Clinical trials: sponsored by Peking University
Small Cell Lung Cancer
Efficacy and Biomarkers of the Second-line Treatment of Adebelizumab Combined With Irinotecan Liposome in Advanced Small Cell Lung Cancer
This study is an open, single-arm, single-center phase II clinical study, which aims to evaluate the efficacy and safety of adebelizumab combined with irinotecan liposome in the second-line treatment of advanced small cell lung…
- Trial name
- NCT07004712
- Testing
- Adebelizumab combined with irinotecan liposome as second-line therapy
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Peking University Cancer Hospital & Institute
Multiple Myeloma and Malignant Plasma Cell Neoplasms
A Molecular Probe Targeting BCMA for the Clinical Diagnosis of Multiple Myeloma
Multiple Myeloma (MM), the second most common hematological malignancy, continues to pose challenges in precise clinical identification.
- Trial name
- NCT06717113
- Testing
- 18F-FDG, 68Ga-BC1
- Where
- 2 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Colorectal Neoplasms, Secondary Malignant Neoplasm of Liver
Iparomlimab/Tuvonralimab Combined With Bevacizumab and CAPEOX as Conversion Therapy for Colorectal Cancer Liver Metastasis
More than half of colorectal cancer (CRC) patients present with RAS mutations or right-sided primary tumors; however, objective response rates (ORRs) to bevacizumab combined with chemotherapy remain suboptimal.
- Trial name
- NCT07007728
- Testing
- Iparomlimab/Tuvonralimab, Bevacizumab + CAPEOX, Surgical resection ± ablation or stereotactic radiotherapy (if applicable)
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Peking University Cancer Hospital & Institute
Oral Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT)
Previous studies confirmed locally advanced oral/oropharyngeal squamous cell carcinoma (LA OSCC or OPSCC) patients with a pathological response had higher probability of survival in neoadjuvant settings.
- Trial name
- NCT06009861
- Testing
- Tislelizumab, Albumin-Bound Paclitaxel, Cisplatin
- Where
- 13 sites in China
- Volunteers
- 110 people
- Sponsor
- Peking University Hospital of Stomatology
NSCLC (Advanced Non-small Cell Lung Cancer)
A Study on the Efficacy and Safety of Golidocitinib Combined With Tislelizumab and Chemotherapy as First-line Treatment for Advanced NSCLC
The goal of this clinical trial is to learn if golidocitinib combined with tislelizumab and chemotherapy works in advanced NSCLC with PD-L1≥1%.
- Trial name
- NCT06969612
- Testing
- Tislelizumab, Pemetrexed, Cisplatin
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Peking University Cancer Hospital & Institute
Precancerous Cervical Lesion
Efficacy and Safety of Photodynamic Therapy for CIN3
To investigate the efficacy and safety of photodynamic therapy (20% 5-amino-ketovalerate 630nm red light) in the treatment of cervical intraepithelial neoplasia 3(CIN 3)in women in the real world
- Trial name
- NCT07009327
- Testing
- ALA-PDT
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Schizophrenia and Schizoaffective Disorder, Bipolar Disorder (BD)
Survey on the Reproductive and Child-Rearing Situations of Patients With Severe Mental Disorders
Severe mental disorders represent a major public health concern, imposing substantial disease burden and adversely affecting multiple dimensions of patients' lives, while also creating intergenerational impacts on their offspring…
- Trial name
- NCT07005245
- Where
- China
- Volunteers
- 77,145 people
- Sponsor
- Peking University
Systemic Lupus Erythematosus
Long-Term Outcomes in SLE at Peking University People's Hospital
This study aims to prospectively follow patients diagnosed with Systemic Lupus Erythematosus (SLE) at Peking University People's Hospital, assessing long-term outcomes such as disease activity, organ involvement, survival, and…
- Trial name
- LOTUS (NCT07005479)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
HBV, HCC
Real-world Study on Liver Cancer Risk in Chronic Hepatitis B Patients With Family History of Liver Cancer
This study is a prospective, multicenter, real-world cohort study designed to compare the long-term outcomes of chronic hepatitis B patients with a family history of HBV-related hepatocellular carcinoma (HCC) who receive PEG…
- Trial name
- NCT07007286
- Testing
- ETV,TDF,TAF,TMF combination with PEG IFNα-2b, ETV,TDF,TAF or TMF
- Where
- 555 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Rheumatoid Arthritis (RA)
Therapy of Niacin for Rheumatoid Arthritis
This study is a study to evaluate the safety and efficacy of administering niacin sustained-release capsules to rheumatoid arthritis with hyperlipidemia patients.
- Trial name
- NCT07004725
- Testing
- niacin sustained release capsules
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
HIV, PrEP
Behavioral Intervention for PrEP Service Utilization Among Chinese MSM: A HAPA and CEI Integrated Model
The goal of this clinical trial is to evaluate the effectiveness of a novel, intelligent intervention platform in bridging the "intention-behavior gap" for pre-exposure prophylaxis (PrEP) uptake among men who have sex with men…
- Conditions
- HIV, PrEP, MSM, Behavior Changes
- Trial name
- NCT06931106
- Testing
- HAPA and CEI behavioral intervention, HAPA-based intervention
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Peking University
Nephrectomy, Nephroureterectomy
Goal-directed Hemodynamic Management and Kidney Injury After Radical Nephrectomy or Nephroureterectomy
Radical nephrectomy and nephroureterectomy are common operations for the treatment of renal cell carcinoma and upper tract urothelial carcinoma, respectively. However, acute kidney injury frequently occurs after surgery.
- Conditions
- Nephrectomy, Nephroureterectomy, Hemodynamic Management, Acute Kidney Injury
- Trial name
- NCT05149196
- Testing
- Targeted hemodynamic management, Routine care
- Where
- China
- Volunteers
- 1,724 people
- Sponsor
- Peking University First Hospital
Microtia, Alcohol Dependence
Nitrate Modulates Cognitive Impairment Via Oral Microbiota.
Alcohol use is increasingly prevalent in modern society and is known to cause cognitive impairment and dysregulation of inflammatory responses.
- Trial name
- NCT05963659
- Testing
- nitrate-rich beetroot juice, nitrate-depleted beetroot juice
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Sixth Hospital
Acute Graft Versus Host Disease
Mini-dose MTX Plus Standard-dose Steroid for the Initial Treatment of Acute GVHD
This trial is a randomized (1:1) phase III open label study of frontline mini-MTX plus methylprednisolone 2mg/kg/day compared to methylprednisolone 2mg/kg in allogeneic stem cell transplant recipients with grade 2-4 aGVHD.
- Trial name
- NCT05921305
- Testing
- MTX, Corticosteroid
- Where
- 2 sites in China
- Volunteers
- 218 people
- Sponsor
- Peking University People's Hospital
Extension Lag, Total Knee Arthroplasty
Correlation Between Preoperative Knee Extension Lag and Functional Outcome After Total Knee Arthroplasty
To explore the relationship between different knee extension hysteresis angles and functional outcome of knee joint after total knee replacement
- Trial name
- NCT05833152
- Testing
- total knee arthroplasty
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Peking University Third Hospital
Vagus Nerve Stimulation, Transcutaneous Electric Nerve Stimulation
Transcutaneous Auricular Vagus Nerve Stimulation and Quality of Recovery After Major Noncardiac Surgery
Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive neuromodulation technique. Existing evidence suggested that taVNS improves pain management, sleep quality, inflammatory responses, and…
- Conditions
- Vagus Nerve Stimulation, Transcutaneous Electric Nerve Stimulation, Noncardiac Surgery, Quality of Recovery
- Trial name
- NCT06957912
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Peking University First Hospital
Myeloid Leukemia, Myelodysplastic Syndromes
Interferon-α for TP53 Myeloid Malignancy Post Allo-HSCT
To investigate the efficacy of interferon-α prophylaxis in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with TP53 mutation who were negative for minimal residual disease (MRD) by flow cytometry…
- Trial name
- NCT06130579
- Testing
- IFN-Α
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Hematologic Malignancy
ATG Plus Low-dose PT-Cy for GVHD Prevention
During the past decades, the wider application of easily available haploidentical donor hematopoietic cell transplant (haplo-HCT) has been made possible through the T cell-replete (TCR) regimens including T cell regulation with…
- Trial name
- NCT06108739
- Testing
- Cyclophosphamid, ATG
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University People's Hospital
Acute GVH Disease
MTX and Steroid as First-line Therapy for aGVHD
The aim of the study is to identify the efficacy and safety of methotrexate (MTX) combined corticosteroid as first-line therapy for acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation…
- Trial name
- NCT04960644
- Testing
- MTX, Corticosteroid
- Where
- China
- Volunteers
- 157 people
- Sponsor
- Peking University People's Hospital
Chronic Obstructive Pulmonary Disease
Air Pollution and Health of COPD Patients
This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.
- Trial name
- NCT05076630
- Testing
- Air pollutants
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking University
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