Clinical trials: sponsored by Poitiers University Hospital
Critical Illness
Comparison of Neuromuscular Blockade's Monitoring and Clinical Assessment During Cisatracurium Paralysis in Critically Ill Patients
The main objectives of the prolonged resuscitation paralysis are usually adaptation to mechanical ventilation, lower insufflation pressures and cough suppression.
- Trial name
- NCT03198637
- Testing
- Cisatracurium's monitoring by TOF (train-of-four) WATCH device., clinical assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Cardiac Output Measurement
Comparative Noninvasive Continuous Cardiac Output by the Clearsight With Invasive Monitoring by Pulsioflex in Abdominal Surgery
In high-risk patients, it is now recommended to guide the intraoperative volume replacement via the stroke volume. Today, the most commonly used technique for estimating the stroke volume is the arterial waveform analysis in the…
- Trial name
- CLEARSIGHT (NCT02717468)
- Testing
- Cardiac output and stroke ejection volume monitoring with arterial waveform analysis in the digital artery (ClearSight®), Cardiac output and stroke ejection volume monitoring with arterial waveform analysis in the radial artery (Pulsioflex®).
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Poitiers University Hospital
Cardiac Output Measurement
Comparative Noninvasive Continuous Cardiac Output by the Clearsight® With Invasive Monitoring by PICCO® in Abdominal Major Surgery
In high-risk patients, it is now recommended to guide the intraoperative volume replacement via the stroke volume. Today, the most commonly used technique for estimating the stroke volume is the transpulmonary thermodilution and…
- Trial name
- CLEARPICCO (NCT02941952)
- Testing
- Cardiac output and stroke ejection volume monitoring with both ClearSight® and PICCO® in major abdominal surgery.
- Where
- France
- Sponsor
- Poitiers University Hospital
Dysfunctions Arterial Catheter
Impact of Radial Arterial Location on Arterial Catheter Lifetime in Surgical Intensive Care
Dysfunctions radial arterial catheter are frequent. This was a prospective, randomized observational study monocentric in ICU in France.
- Trial name
- KARTDISCHO (NCT03455348)
- Testing
- catheter insertion
- Volunteers
- 137 people
- Sponsor
- Poitiers University Hospital
Emergencies
BECOME PATIENTS IN THE EMERGENCIES OF UHC POITIERS
The number of consultations in the emergency services has continued to increase with 19.7 million passages in 2014, an increase of 4% compared to 2013.
- Trial name
- DEPAUG (NCT03449043)
- Testing
- Real care course
- Volunteers
- 450 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Failure
Early Initiation of High-flow Nasal Cannula Oxygen Therapy in Patients With Acute Respiratory Failure in the Emergency Department: A Before-after Study
The aim of the study is to compare the efficiency on respiratory failure regression of high-flow nasal oxygen therapy versus standard oxygen in patients admitted to the ED for de novo acute respiratory failure.
- Trial name
- NCT03447457
- Testing
- High-flow oxygen, Standard oxygen
- Where
- 2 sites in France
- Volunteers
- 102 people
- Sponsor
- Poitiers University Hospital
Eyelid Laxity
Physiological Upper Eyelid Laxity
This is a prospective, single-center study in normal subjects aged 20 to 89 years. The objective was to describe upper eyelid laxity by age group (20/29 years old, 30/39 years old, 40/49 years old, 50/59 years old, 60/69 years…
- Trial name
- LAX (NCT03439644)
- Testing
- Measurement of the upper eyelid laxity
- Where
- France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Sleep Quality, Weaning of Mechanical Ventilation
Impact of Sleep Quality on Respiratory Function and Weaning of Mechanical Ventilation
The aim of the study is to evaluate the impact of sleep quality on the length of mechanical ventilation weaning, in intensive care unit patients
- Trial name
- WEAN SLEEP 1 (NCT02920281)
- Testing
- Polysomnography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Sleep Deprivation, Healthy Volunteers
Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.
The purpose of this study is to assess the impact of sleep deprivation on subjective inspiratory endurance in healthy subjects.
- Conditions
- Sleep Deprivation, Healthy Volunteers, Diaphragm
- Trial name
- NoSleepDiaph (NCT02725190)
- Testing
- Sleepless night, Normal sleep night
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
High Grade Lymphomas CD20 Positive
Phase I/II Study of Escalating Doses of Idarubicin Orally Given With Oral Cyclophosphamide, Etoposide, Prednisolone and Intravenous Rituximab in Elderly Patient With Disseminated High Grade Non Hodgkin Lymphoma
R-CHOP with doxorubicin is the standard first line treatment of high grade non-Hodgkin's lymphoma. In order to avoid central venous system insertion and reduce hospitalization time in elderly patients, we developed an oral…
- Trial name
- NCT01958996
- Testing
- idarubicin
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Failure, Intratracheal Intubation
Comparison of Pre-oxygenation of NIV and HFNC Therapy for Intubation of ICU Patients With Acute Respiratory Failure
The aim of the study is to evaluate the incidence of severe hypoxemia episodes during the intubation procedure with two methods of pre-oxygenation: 1. NIV (Non Invasive Ventilation) 2. HFNC (High-flow nasal canula oxygen therapy)
- Trial name
- FLORALI2 (NCT02668458)
- Testing
- High Flow nasal canula oxygen therapy, Noninvasive ventilation
- Where
- 27 sites in France
- Volunteers
- 320 people
- Sponsor
- Poitiers University Hospital
Observation of Neuromuscular Block, Flexor Hallucis
Evaluation of Monitoring Neuromuscular Blockade the Flexor Hallucis Compared to the Adductor Pollicis
Current guidelines recommend monitoring of neuromuscular blockade at the adductor pollicis by stimulation of the ulnar nerve at the wrist.
- Conditions
- Observation of Neuromuscular Block, Flexor Hallucis, Adductor Pollicis
- Trial name
- CurHaTOF (NCT02825121)
- Testing
- Monitoring Neuromuscular Blockade the Flexor Hallucis, Monitoring Neuromuscular Blockade adductor of the thumb.
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Prostate Cancer
Repeatability of Positron Emission Tomography (TEP) With fluorométhyl-(18F)-diméthyl-2-hydroxyéthyl-ammonium
Monocentric study. Objective : Determination of the repeatability of fluorocholine PET/CT in prostate cancer
- Trial name
- NCT03105869
- Testing
- fluorocholine PET/CT
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital
Major Surgery in Adult Patients
Central Temperature Monitoring by Zero-heath-flux a Non-invasive Technic Compared to Two Invasive Technic During Surgery
Core temperature monitoring is mandatory during major surgery. The accurate techniques currently used are invasive, such as artery catheter and oesophagal probe.
- Trial name
- TEMP CORE BLOC (NCT02869828)
- Testing
- Monitoring by arterial catheter and Spot-on, Monitoring by oesophagal probe and Spot-on
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Development Abnormalies, Inclusion on Clinical Criteria of the Syndrome
Clinical and Molecular Study of CHARGE Syndrom
1. Clinical description of a French cohort of patients with CHARGE syndrome. 2. Search any phenotype-genotype correlation in typical, atypical or incomplete form of the syndrome 3.
- Trial name
- CHARGE (NCT03186144)
- Testing
- Blodd punction for genetic analysis
- Where
- France
- Volunteers
- 141 people
- Sponsor
- Poitiers University Hospital
Antibiotic Prophylaxis Surgery
Study of Repeated Cefoxitin Administration in Major Abdominal Surgery Using a Microdialysis Technique
The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective ways to prevent surgical site infections.
- Trial name
- PROPHYLOXITINE (NCT02703857)
- Testing
- cefoxitin
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Poitiers University Hospital
Metastatic Colon Cancer
Study of Skin Toxicity of Cetuximab: Find a Link Between Skin Inflammation and Tumor Response
Colon cancer is one of the most common cancers in France with more than 36,000 new cases per year. Despite significant advances in therapeutic care, the prognosis of colon cancers with metastases remains bad.
- Trial name
- NCT01292356
- Testing
- cetuximab
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Poitiers University Hospital
Ventilator-associated Pneumonia
A Pharmacokinetic-pharmacodynamic Dose Comparison Study of 8 mg/kg of Inhaled or Parenteral Gentamicin in 12 Mechanically Ventilated Critically Ill Patients Treated for Ventilator-associated Pneumonia
Ventilator associated pneumonia (VAP) remains in the intensive care unit the infection associated with the highest morbidity and mortality. Respiratory infection with resistant organism are increasing in prevalence.
- Trial name
- GENTAERO (NCT02515448)
- Testing
- gentamicin
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Poitiers University Hospital
Stress
Trial of Multidisciplinary Team Stress and Performance in Immersive Simulation for Management of Infant in Shock
The objective of this randomized trial is to study the effect of stress on performance and the effect of repetition of simulation sessions on performance and stress.
- Trial name
- NCT02424890
- Testing
- MDT simulation sessions of management of life-threatening events over 1 year
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Delirium Symptoms
Role of REM Sleep Alterations in Post Operative Delirium After Cardiac Surgery
Acute confusional states known as delirium frequently occur in Intensive Care Units (ICU), mostly after cardiac surgery, leading to serious consequences.
- Trial name
- NCT02801318
- Testing
- Polysomnography
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital