Clinical trials: sponsored by Peking University
Fungal Disease
Azole Susceptibility and Resistance Mechanisms Surveys in Pathogenic Fungi by the CARST-fungi (2023-2024)
The China Antifungal Resistance Surveillance Trial (CARST-fungi) study, which has been starting in July 2019, is a multi-center, prospective, observational, and laboratory-based study of pathogenic fungal isolates causing IFDs.
- Trial name
- NCT06969703
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Chronic Low Back Pain (CLBP), Acute Low Back Pain
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
This prospective cohort study investigates the neurobiological, genetic, and psychosocial mechanisms underlying acute and chronic low back pain (LBP).
- Conditions
- Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain, Chronic Pain
- Trial name
- LBPB (NCT06967363)
- Testing
- Nerve Block, endoscopic spinal disecetomy, Medication
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University Third Hospital
Advanced Gastroesophageal Cancer
Clinical Study on the Treatment of Anorexia and Cachexia in Advanced Gastric and Esophageal Cancer With Nanosized Megestrol Acetate Combined With Immunochemotherapy
This study is a prospective, randomized, parallel-controlled, multicenter clinical study. The purpose of this study is to evaluate the efficacy and safety of nanocrystalline megestrol acetate combined with the first-line standard…
- Trial name
- NCT06963593
- Testing
- Nanocrystal Megestrol Acetate in Combination with First-Line Standard Immuno-Chemotherapy Regimen, First-Line Standard Immuno-Chemotherapy Regimen
- Volunteers
- 220 people
- Sponsor
- Peking University
Anterior Cruciate Ligament Rupture
The Clinical Efficacy of Anterolateral Complex Augmentation in Patients With ACL Rupture Combined With Excessive Internal Tibial Rotation Subluxation: A Bidirectional Cohort Study
This project aims to establish a high-quality, large-scale, single-center bidirectional cohort study to evaluate the postoperative clinical efficacy of ACLR combined with ALC augmentation in a specific high-risk…
- Trial name
- NCT06961292
- Where
- China
- Volunteers
- 335 people
- Sponsor
- Peking University Third Hospital
Low Apgar Scores
Establishment of a Longitudinal Cohort for Newborns With Low Apgar Scores at Birth
The objective of this study is to identify high-risk factors associated with low Apgar scores, implement proactive interventions to reduce their occurrence, and analyze neonatal resuscitation procedures and systemic treatment…
- Trial name
- NCT06961123
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University Third Hospital
Chronic Kidney Disease(CKD)
The Accuracy of Ultrasonic Viscoelastic Imaging in Evaluating the Severity of Chronic Kidney Diseases
The goal of this observational study is to learn about the role of ultrasonic viscoelastic parameters in the assessing the severity of chronic kidney disease.
- Trial name
- NCT06961162
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Peking University Third Hospital
Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia
Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer
To construct a prediction model of progesterone sensitivity in patients with endometrial cancer treated with fertility preservation
- Trial name
- NCT05647109
- Testing
- No intervention
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Peking University People's Hospital
Tumor, Solid
NW-301 TCR-T in Patients With Advanced Solid Tumor
An open label, two cohorts, multiple dose exploratory clinical study to independently evaluate the safety, efficacy, and pharmacokinetics of autologous anti-KRAS G12V/G12D mutation T-cell Receptor T cell in advanced solid tumor
- Trial name
- NCT06956261
- Testing
- NW-301V, Drug: NW-301D
- Where
- 2 sites in China
- Volunteers
- 44 people
- Sponsor
- Peking University
Migraine, Patent Foramen Ovale
Establishment of a Clinical and Prognostic Follow-up Cohort of Migraine Patients With Patent Foramen Ovale
To establish a headache center in China that combines clinical, imaging and laboratory examinations, explore the feasible treatment options for migraine combined with patent foramen ovale, and search for the possible influencing…
- Trial name
- NCT06953622
- Testing
- Conservative treatment, Antipaletet drug, Patent Foramen Ovale Closure
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Peking University Third Hospital
Circadian Rhythm Disorders, Osteoporosis
Chronotherapeutic Optimization of Teriparatide Administration in Postmenopausal Osteoporosis
This is a randomized, controlled, and exploratory study designed to evaluate the chronotherapeutic effects of teriparatide administration in postmenopausal osteoporosis.
- Trial name
- NCT06951776
- Testing
- Morning administration group of teriparatide, Evening administration group of teriparatide
- Volunteers
- 28 people
- Sponsor
- Peking University Third Hospital
Non-small Cell Lung Cancer
Multiomics Tumor Evolution Model of NSCLC
The purpose of this study is to determine the evolutionary mechanism of early-stage non-small cell lung cancer and establish an accurate prognostic model and a recurrence monitoring system by multiomics analysis, which can be…
- Trial name
- NCT05352035
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University People's Hospital
Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I
Progesterone Therapeutic Regimen Plus Statins in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia
To explore the treatment efficacy of Progesterone Therapeutic Regimen Plus Statins in patients with atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EEC) for conservative treatment.
- Trial name
- NCT06102863
- Testing
- statins (oral atorvastatin calcium tablet 20mg/ day; Or rosuvastatin 5mg/ day; Or pivastatin 2mg/ day);
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Peking University People's Hospital
AL Amyloidosis
Prospective Study of Teclistamab in the Treatment of Systemic AL Amyloidosis
This study aims to evaluate the use of teclistamab in systemic AL amyloidosis and answer whether teclistamab can improve the rate of complete hematological response. This is a single-arm, multi-center, prospective study.
- Trial name
- NCT06699394
- Testing
- Teclistamab (Tec)
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Peking University People's Hospital
Endometrium Cancer, Physical Activity
Effect of Physical Activity Intervention on Overweight and Obese Patients With Endometrial Cancer
This study evaluated the clinical outcome of exercise management on patients with endometrial cancer treated with fertility preservation, including the effect of complete response rate, complete response time, recurrence rate…
- Conditions
- Endometrium Cancer, Physical Activity, Weight Management
- Trial name
- NCT06312917
- Testing
- Physical activity
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Peking University People's Hospital
Postoperative Complications, Long-term Outcome
Prophylactic Penehyclidine Hydrochloride Inhalation and 3-year Outcome After Surgery
Postoperative pulmonary complications (PPCs) are major causes of postoperative morbidity, mortality, and prolonged hospital stay.The incidence of PPCs may be as high as 41% to 75% in high-risk patients.
- Trial name
- NCT03868709
- Testing
- Penehyclidine inhalation
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Peking University First Hospital
Lung Cancer (NSCLC), Neoadjuvant Immunotherapy
Safety, Efficacy, and Survival Outcomes of Neoadjuvant/Induction Immunotherapy in Surgical and Radiotherapeutic Management of Non-Small Cell Lung Cancer
This multicenter retrospective real-world study aims to evaluate the safety, efficacy and survival outcomes of neoadjuvant/induction immunotherapy in patients with non-small cell lung cancer (NSCLC).
- Conditions
- Lung Cancer (NSCLC), Neoadjuvant Immunotherapy, Radiotherapy, Lung Surgery
- Trial name
- NCT06926179
- Testing
- neoadjuvant immunotherapy
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Peking University Cancer Hospital & Institute
Non-small Cell Lung Cancer, Minimal Residual Disease
Liquid Biopsy-Based Novel Modality for Postoperative Management of Lung Cancer
The goal of this study is to develop new techniques for minimal residual disease(MRD) monitoring and to confirm the efficacy and safety of MRD-guided postoperative management for early stage non-small cell lung cancer.
- Conditions
- Non-small Cell Lung Cancer, Minimal Residual Disease, Adaptive Treatment
- Trial name
- NCT06930807
- Testing
- Adaptive postoperative management based on minimal residual disease
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Ankle Sprains, Instability, Joint
The Clinical Outcomes of the Modified Broström vs Anatomic Reconstruction Operation in CLAI and GJL
Investigators designed this prospective cohort study to compare the clinical outcomes of modified Broström operation and anatomical reconstruction for the treatment of CLAI and GJL.
- Conditions
- Ankle Sprains, Instability, Joint, Joint Hypermobility
- Trial name
- NCT05196906
- Testing
- Modified Broström operation and anatomic reconstruction operation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Ankle Sprains, Hypermobility Syndrome
Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort Study
GJL is a risk factor for postoperative recurrent instability following an MBR for CLAI. BPR with suture tape augmentation and anatomic reconstruction may provide more strength and stability.
- Trial name
- NCT05698446
- Testing
- Modified Broström + Suture tape augmentation operation, Anatomic reconstruction operation, Open Modified Broström procedure
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Multiple Myeloma, Neoplasms
Aponermin, Pomalidomide, Dexamethasone for Patients With Relapsed/ Refractory Multiple Myeloma
This study aims to evaluate the efficacy and safety of a three drug combination therapy of aponermin, pomalidomide, and dexamethasone in the treatment of relapsed or refractory multiple myeloma
- Trial name
- NCT06924424
- Testing
- Aponermin, pomalidomide, dexamethasone
- Where
- 2 sites in China
- Volunteers
- 105 people
- Sponsor
- Peking University People's Hospital
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