Clinical trials: sponsored by Poitiers University Hospital
Peripheral Arterial Disease
Impact of Virtual Reality on Patient Pain During Lower Limb Revascularization Via Endovascular Surgery Under Local Anesthesia With Sedation
The prevalence of peripheral arterial disease (PAD) increases with age In addition to medical treatment, endovascular procedures can be performed, depending on the stage of the disease, to prevent complications and/or sequelae…
- Trial name
- REVDOU (NCT07181434)
- Testing
- The patient will be equipped with VR headsets
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Poitiers University Hospital
Immunodepressed Patients (Hemato-oncology)
Metagenomic Sequencing for the Identification of Pathogens in Febrile Neutropenic Patients
The development of targeted therapies and intensive protocols in oncohaematology has improved the survival of patients with haematological malignancies.
- Trial name
- ADNEMIA (NCT06075888)
- Testing
- Metagenomic diagnosis (mNGS, DISQVER)
- Where
- 5 sites in France
- Volunteers
- 184 people
- Sponsor
- Poitiers University Hospital
Moderate Asthma Exacerbation, Severe Asthma Exacerbation
Early High-flow Oxygen Therapy With nebuLized Beta-2-agonist Using a Vibrating Mesh for the Management of Moderate to Severe Asthma Exacerbation in the Emergency Department
Acute exacerbation of asthma represents an acute or sub-acute worsening in symptoms and lung function in patients with asthma. It is characterized by a progressive increase in symptoms of shortness of breath, cough, wheezing, or…
- Trial name
- EOLE (NCT05691218)
- Testing
- Standard Nebulization, A - Vibrating mesh nebulization, B - Vibrating mesh nebulisation and high-flow nasal cannula heated and humidified oxygen
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Scoliosis, Restrictive Pulmonary Disease
Cardiorespiratory Assessment Prior to Scoliosis Surgery: a 10-year Experience at a Specialized Scoliosis Center
this study involves adult patients who underwent scoliosis surgery within the last 10 years. The aim of this study is to assess the frequency of scoliosis-related respiratory complications in patients requiring orthopedic…
- Conditions
- Scoliosis, Restrictive Pulmonary Disease, Pulmonary Hypertension, Restrictive Breathing Pattern
- Trial name
- RespiSco (NCT07760441)
- Testing
- respiratory function test
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Poitiers University Hospital
Alzheimer Disease, Memory Disorders
Pilot Study on the Feasibility of Using Smartphone Data as a Diagnostic Marker for Alzheimer's Disease
This study will compare smartphone usage data between three groups of patients diagnosed with either a memory complaint, mild cognitive decline, or Alzheimer's disease.
- Trial name
- IMASMART (NCT05709210)
- Testing
- Recording of smartphone usage data
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Poitiers University Hospital
Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
What is the Role of the Exposome in Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is a rare and incurable disease affecting people of all ages. It is characterized by obstructive remodeling of the small pulmonary arteries, responsible for an increase in pulmonary arterial…
- Trial name
- EXPOSPAH (NCT07172334)
- Testing
- Questionnaires, Samples
- Where
- 10 sites in France
- Volunteers
- 150 people
- Sponsor
- Poitiers University Hospital
Neoplasms (Cancer / Tumors), Geriatric Oncology
Optimising the Cancer Management of Older Patients by Early and Specific Geriatric Interventions.
The WARNING project proposes a new care organisation for older patients with cancer. The aim is to optimise management in daycare with early detection signs of geriatric syndromes and specific interventions.
- Trial name
- WARNING (NCT07704307)
- Testing
- WARNING Pack
- Volunteers
- 1,010 people
- Sponsor
- Poitiers University Hospital
Abemaciclib, Abemaciclib-related Diarrhea
Pharmacokinetic Model of Abemaciclib: Correlation With Severe Diarrhea as the Primary Toxicity Endpoint in Patients With Localized Hormone Receptor-positive Breast Cancer
Remarkable progress has recently been made in the treatment of locally advanced, hormone receptor-positive, HER2-negative breast cancer with a high risk of recurrence, thanks to the addition of abemaciclib to endocrine therapy.
- Conditions
- Abemaciclib, Abemaciclib-related Diarrhea, Breast Cancer
- Trial name
- DOSABEMA (NCT07490509)
- Testing
- Blood samples for PK, Questionnaire
- Volunteers
- 235 people
- Sponsor
- Poitiers University Hospital
Asplenia
Assessment of Complication Risk Factors in a French National Cohort of Asplenic Patients
Spleen could have been surgically removed for trauma, cancer, auto-immune disease, or to perform a diagnosis. Spleen could be non-functional due to radiotherapy or splenic artery embolism.
- Trial name
- SPLEEN (NCT04199403)
- Where
- 12 sites in France
- Volunteers
- 6,000 people
- Sponsor
- Poitiers University Hospital
Chronic Plaque Psoriasis
Skin Transcriptional Profiles In Psoriatic Patients Under Adalimumab Biotherapy
The expertise in the characterization of transcriptomics profile in lesional psoriatic skin and on the availability of innovative therapy for these patients.The investigators propose to follow the modification of the skin…
- Trial name
- CYTOPSO (NCT01872546)
- Testing
- Adalimumab Every Week
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Poitiers University Hospital
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Accuracy of Dexcom G6® and FreeStyle Libre® Sensors in Standardized Hypoxemia Conditions
The major aim is to evaluate accuracy of 2 Continuous Glucose Monitoring Systems (CGMS) : Dexcom G6® and FreeStyle Libre® in standardized hypoxemia conditions (artificial normobaric hypoxia).
- Trial name
- NCT05144802
- Testing
- acute hypoxia
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
High Myopia
Relationships Between Macular Pigment Optical Density and Lacquer Cracks in High Myopic Patients.
Lutein ans zeaxanthin, carotenoids provided by dietary intake are mainly located in the macular area. Its absorption peak at 460 nm may reduce photic damages. The macular pigment density can be evaluated by its optical density.
- Trial name
- NCT02205632
- Testing
- MPS II
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Poitiers University Hospital
Intermittent Hypoxia, Respiratory Endurance
Effect of Intermittent Hypoxia on Ventilatory Endurance in Healthy Volunteers
Sleep apnoea syndrome is a common disorder responsible for poor sleep quality and repeated oxygen depletion in the blood. Patients suffering from this disease experience a reduction in their endurance, i.e.
- Trial name
- ENDUR-HYPOX (NCT06714435)
- Testing
- Intermittent hypoxia, Normoxia
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Burn-Out
Reducing Burnout in Healthcare Workers Through Yoga and Square Breathing Practices
The mental health of healthcare workers, burnout, and the resulting suicides are now described as a real "public health crisis." Emergency departments are not spared by this phenomenon; in fact, up to 71% of emergency physicians…
- Trial name
- RESPYR (NCT07166510)
- Testing
- Yoga and meditation
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- Poitiers University Hospital
Vaccine, Streptococcus Pneumoniae
Clinical Trial Assessing the Immunogenicity of an Anti-pneumococcal Vaccination Strategy (PCV13+PPV23 Versus PREVENAR20) in Adult Patients Treated for a Lymphoma
The French Public Health Council recommended pneumococcal vaccination combined strategy for all immunocompromised patients in 2012.
- Conditions
- Vaccine, Streptococcus Pneumoniae, Lymphoma, Non-Hodgkin
- Trial name
- HEMATOVAC (NCT04460235)
- Testing
- Prevenar 13 + Pneumovax 23, PREVENAR20
- Where
- 7 sites in France
- Volunteers
- 160 people
- Sponsor
- Poitiers University Hospital
Ventricular Arrhythmia, Acute Myocardial Infarction (AMI)
Ventricular Arrhythmias in Acute Myocardial Infarction
Ventricular arrhythmias are a serious complication of myocardial infarction. The aim of this study is to provide reliable data on the management and mortality associated with ventricular arrhythmia in the setting of acute…
- Trial name
- ADVERSE-MI (NCT07517523)
- Where
- 8 sites in France
- Volunteers
- 500 people
- Sponsor
- Poitiers University Hospital
Post Extubation Respiratory Failure
Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units
In intensive care units (ICUs), around 20% of patients experience respiratory failure after planned extubation. Nearly 40-50% of them eventually require reintubation with subsequently high mortality rates reaching 30-40%.
- Trial name
- VENTILO (NCT05686850)
- Testing
- High-Flow Oxygen, Non invasive ventilation
- Where
- 47 sites in Belgium, France and 3 more
- Volunteers
- 670 people
- Sponsor
- Poitiers University Hospital
Post-Concussion Syndrome
Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury
We aimed to conduct a prospective longitudinal interventionnal monocentric study to assess the ability of seven tesla MRI to detect diffuses axonal lesions in patients presenting a post concussional syndrom (PCS) at seven days…
- Trial name
- SPIN (NCT04982562)
- Testing
- 7T MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Poitiers University Hospital
Systemic Sclerosis
Systemic Sclerosis and Innate T Cells
Innate T cells (ITC) are decreased in systemic sclerosis (SS) and an early lymphocyte innateness has been reported. In the other part, ITC are implicated on inflammatory process, including the IL-33/ST2 axis, which is also…
- Trial name
- NCT04995588
- Testing
- Blood test
- Where
- France
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Oxygen, Respiratory Insufficiency
INSPIRatory Efforts Estimation Under High-flow Nasal Oxygen
High-flow nasal oxygen (HFNO) is recommended as first-line treatment to prevent intubation in acute hypoxemic respiratory failure and to prevent reintubation after extubation.
- Conditions
- Oxygen, Respiratory Insufficiency, Work of Breathing, Dyspnea
- Trial name
- INSPIRE-Pilot (NCT07228676)
- Testing
- Non-invasive estimation of inspiratory effort
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Poitiers University Hospital