Clinical trials: active, sponsored by Peking Union Medical College Hospital
Cervical Cancer Screening
Use of cfDNA in Monitoring and Guiding Treatment for Cervical Cancer
This is a prospective, single-center, observational cohort study that plans to enroll 100 women aged 18 years or older with histologically confirmed cervical cancer who are scheduled to receive radical surgery, radiotherapy, or…
- Trial name
- NCT07919431
- Testing
- Low-depth cfDNA fragmentomics testing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer
A Patient-Derived 3D Bioprinted Colorectal Cancer-Stroma-Immune Triad Model Uncovers Microenvironmental Mechanisms of Chemoresistance and Immune Evasion
Colorectal cancer (CRC) has shifted toward a patient-personalized precision medicine paradigm; however, the high heterogeneity and complex tumor microenvironment (TME) of CRC restrict the development of individualized therapy…
- Trial name
- NCT07919418
- Testing
- Surgical resection and adjuvant chemotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Atrial Fibrillation, Atrial Fibrillation Recurrent
Atrial Fibrillation Patients Treated With Catheter Ablation
This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.
- Trial name
- NCT05266144
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Gestational Trophoblastic Neoplasia
Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic Neoplasia
The purpose of this study is to evaluate the efficacy and safety of camrelizumab and apatinib as combination therapy in patients with ultra high-risk (Cohort A) and high-risk chemo-refractory or relapsed (Cohort B) gestational…
- Trial name
- NCT05139095
- Testing
- Camrelizumab plus apatinib CohortA, Camrelizumab plus apatinib Cohort B
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer, Adaptive Radiotherapy
Moderated Hypofractionated Online Adaptive Radiotherapy in Cervical Cancer
The most common external beam radiotherapy fractionation scheme for cervical cancer is 45-50.4 Gy delivered in 25-28 fractions. However, prolonged treatment duration can lead to insufficient availability of medical resources.
- Trial name
- NCT06641635
- Testing
- Moderated hypofractionated online adaptive radiotherapy, Conventional radiotherapy
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Peking Union Medical College Hospital
Cushing s Syndrome
Diagnostic Value of CXCR4-targeted PET/CT in ACTH-dependent and Independent Cushing's Syndrome
In previous clinical practice, 68Ga-Pentixafor PET/CT has demonstrated promising diagnostic utility in various neuroendocrine tumors by targeting CXCR4, a chemokine receptor overexpressed in several ACTH-secreting neoplasms.
- Trial name
- NCT07350707
- Testing
- 68Ga-Pentixafor
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking Union Medical College Hospital
Glycogen Storage Disease
Neurocognitive Function and Neuroimaging Features in Patients With Glycogen Storage Diseases
The goal of this observational study is to learn about cognitive function and brain imaging findings in people with glycogen storage disease (GSD).
- Trial name
- NEURO-GSD (NCT07908212)
- Where
- China
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Cervical Neuroendocrine Carcinoma
Immunotherapy in Neuroendocrine Carcinoma of the Cervix
This retrospective study reviews existing medical records. No new treatments or tests are given. The study asks how well immunotherapy worked for people with a rare cancer called neuroendocrine carcinoma of the cervix.
- Trial name
- NCT07911423
- Testing
- No study intervention; observational study.
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Cerebral Small Vessel Disease, Ischemic Stroke
Treatment of Acute Ischemic Stroke With Edaravone Dexborneol Sublingual Tablets in Small Vessel Disease
This study is a multicenter, randomized, double-blind, placebo-controlled trial designed to evaluate the efficacy and safety of Edaravone Dexborneol Sublingual Tablets in patients with acute ischemic stroke due to small vessel…
- Trial name
- TASTE-SVD (NCT06674460)
- Testing
- Edaravone Dexborneol Sublingual Tablets
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking Union Medical College Hospital
Crerbral Angiography
A Clinical Trial of Vascular Interventional Robotic System for Cerebral Angiography
This study aims to conduct a post-market, multicenter clinical trial utilizing an interventional robotic system for cerebral angiography.
- Trial name
- NCT07182188
- Testing
- Vascular Interventional Robotic System
- Where
- 2 sites in China
- Volunteers
- 660 people
- Sponsor
- Peking Union Medical College Hospital
Gastrointestinal Neuroendocrine Carcinoma, Adjuvant Treatment
Oxaliplatin-Based Adjuvant Therapy for Gastrointestinal Neuroendocrine Carcinoma**
Patients with pathologically-confirmed gastrointestinal neuroendocrine carcinoma will be enrolled, to explore the efficacy and safety of oxaliplatin-based doublet chemotherapy in the adjuvant treatment of gastrointestinal…
- Conditions
- Gastrointestinal Neuroendocrine Carcinoma, Adjuvant Treatment, Resection
- Trial name
- NCT07891572
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis
Perfusion Efficiency-Guided MAP De-escalation in Elderly Septic Shock
This is a single-center, prospective, randomized crossover physiological trial conducted in elderly patients (≥65 years) with septic shock in the intensive care unit (ICU).
- Trial name
- NCT07887854
- Testing
- Ascending MAP titration sequence, Descending MAP titration sequence
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Hepatocellular Carcinoma (HCC)
68Ga-NYM207 PET/CT Imaging in Hepatocellular Carcinoma
This is a prospective, single-center, single-arm, phase I/II study designed to evaluate (1) the safety, tolerability, and imaging characteristics of 68Ga-NYM207 (Phase A), and (2) the diagnostic performance of 68Ga-NYM207 in…
- Trial name
- NYHCC (NCT07590336)
- Testing
- 68Ga-NYM207 PET/CT
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer
Hypofractionated Online Adaptive Radiotherapy of Breast Cancer
The goal of this clinical trial is to explore the application of online adaptive radiotherapy in patients who receive moderate hypofractionated or ultrafractionated radiotherapy after breast cancer surgery.
- Trial name
- NCT06568705
- Testing
- Moderate hypofractionated Radiation Treatment, Ultrafractionated Radiation Treatment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Nonischemic Cardiomyopathy
FAPI PET Imaging in Nonischemic Cardiomyopathy
This study aims to evaluate the clinical value of [¹⁸F]AlF-NOTA-FAPI-04 PET/CT for the noninvasive assessment of myocardial fibroblast activation in patients with nonischemic cardiomyopathy.
- Trial name
- FAPI-NICM (NCT07878338)
- Testing
- [¹⁸F]AlF-NOTA-FAPI-04
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking Union Medical College Hospital
Inherited Retinal Diseases
Extension Study of the PUMCH-E101 Clinical Trial：Safety and Efficacy Study of PUMCH-E101 Injection in the Contralateral Eye
The goal of this clinical trial is to evaluate the safety and efficacy of PUMCH-E101 injection in the contralateral eye of subjects with RDH12 retinopathy.
- Trial name
- NCT07878572
- Testing
- PUMCH-E101 Injection(High dose)
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Neuroendocrine Carcinoma
Multi-omics Study of Cervical Neuroendocrine Carcinoma
This is a retrospective study using archived tumor tissue and medical records from patients with cervical neuroendocrine carcinoma treated at Peking Union Medical College Hospital since January 1, 2015.
- Trial name
- NCT07879339
- Testing
- Multi-omics profiling of archived tumor tissue (observational)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
IgG4 Related Disease
Tripterygium Wilfordii Plus Prednisone for Active IgG4-Related Disease
The goal of this clinical trial is to learn if tripterygium wilfordii added to prednisone can treat active IgG4-related disease (IgG4-RD) in adults 45 to 80 years of age. Women in the study must be postmenopausal.
- Trial name
- NCT07878585
- Testing
- Prednisone, tripterygium wilfordii
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Peking Union Medical College Hospital
Biliary Tract Cancer (BTC)
Polymeric Micellar Paclitaxel-Based Combination Therapy for Advanced Biliary Tract Cancer
After the standard first-line treatment, the treatment regimen was adjusted to a paclitaxel polymer micellar-based immunotherapy combination regimen
- Trial name
- PILOT-BTC (NCT07159204)
- Testing
- Paclitaxel polymer micelle immunocombination
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Peking Union Medical College Hospital
Thoracoabdominal Aortic Aneurysm, Endovascular Repair
Clinical Trial of BAO-G Technique in Complex Aortic Aneurysm Endovascular Repair (BAO-G-02)
Multi-Branch AOrtic Reconstruction With G-iliac System (BAO-G) Technique is a novel technique of endovascular repair of complex aortic aneurysm, which using off-the-shelf iliac branched devices to reconstruct the visceral…
- Conditions
- Thoracoabdominal Aortic Aneurysm, Endovascular Repair, Complex Aortic Aneurysms
- Trial name
- BAO-G-02 (NCT07141251)
- Testing
- BAO-G
- Where
- 11 sites in China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital