Clinical trials: sponsored by Oslo University Hospital
Exudative Age-related Macular Degeneration
Plasma Levels of Vascular Endothelial Growth Factor Before and After Intravitreal Injection of Aflibercept
The purpose of this study is to examine the plasma concentration of vascular endothelial growth factor (VEGF) after standard treatment with one of the newest growth factor inhibitors, aflibercept (Eylea).
- Trial name
- Eylea-2014 (NCT02125864)
- Testing
- intravitreal injection
- Volunteers
- 16 people
- Sponsor
- Oslo University Hospital
Atherosclerosis, Inflammation
Atherosclerosis and Acute Ischemic Stroke Study
A significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaque at the carotid bifurcation. It is now wellknown that inflammation plays a key role in atherogenesis and plaque destabilization.
- Conditions
- Atherosclerosis, Inflammation, Ischemic Stroke
- Trial name
- NCT03685006
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Internal Carotid Artery Stenosis With Infarction
Advanced Ultrasound Methods in the Assessment of Carotid Plaque Instability
The primary aim of this project is to assess if advanced ultrasound methods such as SMI (Superb microvascular Imaging) and SWE (Shear Wave Elastography) can identify intraplaque neovascularization and plaque tissue stiffness in…
- Trial name
- NCT03672955
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Breast Cancer
Secondary Adjuvant Treatment for Patients With Isolated Tumor Cells in Bone Marrow
The purpose of this study is to identify patients with persisting tumor cells after standard epirubicin-containing treatment to test a non-cross resistant chemotherapy regimen (docetaxel) for these patients, and to explore the…
- Trial name
- NCT00248703
- Testing
- Docetaxel
- Where
- Norway
- Volunteers
- 1,128 people
- Sponsor
- Oslo University Hospital
Cervical Cancer
Self-sampling Among Long-term Non-attenders to Cervical Cancer Screening
The trial will evaluate whether human papillomavirus (HPV) self-sampling may increase cervical cancer screening attendance among under-screened women in Norway, how different ways of offering self-sampling and follow-up may…
- Trial name
- NCT03873376
- Testing
- Opt-in; Receive offer to order self-sampling kit, Opt-out; Receive self-sampling kit unsolicited, Control; Receive open reminder to be screened by physician
- Where
- Norway
- Volunteers
- 5,669 people
- Sponsor
- Oslo University Hospital
Fatigue, Lymphoma
A Feasibility Study in Chronically Fatigued Cancer Survivors
Improved cancer survival has led to increased attention on long-term health and quality of life (QoL) among the survivors. Both the cancer diagnosis and intensive treatments increase the risk of late effects which may interfere…
- Trial name
- NCT04931407
- Testing
- A 12-week interdisciplinary complex intervention
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Foot Diseases, Plantar Fascitis
Translation and Psychometric Testing of the Norwegian Foot Functional Index Revised, Short Version.
The aim of this study is to translate into Norwegian and cross-culturally adapt the Foot Functional Index- revised, short form (FFI-RS) according to international guidelines.
- Trial name
- NCT04207164
- Where
- Norway
- Volunteers
- 139 people
- Sponsor
- Oslo University Hospital
Covid-19, Respiratory Tract Infections
Cod Liver Oil for Covid-19 Prevention Study
A randomized, parallel-group treatment, quadruple masked, two-arm study to assess the effectiveness of cod liver oil compared to placebo in the prevention of Covid-19 and airway infections in healthy adults.
- Trial name
- NCT04609423
- Testing
- Cod liver oil
- Where
- Norway
- Volunteers
- 47,210 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Traumatic Brain Injury
Traumatic Brain Injury; Needs and Treatment Options in the Chronic Phase
Traumatic brain injury (TBI) is a condition affecting the persons' central nervous system with a need for extensive and highly specialized initial health care provision followed by comprehensive rehabilitation efforts.
- Trial name
- NCT03545594
- Testing
- Patient-centered in home rehabilitation, Control
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Hip Fracture, Vertebral Fracture
Norwegian Capture the Fracture Initiative
The main aim is to assess the effectiveness of introducing a standardized intervention program for treatment of patients with a fragility fracture as measured by changes in the fracture rates and the mortality.
- Conditions
- Hip Fracture, Vertebral Fracture, Other Low-trauma Fracture
- Trial name
- NoFRACT (NCT02536898)
- Testing
- Fracture Liaison Service, Current treatment
- Where
- 7 sites in Norway
- Volunteers
- 94,260 people
- Sponsor
- Oslo University Hospital
Thyroid Nodule, Thyroid Cancer
HRQOL in Thyroid Cancer and Thyroid Tumours
Background: Most patients with thyroid cancer have a long life expectancy, and it has been assumed among health professionals that therefore the quality of life (QOL) is good.
- Conditions
- Thyroid Nodule, Thyroid Cancer, Quality of Life
- Trial name
- NCT03676348
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Gastrointestinal Stromal Tumor
SSG XXV: The Stop-GIST Trial; Discontinuation of Imatinib in Patients With Oligo-metastatic GIST
The trial "The stop-GIST trial" is an Oslo University Hospital sponsored, prospective, open-label, 1-group, multicenter phase II trial evaluating discontinuation of imatinib in highly selected patients treated with imatinib…
- Trial name
- NCT02924714
- Testing
- Discontinuation of imatinib
- Where
- Norway
- Volunteers
- 31 people
- Sponsor
- Oslo University Hospital
Peripheral Neuropathy, Intraoperative Injury
Steep Trendelenburg With or Without Lithotomy Positioning on the Operating Table.
Robotic assisted laparoscopic and laparoscopic gynecological, colon-rectal and urological surgical procedures require that patients be placed in steep Trendelenburg positioning with or without lithotomy on operating table.
- Conditions
- Peripheral Neuropathy, Intraoperative Injury, Intraoperative Complications, Patient Positioning
- Trial name
- NCT05237700
- Testing
- Patient positioning on operating table
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Atrial Fibrillation, Ischemic Stroke
Atrial Fibrillation in Cryptogenic Stroke and TIA
Background: Different studies with real-life data and randomized controlled trials have shown a detection rate of paroxysmal atrial fibrillation (AF) of 10-20% in patients with cryptogenic stroke using insertable continuous…
- Conditions
- Atrial Fibrillation, Ischemic Stroke, TIA
- Trial name
- NOR-FIB (NCT02937077)
- Testing
- Medtronic Reveal LINQ
- Where
- 2 sites in Norway
- Volunteers
- 259 people
- Sponsor
- Oslo University Hospital
Intensive Care Patients
Longitudinal Prospective Study in a Mixed ICU Population
Longitudinal prospective observational multicenter study in a mixed population of intensive care unit (ICU) patients (n=650). The overall purpose of this research proposal is to increase the knowledge in how pre-morbid condition…
- Trial name
- NCT03714230
- Where
- Norway
- Volunteers
- 603 people
- Sponsor
- Oslo University Hospital
Coronavirus
Risk Factors for Community- and Workplace Transmission of COVID-19
The project is an epidemiological observational study based on an electronic questionnaire on risk factors for COVID-19 in the community and healthcare setting.
- Trial name
- NCT04320732
- Testing
- Observation of behavior and COVID-19 infection will be conducted.
- Where
- Norway
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Prostate Biopsy, Antibiotic
Transperineal MRI-TRUS Fusion Guided Prostate Biopsy With vs Without Antibiotic Prophylaxis
Prostate biopsy is indicated in patients with suspected prostate cancer and has been traditionally performed through the rectum using antibiotic prophylaxis.
- Trial name
- NORAPP (NCT04146142)
- Testing
- Transperineal prostate biopsy with or without antibiotic prophylaxis
- Where
- 2 sites in Germany, Norway
- Volunteers
- 550 people
- Sponsor
- Oslo University Hospital
Human Immunodeficiency Virus
Improving Prognosis in HIV Infection
The primary objective of this study is to assess the safety of probiotics in cART-treated immunologic non-responder (INR) patients with chronic HIV infection.
- Trial name
- NCT02640625
- Testing
- Probiotic compound
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
COVID-19, Critical Care
The COVID-ICU Healthcare Professional Study
The project is a longitudinal cohort study based on an electronic questionnaire on views and experiences of COVID-ICU Health care professionals during the pandemic.
- Conditions
- COVID-19, Critical Care, Intensive Care Units, Health Personnel
- Trial name
- NCT04372056
- Testing
- Views and experiences of health care professionals working in intensive care units during the COVID-19 pandemic
- Where
- Norway
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Dry Eye Syndromes, Meibomian Gland Dysfunction
Optimization of the Treatment of Dry Eye Disease Caused by Meibomian Gland Dysfunction
An open label, randomized controlled study in a Norwegian population with meibomian gland dysfunction. Patients will be randomized to one of two groups: THERA°PEARL Eye Mask (Bausch \& Lomb Inc., New York, USA) or Blephasteam®…
- Trial name
- NCT03318874
- Testing
- Blephasteam, THERA°PEARL Eye Mask, Hylo-comod
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Oslo University Hospital