Clinical trials: sponsored by Oregon Health and Science University
Type 1 Diabetes
Two Way Crossover Closed Loop Study R-AP vs MPC
An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a missed meal bolus detection algorithm for use within an AP control system.
- Trial name
- NCT05083559
- Testing
- MPC AP algorithm, Robust R-AP algorithm
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Dementia, Alzheimer Disease
REmote Assessment and Dynamic Response Intervention II
The purpose of the READyR II Study is to test a dynamic tailoring phase of a remote assessment for changing dementia-related care needs.
- Conditions
- Dementia, Alzheimer Disease, Relationship, Marital, Caregiver Stress Syndrome
- Trial name
- READyR-II (NCT04686838)
- Testing
- READyR II: A, READyR II: B
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Obesity, Menopausal Syndrome
Regulation of Cortisol Metabolism and Fat Patterning
The purpose of this study is to determine if estrogen or testosterone can affect cortisol levels and where fat builds up in our bodies.
- Trial name
- NCT00694733
- Testing
- Depo Lupron/Aromatase inhibitor, Estrogen cream
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obesity
A Study of the Functional Magnetic Resonance Imaging Response to Leptin and Pramlintide
The purpose of this study is to identify how certain parts of the brain that help control body weight respond to an infusion of hormones called leptin and amylin.
- Trial name
- NCT00691158
- Testing
- Pramlintide (Amylin), 2 Metreleptin, Leptin plus Pramlintide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Prader Willis Syndrome
Ghrelin Suppression by Octreotide in Prader-Willi
The purpose of this study is to learn more about how octreotide (Sandostatin LAR® Depot) affects levels of ghrelin, hunger, and body weight in people with Prader-Willi Syndrome.
- Trial name
- NCT01613495
- Testing
- Octreotide
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obesity, Diabetes Mellitus
Longitudinal Assessment of Bariatric Surgery Sub-Study
The goal of this project is to examine the physical mechanisms that contribute to improvements of glucose tolerance in type 2 diabetes mellitus (DM) following certain types of bariatric surgery.
- Trial name
- LABS-3 (NCT02985853)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Dementia, Advance Care Planning
Advance Care Planning (ACP) in Primary Care for Dementia
ADVANCE-PC: Aligning Dementia \& adVANce Care planning Education in Primary Care, is a communications and implementation support intervention that builds on existing ACP programs, understanding of dementia, and clinical expertise…
- Trial name
- ADVANCE-PC (NCT05322317)
- Testing
- ADVANCE-PC training via ECHO
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Oregon Health and Science University
Tobacco Use
Choose2Quit: Improving Equity in Smoking Cessation for Low Income Adults
The goal of this study is to evaluate the effectiveness of a tobacco treatment navigator to improve primary care patient engagement in tobacco cessation support. We compare an ask, advise and connect to the quitline approach vs.
- Trial name
- NCT05612152
- Testing
- Referral to Quitline, Choose2Quit
- Volunteers
- 1,600 people
- Sponsor
- Oregon Health and Science University
Herpes Simplex Dendritic Keratitis
Evaluating Adjunctive Cryopreserved Amniotic Membrane Treatment in Herpes Simplex Dendritic Keratitis
To prospectively evaluate the effectiveness of Prokera Slim in adults with primary or recurrent herpetic epithelial keratitis in terms of visual function, corneal opacity, time to resolution, cost of care, number of patient…
- Trial name
- NCT04598282
- Testing
- Prokera Slim, Standard of Care
- Where
- United States
- Sponsor
- Oregon Health and Science University
Sedentary Behavior, Cardiovascular Function
Sedentary Behavior, Cardiovascular Function, and Sleep
This is an interventional study that will examine how sedentary behavior (decreased physical inactivity) over time affects cardiovascular health (i.e. heart rate and blood pressure) and sleep quality/duration.
- Conditions
- Sedentary Behavior, Cardiovascular Function, Sleep
- Trial name
- PACE (NCT04137068)
- Testing
- Reduced Activity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes
Assessment of a Decision Support Tool in Participants With Type 1 Diabetes
Type 1 diabetes (T1D) is a complex disease with a high risk of both hyper- and hypoglycemia which can lead to severe acute and chronic complications.
- Trial name
- NCT04428645
- Testing
- DailyDose Decision Support
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Stress Urinary Incontinence
Yoga-Pilates Exercise & the Effects on Urethral Rhabdosphincter Morphology and Stress Urinary Incontinence
This is a prospective interventional study conducted at Oregon Health \& Science University that will measure the pre- and post-intervention characteristics of women with stress urinary incontinence undergoing an 8-week home…
- Trial name
- Y-PEE (NCT04298671)
- Testing
- Yoga-Pilates
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Oregon Health and Science University
Dementia, Alzheimer Disease
REmote Assessment and Dynamic Response Intervention
The purpose of the READyR study (originally called SHARE-sense) is to redevelop and test an intervention program to remotely assess for changing dementia-related care needs.
- Conditions
- Dementia, Alzheimer Disease, Relationship, Marital, Caregiver Stress Syndrome
- Trial name
- READyR (NCT04542109)
- Testing
- READyR A, READyR B
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Cognitive Decline
Cohort Study of Risk Factors for Postoperative Cognitive Decline
Presently, the role of either genetic factors or biological sex in the development of postoperative cognitive dysfunction (POCD) is unknown.
- Trial name
- POCD (NCT03676738)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Oregon Health and Science University
HIV, Substance Related Disorders
Buprenorphine to Improve HIV Care Engagement and Outcomes
The purpose of this study is to compare two models of substance abuse treatment in Vietnam, and how they each affect HIV care. In Vietnam, the current model for treating people with HIV who are also dependent on opioids is to…
- Trial name
- BRAVO (NCT01936857)
- Testing
- Buprenorphine/naloxone, Methadone Maintenance Therapy
- Where
- 6 sites in Vietnam
- Volunteers
- 281 people
- Sponsor
- Oregon Health and Science University
Developmental Disability, Food Assistance
Integrating WIC With Early Childhood Systems of Developmental Care
This study's goals are to improve connections between Oregon Women, Infants, \& Children (WIC) clinics, primary care providers, and Early Intervention/Early Childhood Special Education programs (EI/ECSE), in order to help…
- Conditions
- Developmental Disability, Food Assistance, Health Care Disparity
- Trial name
- CDC-WIC (NCT04159038)
- Testing
- Intervention Group, Control group
- Where
- 4 sites in United States
- Volunteers
- 46 people
- Sponsor
- Oregon Health and Science University
Urinary Incontinence
Pacific Northwest Female Urinary Incontinence Treatment Digital Awareness Project
The investigators will compare whether advertisements on Google or Facebook are more effective to reach women in the Pacific Northwest about treatment options for urinary incontinence through the American Urogynecologic Society's…
- Trial name
- PNW-IP (NCT04464928)
- Testing
- Facebook Advertisements, Google Advertisements
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Provoked Localized Vulvodynia
M-gCBT for Women With Provoked Localized Vulvodynia
The purpose of this study is to learn more about Mindfulness based Group Cognitive Behavior Therapy (M-gCBT) as a treatment for Provoked Localized Vulvodynia (PLV).
- Trial name
- NCT02919813
- Testing
- Mindfulness Based Group Cognitive BehaviorTherapy, Educational Seminars
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Oregon Health and Science University
Cognitive Impairment, Elderly
Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment
This study will measure the oral bioavailability and pharmacokinetics of known bioactive compounds from a standardized Centella asiatica water extract product (CAP) in mildly demented elders on cholinesterase inhibitor therapy.
- Trial name
- NCT03937908
- Testing
- 2g Centella asiatica water extract product, 4g Centella asiatica water extract product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Obesity, Childhood
Parent Mentor Interventions for Early Childhood Obesity
The purpose of this clinical trial is to identify the most effective strategy for intervention to change behaviors and affect weight status in obese children 2-5 years of age within the context of early childhood education…
- Trial name
- NCT03330743
- Testing
- Parent Mentor with Standard Education, Parent Mentor with Positive Deviance
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University