Clinical trials: sponsored by Radboud University Medical Center
Multiple Myeloma
Anakinra: Safety and Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT
Oral and intestinal mucositis are major risk factors for the occurrence of fever during neutropenia and bloodstream infections after intensive chemo- and radiotherapy.
- Trial name
- AFFECT-1 (NCT03233776)
- Testing
- Anakinra
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- Radboud University Medical Center
Movement Disorders, Parkinson Disease
A Smartphone Based, Titrated Exercise Solution for Patients With Parkinson's Disease in Daily Life: Pilot Study
The aim of this pilot randomized controlled trial is to test whether it's feasible to increase participants' step counts within four weeks with a developed motivational smartphone application.
- Trial name
- STEPWISE (NCT06692387)
- Testing
- Step count increase with the use of a motivational application
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
TREAT Study - Improving the Interpretation of Troponin Concentrations Following Exercise and Their Clinical Significance
The goal of this observational study is to learn about cardiac biomarker release following exercise in amateur athletes. The main questions it aims to answer are: Question 1: What are the reference values for exercise-induced…
- Trial name
- TREAT (NCT06295081)
- Testing
- Exercise exposure
- Where
- Netherlands
- Volunteers
- 1,015 people
- Sponsor
- Radboud University Medical Center
Recurrent Urinary Tract Infection
Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard Study
The GT RACING is a study comparing the efficacy of HA-CS bladder installations with prophylactic antibiotics in the prevention of recurrent urinary tract infections (rUTI).
- Trial name
- GT RACING (NCT05652374)
- Testing
- Ialuril 50ml Prefill, Nitrofurantoin
- Where
- 3 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Cardiac Arrest (CA), Sudden Death, Cardiac
Automated Cardiac Arrest Detection and Alerting in Daily Life
Surviving a cardiac arrest that happens outside the hospital depends on quickly recognizing the event and immediately starting CPR.
- Trial name
- DETECT-4b (NCT06692374)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Intracerebral Hemorrhage
Studying Anakinra to Reduce Secondary Brain Damage After Spontaneous Haemorrhagic Stroke
The goal of this clinical trial] is to determine if anakinra can ameliorate the formation of perihaematomal oedema in patients with spontaneous intracerebral haemorrhage (ICH).
- Trial name
- ACTION (NCT04834388)
- Testing
- Anakinra
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Radboud University Medical Center
Chronic Condition, Chronic Conditions, Multiple
OPTIMA FORMA Phase 3
Chronic diseases and multimorbidity are increasingly prevalent. However, over the last decades, attempts at improving primary care for chronic diseases have been focussed on the management of individual chronic diseases and…
- Trial name
- OPTIMAFORMA3 (NCT05495230)
- Testing
- Person-centred integrated care intervention, Usual care
- Where
- Netherlands
- Volunteers
- 842 people
- Sponsor
- Radboud University Medical Center
Secondary Angiosarcoma, Locally Advanced Sarcoma
Cemiplimab for Secondary Angiosarcomas
Secondary angiosarcomas are aggressive mesenchymal tumors with a poor prognosis and limited therapeutic options. Recent studies conducted in patients with cutaneous squamous-cell carcinoma provide evidence that cemiplimab has the…
- Conditions
- Secondary Angiosarcoma, Locally Advanced Sarcoma, Metastasis
- Trial name
- NCT04873375
- Testing
- Cemiplimab
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Radboud University Medical Center
Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload
The Efficient PICU Fluid Care Evaluation
The goal of this clinical trial is to evaluate and prevent fluid overload in critically ill, mechanically ventilated children. The main questions it aims to answer are: 1.
- Conditions
- Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload, Fluid Balance
- Trial name
- LESSER-2 (NCT06644508)
- Testing
- Strict adherence to European guidelines
- Where
- 3 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
COVID-19
Non-specific Effects of FLU-MMR Vaccines in Adults
Various observational studies have reported an association between influenza vaccination and lower rates of infection with SARS-Cov-2 and less COVID-19 disease severity have been reported in large epidemiological studies in US…
- Trial name
- FLUMMR-BRA (NCT05401448)
- Testing
- Influenza, MMR vaccines
- Where
- Brazil
- Volunteers
- 638 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Point-of-care-ultrasound, Gastric Ultrasonography
Feasibility of Nurse-performed Gastric Ultrasound After Surgery
Gastric ultrasound is a quick and non-invasive tool to evaluate gastric content. Emptying of gastric content can be affected after abdominal surgery leading to the inability of tolerating oral foods.
- Conditions
- Point-of-care-ultrasound, Gastric Ultrasonography, Gastric Ultrasound, Gastro Intestinal Surgery
- Trial name
- SKILLS-2 (NCT06620549)
- Testing
- gastric ultrasonograppy
- Where
- 2 sites in Netherlands
- Volunteers
- 135 people
- Sponsor
- Radboud University Medical Center
Pain, Acute, Burns
Distraction As Multimodal Pain Management
A randomized controlled trial will be performed at the Ngwelezana Hospital, Empangeni, South Africa. Paediatric patients between the age of 5-12 years with minor and superficial partial thickness burn injuries who require…
- Conditions
- Pain, Acute, Burns, Pediatric ALL
- Trial name
- DISTRACT (NCT06591195)
- Testing
- Distraction by use of kaleidoscope
- Volunteers
- 126 people
- Sponsor
- Radboud University Medical Center
Neuromuscular Blockade, Innate Inflammatory Response
Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function
Monocenter randomized controlled trial to compare the effect of deep neuromuscular blockade (NMB) versus moderate NMB during total hip replacement surgery on postoperative quality of recovery and innate immune function.
- Conditions
- Neuromuscular Blockade, Innate Inflammatory Response, Quality of Life, Postoperative Complications
- Trial name
- HIPPO (NCT05562999)
- Testing
- Rocuronium Bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Feeding and Eating Disorders
Improving Gastrointestinal Function In High-Risk Newborns By Stimulation Of The Enteric Nervous System
The goal of this therapeutical intervention trial is to investigate whether tactile-kinesthaetic and oral sensorimotor stimulation can improve gastrointestional function in preterm infants born before gestational age of 30 weeks…
- Trial name
- NeoHemoHapt (NCT06057415)
- Testing
- HAPTOS (Handling Adapted to Postnatal age with Tactile-kinaesthetic and Oral sensorimotor Stimulation
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Cancer, Oncology
The ROAD 2.0 to Sustainable Medication Use: Redispensing Unused Oral Anticancer Drugs
The goal of this prospective intervention study is to investigate the effectiveness of redispensing unused oral anticancer drugs.
- Conditions
- Cancer, Oncology, Pharmacy, Drug Prescriptions
- Trial name
- NCT06566560
- Testing
- redispensing oral anticancer drugs
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- Radboud University Medical Center
Central Core Disease, Multi-Minicore Disease
The Natural History and Muscle Fatigability of Patients With Congenital Myopathies.
Core myopathies (CCD/MmD), nemaline myopathies (NEM) and centronuclear myopathies (CNM) are three types of rare congenital myopathies.
- Conditions
- Central Core Disease, Multi-Minicore Disease, Nemaline Myopathy, Centronuclear Myopathy
- Trial name
- READYCOM (NCT06157268)
- Testing
- Natural history and non therapeutical therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
AADC/TDC in Advanced Parkinson's Disease
Rationale: Many persons with Parkinson's disease (PD) develop a progressive resistance to levodopa, which is the pharmacological mainstay of PD treatment.
- Trial name
- AADCTDC (NCT05558787)
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Radboud University Medical Center
Noise Exposure, Intensive Care Unit
Effective Strategies to Reduce Noise and Related Distractions
Patients admitted to the intensive care unit (ICU) undergo complex critical care treatment and are consequently surrounded by equipment and monitors contributing to high sound pressure levels.
- Conditions
- Noise Exposure, Intensive Care Unit, Safety Issues
- Trial name
- NOISY (NCT04643652)
- Testing
- Noise Reduction Bundle
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Recurrent Ovarian Carcinoma, Recurrent Fallopian Tube Carcinoma
Intraperitoneal Infusion of ex Vivo-cultured Allogeneic NK Cells in Recurrent Ovarian Carcinoma Patients
This study investigates an innovative treatment for recurrent ovarian cancer exploiting ex vivo-generated allogeneic natural killer (NK) cells with or without preceding non-myeloablative conditioning chemotherapy.
- Conditions
- Recurrent Ovarian Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Primary Peritoneal Carcinoma
- Trial name
- INTRO (NCT03539406)
- Testing
- UCB-NK cells, Chemotherapy
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Radboud University Medical Center
Scabies
Sensitivity of Self-collected Skin Sampling for Scabies: a Pilot Study
In this cross-sectional diagnostic study, healthy adults aged 18 and older with suspected, clinical, or confirmed scabies will be recruited.
- Trial name
- SCRAPE (NCT06546579)
- Testing
- Skin sampling
- Where
- Netherlands
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center