Clinical trials: sponsored by Oregon Health and Science University
Obstructive Sleep Apnea
Circadian Rhythms and Cardiovascular Risk
The purpose of this study is to understand how behaviors and the effects of the body's internal clock (called the circadian pacemaker) affect the control of the heart and blood pressure.
- Trial name
- NCT02202811
- Testing
- Forced Desynchrony
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hypertension
Community Vital Signs (CVS): An Integrated Community-Based Approach to Identify Undiagnosed Hypertension in Nigeria
If detected early, hypertension (HTN) is treatable; yet, HTN screening rates are low and inequitable in Sub-Saharan Africa (SSA) leaving many people with undiagnosed HTN, especially in urban areas.
- Trial name
- NCT06659900
- Testing
- CORE Plus (+), CORE
- Where
- Nigeria
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Brain Injury
Assessment and Rehabilitation of Central Sensory Impairments for Balance in mTBI
Our central hypothesis is that chronic balance deficits after mild traumatic brain injury (mTBI) result from impairments in central sensorimotor integration (CSMI) that may be helped by rehabilitation.
- Trial name
- NCT02748109
- Testing
- Vestibular Rehabilitation + audio biofeedback, Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mild Traumatic Brain Injury, Gait
Objective Dual-task Turning Measures for Return-to-duty Assessments
The overall objective is to evaluate objective dual-task turning measures for use as rehabilitative outcomes and as tools for return-to-duty assessments in individuals with mild traumatic brain injury (mTBI).This project consists…
- Conditions
- Mild Traumatic Brain Injury, Gait, Balance, Veterans
- Trial name
- reTURN (NCT03892291)
- Where
- 6 sites in United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Huntington Disease
Time-Restricted Eating in Huntington's Disease: A Clinical Pilot Study
This trial examines whether 12 weeks of time-restricted eating (TRE), otherwise known as intermittent fasting, appears safe and feasible in persons with early-stage Huntington's disease (HD).
- Trial name
- TREHD (NCT06490367)
- Testing
- Time-Restricted Eating Diet
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon Health and Science University
Post-Abortion, Hemorrhage, Obstetric
Oxytocin Receptor Expression in Pregnancy
This study aims to determine when during gestation oxytocin receptor (OXTR) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and…
- Trial name
- NCT03907735
- Testing
- Myometrial tissue sample collection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes Mellitus With Hypoglycemia
DailyDose Smart Snack Study for T1D on MDI
This is a single-center, open-label, crossover trial with two arms and two periods (2x2) and one-week washout period. The study is designed to evaluate the efficacy of an AI-based bedtime smart snack intervention in reducing…
- Trial name
- NCT05967260
- Testing
- DailyDose Smart Snack app, Dexcom G6 CGM
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pyoderma Gangrenosum, Skin Diseases
Baricitinib in the Treatment of Adults With Pyoderma Gangrenosum (PG)
An Open-Label, Proof-Of-Concept, Study of Baricitinib for the Treatment of Pyoderma Gangrenosum
- Conditions
- Pyoderma Gangrenosum, Skin Diseases, Wound Heal, Pyoderma
- Trial name
- NCT04901325
- Testing
- Baricitinib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Contraception, Contraception Behavior
The Over The Counter Pill National Study
This is a prospective cohort study of individuals purchasing the oral contraceptive pill over the counter (OTC) in pharmacies in 32 US states. The comparison group is people receiving a prescription (Rx) for oral contraception.
- Conditions
- Contraception, Contraception Behavior, Contraceptive Usage, Health Care Utilization
- Trial name
- NCT05988983
- Testing
- Availability of OTC contraceptive pill
- Where
- United States
- Volunteers
- 1,026 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Heart Disease
Diet and Active Lifestyle - Yuuyaraq (The Yup'ik Way of Life)
Heart disease is the leading cause of death for Alaska Native men and the second leading cause of death (after cancer) among women and Alaska Native people overall.
- Trial name
- DAiLY (NCT06629610)
- Testing
- DAiLY
- Where
- 2 sites in United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Neural Tube Defects, Spina Bifida
Fetoscopic Neural Tube Defect Repair
This is a single-arm prospective study to record maternal and neonatal outcomes on subjects who undergo fetoscopic repair of Neural Tube Defects (NTD) at Oregon Health \& Science University (OHSU).
- Trial name
- NTD (NCT06946563)
- Testing
- Fetoscopic Neural Tube Defect Repair Devices
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Pregnancy Related
eDoula Feasibility and Acceptability
eDoula is an app that will give patients reading material and videos to watch based on their due date. It also provides helpful postpartum guidance.
- Trial name
- NCT06785467
- Testing
- eDoula App
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Fall Risk Factors, Physical Activity
OTAGO Exercise Program and Motivational Interviewing
The goal of this study is to see if OTAGO instructors, who have been trained in a special communication method called motivational interviewing, can help older adults start and stick with the OTAGO exercise program.
- Conditions
- Fall Risk Factors, Physical Activity, Engagement, Patient, Community-dwelling Older Adults
- Trial name
- NCT06931067
- Testing
- OTAGO Exercise Program with motivational interviewing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Mild Cognitive Impairment, Alzheimer's Disease
Safety and Target Engagement of Centella Asiatica in Cognitive Impairment
This clinical trial is focused on determining whether biological signatures of target engagement by a Centella asiatica water extract product administered orally for 6 weeks can be measured in comparison to placebo.
- Trial name
- NCT05591027
- Testing
- Centella asiatica product
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes
Closed Loop Context Aware AID
An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a high blood sugar detection and dosing algorithm for use within an AP control system.
- Trial name
- NCT06676657
- Testing
- iPancreas automated insulin delivery system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Health Behavior, Well-Being
Readiness Supportive Leadership Training
This study is a randomized controlled trial that assesses the effects of an evidence based, multi-component, leadership support intervention, Resilience-Supportive Leadership Training (RESULT), using accelerated learning…
- Trial name
- RESULT (NCT04152824)
- Testing
- Resilience-Supportive Leadership Training (RESULT)
- Where
- United States
- Volunteers
- 1,890 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Attention Deficit Hyperactivity Disorder
Feasibility and Acceptability of Powdered Multinutrient Formula
The study aims to test the feasibility and acceptability of 1) consumption of EMPowerplus Lightning Sticks, 2) at-home collection of blood and urine samples, and 3) remote visits and completion of online behavioral questionnaires.
- Trial name
- NCT05234593
- Testing
- EmpowerPlus Lightning Sticks
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Attention Deficit/Hyperactivity Disorder, Emotional Dysfunction
Focus Groups in Ethnically and Racially Diverse Families
Focus groups to identify treatment needs and barriers to participation in the planned multinutrient study among racially and ethnically diverse (Black and Hispanic) communities.
- Conditions
- Attention Deficit/Hyperactivity Disorder, Emotional Dysfunction, Irritable Mood
- Trial name
- NCT05930886
- Testing
- Focus Group
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University