Clinical trials: sponsored by Peking Union Medical College Hospital
Left Bundle Branch Area Pacing, Right Ventricular Pacing
The Impact of LBBAP vs RVP on the Incidence of New-onset Atrial Fibrillation in Patients With Atrioventricular Block
This is a single-center, randomized controlled study. The aim of this study is to compare the impact of left bundle branch area pacing versus traditional right ventricular pacing on the incidence of atrial fibrillation in…
- Conditions
- Left Bundle Branch Area Pacing, Right Ventricular Pacing, Atrioventricular Block, Atrial Fibrillation
- Trial name
- NCT06023784
- Testing
- left bundle branch area pacing, right ventricular pacing
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Peking Union Medical College Hospital
Behcet Syndrome, Intestinal Type
Baricitinib in the Treatment of Intestinal Behçet's Syndrome
This study aims to conduct a randomized controlled trial to compare the efficacy and safety of Baricitinib and Adalimumab (ADA) in the treatment of refractory intestinal Behçet's Syndrome (BS).
- Trial name
- NCT06849908
- Testing
- Baricitinib, Adalimumab
- Where
- 2 sites in China
- Volunteers
- 56 people
- Sponsor
- Peking Union Medical College Hospital
Postprandial Hypotension, Post-induction Hypotension
Correlation Between Postprandial Hypotension and Post-induction Hypotension in the Elderly.
Postprandial hypotension (PPH) and post-induction hypotension (PIH) are very common in the elderly population and are associated with a variety of poor outcomes.The purpose of this study is to investigate the correlation between…
- Trial name
- NCT05575661
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer
Application of 68GA-labeled CD73 Targeting Probe PET/CT Imaging in the Diagnosis of Breast Cancer
The investigators plan to conduct a 68Ga-DOTA-dPNE PET/CT imaging study in breast cancer patients to observe the binding of the tracer to tumor lesions and evaluate CD73 expression.
- Trial name
- NCT06411678
- Testing
- 68GA-DOTA-dPNE
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Locally Advanced Rectal Adenocarcinoma
Simultaneous Boost in Neoadjuvant Radiotherapy for Rectal Cancer
The goal of this clinical trial is to learn whether new adjuvant radiotherapy with gross tumor volume(GTV) escalated to 58.75 Gy can improve complete response (CR) rates compared with GTV dose of 50 Gy in adult patients (18-79…
- Trial name
- SIB-NCRT (NCT07200141)
- Testing
- GTV 58.75 Gy/25 fractions(Simultaneous Integrated Boost), GTV 50 Gy/25 fractions(Simultaneous Integrated Boost), Concurrent Chemotherapy
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Peking Union Medical College Hospital
Light Chain Cardiac Amyloidosis
Beta-amyloid PET/CT to Measure Potential Therapeutic Response in AL-CA
This was a single center, prospective cohort study that is evaluating the ability of beta-amyloid dynamic PET/CT to detect potential therapeutic changes in subjects under treatment for AL-CA after one year had elapsed since their…
- Trial name
- Abeta-MTRALCA (NCT07829705)
- Testing
- 11C-PIB, 18F-Florbetapir
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Langerhans Cell Histiocytosis
Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
Study Type: Interventional Study Design: Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment purpose: This single arm clinical trial is studying…
- Trial name
- MAALCH (NCT02389400)
- Testing
- methotrexate
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Peking Union Medical College Hospital
Rheumatoid Arthritis
Faecal Microbiota Transplantation in Patients With Refractory Rheumatoid Arthritis
In this 24-week, single center, randomized, double-blind, placebo-controlled study, the efficacy and safety of lyophilised oral fecal microbiota transplantation in patients with active refractory rheumatoid arthritis will be…
- Trial name
- NCT07639177
- Testing
- lyophilised oral capsules with faecal microbiota
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Esophagogastroduodenoscopy, Upper Gastrointestinal Bleeding (UGIB)
Effect of Ondansetron on Patient Tolerance, Efficacy and Endoscopist Workload in Unsedated Endoscopy for Upper Gastrointestinal Bleeding
The goal of this clinical trial is to evaluate whether intravenous ondansetron can improve patient tolerance and reduce discomfort during unsedated emergency esophagogastroduodenoscopy (EGD).
- Trial name
- NCT07336680
- Testing
- intravenous ondansetron
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Tumor
Research on NI-FAPI-04 for the Treatment of Hypoxic and Fibroblast Activation Protein Related Tumors
Exploring the therapeutic value of a novel dual target molecular probe NI-FAPI-04 PET/CT with hypoxia and fibroblast activation related proteins in fibroblast activation related tumors.
- Trial name
- NCT07822347
- Testing
- Injection of 177Lu-NI-FAPI
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Esophageal Achalasia
Assessment of Different Modified POEM for Achalasia
The aims of this study is to compare the efficacy and safety of conventional myotomy (circular myotomy) and modified myotomy (full-thickness myotomy) in the treatment of achalasia patients.
- Trial name
- NCT04578769
- Testing
- conventional myotomy, full-thickness myotomy
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Peking Union Medical College Hospital
Gut Microbiota, Postoperative Pulmonary Complications
Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
An observational cohort was established using preoperatively collected biospecimens and prospectively ascertained postoperative outcomes.
- Trial name
- NCT06513416
- Testing
- Elective abdominal surgery
- Where
- China
- Volunteers
- 265 people
- Sponsor
- Peking Union Medical College Hospital
Intracranial Arteriosclerosis, Cognitive Impairment
Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial
This study aims to evaluate whether digital cognitive training and/or PCSK9 inhibitor-enhanced lipid-lowering therapy on top of moderate-intensity statin can improve cognitive function in patients with intracranial…
- Trial name
- NCT07605130
- Testing
- Rosuvastatin, Ezetimibe, Recaticimab
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Peking Union Medical College Hospital
Insulinoma
Comparison of [68Ga]Ga-HBED-CC-PEG6-Exendin-4 and [68Ga]Ga-HBED-CC-Exendin-4 PET/CT for Insulinoma Localization
This clinical research evaluates a new PET/CT imaging agent, [68Ga]Ga-HBED-CC-PEG6-exendin-4, for localizing insulinoma, a rare pancreatic tumor that causes severe low blood sugar.
- Trial name
- HBED-CC-PEG6-E (NCT07808879)
- Testing
- [68Ga]Ga-HBED-CC-PEG6-exendin-4 PET/CT, [68Ga]Ga-HBED-CC-exendin-4 PET/CT
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Primary Intraocular Lymphoma
ZR-MTX for PIOL Phase II Trial
This is a prospective single-arm phase II study, with the purpose of evaluating the efficiency of ZR-MTX regimen (Rituximab, Zanubrutinib and methotrexate) combined with intravitreal methotrexate, then followed by minimal…
- Trial name
- ZR-MTX (NCT06973811)
- Testing
- Methotrexate, Rituximab (R), Zanubrutinib
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Peking Union Medical College Hospital
Drug Resistance, Bacterial, Carbapenems
Wastewater Surveillance for Carbapenem-Resistant Organism Outbreak Prediction in a Chinese Tertiary Hospital
Carbapenem-resistant organisms (CRO) pose a critical threat to global public health, and hospitals serve as major epicenters for their emergence and spread.
- Conditions
- Drug Resistance, Bacterial, Carbapenems, Wastewater
- Trial name
- WW-CRO-PREDICT (NCT07804433)
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Peking Union Medical College Hospital
Pulmonary Nodules
A Randomized Controlled Trial of 3D Airway Reconstruction for Precise Double-Lumen Bronchial Intubation
This is a very safe and beneficial clinical study. We hope to obtain near-real airway anatomical parameters of patients before surgery through airway three-dimensional reconstruction technology, to assist anesthesiologists in…
- Trial name
- NCT07719959
- Testing
- 3D Airway Reconstruction-Guided Double-Lumen Tube Intubation, Gender and Height-Based Double-Lumen Tube Selection
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Peking Union Medical College Hospital
Non Small Cell Lung Cancer
Assessing an Oral EGFR Inhibitor, DZD9008 in Patients With Advanced Non-small Cell Lung Cancer(NSCLC) With EGFR Mutations (WU-KONG15)
This study is a single center cohort study to access the anti-tumor efficacy, safety and tolerability of DZD9008 in patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) harboring epidermal growth factor…
- Trial name
- WU-KONG15 (NCT05559645)
- Testing
- DZD9008
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking Union Medical College Hospital
Anemia
Wearable Device-Based Screening for Anemia Risk
Anemia is a common condition, but it often goes undiagnosed because confirming it requires a venous blood test. This study looks at whether a commercially available wrist-worn smartwatch can help identify people who may have…
- Trial name
- WEAR-ANEMIA (NCT07796542)
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Paroxysmal Nocturnal Hemoglobinuria, PNH
Efficacy and Safety of Lanoracopan in the Treatment of PNH
This study aimed to evaluate the efficacy and safety of Lanoracopan Hydrochloride in the treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH)
- Trial name
- NCT07788105
- Testing
- Lanoracopan Hydrochloride
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
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