Clinical trials: sponsored by Oregon Health and Science University
Obesity
Evaluation of Safety and Health Involvement For Truck Drivers
The current project is a randomized, controlled evaluation of a new weight loss and health promotion intervention for truck drivers.
- Trial name
- SHIFT (NCT02105571)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Bleeding, Contraceptive Device; Complications
Tranexamic Acid to Reduce Contraceptive-related Bleeding Side Effects
This randomized double blinded trial seeks to determine whether tranexamic acid (TXA) is an efficacious treatment for contraceptive induced menstrual changes (CIMC) including irregular, bothersome bleeding caused by the…
- Trial name
- NCT06000423
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis, Sclerosis
Aerobic Exercise for Remyelination in Multiple Sclerosis
This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Sclerosis, Demyelinating Diseases, Autoimmune Diseases of the Nervous System
- Trial name
- NCT04539002
- Testing
- Aerobic exercise, Education Group Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Hypertension, Cardiovascular Risk Factor
Sleep and Circadian Mechanisms of Non-dipping Blood Pressure
This study will be the first to distinguish the relative contributions of sleep, circadian and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the groundwork for optimizing therapies dependent on…
- Trial name
- NCT03558893
- Testing
- Forced Desynchrony
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes
Two Way Crossover Closed Loop Study Insulin vs Insulin and Pramlintide
The purpose of this study is to test how well a new investigational closed loop system manages your blood sugar with the ability to deliver insulin and pramlintide.
- Trial name
- NCT06422325
- Testing
- MPC closed-loop system in insulin only mode, MPC closed-loop system in insulin/pramlintide mode
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes
Two Way Crossover Closed Loop MPC vs Control IQ
An artificial pancreas (AP) is a control system for automatic insulin delivery. The investigators have implemented a missed meal bolus detection algorithm for use within an AP control system.
- Trial name
- NCT05799781
- Testing
- MPC closed-loop system, t:slim X2 pump with Dexcom G6 CGM and Control IQ
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Oregon Health and Science University
Cardiovascular Risk Factor, Circadian Dysregulation
Body Weight, Sleep, and Heart Health
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity.
- Conditions
- Cardiovascular Risk Factor, Circadian Dysregulation, Obesity
- Trial name
- NCT03388788
- Testing
- Positron Emission Tomography (PET) scanning of cardiac function at 3 time points across the 24 hour circadian cycle
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Asthma in Children
Treating Respiratory Emergencies in Children Study
Over 200,000 children have a 911 Emergency Medical Services (EMS) activation for respiratory distress each year, most of whom have acute wheezing.
- Trial name
- T-RECS (NCT06074185)
- Testing
- Ipratropium Bromide
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Oregon Health and Science University
Healthy, Aging
Ashwagandha Pharmacokinetics Study in Older Adults
This study will measure the oral bioavailability and pharmacokinetics of known compounds from a standardized Withania somnifera botanical dietary supplement in healthy older adults.
- Trial name
- NCT06171724
- Testing
- Shoden
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Dementia, Alzheimer Disease
Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA
The purpose of this study is to test a revised psychoeducational intervention to help Care Partners for family members with dementia understand and reduce the distressing behaviors that come with progressive dementia.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burnout, Family Members
- Trial name
- Tele-STELLA (NCT04627662)
- Testing
- Tele-STELLA
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Oregon Health and Science University
Spinal Cord Injury
Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury
The purpose of this study is to learn more about how participants heal from acute spinal cord injury.
- Trial name
- TEMPLE (NCT02878850)
- Testing
- Augmented Blood Pressure
- Where
- 11 sites in United States
- Volunteers
- 94 people
- Sponsor
- Oregon Health and Science University
Pancreatitis, Pancreas Divisum
SpHincterotomy for Acute Recurrent Pancreatitis
The purpose of this study is to determine if a procedure called Endoscopic Retrograde CholangioPancreatography (ERCP) with sphincterotomy reduces the risk of pancreatitis or the number of recurrent pancreatitis episodes in…
- Conditions
- Pancreatitis, Pancreas Divisum, Pancreatitis, Acute, Pancreatitis Idiopathic
- Trial name
- SHARP (NCT03609944)
- Testing
- ERCP with miES, EUS
- Where
- 21 sites in United States, Canada
- Volunteers
- 181 people
- Sponsor
- Oregon Health and Science University
Caregivers Burnout, Frontotemporal Dementia
Support Via Technology: Living and Learning With Advancing FTD
Much effort over the last several decades has been devoted to developing and implementing psychoeducational interventions for family caregiving partners for those with Alzheimer's and relatedm dementias (ADRD).
- Trial name
- STELLA-FTD (NCT05338710)
- Testing
- STELLA-FTD
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pantothenate Kinase-Associated Neurodegeneration
CoA-Z in Pantothenate Kinase-associated Neurodegeneration (PKAN)
The purpose of this study is to learn more about how people with the condition pantothenate kinase-associated neurodegeneration (PKAN) respond to a specialized study product.
- Trial name
- NCT04182763
- Testing
- CoA-Z
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Oregon Health and Science University
CSF Circulation
Influence of Yogic Breathwork on CSF Circulation
The purpose of this research study is to determine the influence of yoga breathing practices on cerebrospinal fluid (CSF) circulation, and to find out primarily if a regular practice of 8-week yoga breathing would enhance CSF…
- Trial name
- CSF (NCT03858309)
- Testing
- Breathing Group 1, Breathing Group 2
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pancreatic Duct Stone, Pancreatic Duct Stricture
Pancreatic Endotherapy for Refractory Chronic Pancreatitis
The purpose of this study is to evaluate whether endoscopic ultrasound (EUS) only versus EUS + endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic endotherapy reduces pain in the treatment of chronic…
- Conditions
- Pancreatic Duct Stone, Pancreatic Duct Stricture, Pancreatic Duct Dilatation
- Trial name
- PERCePT (NCT04232670)
- Testing
- EUS + Pancreatic Endotherapy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Oregon Health and Science University
Traumatic Brain Injury, Critical Illness
Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin
Sleep wake disturbances compound recovery in over half of pediatric traumatic brain injury survivors, leading to impaired quality of life, and few effective interventions exist to treat this important morbidity.
- Conditions
- Traumatic Brain Injury, Critical Illness, Sleep
- Trial name
- SMARTKids (NCT04932096)
- Testing
- melatonin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Atopic Dermatitis, Atopic Disorders
A Community-based Assessment of Skin Care, Allergies, and Eczema
Atopic dermatitis (AD) affects over 9 million children in the U.S. and often heralds the development of asthma, food allergy, skin infections and neurodevelopmental disorders.
- Conditions
- Atopic Dermatitis, Atopic Disorders, Eczema, Atopic Eczema
- Trial name
- CASCADE (NCT03409367)
- Testing
- Participant choice of over-the-counter emollients: Vaseline, Vanicream, CeraVe Healing Ointment, CeraVe cream, Cetaphil cream
- Where
- 4 sites in United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Healthy, Elderly
Pharmacokinetics of Centella Asiatica in the Elderly
This study will measure the oral bioavailability and pharmacokinetics of known bioactive compounds from a standardized Centella asiatica water extract (CAW) product (CAP) in cognitively healthy elders.
- Trial name
- NCT03929250
- Testing
- 2g Centella asiatica water extract product, 4g Centella asiatica water extract product
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University