Disease
Effect of GOCOVRI (Amantadine, Extended Release Capsules) on Gait in Parkinson's Disease
The purpose of the study is to learn about the effect of GOCOVRI (Amantadine extended release) on activity levels and measures of gait and balance quality in people with Parkinson's disease (PD) and levodopa induced dyskinesia…
- Trial name
- NCT04387773
- Testing
- GOCOVRI
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oregon Health and Science University
Hepatitis C
TeleHepC Treatment Trial
The main goal of this study is to test the efficacy of a peer-facilitated telemedicine HCV treatment implementation strategy for people who use drugs versus local HCV treatment referral for achieving HCV sustained viral response…
- Trial name
- NCT04798521
- Testing
- Tele-HCV, Community Linkage to Care
- Where
- 3 sites in United States
- Volunteers
- 203 people
- Sponsor
- Oregon Health and Science University
Obstetric Labor Complications
Monoferric for Prenatal Iron Deficiency
A prospective observational study of pregnant women with iron deficiency anemia and oral iron intolerance or advanced gestational age.
- Trial name
- NCT05763043
- Testing
- Ferric derisomaltose
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cesarean Section
Chloroprocaine Lavage to Improve Outcomes Related to Operative Cesarean Delivery
The long term objective is to show that intraperitoneal chloroprocaine can be used an alternative option to avoid general anesthesia during cesarean delivery, to alleviate mother's discomfort from surgical pain, reduce…
- Trial name
- CLOR-PRO (NCT03760718)
- Testing
- Preservative free 1% Chloroprocaine, Preservative free 2% Chloroprocaine, Preservative free 3% Chloroprocaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Menstrual Bleeding, Heavy
PAI-1, tPA, TFPI and HEECs in Uterine Hemostasis
The purpose of the study is to learn more about the role of blood clotting factor proteins and cells in menstrual (period) bleeding.
- Trial name
- NCT05862805
- Testing
- Sample Collection and Endometrial Biopsy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Fall, Motivation
Engaging Older Adults in Fall Prevention Using Motivational Interviewing (MI)
This mixed-methods, two-arm, randomized controlled trial will evaluate the impact of Motivational Interviewing (MI) as a follow-up care to patients who received fall prevention recommendations at Oregon Health \& Science…
- Conditions
- Fall, Motivation, Behavior, Coping Behavior
- Trial name
- NCT04612842
- Testing
- Motivational Interviewing
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
RAD
Dosimeter Location in Pain Physicians
The primary objective is to determine if there is a significant difference in radiation readings between dosimeters worn on the chest versus the hand of interventional pain management physicians and elucidate which dosimeter had…
- Trial name
- NCT06309407
- Testing
- Hand Dosimeters, Standard Practice
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Perinatal Depression
Preventing Perinatal Depression
The goal of this pilot study is to evaluate the acceptability, feasibility, mechanisms of action, and efficacy of Center M. Center M is a group-based, mindfulness-based Cognitive Behavioral Therapy (CBT) intervention to treat…
- Trial name
- NCT06525922
- Testing
- Center M
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Bowel Dysfunction, Postoperative Complications
Sugammadex To IMprove Bowel Function
Colon and rectal surgery is associated with high cost, long length of stay, high postoperative surgical site infection rate, high incidence of postoperative nausea and vomiting, and a high rate of hospital readmission.
- Conditions
- Bowel Dysfunction, Postoperative Complications, Neuromuscular Blockade
- Trial name
- STIM_Bowel (NCT04546672)
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Oregon Health and Science University
Sleep, Sleep Disturbance
Tech4Rest Trial With Team Truck Drivers
The current project is a safety and health intervention focused on sleep and fatigue among truck driver teams (pairs), where one driver sleeps in a moving vehicle while the other partner drives.
- Conditions
- Sleep, Sleep Disturbance, Sleep Disorder, Shift Work, Health Knowledge, Attitudes, Practice
- Trial name
- Tech4Rest (NCT03108599)
- Testing
- Enhanced Cab, Fit4Sleep
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Bleeding, Implants
Use of Curcumin to Treat Unfavorable Bleeding Patterns in Contraceptive Implant Users
The investigators plan to study the effects of curcumin, the active ingredient in the spice turmeric, on the irregular bleeding experienced by women who use the contraceptive implant.
- Conditions
- Bleeding, Implants, Breakthrough Bleeding
- Trial name
- NCT04205929
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Anesthesia, Spinal
Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery
The following obstetric procedures are commonly performed with spinal anesthesia on labor and delivery: bilateral tubal ligation, external cephalic version, cerclage insertion, cerclage removal, minimally invasive fetal surgery…
- Trial name
- CLIMB (NCT03967288)
- Testing
- Chloroprocaine Injection [Clorotekal], Bupivacaine Hydrochloride 0.75% Injection Solution
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Surgical Wound Infection, Cross Infection
Reducing Intraoperative ESKAPE Transmission Through Use of a Personal Hand Hygiene System
The investigators hypothesize that the use of a personal hand hygiene system (SafeHavenTM) by anesthesia providers in the adult operating room, combined with a novel infectious pathogen tracking system (OR PathTrac) will decrease…
- Trial name
- ESKAPE (NCT04900298)
- Testing
- SafeHaven Automated Hand Hygiene Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Sleep Deprivation
Glymphatic MRI Study
This study aims at identifying neuroimaging markers of glymphatic function in humans.
- Trial name
- NCT06452459
- Testing
- No interventinon
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Program Evaluation
Evaluating System Change to Advance Learning and Take Evidence to Scale (ESCALATES)
The purpose of this study is to evaluate approximately eight grants that will test interventions to improve cardiovascular disease prevention.
- Trial name
- ESCALATES (NCT02560428)
- Testing
- ESCALATES
- Volunteers
- 7 people
- Sponsor
- Oregon Health and Science University
Gestational Diabetes
Time-in-range Using Continuous Glucose Monitoring Management of Gestational Diabetes Mellitus
The continual glucose is going to increase time-in-range compared to the standard method in women with gestational diabetes
- Trial name
- NCT04605497
- Testing
- Continuous glucose monitoring (CGM), Self-Capillary Blood Glucose Monitoring (SCBG)
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Oregon Health and Science University
Pityriasis Rubra Pilaris
Guselkumab in the Treatment of Pityriasis Rubra Pilaris (PRP)
15 patients with PRP will be treated with guselkumab for 20 weeks to determine safety and efficacy. Participants are required to travel to Portland, OR only for the first visit, week-4 visit, and week-24 visit.
- Trial name
- NCT03975153
- Testing
- guselkumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Fracture of Shaft of Humerus
Acute Management of Humeral Shaft Fractures: Sling vs. Splint
When people break their arm and arrive at Oregon Health and Science University's Emergency Department (OHSU ED), they are treated with a short-term means of immobilizing their broken arm.
- Trial name
- NCT01869322
- Testing
- Sling and Swathe, Coaptation Splint
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Amphetamine-Related Disorders
Hospital-Based Contingency Management
This study aims to adapt an outpatient mobile app-based contingency management intervention to the hospital setting to understand how we can use contingency management to improve health outcomes in hospitalized patients with…
- Trial name
- NCT05515757
- Testing
- Mobile-app based contingency management
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University