Clinical trials: sponsored by Oregon Health and Science University
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes Mellitus With Hypoglycemia
DailyDose Smart Snack Study for T1D on MDI
This is a single-center, open-label, crossover trial with two arms and two periods (2x2) and one-week washout period. The study is designed to evaluate the efficacy of an AI-based bedtime smart snack intervention in reducing…
- Trial name
- NCT05967260
- Testing
- DailyDose Smart Snack app, Dexcom G6 CGM
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Health Behavior, Well-Being
Readiness Supportive Leadership Training
This study is a randomized controlled trial that assesses the effects of an evidence based, multi-component, leadership support intervention, Resilience-Supportive Leadership Training (RESULT), using accelerated learning…
- Trial name
- RESULT (NCT04152824)
- Testing
- Resilience-Supportive Leadership Training (RESULT)
- Where
- United States
- Volunteers
- 1,890 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Type II Diabetes, Primary Health Care
INTEGRATE-D: A Pilot Test to Support Integration of Medical and Psychosocial Care for People With Type II Diabetes
In 2016, the American Diabetes Association (ADA) published its first-ever recommendations for integrating medical and psychosocial care for patients with Type II Diabetes Mellitus (DMII) and common mental and behavioral health…
- Conditions
- Type II Diabetes, Primary Health Care, Behavioral Health
- Trial name
- NCT04461405
- Testing
- INTEGRATE-D
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cognitive Impairment, Mild, Cognitive Decline
Efficacy of a Multimodal Brain Health Intervention for Older African Americans
This study tests the feasibility, acceptability, and efficacy of a multimodal intervention (walking, social engagement, and reminiscence), including the use of wearable digital biomarkers, for cognitively healthy and mildly…
- Trial name
- SHARP (NCT04863378)
- Testing
- Walking conversational reminiscence
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Well-Being, Sleep
Oregon Military Employee Sleep and Health Study
This study is a randomized controlled trial that assesses the effects of (1) the Family-Supportive Supervisor Behavior (FSSB) and Sleep Leadership training and (2) sleep/cognitive effectiveness feedback intervention on health and…
- Conditions
- Well-Being, Sleep, Health Behavior
- Trial name
- MESH (NCT02946736)
- Testing
- FSSB/Sleep Leadership Training, Actigraphy Feedback
- Where
- United States
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Methamphetamine-dependence
Effects of Genotype on Resting State Connectivity During Methamphetamine Administration
Addiction to methamphetamine (MA) is a serious health problem in the United States. Right now, there are no medically approved treatments for MA dependence.
- Trial name
- MATAAR (NCT03973489)
- Testing
- Magnetic resonance imaging (MRI), Methamphetamine Hydrochloride Tablets
- Where
- 2 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Ptsd
Feasibility and Acceptability of Stress Induction, Physiological Data Collection, and Mindfulness-Based Stress Reduction Among Combat Veterans With PTSD
Investigators will recruit up to 20 veterans with PTSD. Participants will be randomized into two conditions: MBSR and Health and Wellness Education (HWE; control group). Participants will be randomized at a 1:1 ratio.
- Trial name
- NCT05938816
- Testing
- Mindfulness-Based Stress Reduction (MBSR), Health and Wellness Education (HWE)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Oregon Health and Science University
Parkinson Disease
Effect of GOCOVRI (Amantadine, Extended Release Capsules) on Gait in Parkinson's Disease
The purpose of the study is to learn about the effect of GOCOVRI (Amantadine extended release) on activity levels and measures of gait and balance quality in people with Parkinson's disease (PD) and levodopa induced dyskinesia…
- Trial name
- NCT04387773
- Testing
- GOCOVRI
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oregon Health and Science University
Hepatitis C
TeleHepC Treatment Trial
The main goal of this study is to test the efficacy of a peer-facilitated telemedicine HCV treatment implementation strategy for people who use drugs versus local HCV treatment referral for achieving HCV sustained viral response…
- Trial name
- NCT04798521
- Testing
- Tele-HCV, Community Linkage to Care
- Where
- 3 sites in United States
- Volunteers
- 203 people
- Sponsor
- Oregon Health and Science University
Cesarean Section
Chloroprocaine Lavage to Improve Outcomes Related to Operative Cesarean Delivery
The long term objective is to show that intraperitoneal chloroprocaine can be used an alternative option to avoid general anesthesia during cesarean delivery, to alleviate mother's discomfort from surgical pain, reduce…
- Trial name
- CLOR-PRO (NCT03760718)
- Testing
- Preservative free 1% Chloroprocaine, Preservative free 2% Chloroprocaine, Preservative free 3% Chloroprocaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Fall, Motivation
Engaging Older Adults in Fall Prevention Using Motivational Interviewing (MI)
This mixed-methods, two-arm, randomized controlled trial will evaluate the impact of Motivational Interviewing (MI) as a follow-up care to patients who received fall prevention recommendations at Oregon Health \& Science…
- Conditions
- Fall, Motivation, Behavior, Coping Behavior
- Trial name
- NCT04612842
- Testing
- Motivational Interviewing
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
RAD
Dosimeter Location in Pain Physicians
The primary objective is to determine if there is a significant difference in radiation readings between dosimeters worn on the chest versus the hand of interventional pain management physicians and elucidate which dosimeter had…
- Trial name
- NCT06309407
- Testing
- Hand Dosimeters, Standard Practice
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Bowel Dysfunction, Postoperative Complications
Sugammadex To IMprove Bowel Function
Colon and rectal surgery is associated with high cost, long length of stay, high postoperative surgical site infection rate, high incidence of postoperative nausea and vomiting, and a high rate of hospital readmission.
- Conditions
- Bowel Dysfunction, Postoperative Complications, Neuromuscular Blockade
- Trial name
- STIM_Bowel (NCT04546672)
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Oregon Health and Science University
Bleeding, Implants
Use of Curcumin to Treat Unfavorable Bleeding Patterns in Contraceptive Implant Users
The investigators plan to study the effects of curcumin, the active ingredient in the spice turmeric, on the irregular bleeding experienced by women who use the contraceptive implant.
- Conditions
- Bleeding, Implants, Breakthrough Bleeding
- Trial name
- NCT04205929
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pityriasis Rubra Pilaris
Guselkumab in the Treatment of Pityriasis Rubra Pilaris (PRP)
15 patients with PRP will be treated with guselkumab for 20 weeks to determine safety and efficacy. Participants are required to travel to Portland, OR only for the first visit, week-4 visit, and week-24 visit.
- Trial name
- NCT03975153
- Testing
- guselkumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Obesity, Contraception
Effectiveness of Orally Dosed Emergency Contraception in Obese Women - UPA
Obese women are significantly more likely than their normal BMI counterparts to experience failure of orally-dosed emergency contraceptives.
- Trial name
- UPA-Obesity (NCT02859337)
- Testing
- UPA-ECx1, UPA-ECx2
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency
Fatty Acid Oxidation Defects and Insulin Sensitivity
The purpose of this study is to learn more about what causes insulin resistance. It has been suggested that proper breakdown of fat into energy (oxidation) in the body is important to allow insulin to keep blood sugar in the…
- Conditions
- Very Long-chain Acyl-CoA Dehydrogenase Deficiency, Trifunctional Protein Deficiency, Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency, Medium-chain Acyl-CoA Dehydrogenase Deficiency
- Trial name
- NCT02517307
- Testing
- Intralipid/Heparin, Glycerol/Saline, Hyperinsulinemic euglycemic clamp
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Nervous System Diseases, Diagnostic Imaging
MR, Histologic And EM Imaging Of Intravenous Ferumoxytol In Central Nervous System (CNS) Inflammation
This exploratory study utilizes ferumoxytol, an iron oxide nanoparticle MR contrast agent for imaging various inflammatory processes in the head and neck region, spine, including the central nervous system.
- Trial name
- NCT00659776
- Testing
- Ferumoxytol
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Oregon Health and Science University
Dementia, Alzheimer Disease
Assessing Acceptability, Cost, and Efficacy of STELLA-Support Via Technology
STELLA (Support via Technology Living and Learning with Advancing Alzheimer's disease and related dementias) is a multicomponent video-conference based intervention that aims to help family members caring for persons of dementia…
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burnout, Family Members
- Trial name
- STELLA (NCT04335110)
- Testing
- STELLA (Support via TEchnology: Living and Learning with Advancing Alzheimer's disease and related dementias)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Oregon Health and Science University