Clinical trials: sponsored by Oregon Health and Science University
CIDP, Chronic Inflammatory Demyelinating Polyneuropathy
Lipoic Acid to Treat Chronic Inflammatory Demyelinating Polyneuropathy
The purpose of the study is to examine if alpha lipoic acid is an effective treatment for chronic inflammatory demyelinating polyneuropathy (CIDP).
- Trial name
- NCT00962429
- Testing
- lipoic acid
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Oregon Health and Science University
Sedentary Lifestyle, Occupational Exposure
Active Workplace Study
Exposure to sedentary work is an occupational hazard with significant health and safety consequences. Sedentary behavior is an independent predictor of heart disease, diabetes, early mortality, and accounts for the majority of…
- Conditions
- Sedentary Lifestyle, Occupational Exposure, Health Behavior, Safety Issues
- Trial name
- NCT03556670
- Testing
- Total Worker Health, Control
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Bleeding, Implants
Treatment of Unfavorable Bleeding Patterns in Contraceptive Implant Users
The etonogestrel (ENG) subdermal contraceptive implant (ENG implant) is a highly effective method of preventing pregnancy, but it has bleeding side effects that make it unappealing for many women.
- Conditions
- Bleeding, Implants, Breakthrough Bleeding
- Trial name
- Tamoxifen/BTB (NCT02903121)
- Testing
- Tamoxifen, Tamoxifen (open label)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cardiovascular Disease
FEIBA and Use of Blood Products in Cardiac Surgery
The purpose of this pilot study is to evaluate the feasibility of the prophylactic administration of Factor VIII Inhibitor Bypass Activity (FEIBA) at termination of cardiopulmonary bypass (CPB) period.
- Trial name
- FEIBA (NCT02577614)
- Testing
- FEIBA, Normal Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Parkinson's Disease
Cognitive Decline in Non-demented PD
The purpose of this study is to determine the relationship between attention and quality of life and how rivastigmine and atomoxetine alter attention in non-demented persons with Parkinson's disease (PD).
- Trial name
- NCT01340885
- Testing
- Strattera, Exelon
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Oregon Health and Science University
Pityriasis Rubra Pilaris
Ixekizumab in the Treatment of Pityriasis Rubra Pilaris (PRP)
15 patients with PRP will be treated with ixekizumab for 24 weeks to determine safety and efficacy. Participants are required to travel to Portland, OR only for the first visit and week-24 visit.
- Trial name
- NCT03485976
- Testing
- Ixekizumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Labor Onset Biomarkers, Labor Onset
Pregnancy and Latent Labor Biomarkers and Symptoms to Predict Cervical Dilation at Hospital Admission.
The proposed pilot investigation is a prospective, observational study of 300 healthy nulliparous women with spontaneous term labor onset.
- Conditions
- Labor Onset Biomarkers, Labor Onset, Cervical Dilation
- Trial name
- NCT04437576
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Type1diabetes
Three Way Crossover Closed Loop Study With Xeris Glucagon
Closed-loop systems are an emerging technology that automate hormone delivery. They are quickly paving the way to revolutionize the treatment of type 1 diabetes.
- Trial name
- NCT03424044
- Testing
- Artificial Pancreas Controller in Dual Hormone Mode, Artificial Pancreas Controller in Single Hormone Mode, Artificial Pancreas Controller in Predictive Low Glucose Suspend Mode
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Oregon Health and Science University
Preeclampsia
Magnesium Sulfate in Obese Preeclamptics
The purpose of this study is to learn how medications participant will receive in the course of their delivery are metabolized (broken down by the body).
- Trial name
- NCT02835339
- Testing
- Magnesium sulfate 4g loading dose, 1g/hr infusion, Magnesium sulfate 6g loading dose, 2g/hr infusion
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson Disease
Improving Walking Automaticity in Parkinson's Disease: Levodopa or Donepezil
Safe and independent mobility at home and in the community requires control of walking while accomplishing other functional tasks.
- Trial name
- NCT03599726
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Parkinson Disease, Stroke
Mobility Rehab, a Therapist-assisted System for Gait Rehabilitation
Phase II of this study includes a pragmatic clinical trial which will take place at Northwest Rehabilitation Associates (NWRA) in Salem, OR to verify the efficacy of the system in a physical therapy clinic.
- Conditions
- Parkinson Disease, Stroke, Multiple Sclerosis, Gait Disorders, Neurologic
- Trial name
- NCT03869879
- Testing
- Feedback-assisted physical therapy, Traditional physical therapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency
High Protein Diet in Patients With Long-chain Fatty Acid Oxidation Disorders
The study also determines if eating a diet higher in protein alters body composition, energy balance and metabolic control among patients with a long-chain fatty acid oxidation disorder.
- Conditions
- Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency, Carnitine Palmitoyltransferase 2 Deficiency, Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency
- Trial name
- NCT01494051
- Testing
- Diet counseling
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
Dehydration in Children
Capillary Refill for Assessment of Dehydration
Capillary refill is used clinically to assess multiple things in children. This is a prospective observational study of the correlation between capillary refill time and degree of dehydration in children seen in a pediatric ED.
- Trial name
- NCT03670394
- Testing
- Capillary Refill
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Oregon Health and Science University
Pain, Postoperative, Obstructive Sleep Apnea of Child
Use of Analgesics and Pain Scores After Pediatric Adenotonsillectomy
The purpose of the study is to quantify the use of pain medications given to children aged 3 - 12 years as well as their pain level through pain scores after they have undergone a tonsillectomy or adenotonsillectomy surgery at…
- Trial name
- NCT04349397
- Testing
- Medication Tracking Form
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
Medical Abortion, Pain
Cannabinoids for Pain Control During Medical Abortion
The objective of this study is to determine if a synthetic cannabis derivative, dronabinol, in addition to ibuprofen, decreases maximum pain scores compared to ibuprofen and placebo in women undergoing medical abortion.
- Trial name
- NCT03604341
- Testing
- Dronabinol 5mg Cap
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Oregon Health and Science University
Thromboembolic Complications
Thrombelastography Based Dosing of Enoxaparin
The risk of developing a blood clot occurs in up to 60% of all critical care patients. Many times enoxaparin (or Lovenox®) is given to patients who are at a higher risk of developing clots in their legs or lungs.
- Trial name
- NCT00990236
- Testing
- Enoxaparin dose adjusted Lovenox based on TEG, Enoxaparin 30 mg BID
- Where
- 3 sites in United States
- Volunteers
- 185 people
- Sponsor
- Oregon Health and Science University
Hemophilia, Bone Disease
Prospective Biomarkers of Bone Metabolism in Hemophilia A
One of the major shortcomings in studying bone disease in hemophilia is the lack of fracture outcome data demonstrating the clinical significance of decreased BMD and altered bone biomarkers in the hemophilia population.
- Trial name
- NCT02306694
- Testing
- Advate
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Oregon Health and Science University
Postoperative Complications, Neuromuscular Blockade
The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications
Substantial respiratory morbidity has been associated with postoperative residual paralysis, which is fairly common after general anesthesia involving a neuromuscular blocking agent.
- Trial name
- NCT02861131
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hip Osteoarthritis
Hip Osteoarthritis: Effects of Exercise Programs on Pain and Disability
Osteoarthritis is the most common form of arthritis in the United States. It is estimated that 20 million Americans have arthritis, and the annual societal cost is $95 billion.
- Trial name
- NCT00682617
- Testing
- Structured exercise program, Waitlist, delayed intervention
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Delirium, Respiratory Depression
Acupuncture for Sedation in the Intensive Care Unit (ICU)
BACKGROUND Many patients in the trauma intensive care unit (TICU) require mechanical ventilation and sedation or anxiolysis. Mechanical ventilation means that a machine is helping a patient breathe if he can't breathe on his own.
- Conditions
- Delirium, Respiratory Depression, Overmedication
- Trial name
- NCT01362270
- Testing
- Verum Acupuncture
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University