Clinical trials: sponsored by Radboud University Medical Center
Breast Cancer
Dedicated Breast CT for Diagnosis of Breast Cancer
Dedicated breast computed tomography (BCT) is being developed as a new x-ray based tomographic breast imaging method for early breast cancer detection and/or diagnosis.
- Trial name
- NCT05458427
- Where
- 2 sites in Netherlands
- Volunteers
- 210 people
- Sponsor
- Radboud University Medical Center
Tooth Wear, Reflux Acid
7 Year Follow up Analysis on the Speed of Progression of Tooth Wear Using 3D Subtraction
Prospective observational study with 7-year follow up. 55 patients are included with moderate to severe tooth wear, whereby through informed consent the decision was taking to monitor the patients.
- Conditions
- Tooth Wear, Reflux Acid, Bruxism
- Trial name
- NCT04790110
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Prostate Cancer, Prostate Neoplasm
Effectiveness of Focal Therapy in Men With Prostate Cancer
In the Netherlands, most men with prostate cancer (PCa) are treated with radical whole-gland treatment, i.e. prostatectomy or radiotherapy.
- Trial name
- ENFORCE (NCT06223295)
- Testing
- Focal therapy, Usual care
- Where
- 5 sites in Netherlands
- Volunteers
- 356 people
- Sponsor
- Radboud University Medical Center
Aortic Valve Stenosis
Upper Extremity Versus Lower Extremity Accessory Access Sites During Transcatheter Aortic Valve Implantation
The goal of this prospective, multicenter, investigator-initiated, randomized clinical trial is to assess the safety and efficacy of a 'minimally invasive, upper extremity' approach versus the standard 'lower extremity' approach…
- Trial name
- TAVIXS (NCT05672823)
- Testing
- Transcatheter Aortic Valve Implantation (TAVI)
- Where
- 8 sites in Netherlands
- Volunteers
- 238 people
- Sponsor
- Radboud University Medical Center
Depressive Disorder, Major
Mindfulness Based Cognitive Therapy for Recurrent Depression
The purpose of this study is to investigate the effectiveness and possible mediating factors of Mindfulness Based Cognitive Therapy (MBCT) for recurrent depression.
- Trial name
- NCT01038765
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Radboud University Medical Center
Risk Reduction, Ovarian Cancer
STOP OVarian CAncer; Implementation of the Opportunistic Salpingectomy in the Netherlands
The aim of this study is to optimize implementation of the opportunistic salpingectomy throughout the Netherlands.
- Trial name
- STOPOVCA (NCT04470921)
- Testing
- Opportunistic Salpingectomy
- Where
- 27 sites in Netherlands
- Volunteers
- 10,000 people
- Sponsor
- Radboud University Medical Center
Salpingectomy, Tubal Ligation
Stop Ovarian Cancer Young; Effect of the Opportunistic Salpingectomy on Age of Menopause
The aim of this study is to evaluate the long-term safety of on the onset of menopause.
- Conditions
- Salpingectomy, Tubal Ligation, Menopause
- Trial name
- STOPOVCAyoung (NCT04757922)
- Testing
- Opportunistic salpingectomy / bilateral salpingectomy
- Where
- Netherlands
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Inflammatory Bowel Diseases
Mindfulness-based Cognitive Therapy for Patients With Inflammatory Bowel Disease
Considering the limited availability of psychosocial interventions for IBD, this study aims to investigate MBCT as an adjunctive treatment to treatment as usual to reduce psychological stress and improve sleep quality/regularity…
- Trial name
- NCT04646785
- Testing
- Mindfulness-based cognitive therapy + TAU, Treatment as usual (TAU)
- Where
- 4 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- Radboud University Medical Center
Lung Cancer
Validation of Rapid On-site Diagnostics in Early Stage Lung Cancer Sampling With a Higher Harmonic Generation Microscope
The aim of this study is to verify a new microscopic technique in diagnosing patients suspected of lung cancer. Patients will undergo navigational bronchoscopy or surgical resection as a part of standard of care.
- Trial name
- VALIDIAG (NCT06007261)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Stress, Ischemia
Assessing the Effect of the 'Wavy' Application, on Stress and Burden of Disease in Women With INOCA
For women that experience angina symptoms with underlying vascular spasm as the cause, stress has an aggravating role. Coping with stress is therefore included as an important pillar in dealing with this chronic disease, see the…
- Conditions
- Stress, Ischemia, Vasospasm, Coronary, Vasomotor; Spasm
- Trial name
- NCT06171893
- Testing
- Wavy stress application
- Where
- 6 sites in Netherlands
- Volunteers
- 117 people
- Sponsor
- Radboud University Medical Center
Transcatheter Aortic Valve Replacement, Hemodynamic Monitoring
Assessment of Paravalvular Leak After TAVI by Hemodynamic Measurements and Cardiac MRI
Rationale: Transcatheter aortic valve implantation (TAVI) has become the standard therapy for elderly patients with high surgical risks.
- Conditions
- Transcatheter Aortic Valve Replacement, Hemodynamic Monitoring, Aortic Valve Insufficiency, Aortic Valve Stenosis
- Trial name
- APPOSE (NCT04281771)
- Testing
- cardiac MRI
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Radboud University Medical Center
Endometrial Cancer
Dendritic Cells for Immunotherapy of Metastatic Endometrial Cancer Patients
Prevention of infectious diseases through immunization is one of the greatest achievements of modern medicine. Nonetheless, considerable challenges remain for improving the efficacy of existing vaccines for therapeutic…
- Trial name
- DECENDO (NCT04212377)
- Testing
- Dendritic Cells for endometrial cancer
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes Mellitus
Beta Cell Imaging During and Shortly After the Honeymoon Phase of T1D
The primary goal is to correlate beta cell mass to beta cell function from measurements during and shortly after the honeymoon phase of type 1 diabetes, to improve understanding of the change in metabolic control after the…
- Trial name
- Honeymoon (NCT03917238)
- Testing
- gallium-68-exendin injection followed by PET/CT scan
- Where
- 2 sites in Netherlands
- Volunteers
- 14 people
- Sponsor
- Radboud University Medical Center
Gestational Diabetes
Visualizing Beta Cells in Patients With a History of Gestational Diabetes
In order to evaluate the difference in beta cell mass in women with and without a history of gestational diabetes mellitus (GDM), investigators aim to compare quantitative PET imaging of the pancreas between these groups.
- Trial name
- NCT03182296
- Testing
- 68Ga-NODAGA-exendin-4 PET/CT
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Post-Intensive Care Syndrome (PICS)
MONITOR-IC: Determining and Improving Long-term Consequences of ICU Care
Due to advances in critical care medicine, more patients survive their critical illness. However, intensive care unit (ICU) survivors often experience long-term physical, cognitive and mental problems, summarized as post…
- Trial name
- MONITOR-IC (NCT03246334)
- Where
- Netherlands
- Volunteers
- 50,000 people
- Sponsor
- Radboud University Medical Center
Polyps of Colon, Recurrence, Local Neoplasm
Recurrences After Standard EMR vs Plus Thermal Ablation EMR
The primary objective of this trial is to investigate whether thermal ablation EMR with soft tip snare coagulation (STSC) reduces the recurrence rate of lateral spreading or sessile polyps ≥20mm compared to standard EMR.
- Trial name
- RESPECT (NCT05121805)
- Testing
- Snare tip soft coagulation
- Where
- Netherlands
- Volunteers
- 306 people
- Sponsor
- Radboud University Medical Center
Hypertension, Small Vessel Cerebrovascular Disease
Hyperintense: Midlife Hypertension and the Brain
Cerebral small vessel disease (SVD) describes a set of pathologies affecting the smallest blood vessels in the brain. SVD contributes to up to a fifth of ischemic and hemorrhagic strokes en is the main vascular cause of dementia.
- Trial name
- NCT06175663
- Testing
- Antihypertensive medication withdrawal
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Surgery
Incremental Cost-Utility Study on Prehabilitation Among Older Patients With Colorectal Cancer Undergoing Surgery
A prospective multicenter observational cost-utility study following older or high-risk patients with colorectal cancer with and without prehabilitation before surgery.
- Trial name
- PreColo CU (NCT04097795)
- Testing
- Prehabilitation
- Where
- 5 sites in Netherlands
- Volunteers
- 72 people
- Sponsor
- Radboud University Medical Center
Kidney Transplant Failure and Rejection, Pediatric Kidney Disease
Risk Assessment Tool for Graft Survival in Pediatric Kidney Transplantation
Registry study in which data of all pediatric kidney recipients in the Netherlands (registered in the Nederlandse Orgaan Transplantatie Registry) are studied to develop a risk calculator for graft loss.
- Trial name
- NCT05388955
- Testing
- None, transplantation recipients
- Volunteers
- 1,425 people
- Sponsor
- Radboud University Medical Center
Hypoglycemia
GLP1R-imaging in Hypoglycemia
Hyperinsulinemic hypoglycemia (HH) is a rare complication that occurs 1 to 5 years after gastric bypass surgery. The underlying mechanism of this complication is not yet completely understood.
- Trial name
- NCT03182192
- Testing
- 68Ga-NODAGA-exendin-4 PET/CT
- Where
- 2 sites in Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center