Clinical trials: sponsored by Peking University
Leukemia, MDS
Comparison of ATLG and ATG for Immune Reconstitution After Allo-HSCT for Hematologic Malignancy
Allogeneic hematopoietic stem cell transplantation is the only curative treatment for malignant hematologic diseases. However, immune rejection is a major limitation in its application.
- Conditions
- Leukemia, MDS, Lymphoma
- Trial name
- NCT06895538
- Testing
- Rabbit Anti-Human T-Lymphocyte Immunoglobulin (ATLG)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking University First Hospital
Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms
Spatial MSC Index for Predicting Anti-PD-1 Efficacy in Esophageal Cancer
The intratumoral microbiota is a key modulator of the tumor immune microenvironment. This study aims to clinically validate a novel, AI-driven digital pathology biomarker-the Microbial-Sensory Coupling (MSC) index-which measures…
- Trial name
- NCT07745322
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Peking University Cancer Hospital & Institute
Adenomyosis of Uterus
Evaluation of the Efficacy and Safety of Microwave Ablation of Uterine Adenomyosis Under Improved Ultrasound Guidance
This study aims to compare the safety and efficacy of segmental power adjustment combined with uterine cavity hydro-isolation in microwave ablation of adenomyosis
- Trial name
- NCT06751264
- Testing
- Peritoneal combined with intrauterine water isolation, Peritoneal water isolation
- Where
- China
- Volunteers
- 137 people
- Sponsor
- Peking University Aerospace Center Hospital
Osteoarthritis (OA) of the Knee
Comparison of Postoperative Functional Outcomes Between Subvastus and Medial Parapatellar Approach in Total Knee Arthroplasty
This study aims to compare the effects of the medial parapatellar approach (MP) and the subvastus approach (SV) on postoperative clinical function in total knee arthroplasty (TKA).
- Trial name
- NCT07742696
- Testing
- subvastus, medial parapatellar
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Peking University Third Hospital
PROC
Mirvetuximab Soravtansine Combined With Suvemcitug in Platinum-Resistant Recurrent Ovarian Cancer
his is an open-label, single-center, single-arm, prospective Phase II trial evaluating the efficacy and safety of Mirvetuximab Soravtansine (MIRV) combined with Suvemcitug (SV) in patients with folate receptor alpha…
- Trial name
- NCT07741630
- Testing
- Mirvetuximab soravtansine, Suvemcitug
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Cancer
18F-grazy-02 PET/CT of Granzyme B Expression for Monitoring Immunotherapy
This is an open-label PET/CT study to investigate the safety and clinical monitoring value of 18F-grazy-02 in patients with lymphoma or solid tumors receiving immunotherapy, including immune checkpoint inhibition and CAR-T cell…
- Trial name
- NCT07724535
- Testing
- 18F-grazy-02
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Coronary Microvascular Dysfunction (CMD)
Multisensor Wireless Pressure Microcatheter For Microvascular Function Assessment In ANOCA/INOCA Patients: A Prospective, Multicenter, Single-Group Target Value Study
This study aims to evaluate the sensitivity and specificity of a multi-sensor wireless pressure microcatheter for the diagnosis of CMD in patients with ANOCA/INOCA, using quantitative myocardial perfusion imaging of cardiac…
- Trial name
- NCT07453381
- Where
- 5 sites in China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Large Language Models, Lung Cancer (NSCLC)
Preliminary Evaluation of a Large Language Model-Based Tool for Complex Surgical Decision Support in Lung Cancer
This study is an exploratory effect-size estimation study, with the following specific objectives: ① to estimate the point estimate and 95% confidence interval of the Win Ratio for the experimental group (GAPS-Agent) versus the…
- Trial name
- NCT07654036
- Testing
- GAPS-Agent, LLM
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking University People's Hospital
Hypertension
A Blood Pressure-Lowering Diet for Preventing and Managing Hypertension
This cluster-randomized controlled trial will evaluate whether a 3-month culturally adapted blood pressure-lowering dietary, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure and related health outcomes…
- Trial name
- NCT07735091
- Testing
- Standard Hypertension Management, Eastern Blood Pressure-Lowering Diet
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Peking University
Immune Thrombocytopenia (ITP)
Fecal Microbiota Transplantation for Steroid-resistant or Relapsed Immune Thrombocytopenia
This is a randomized, double-blind, placebo-controlled phase 2 trial to evaluate the safety and efficacy in immune thrombocytopenia patients receiving fecal microbiota transplantation
- Trial name
- PKU-ITP-FMT (NCT07733037)
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University People's Hospital
AL Amyloidosis (AL), t(11;14) Positive
Sonrotoclax Plus Dexamethasone With or Without Daratumumab Regimen in Patients With t(11;14) Primary AL Amyloidosis
The goal of this study is to evaluate the efficacy and safety of Sonrotoclax combined Regimen in patients with t(11;14) AL amyloidosis.
- Trial name
- NCT07335887
- Testing
- sonrotoclax, Daratumumab, Dexamethasone
- Where
- 3 sites in China
- Volunteers
- 39 people
- Sponsor
- Peking University People's Hospital
PTSD
The Effectiveness of Group-Delivered Guided Written Exposure Therapy for PTSD and CPTSD Among Adolescents : A Pilot Study
The study aims to examine the effectiveness of group-delivered guided written exposure therapy (GWE) for post-traumatic stress disorder (PTSD) and complex PTSD in Chinese adolescents through a randomized controlled trial.
- Trial name
- NCT06403449
- Testing
- Group-delivered guided written exposure therapy, Waiting-List (WL) condition
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Peking University
CBTI Insomnia
CBT-I for the Patients With Chronic Insomnia in China
Insomnia is one of major public health problems.This study aimed to assess benefits and problems of CBT-I for chronic insomnia based on the influence of Chinese tradition and culture.
- Trial name
- CBT-I (NCT07730593)
- Testing
- cognitive behavioral therapy for insomnia
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Peking University People's Hospital
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012971
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Phelan-McDermid Syndrome, SHANK3 Haploinsufficiency
RB001 Gene Therapy Study in Children With SHANK3-related Phelan-McDermid Syndrome (PMS)
This is an open-label, dose-escalation study to evaluate the safety, tolerability, and clinical activity of a single dose of RB001 administered via intracerebroventricular (ICV) injection in pediatric with SHANK3 related…
- Trial name
- NCT07014020
- Testing
- RB001
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking University First Hospital
Liver Metastasis Colon Cancer, ctDNA Genotype
Targeted Treatment Plus Tislelizumab and HAIC for Advanced CRCLM Failed From Standard Systemic Treatment
Hepatic arterial infuison chemothearpy (HAIC), targeted therapy, and programmed death-1 (PD-1) inhibitors have been demonstrated to be effective for colorectal cancer liver metastasis (CRCLM).
- Conditions
- Liver Metastasis Colon Cancer, ctDNA Genotype, MSS, Failed From Standard Treatment
- Trial name
- NCT06199232
- Testing
- HAIC+targeted therapy+PD-1 inhibitor
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Peking University
Cesarean Section
Development of a Risk Prediction Model for Post-Spinal Anesthesia Hypotension During Cesarean Delivery Using Heart Rate, Blood Pressure, Perfusion Index, ECG Waveforms, and SpO₂ Waveforms
Spinal anesthesia is the preferred anesthetic technique for patients undergoing cesarean section. Compared with general anesthesia, spinal anesthesia offers multiple advantages.
- Trial name
- NCT07689825
- Testing
- Standard clinical spinal anesthesia and routine intraoperative monitoring
- Where
- China
- Volunteers
- 145 people
- Sponsor
- Peking University Shenzhen Hospital
Ewing Sarcoma
Prospective Evaluation of Dynamic Serum ProGRP for Treatment Response Monitoring in Ewing Sarcoma
This single-center prospective observational study aims to evaluate whether longitudinal changes in serum pro-gastrin-releasing peptide (ProGRP) reflect treatment response in patients with newly diagnosed Ewing sarcoma.
- Trial name
- NCT07725783
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Tetanus
A Study of Tetanus Antibody of Healthy Adults
The goal of this observational study is to learn about antibody level of tetanus of adults in high-income city of china. The main question it aims to answer is: 1.
- Trial name
- tetanus (NCT07724379)
- Where
- China
- Volunteers
- 2,009 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Obesity; Impaired Glucose Regulation; Prediabetes; Type 2 Diabetes Mellitus
Time-Restricted Eating and Staple Food Reduction Combined With App-Supported Exercise for Weight and Glycemic Control
This multicenter, three-arm randomized controlled trial will evaluate the effects of early time-restricted eating and staple food reduction, each combined with an app-supported exercise intervention, on body weight and glycemic…
- Trial name
- TRE-SFR-EX (NCT07726615)
- Testing
- App-Supported Exercise Intervention, Staple Food Reduction, Early Time-Restricted Eating
- Volunteers
- 300 people
- Sponsor
- Peking University
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