Clinical trials: sponsored by Oregon Health and Science University
COPD, Dyspnea
Ventilation Imbalances in Mild to Moderate Chronic Obstructive Pulmonary Disease
The Investigators plan a single center study to get preliminary data to answer a number of fundamental questions directly related to management of COPD.
- Conditions
- COPD, Dyspnea, Respiratory Disease, Lung Diseases
- Trial name
- VAPOR (NCT04880551)
- Testing
- Fluoroscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Bell Palsy
Electrical Stimulation to Promote Recovery in Bells Palsy
A feasibility pilot study to exam the necessary methodology for conducting a larger clinical trial for Bell's Palsy patients with a poor prognosis and the use of electrical stimulation.
- Trial name
- NCT03836989
- Testing
- Electrical stimulation device (tens unit)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Oregon Health and Science University
Congestive Heart Failure, Cancer
Team-based Versus Primary Care Clinician-led Advance Care Planning in Practice-based Research Networks
This project compares two models of the Serious Illness Care Program (SICP) in primary care: clinician-focused SICP and team-based SICP.
- Conditions
- Congestive Heart Failure, Cancer, Chronic Obstructive Pulmonary Disease, Cerebrovascular Accident
- Trial name
- NCT03577002
- Testing
- Serious Illness Care Program (SICP)
- Where
- 7 sites in United States, Canada
- Volunteers
- 1,120 people
- Sponsor
- Oregon Health and Science University
HIV Seropositivity
Telephone Counseling to Enhance the Quality and Safety of Romantic and Sexual Relationships in People Living and Aging With HIV
The purpose of this study is to determine if a brief behavioral intervention delivered over the telephone is effective at reducing occasions of condomless sex in persons living and aging with HIV.
- Trial name
- NCT03004170
- Testing
- Telephone-Administered Motivational Interviewing Plus Behavioral Skills Training, Telephone-Administered Coping Effectiveness Training
- Where
- United States
- Volunteers
- 343 people
- Sponsor
- Oregon Health and Science University
Hyperlipidemia
Acute Microvascular Changes With LDL Apheresis
Severe hypercholesterolemia produced by conditions such as heterozygous familial hypercholesterolemia is associated with multiple complications including premature atherosclerotic disease.
- Trial name
- NCT02388633
- Testing
- Plasmapharesis
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oregon Health and Science University
Upper Limb Deformities, Congenital
Prosthetic Device in Children With Upper Congenital Limb Deficiency
This is a study being performed to evaluate the safety and effectiveness of 3D printed myoelectric prosthetic devices in children with a congenital upper limb deficiency.
- Trial name
- NCT04059107
- Testing
- 3D Printed Myoelectric Prosthetic Device
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Parkinson's Disease, Dyskinesias
Buspirone, in Combination With Amantadine, for the Treatment of Levodopa-induced Dyskinesia
The primary objective of this study is to evaluate the efficacy of buspirone in combination with amantadine in reducing levodopa-induced dyskinesia (LID) in patients with Parkinson's disease (PD).
- Conditions
- Parkinson's Disease, Dyskinesias, Movement Disorders
- Trial name
- BUS-PD (NCT02589340)
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Alzheimer Disease
Neurofeedback in Alzheimer's Disease
This study will evaluate behavioral and electrophysiological changes in a sample of adults with possible or probable Alzheimer's disease (AD), before and after undergoing training using a brain-computer interface (BCI) system…
- Trial name
- NCT03790774
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis
Low Fat Diet for Fatigue in MS
A randomized, controlled pilot trial of a dietary intervention vs. wait-list control in patients with MS and fatigue for management of their fatigue.
- Trial name
- NCT03322982
- Testing
- Low-fat diet
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Intensive Care (ICU) Myopathy
Neurosciences-Intensive Care Unit Electrical Stimulation
Patients admitted to the Neurosciences Intensive Care Unit (NSICU) are at particular risk of developing ICU-associated weakness and myopathy, given the unique risks of early mobilization in these patients, which include increased…
- Trial name
- NCT03547687
- Testing
- Electrical Stimulation Treatment, Neuromuscular Electrical Stimulation Treatment
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Oregon Health and Science University
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
- Trial name
- SUSHI (NCT03318783)
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Keratoplasty, Grafting, Corneal
Descemet Endothelial Thickness Comparison Trial
The purpose of this study is to compare visual acuity outcomes of two types of endothelial keratoplasty: 1) Ultrathin Descemet's Stripping Endothelial Keratoplasty (DSAEK) or 2) Descemet's Membrane Endothelial Keratoplasty…
- Conditions
- Keratoplasty, Grafting, Corneal, Transplantation, Corneal, Transplantation, Cornea
- Trial name
- DETECT (NCT02373137)
- Testing
- DSAEK, DMEK, Endoserter
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Oregon Health and Science University
Hepatitis C, Substance Use Disorders
Hepatitis C Treatment in PWIDs: MAT or Syringe Exchange Assisted-therapy vs Standard of Care
hepatitis C virus (HCV) has traditionally been treated in subspecialty health centers given the complexity of older pegylated interferon containing regimens, formerly the standard of care.
- Conditions
- Hepatitis C, Substance Use Disorders, Substance Abuse, Intravenous
- Trial name
- NCT03093415
- Testing
- elbasvir-grazoprevir (50 mg/100 mg)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
COVID-19, SARS-CoV-2
Assessing Hydroxychloroquine in Patients With SARS-CoV-2 (COVID-19)
This is a prospective, randomized, double-blinded, placebo-controlled, pilot study to assess the preliminary efficacy and safety of hydroxychloroquine for the treatment of patients with lower respiratory tract SARS-CoV-2…
- Trial name
- NCT04363866
- Testing
- Hydroxychloroquine
- Where
- United States
- Sponsor
- Oregon Health and Science University
High Risk Pregnancy
Placenta Imaging Project
The purpose of this study is to test the application of newly generated magnetic resonance imaging (MRI) protocols for the assessment of placental perfusion in human subjects.
- Trial name
- PIP (NCT02749851)
- Testing
- MRI, MRI - IUGR
- Where
- 2 sites in United States
- Volunteers
- 379 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Essential Tremor, Deep Brain Stimulation
Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect
The proposed study aims to characterize ataxia occurring in essential tremor and essential tremor with DBS.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Ataxia, Cerebellar Diseases
- Trial name
- ATAX (NCT03769961)
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Hypertrophic Cardiomyopathy, Coronary Artery Disease
Hypertrophic Cardiomyopathy Pilot Study
This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from…
- Trial name
- NCT02806479
- Testing
- Observational: Arrhythmogenic Substrate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Stress Urinary Incontinence
Changes in the Bladder Micro-environment Following Midurethral Sling Surgery for Stress Urinary Incontinence
This observational cohort study is aimed at determining changes in the cytokine expression profile as well as the urinary and vaginal microbiome of women undergoing midurethral sling placement for the treatment of stress urinary…
- Trial name
- NCT03942549
- Testing
- Retropubic midurethral sling
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Contraception, Body Weight
Oral Contraceptive Efficacy and Body Weight
The purpose of the blood spot validation portion of the study is to test if measuring female hormone levels in the blood is as accurate through a finger stick, as it is by a blood draw from a vein.
- Trial name
- NCT00662454
- Testing
- ethinyl estradiol / levonorgestrel
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Age Related Cognitive Decline, Alzheimer's Disease
n-3 PUFA for Vascular Cognitive Aging
Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain…
- Conditions
- Age Related Cognitive Decline, Alzheimer's Disease, Vascular Dementia, Endothelial Dysfunction
- Trial name
- NCT01953705
- Testing
- Omega 3 PUFA
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University