Clinical trials: sponsored by Peking University First Hospital
Prenatal Depression, Ketamine
Low-dose S-Ketamine and Postpartum Depression in Parturients With Prenatal Depression
Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ketamine in anti-depression.
- Conditions
- Prenatal Depression, Ketamine, Postpartum Depression
- Trial name
- NCT03927378
- Testing
- S-ketamine
- Where
- 7 sites in China
- Volunteers
- 364 people
- Sponsor
- Peking University First Hospital
Prenatal Depression, Ketamine
Low-dose S-ketamine in Women With Prenatal Depression
Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ketamine in anti-depression.
- Conditions
- Prenatal Depression, Ketamine, Postpartum Depression
- Trial name
- NCT04414943
- Testing
- S-ketamine
- Where
- 7 sites in China
- Volunteers
- 364 people
- Sponsor
- Peking University First Hospital
Coronary Artery Disease, Coronary Stenosis
The Flash FFR Ⅱ Study
The overall purpose of Flash FFR Ⅱ is to investigate whether coronary angiography-derived fractional flow reserve (caFFR), compared with fractional flow reserve (FFR) measured by a pressure wire, has non-inferior clinical effect…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Myocardial Ischaemia, Coronary Circulation
- Trial name
- NCT04575207
- Testing
- caFFR, FFR
- Where
- 13 sites in China
- Volunteers
- 2,132 people
- Sponsor
- Peking University First Hospital
Novel Oral Anticoagulants, NOACs
Imapct of bioMarkers on Pharmacodynamics and Bleeding Risk of Direct Oral AntiCoagulants and Ticagrelor Study II
Individual differences in drug efficacy and adverse reactions are common in the clinical application of drugs. Individual differences are caused by many factors, among which genetic factors account for more than 20%.
- Conditions
- Novel Oral Anticoagulants, NOACs, Rivaroxaban, Apixaban
- Trial name
- NCT05764356
- Testing
- Detection of genotype and RNA profile in platelet and white blood cell, Indicators test related to coagulation function, Indicators test related to platelet function
- Where
- 6 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Peking University First Hospital
Anemia
A Retrospective Observational Study to Describe Anaemia Management, Burden of Disease and Outcomes in Chinese Patients on Peritoneal Dialysis Using a Clinical Database
The overall objective is to describe the epidemiology, health care resource utilisation (HCRU) and selected clinical outcomes in patients initiating PD by anaemia status in real-world setting in China.
- Trial name
- NCT04948424
- Where
- China
- Volunteers
- 2,519 people
- Sponsor
- Peking University First Hospital
Alport Syndrome, Metformin
Treatment With Metformin in Chinese Children With Alport Syndrome
This single-center, prospective, double-blind randomized placebo-controlled trial will evaluate the efficacy and safety of metformin in Chinese children with Alport syndrome who have received (and continue to receive)) ACEi/ARB.
- Trial name
- NCT05655728
- Testing
- Metformin
- Volunteers
- 78 people
- Sponsor
- Peking University First Hospital
Scoliosis Correction, Postoperative Analgesia
Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia
Scoliosis correction surgery is followed with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and even drug tolerance.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, S-ketamine, Dexmedetomidine
- Trial name
- NCT04791059
- Testing
- S-ketamine, Dexmedetomidine, Sufentanil
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Obstructive Sleep Apnea, Analgesia
Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common sleep disturbance that can cause intermittent hypoxia, hypercapnia, and sleep structure disorders.
- Conditions
- Obstructive Sleep Apnea, Analgesia, Dexmedetomidine, High-flow Nasal Cannula
- Trial name
- NCT04608331
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Peking University First Hospital
Chronic Insomnia
Digital Cognitive Behavioral Therapy for Insomnia (dCBT-I) for Chronic Insomnia ：A Randomized Controlled Trial
This randomized, open, parallel controlled study aims to explore the clinical effectiveness of smartphone-based digital Cognitive behavioural therapy for insomnia（dCBT-I）.
- Trial name
- NCT04779372
- Testing
- smartphone-based dCBT-I from a Wechat applet, sleep education
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Peking University First Hospital
Helicobacter Pylori Infection
Jinghua Weikang Capsule Containing Quadruple Therapy for IgAN With Helicobacter Pylori Infection
This study is to evaluate the efficacy and safety of the Jinghua Weikang Capsule (a Chinese patent medicine for peptic ulcer and gastritis) containing quadruple therapy (Jinghua Weikang Caplsule plus triple therpy) for…
- Trial name
- NCT05320133
- Testing
- JWC containing quadruple therapy, Bismuth-containing quadruple therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Helicobacter Pylori Infection
Qingre Huashi Granules Combined the Modified Dual Therapy for Helicobacter Pylori Infection
This is an open-label, randomized controlled trial. The aim of the study is to evaluate the efficacy and safety of the Qingre Huashi Granules combined the modified dual therapy (or called high dose dual therapy) for Helicobacter…
- Trial name
- NCT05364619
- Testing
- Qingre Huashi Granules combined the modified dual therapy, Bismuth containing quadruple therapy
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
HER2-negative Breast Cancer, Neoadjuvant Therapy
Efficacy and Safety of Combinition of Camrelizumab in Second-line Neoadjuvant Chemotherapy and Adjuvant Therapy
The achievement of pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) is associated with improved outcome across all breast cancer (BC) subtypes.
- Conditions
- HER2-negative Breast Cancer, Neoadjuvant Therapy, Pathological Complete Response, Immunotherapy
- Trial name
- NCT04848454
- Testing
- Camrelizumab with vinorelbine and cisplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Renal Insufficiency, Chronic, Chronic Kidney Diseases
The Relationship Between Salt Restriction and Taste Sensitivity in Patients With Chronic Kidney Disease
The compliance of salt restriction in patients with CKD may be associated with taste sensitivity.
- Trial name
- NCT03397550
- Testing
- salt restriction education
- Where
- China
- Sponsor
- Peking University First Hospital
Peritonitis, Resting Energy Expenditure
The Relationship Between the Change of Resting Energy Expenditure and Nutritional Status .
Peritonitis is a common and devastating complication in patients on peritoneal dialysis (PD). It is a known fact that persistent inflammatory state and nutritional deterioration are closely associated with increased mortality in…
- Conditions
- Peritonitis, Resting Energy Expenditure, Nutrition
- Trial name
- NCT03511950
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Resting Energy Expenditure, Peritoneal Dialysis
Novel Equation for Estimating Resting Energy Expenditure in Dialysis Patients
The energy and nutrition states are closely associated with dialysis patients' complications and outcomes. To reach the energy balance target, we need the accurate resting energy expenditure level of patients.
- Conditions
- Resting Energy Expenditure, Peritoneal Dialysis, Equation
- Trial name
- NCT04947839
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Carcinoma, Hepatocellular
Anti-angiogenesis Combined With PD-1/PD-L1 Therapy in Patients With Advanced Liver Cancer
To observe and explore the effect of anti-angiogenesis combined with PD-1/PD-L1 therapy in the real world on the survival prognosis of patients with advanced liver cancer, and to summarize the treatment experience of a wide range…
- Trial name
- NCT05383066
- Volunteers
- 490 people
- Sponsor
- Peking University First Hospital
Obstructive Sleep Apnea, Non-small Cell Lung Cancer
Obstructive Sleep Apnea Influences Efficacy of PD-1-Based Immunotherapy Against Non-Small Cell Lung Cancer
This prospective, observational cohort study aims to explore the influence of obstructive sleep apnea(OSA) on the efficacy of PD-1-based immunotherapy in patients with non-small cell lung cancer(NSCLC).
- Trial name
- NCT04743752
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Elderly, Total Knee Arthroplasty
Dexmedetomidine as an Adjuvant for Femoral Nerve Block and Functional Recovery After Total Knee Arthroplasty
Femoral nerve block (FNB) is a first-line analgesic technique for multimodal analgesia after total knee arthroplasty (TKA). Recent studies and meta-analysis indicate that dexmedetomidine combined with local anesthetics for FNB…
- Conditions
- Elderly, Total Knee Arthroplasty, Femoral Nerve Block, Dexmedetomidine
- Trial name
- NCT04642651
- Testing
- Dexmedetomidine
- Where
- 2 sites in China
- Volunteers
- 170 people
- Sponsor
- Peking University First Hospital
Overall Survival
Intraoperative Dexmedetomidine and Long-term Outcomes in Elderly After Major Surgery
This is a 3-year follow-up of patients enrolled in a previous randomized controlled trial which showed that intraoperative dexmedetomidine reduced delirium in elderly patients after major non-cardiac surgery.
- Trial name
- NCT04111926
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 619 people
- Sponsor
- Peking University First Hospital
Intraperitoneal Pressure, Peritoneal Dialysis
Novel Equation for Estimating Intraperitoneal Pressure
Intraperitoneal Pressure is associated with the complications of increased intra-abdominal pressure in peritoneal dialysis patients.
- Conditions
- Intraperitoneal Pressure, Peritoneal Dialysis, Equation
- Trial name
- NCT05313841
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital