Clinical trials: sponsored by Peking Union Medical College Hospital
Gastrointestinal Neuroendocrine Carcinoma, Adjuvant Treatment
Oxaliplatin-Based Adjuvant Therapy for Gastrointestinal Neuroendocrine Carcinoma**
Patients with pathologically-confirmed gastrointestinal neuroendocrine carcinoma will be enrolled, to explore the efficacy and safety of oxaliplatin-based doublet chemotherapy in the adjuvant treatment of gastrointestinal…
- Conditions
- Gastrointestinal Neuroendocrine Carcinoma, Adjuvant Treatment, Resection
- Trial name
- NCT07891572
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking Union Medical College Hospital
Hepatocellular Carcinoma (HCC)
68Ga-NYM207 PET/CT Imaging in Hepatocellular Carcinoma
This is a prospective, single-center, single-arm, phase I/II study designed to evaluate (1) the safety, tolerability, and imaging characteristics of 68Ga-NYM207 (Phase A), and (2) the diagnostic performance of 68Ga-NYM207 in…
- Trial name
- NYHCC (NCT07590336)
- Testing
- 68Ga-NYM207 PET/CT
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis
Perfusion Efficiency-Guided MAP De-escalation in Elderly Septic Shock
This is a single-center, prospective, randomized crossover physiological trial conducted in elderly patients (≥65 years) with septic shock in the intensive care unit (ICU).
- Trial name
- NCT07887854
- Testing
- Ascending MAP titration sequence, Descending MAP titration sequence
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer
Hypofractionated Online Adaptive Radiotherapy of Breast Cancer
The goal of this clinical trial is to explore the application of online adaptive radiotherapy in patients who receive moderate hypofractionated or ultrafractionated radiotherapy after breast cancer surgery.
- Trial name
- NCT06568705
- Testing
- Moderate hypofractionated Radiation Treatment, Ultrafractionated Radiation Treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Hypoparathyroidism
Efficacy and Safety of XH02 for the Treatment of Hypoparathyroidism
This study aims to evaluate the safety and efficacy of a novel PTH replacement therapy drug in patients with hypoparathyroidism.
- Trial name
- XH02 (NCT07197450)
- Testing
- intravenous administration of PTH1-84 mRNA
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Peking Union Medical College Hospital
Nonischemic Cardiomyopathy
FAPI PET Imaging in Nonischemic Cardiomyopathy
This study aims to evaluate the clinical value of [¹⁸F]AlF-NOTA-FAPI-04 PET/CT for the noninvasive assessment of myocardial fibroblast activation in patients with nonischemic cardiomyopathy.
- Trial name
- FAPI-NICM (NCT07878338)
- Testing
- [¹⁸F]AlF-NOTA-FAPI-04
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking Union Medical College Hospital
Inherited Retinal Diseases
Extension Study of the PUMCH-E101 Clinical Trial：Safety and Efficacy Study of PUMCH-E101 Injection in the Contralateral Eye
The goal of this clinical trial is to evaluate the safety and efficacy of PUMCH-E101 injection in the contralateral eye of subjects with RDH12 retinopathy.
- Trial name
- NCT07878572
- Testing
- PUMCH-E101 Injection(High dose)
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking Union Medical College Hospital
IgG4 Related Disease
Tripterygium Wilfordii Plus Prednisone for Active IgG4-Related Disease
The goal of this clinical trial is to learn if tripterygium wilfordii added to prednisone can treat active IgG4-related disease (IgG4-RD) in adults 45 to 80 years of age. Women in the study must be postmenopausal.
- Trial name
- NCT07878585
- Testing
- Prednisone, tripterygium wilfordii
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Neuroendocrine Carcinoma
Multi-omics Study of Cervical Neuroendocrine Carcinoma
This is a retrospective study using archived tumor tissue and medical records from patients with cervical neuroendocrine carcinoma treated at Peking Union Medical College Hospital since January 1, 2015.
- Trial name
- NCT07879339
- Testing
- Multi-omics profiling of archived tumor tissue (observational)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Thoracoabdominal Aortic Aneurysm, Endovascular Repair
Clinical Trial of BAO-G Technique in Complex Aortic Aneurysm Endovascular Repair (BAO-G-02)
Multi-Branch AOrtic Reconstruction With G-iliac System (BAO-G) Technique is a novel technique of endovascular repair of complex aortic aneurysm, which using off-the-shelf iliac branched devices to reconstruct the visceral…
- Conditions
- Thoracoabdominal Aortic Aneurysm, Endovascular Repair, Complex Aortic Aneurysms
- Trial name
- BAO-G-02 (NCT07141251)
- Testing
- BAO-G
- Where
- 11 sites in China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Biliary Tract Cancer (BTC)
Polymeric Micellar Paclitaxel-Based Combination Therapy for Advanced Biliary Tract Cancer
After the standard first-line treatment, the treatment regimen was adjusted to a paclitaxel polymer micellar-based immunotherapy combination regimen
- Trial name
- PILOT-BTC (NCT07159204)
- Testing
- Paclitaxel polymer micelle immunocombination
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Peking Union Medical College Hospital
Sarcoidosis, Pulmonary
Evaluation of the Efficacy and Safety of Compound Betamethasone in Pulmonary Sarcoidosis
The goal of this clinical trial is to learn whether a study drug called Compound Betamethasone (also known as Diprospan) works to treat pulmonary sarcoidosis in people with early-stage disease (stage I or II).
- Trial name
- NCT07668895
- Testing
- Prednisone, Compound betamethasone
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Peking Union Medical College Hospital
Delirium
40 Hz Gamma Auditory Stimulation for Delirium Prevention in Critically Ill ICU Patients
Delirium is a common acute disturbance of attention and cognition among critically ill patients and is associated with prolonged mechanical ventilation, longer hospital stays, and increased mortality.
- Trial name
- NCT07875374
- Testing
- 40 Hz Gamma Auditory Stimulation, Silent Audio Control
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Peking Union Medical College Hospital
Rare Disorders, Rare Diseases
Artificial Intelligence for General and Rare Disease Diagnosis
A multicentre, randomised diagnostic accuracy study to evaluate whether the GENESIS AI diagnostic support system can improve diagnostic accuracy and efficiency for physicians managing real-world clinical general and rare cases.
- Conditions
- Rare Disorders, Rare Diseases, Generalist AI
- Trial name
- NCT07625436
- Testing
- AI-Assisted Diagnosis
- Where
- 11 sites in China
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Anemia
POASAC Study (Preoperative Anemia Severity and Classification Study)
The goal of this observational study focuses on the effect of different preoperative anemia status on perioperative complications in patients under moderate- to high-risk surgery.
- Trial name
- NCT06499974
- Where
- 11 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Scoliosis; Adolescence, Pain After Surgery
Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery
The goal of this clinical trial is to see if a new pain medicine called Tegileridine is at least as effective as morphine (the standard treatment) for pain relief after spinal surgery in teenagers with scoliosis.
- Conditions
- Scoliosis; Adolescence, Pain After Surgery, Analgesia, Patient-controlled
- Trial name
- NCT07229495
- Testing
- Tegileridine, morphine
- Where
- 6 sites in China
- Volunteers
- 171 people
- Sponsor
- Peking Union Medical College Hospital
Rare Disorders, Rare Diseases
AI-assisted Rare Disease Diagnosis
A multicentre randomised controlled trial evaluating whether a rare-disease diagnostic large language model can improve diagnostic quality, efficiency, and health-economic outcomes for physicians managing patients with suspected…
- Trial name
- NCT07650799
- Testing
- AI system
- Where
- 12 sites in China
- Volunteers
- 1,056 people
- Sponsor
- Peking Union Medical College Hospital
Cystic Fibrosis (CF), Gene Therapy
A Prospective, Single-center, Open-label Study of Inhaled BMD003 (CFTR mRNA) in Chinese Adults With Cystic Fibrosis
The study uses a prospective, single-center, open-label clinical trial design to evaluate the safety and efficacy of inhaled BMD003 (CFTR mRNA) in adult Chinese patients with cystic fibrosis.
- Trial name
- NCT06963008
- Testing
- inhaled BMD003(CFTR mRNA)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking Union Medical College Hospital
Cystic Fibrosis
Safety and Efficacy of Inhaled BMD003 (CFTR mRNA) in Chinese Cystic Fibrosis Patients Aged ≥12 Years
This is a prospective, single-center, open-label clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of inhaled BMD003 (CFTR mRNA) in Chinese patients aged 12 years and above with cystic…
- Trial name
- NCT07485543
- Testing
- BMD003 (CFTR mRNA)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Hypoparathyroidism
A Cohort Study on the Safety and Efficacy of XH-02 in Treating Hypoparathyroidism
XH-02 is an mRNA nucleic acid drug that expresses PTH in the body following intravenous or subcutaneous injection, providing PTH replacement therapy for patients with hypoparathyroidism.
- Trial name
- NCT07540286
- Testing
- Single subcutaneous injection, Multiple subcutaneous injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital