Clinical trials: sponsored by Penn State University
Pre-diabetes
Diabetes Prevention Program Pilot
This initiative, which is a partnership between State College area Penn State Health ambulatory care clinics located off campus in the State College area, has two primary goals: 1) improve the health and quality of life of Penn…
- Trial name
- NCT04651816
- Testing
- Financial Incentives, Motivational Message, DPP Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Penn State University
Metabolic Syndrome
Weight Loss and Cardiovascular Disease (CVD) Prevention Via a Whole Grain Diet in Men and Women With Metabolic Syndrome
The purpose of this study is to determine if intake of whole grain foods as part of a hypocaloric diet enhances weight loss and improves cardiovascular disease risk factors in men and women with metabolic syndrome.
- Trial name
- NCT00455065
- Testing
- Whole Grain Foods
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease
Postprandial Effects of Walnut Components Versus Whole Walnuts on Cardiovascular Disease (CVD) Risk Reduction
The purpose of this study is to evaluate the acute, postprandial effects and mechanism of action of various walnut components (separated nut skins, de-fatted nut meat, nut oil) versus whole walnuts on oxidative stress…
- Trial name
- NCT00938340
- Testing
- Walnut "meat", Walnut Oil, Walnut Skins
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease
Effects of Peanut Consumption on Postprandial Inflammation, Glucose and Triglycerides
This pilot study will investigate the effects of acute peanut consumption on markers of inflammation, triglycerides and glucose.
- Trial name
- PKEPEANUT (NCT01173042)
- Testing
- Peanuts, Glucose and whipping cream, Oil Blend
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease, Metabolic Syndrome
Canola Oil Multi-center Intervention Trial II
Building on the findings from the investigators previous study, COMIT I, the purpose of the COMIT II study is to supplement the DEXA measurement of body composition with a supplementary DEXA measurement of visceral adipose tissue…
- Trial name
- COMITII (NCT03054779)
- Testing
- Canola Oil, High oleic acid canola oil, Western diet oil combination
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hypercholesterolemia, Hypertriglyceridemia
Beef in an Optimal Lean Diet (BOLD) Effects on Cardiovascular Disease (CVD) Risk
The study is designed to assess the effects of a heart-healthy diet that includes lean beef as the primary source of high quality protein on risk factors for cardiovascular disease.
- Trial name
- BOLD (NCT00937898)
- Testing
- BOLD+ Diet, BOLD diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Penn State University
Inflammatory Responses
Effects of a Prescription Omega-3 Fatty Acid Concentrate on Induced Inflammation
The purpose of this study is to assess whether the marine omega-3 fatty acids can attenuate inflammatory responses to endotoxin challenge.
- Trial name
- PRONOVA (NCT01813110)
- Testing
- 4 g prescription omega-3 concentrate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease
The Effects of Peanuts and Peanut Products on Glucose Control and Vascular Function
Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal.
- Trial name
- NCT01405300
- Testing
- Control, Peanut
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Delayed Transit Time, Irregular Bowel Function
Influence of a Delivery System on the Efficacy of a Probiotic Intervention
In the proposed work we will evaluate the efficacy of a probiotic bacterium (Bifidobacterium animalis subsp. lactis BB12) delivered in a yogurt smoothie (organism to be added before or after fermentation) or as a supplement…
- Trial name
- NCT01399996
- Testing
- Yogurt smoothie without probiotic, Yogurt smoothie with probiotic added post fermentation, Yogurt smoothie with probiotic added pre-fermentation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease
Effect of Strawberries on Cardiovascular Disease Risk
It is important to identify and evaluate foods, such as strawberries, that can improve established and emerging cardiovascular risk factors, such as postprandial lipid and glycemic responses, and vascular health.
- Trial name
- NCT01989637
- Testing
- Strawberry Meal, Control Meal
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease
Healthy Fatty Acids in Transition
Diacylglycerol (DAG) is a molecule that consists of two fatty acid chains bound by ester links to a glycerol molecule, in the form of 1,2 and 1,3 structural isomers.
- Trial name
- FAT (NCT00937963)
- Testing
- Palm DAG Oil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease
The Effect of Processed Tomato Products on CVD Risks
The primary working hypothesis is that consuming processed tomatoes frequently/daily will favorably improve endothelium and platelet function disease-risk biomarker profiles in adult men and women compared to consuming no or…
- Trial name
- TOMATO (NCT00937742)
- Testing
- Tomato products
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease, Inflammation
Dose Response Effects of Marine Omega-3 Fatty Acids on Inflammation
The purpose of this study is to determine the lowest effective dose of EPA + DHA (300, 600, 900 and 1,800 mg/day delivered as fish oil supplements) that significantly attenuates the inflammatory response to in vivo and ex vivo…
- Trial name
- NCT01078909
- Testing
- Eicosapentaenoic Acid and Docosahexaenoic Acid (EPA + DHA)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cardiovascular Disease
Effects of Walnuts on Central Blood Pressure, Arterial Stiffness Indices, Lipoproteins, and Other CVD Risk Factors
This study will evaluate the effects of walnut-derived ALA and bioactives on multiple CVD risk factors, including central blood pressure, arterial stiffness indices, inflammatory markers, urinary isoprostanes, vascular adhesion…
- Trial name
- NCT02210767
- Testing
- Walnut Diet, Walnut Control Diet, Low ALA Diet
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Penn State University
Oxidative Stress
The Acute Effect of Spices on Vascular Health
The investigators aim to conduct a 3-period randomized controlled crossover study to investigate the postprandial effects of a high fat meal with spice on endothelial function, lipids/lipoproteins, immune function and plasma…
- Trial name
- NCT03064958
- Testing
- Herbs and spices, High fat meal
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Penn State University
Metabolic Syndrome, Cardiovascular Disease
Beef in an Optimal Lean Diet (BOLD) Effects on Metabolic Syndrome
The proposed research will provide important information about the role of 2 intervention diets that provide different amounts of lean beef and meet current nutrient recommendations for the treatment of Metabolic Syndrome…
- Trial name
- BOLD-X (NCT00937638)
- Testing
- BOLD Diet, BOLD-X Diet, Modified DASH Diet
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Penn State University
Cardiovascular Disease
Effects of Polyphenolic-rich Dark Chocolate/Cocoa and Almonds on Cardiovascular Disease Risk Factors
The purpose of this study is to investigate the individual and combined effects of dark chocolate/cocoa and almonds on lipids, lipoproteins, antioxidant defense, lipid peroxidation, phenolic acids, inflammatory status, blood…
- Trial name
- CAS (NCT01882881)
- Testing
- Healthy American Control Diet, Dark Chocolate/Cocoa Diet, Almond Diet
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Penn State University
Cardiovascular Disease
Effect of Soy on HDL-C Function, Central Blood Pressure, and Arterial Stiffness
The purpose of the proposed pilot study is to evaluate the effects of a soy protein isolate with naturally occurring isoflavones on the properties of HDL-C (total HDL-C, HDL particle size and HDL function), central blood…
- Trial name
- SOY (NCT02180841)
- Testing
- Soy Protein Powder (25g/d), Soy Protein Powder (50g/d)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Penn State University
Metabolic Syndrome, Insulin Resistance
Grains Reduce Adiposity and Improve Nutrition Study
Whole grain intake beneficially affects body weight, body fat and glucose metabolism, and the investigators' previous work has shown that a high whole grain intake significantly reduced body fat in the abdominal region as…
- Trial name
- GRAIN (NCT00924521)
- Testing
- Whole grain diet, Refined grain
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Penn State University
Cardiovascular Disease
Effects of Almonds on Cardiovascular Risk Factors
The purpose of this research is to build the evidence base for approval of FDA health claims related to almonds and cardiovascular disease.
- Trial name
- ALD (NCT01101230)
- Testing
- Almonds
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Penn State University