Clinical trials: sponsored by Ottawa Hospital Research Institute
Cancer, Venous Thromboembolism
WAVe Study - Weight Adjusted Dalteparin for Patients Over 90 kg With Acute Cancer Associated Venous Thromboembolism
Cancer patients that develop blood clots are treated with low molecular weight heparin injections (LMWH). One kind of these LMWHs, dalteparin, has its dose determined based on a patient's weight using a formula of 200…
- Conditions
- Cancer, Venous Thromboembolism, Obesity
- Trial name
- WAVe (NCT03297359)
- Testing
- Dalteparin
- Where
- 5 sites in Canada
- Volunteers
- 92 people
- Sponsor
- Ottawa Hospital Research Institute
Smoking Cessation
Smoking Cessation With the Ottawa Model and SmartCard in Out-patient Respirology Clinic Setting
Cigarette smoking is the most harmful and quitting smoking is very difficult. Despite quitting, it is very difficult to stay quit for long term.
- Trial name
- Quit&Win (NCT01495689)
- Testing
- Ottawa Model with SmartCard, Usual care
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- Ottawa Hospital Research Institute
Prostatic Neoplasms
Dose Escalation For INtraprostatic LEsions
External beam radiotherapy combined with androgen deprivation therapy is a standard treatment option for localized prostate cancer.
- Trial name
- DEFINE (NCT05851547)
- Testing
- Prostate SBRT with Focal Boost, Triptorelin Injection
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis, Arthroplasty
Mobility Assessment of Patients With Total Hip Arthroplasty
The purpose of this study is to describe the 3D joint biomechanics of the lower extremities of patients having had a total hip replacement or hip resurfacing surgery as compared to a healthy age and weight matched control group…
- Conditions
- Osteoarthritis, Arthroplasty, Hip Replacement
- Trial name
- NCT00664508
- Testing
- Motion analysis
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Femoracetabular Impingement
Efficacy of an Exercise Program for Patients With Femoro-acetabular Impingement
The purpose of this study is to examine whether using an exercise regime on people with femoroacetabular impingement (FAI) can help reduce pain and improve function.
- Trial name
- NCT03949127
- Testing
- Exercise Group
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- Ottawa Hospital Research Institute
Femoroacetabular Impingement
Hip Impingement - Understanding Cartilage Damage
Femoro-acetabular impingement (FAI) is a known cause of hip pain and possibly a major cause of adult hip osteoarthritis. The relationship between cam-type FAI deformity characteristics and joint degradation to better identify…
- Trial name
- NCT01546493
- Testing
- MRI, qCT, Motion Analysis
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Ottawa Hospital Research Institute
Hip Dysplasia, Femoroacetabular Impingement
Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA
An abnormally formed hip joint (cam deformity) is a major cause of osteoarthritis (OA). Individuals may not experience any symptoms until OA is severe due to extensive cartilage loss and changes in underlying bone.
- Conditions
- Hip Dysplasia, Femoroacetabular Impingement, Osteoarthritis
- Trial name
- NCT04080466
- Testing
- Low-dose CT Scan, Blood/Urine Collection, Patient Reported Questionnaires
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Calcium Supplementation in HIV Patients Using Raltegravir
The Influence of Concurrent Oral Calcium Carbonate Supplementation on Steady State Pharmacokinetics of Oral Raltegravir.
The purpose of this study is to measure change in raltegravir serum pharmacokinetics in steady state, when co-administered with calcium carbonate formulated as antacid.
- Trial name
- RCPK (NCT04258475)
- Testing
- Raltegravir standard dosage of 1200 mg (two 600 mg tablets) orally once daily., Calcium carbonate antacid tablet
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Ottawa Hospital Research Institute
Burnout, Professional
Resource Optimization in the Intensive Care Unit Setting
The purpose of the study is to facilitate cost-effective, high quality care within the the ICUs of two Ottawa teaching hospitals through educational workshops and nurse scheduling optimization.
- Trial name
- NCT04665505
- Testing
- Educational Workshop, Optimizing Staff Scheduling
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Atrial Fibrillation, Atrial Flutter
RAFF5 Proposal: Improve the Quality and Safety of Patients Seen in the Emergency Department for Acute Atrial Fibrillation and Flutter
Acute atrial fibrillation (AF) and flutter (AFL) are the most common arrhythmias requiring management in the emergency department (ED).
- Trial name
- RAFF5 (NCT05468281)
- Testing
- Checklist implementation
- Where
- Canada
- Volunteers
- 1,108 people
- Sponsor
- Ottawa Hospital Research Institute
Obesity, Knee Osteoarthritis
BLOOM Forward: Investigating Weight Loss Impact on TJAC Patients
The goal of this clinical trial is to prospectively assess the efficacy of the BLOOM program, a comprehensive weight loss dietary and lifestyle program, in a population of patients living with obesity and awaiting hip or knee…
- Conditions
- Obesity, Knee Osteoarthritis, Hip Osteoarthritis, Arthroplasty Complications
- Trial name
- NCT06103552
- Testing
- Building Lifestyle Options for Orthopedic Mobility (BLOOM)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Tennis Elbow
Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement
We propose a randomized, double-blind controlled trial comparing arthroscopic release with arthroscopic debridement for the management of chronic tennis elbow in an effort to definitively determine whether arthroscopic tennis…
- Trial name
- NCT02236689
- Testing
- Non operative, Arthroscopic tennis elbow release
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Ottawa Hospital Research Institute
Hip Fractures
Comparison of Direct Anterior Approach vs. Lateral Hemiarthroplasty for Femoral Neck Fracture Repair
Recent research has demonstrated that a hemiarthroplasty (replacement of half the joint) has lower rates of post-surgical complications than a total hip arthroplasty does.
- Trial name
- NCT05173155
- Testing
- surgical approach
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Hospital Research Institute
Arteriovenous Fistula, Arteriovenous Graft
Access Creation for Hemodialysis: Association With Structural Changes of the Heart
The purpose of this study is to determine if the creation of a fistula or a graft plays a role in the development of heart disease for patients undergoing hemodialysis
- Conditions
- Arteriovenous Fistula, Arteriovenous Graft, Left Ventricular Hypertrophy, Brain Natriuretic Peptide
- Trial name
- NCT00368147
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
TAP vs QL for Postoperative Analgesia After DIEP Free Flap Breast Reconstruction
The purpose of this study is to compare the efficacy of Transversus abdominus plane (TAP) block and Quadratus Lumborum (QL) block on the quality of recovery after breast reconstruction with deep inferior epigastric perforator…
- Trial name
- NCT05301595
- Testing
- TAP block, QL Block
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Distress, Emotional, Burnout
Effect of a Life Coaching Intervention on the Well-being and Distress of Physicians
There is a widespread epidemic of distress and burnout (i.e., extreme distress) among Canadian physicians. Burnout is costly to physicians, patients, and healthcare organizations as it compromises physicians' own health and…
- Trial name
- NCT05149911
- Testing
- Life Coaching
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis of Knee
Outcome Following Orthopaedic Surgery
By investigating the long-term functional status of patients who have undergone various types of orthopaedic surgery we will have a basis for devising guidelines for future patients and surgeons.
- Trial name
- NCT00261066
- Where
- Canada
- Volunteers
- 8,439 people
- Sponsor
- Ottawa Hospital Research Institute
Surgery, Anesthesiology
Reducing Low-Value Preoperative Investigations in Patients Undergoing Low Risk Surgery
The purpose of this study is to evaluate if a multi-component behavioral intervention given to anesthesiologists and surgeons is associated with decreasing low value preoperative testing orders in patients undergoing low risk…
- Trial name
- Pre-Op (NCT05526495)
- Testing
- Reducing preoperative low-value test ordering
- Where
- 4 sites in Canada
- Volunteers
- 22 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Arrest
A Survey of Factors Associated With the Successful Recognition of Agonal Breathing and Cardiac Arrest.
The overall goal of this pilot study is to design and conduct a survey of 9-1-1 call takers in the province of Ontario, Canada to better understand the factors associated with the successful identification of cardiac arrest…
- Trial name
- NCT00848588
- Where
- Canada
- Volunteers
- 404 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer
PD-1 +/- IL-4 Inhibition in ER+ Breast Cancer
This proposal is for a Window of Opportunity (WOO) clinical trial using a novel combination of two Health Canada approved agents, cemiplimab (Libtayo) and dupilumab (Dupixent), for off label use in early-stage estrogen receptor…
- Trial name
- NCT05967884
- Testing
- Arm A: Cemiplimab, Arm B: Cemiplimab + Dupilumab
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute