Clinical trials: sponsored by Oslo University Hospital
Coronary Artery Disease, Intestinal Disease
The Role of Gut Leakage Markers and Microbiota Signature in Coronary Artery Disease.
Define a signature of gut microbiota composition and related metabolites in patients with ST-elevation myocardial infarction, non ST-elevation myocardial infarction and chronic coronary disease (CAD).
- Trial name
- GUT-ACS (NCT04605627)
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Action Tremor
A Controlled Comparison of Two DBS Targets for Upper Extremity Action Tremor
Action tremor of the arms can be an invalidizing symptom of diseases such as Essential Tremor, Dystonic Tremor, Parkinson's disease and Multiple Sclerosis.
- Trial name
- Tremorstim (NCT03156517)
- Testing
- Deep Brain Stimulation
- Where
- Norway
- Volunteers
- 45 people
- Sponsor
- Oslo University Hospital
Hemodynamics, Biosensors
Validation of Ballistocardiographic Biosensors and Other Hemodynamic Measures for Healthy Subjects
Ballistocardiographic (BCG) biosensors reflecting the patients' current state is established. There are few studies documenting BCG biosensors efficacy, effectiveness, and efficiency.
- Conditions
- Hemodynamics, Biosensors, Cardiac
- Trial name
- NCT04585568
- Testing
- Biosensors
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Osteosarcoma
A Study of Pembrolizumab in Patients With Relapsed Or Metastatic Osteosarcoma Not Eligible for Curative Surgery
This is a phase II, single arm, open-label, interventional trial of pembrolizumab (MK-3475) in patients with osteosarcoma who have experienced disease relapse or progression after at least one line of systemic treatment, and who…
- Trial name
- PROMO (NCT03013127)
- Testing
- Pembrolizumab
- Where
- 2 sites in Italy, Norway
- Volunteers
- 12 people
- Sponsor
- Oslo University Hospital
Acute ST-elevation Myocardial Infarction
Thrombus Aspiration in Acute ST-elevation Myocardial Infarction
Thirty patients with acute ST-elevation myocardial infarction treated with primary PCI and aspiration of thrombus material from the infarct related coronary artery will be included.
- Trial name
- TASTI (NCT02746822)
- Where
- Norway
- Volunteers
- 36 people
- Sponsor
- Oslo University Hospital
Ulcerative Colitis, Crohn's Disease
Anti-inflammatory Effect of Agaricus Blazei Murill in Inflammatory Bowel Disease (IBD)
Examine whether daily oral ingestion of a immunomodulatory mushroom extract (AndoSanTM) in patients with ulcerative colitis (UC) and Crohn's disease (CD), experience clinical, biochemical and genetical improvement in their…
- Conditions
- Ulcerative Colitis, Crohn's Disease, Inflammatory Bowel Disease
- Trial name
- NCT01496053
- Testing
- AndoSan, Sugar Extract
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Addiction
YATEP - The Impact of Horse Assisted Therapy (HAT) on Treatment Outcomes
The objective of the study is to assess the impact of horse assisted therapy (HAT) on: Addiction treatment outcomes (its effectiveness as an alternative therapy) Addiction treatment dropout \& addiction relapse (its efficacy in…
- Trial name
- HAT (NCT01795755)
- Testing
- Mentalization based inpatient treatment., Horse assisted Therapy (HAT)
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Circulatory; Change, Microcirculation
Evaluation of the Circulatory Status of Stomach Tube and Gastrooesophageal Anastomosis
The incidence of anastomotic leaks after gastroesophageal anastomosis after thoracolaparoscopic cancer esophagus surgery is high at the Oslo University Hospital.
- Trial name
- NCT03724162
- Where
- 2 sites in Norway
- Volunteers
- 12 people
- Sponsor
- Oslo University Hospital
Massive Rotator Cuff Tears
Arthroscopic Treatment of Massive Rotator Cuff Tears With Debridement and Biodegradable Spacer.
Massive rotator cuff tears are common in the adult population. It is estimated that about 12 % of adults 60 years of age or older suffer from a rotator cuff injury.
- Trial name
- AMRIS (NCT04571918)
- Testing
- Biodegradable spacer, Debridement and biceps tenotomy
- Where
- 2 sites in Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Hip Fractures, Trochanteric Fractures
Trochanteric Hip Fractures (AO A2) SHS With or Without Trochanteric Stabilizing Plate - Rct Using RSA
Trochanteric fractures represent about half of the hip fractures (with femoral neck fractures as the other half). Trochanteric hip fractures are almost always treated surgically with internal fixation of the fracture.
- Conditions
- Hip Fractures, Trochanteric Fractures, Intertrochanteric Fractures
- Trial name
- NCT02294747
- Testing
- Sliding Hip Screw with Trochanteric Stabilization Plate, Sliding Hip Screw without Trochanteric Stabilization Plate
- Where
- 2 sites in Norway
- Volunteers
- 31 people
- Sponsor
- Oslo University Hospital
Clostridium Difficile Infection
IMT for Primary Clostridium Difficile Infection
This is a randomized controlled trial to compare the effect of a 10-day course of per oral metronidazole versus a one-time rectal instillation of an anaerobically cultivated human intestinal microbiota for the treatment of a…
- Trial name
- NCT02301000
- Testing
- Intestinal microbiota therapy, Metronidazole
- Where
- 7 sites in Norway
- Volunteers
- 21 people
- Sponsor
- Oslo University Hospital
Brachial Plexus Block, Pain, Postoperative
Rebound Pain After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block
Many patients have strong pain at brachial plexus block resolution after operations for distal radius fractures with a volar plate.
- Trial name
- NCT03011905
- Testing
- Dexamethasone, NaCl (Control), Paracetamol
- Where
- Norway
- Volunteers
- 53 people
- Sponsor
- Oslo University Hospital
Diabetes Type 2
Effects of Prebiotics on GLP-1 in Type 2 Diabetes
The aim of the study is to compare the effects of prebiotics versus placebo on blood concentrations of glucagon-like peptide-1 in subjects with diabetes type 2.
- Trial name
- NCT02569684
- Testing
- Prebiotic fibers: oligofructose and inulin, Maltodextrin
- Where
- Norway
- Volunteers
- 37 people
- Sponsor
- Oslo University Hospital
Myocardial Infarction, Heart Failure
Omega-3 Fatty Acids in Elderly Patients With Acute Myocardial Infarction
The aim of the present study is to investigate the possible effects of supplementation with 1.8 g/day of n-3 polyunsaturated fatty acids on cardiovascular morbidity and mortality during a follow-up period of 2 years in an elderly…
- Conditions
- Myocardial Infarction, Heart Failure, Myocardial Revascularization, Atrial Fibrillation
- Trial name
- OMEMI (NCT01841944)
- Testing
- Pikasol, Corn oil
- Where
- 4 sites in Norway
- Volunteers
- 1,027 people
- Sponsor
- Oslo University Hospital
Leiomyoma, Uterine
Fibroids and Infertility - a Study of the Significance of Removal of Fibroids With Regard to Endometrial Receptivity
We aim to explore some of the molecular factors that reduce fertility for women with leiomyomas, taking into account leiomyoma location, size, number and vascularity.
- Trial name
- FIN (NCT04426760)
- Testing
- Transcervical resection of fibroids, Myomectomy per laparoscopy or laparotomy
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Childbirth Experience, Urinary Retention
Analgesia in the Second Stage of Labour
This study investigates efficacy, safety and childbirth experience in women receiving pudendal block during the final stage of delivery. It is an observational study and half of included primarous women recieve a pudendal block.
- Conditions
- Childbirth Experience, Urinary Retention, Satisfaction, Personal, Pain, Obstetric
- Trial name
- ASL (NCT04391075)
- Testing
- Pudendal nerve block
- Volunteers
- 1,007 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
SARS Virus, Severe Acute Respiratory Syndrome
Norwegian SARS-CoV-2 Study - Virological, Clinical and Immunological Characterisation of COVID-19
Oslo University Hospital has initiated an observational study on hospitalised patients with confirmed COVID-19, the infection caused by Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2).
- Trial name
- NCT04381819
- Testing
- SARS-CoV-2 PCR
- Where
- 7 sites in Norway
- Volunteers
- 1,000 people
- Sponsor
- Oslo University Hospital
Obesity, Metabolic Syndrome
Fish or Nuts? Dietary Effects on Cardiometabolic Risk Factors and Persistent Organic Pollutants
Obesity represents one of the most important public health challenges for the societies. Although excess energy intake and physical inactivity are major causes of obesity and cardiometabolic disorders, emerging evidence has…
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT02589756
- Testing
- The fatty fish group, The nut group, The control group
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
SARS-CoV Infection, COVID 19
The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients
The (World Health Organization) WHO NOR- (Coronavirus infectious disease) COVID 19 study is a multi-centre, adaptive, randomized, open clinical trial to evaluate the safety and efficacy of hydroxychloroquine, remdesivir and…
- Conditions
- SARS-CoV Infection, COVID 19, Acute Respiratory Distress Syndrome ARDS
- Trial name
- NCT04321616
- Testing
- Hydroxychloroquine, Remdesivir, (Standard of Care) SoC
- Where
- Norway
- Volunteers
- 700 people
- Sponsor
- Oslo University Hospital
Healthy Skin, Sunburned Skin
Pilot Study - Putative Penetration of Nanoparticles in Sunscreen in Intact or Sunburned Skin
The investigators want to study if nanoparticles of titaniumdioxide are penetrating skin when the skin is intact and when the skin is sunburned. The hypothesis is "Does nanotitandioxide penetrate intact or sunburned skin?"
- Conditions
- Healthy Skin, Sunburned Skin, Titanium Dioxide, Nanoparticles
- Trial name
- NCT01552135
- Where
- Norway
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital