Clinical trials: sponsored by Radboud University Medical Center
Standardized Structured Reporting
Nationwide Implementation of Standardized Structured Reporting
The first objective is to explore factors that impede or facilitate implementation of SSR in pathology (and other disciplines) among the MDT members receiving SSRs.
- Trial name
- IMPROVING (NCT03649126)
- Testing
- Implementation tools
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Idiopathic Nephrotic Syndrome, Minimal Change Disease
Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome
This will be an open-label, randomized controlled trial which compares continued treatment with high dose prednisone (standard therapy) to treatment with rituximab in patients with minimal change disease or focal segmental…
- Conditions
- Idiopathic Nephrotic Syndrome, Minimal Change Disease, Focal Segmental Glomerulosclerosis
- Trial name
- NCT03298698
- Testing
- Rituximab, Prednisone
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
PTEN Hamartoma Tumor Syndrome
Response of Immune System to Flu Vaccination in PHTS
this study evaluates the cellular and humoral immune response to seasonal influenze vaccination in PTEN Hamartoma Tumor Syndrome. All subjects will be administered flu vaccination, half of the subjects will be control subjects.
- Trial name
- RIPS (NCT03630523)
- Testing
- Influvac Tetra
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Efavirenz, Child Behavior
Neuropsychiatric Side Effects of Efavirenz in Children Living With HIV
Efavirenz is among the preferred antiretroviral drugs for HIV-infected children. Increasing evidence shows that central nervous system side-effects in adults are more common than previously thought.
- Conditions
- Efavirenz, Child Behavior, Cognitive Symptom, Medication Adherence
- Trial name
- NCT03227653
- Testing
- Efavirenz, Nevirapine, Lopinavir-Ritonavir Drug Combination
- Where
- 6 sites in Tanzania
- Volunteers
- 144 people
- Sponsor
- Radboud University Medical Center
Systemic Inflammatory Response Syndrome, Coronary Artery Bypass Grafting
Immunomodulation of EA-230 Following On-pump Coronary Artery Bypass Grafting (CABG)
EA-230 is a newly developed synthetic compound with anti-inflammatory properties, it is a linear tetrapeptide derived from the human chorionic gonadotropin hormone (hCG).
- Trial name
- EASI (NCT03145220)
- Testing
- EA-230
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Radboud University Medical Center
Ovulation Disorder
"Stair Step Study"
Rationale: There is some information suggesting that a progesterone-induced withdrawal bleeding before the start of ovulation induction in women suffering from oligo- or amenorrhea reduces pregnancy and live birth rate.
- Trial name
- NCT03309176
- Testing
- Medroxyprogesterone Acetate 10 MG, Stair step protocol without Medroxyprogesterone Acetate
- Where
- 3 sites in Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Salivary Gland Cancer, Adenoid Cystic Carcinoma
PSMA-PET Imaging for Advanced ACC/SDC
Diagnostic study which evaluates the level of PSMA expression in patients with locally advanced, recurrent and/or metastatic ACC/SDC of ≥18 years old with 68Ga-PSMA-PET/CT imaging in order to establish whether these patients are…
- Conditions
- Salivary Gland Cancer, Adenoid Cystic Carcinoma, Salivary Duct Carcinoma
- Trial name
- NCT03319641
- Testing
- PSMA-PET/CT scan
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Hereditary Hemorrhagic Telangiectasia, Gastrointestinal Hemorrhage
Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber
The purpose of this study is to determine whether long-acting octreotide is safe and effective in the treatment of patients with Rendu-Osler-Weber (e.g. HHT).
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Gastrointestinal Hemorrhage, Anemia
- Trial name
- ROW (NCT02874326)
- Testing
- Octreotide LAR
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
ADHD
Mindfulness Training in Adults With ADHD
The primary aim of this study is to investigate clinical effectiveness of mindfulness training versus treatment as usual (TAU) in adults with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT02463396
- Testing
- MBCT for ADHD
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Heart Failure
Effects of 'NHGDoc' on Quality of Care
The purpose of this study is to determine whether the computerized decision support system 'NHGDoc' is effective in improving quality of primary care in terms of processes of care (e.g.
- Trial name
- NHGDoc (NCT01773057)
- Testing
- NHGDoc domain Heart Failure
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Lungcancer
HD+ I-scan Bronchoscopy Vascular Abnormalities Detection Multicenter Study
Videobronchoscopy is an essential diagnostic procedure for evaluation of the central airways and pivotal for the diagnosis and staging of lung cancer.
- Trial name
- i-scan (NCT02285426)
- Testing
- Pentax EB-1990i HD-bronchoscope guided biopsy
- Where
- 4 sites in Italy, Netherlands and 2 more
- Volunteers
- 134 people
- Sponsor
- Radboud University Medical Center
Breast Neoplasms
Prediction of Everolimus-induced Interstitial Lung Disease
The investigators will determine which factors are predictive for the development and severity of everolimus-induced interstitial lung disease and will develop a prediction model based on these risk factors.
- Trial name
- PREVENT (NCT01978171)
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 1, Hypoglycemia
Exenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes
Approximately 25% of patients with type 1 diabetes have lost the capacity to timely detect hypoglycaemia, a condition referred to as impaired hypoglycaemic awareness (IHA) that causes a six-fold higher risk of severe, potentially…
- Trial name
- NCT02735031
- Testing
- Exenatide
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Malaria
Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1
This is a single-center, open label study. The primary aim of this project is to develop a controlled human malaria infection transmission model ("CHMI-trans") or "challenge model" to evaluate the capacity of vaccines, biologics…
- Trial name
- CHMI-trans1 (NCT02836002)
- Testing
- Sulfadoxine-pyrimethamine (low dose), Piperaquine (low dose), Sulfadoxine-pyrimethamine (high dose)
- Where
- Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Well-being, Depressive Symptoms
Integration of Social Art Activities and Qigong for Older People in Nursing Home in Indonesia
This project will be a randomised controlled trial to investigate the effectiveness of an integrated programme by using social art activity (SA) and exercise, for instance, Qigong (QG, a traditional Chinese exercise) as a…
- Trial name
- NCT02957773
- Testing
- Qigong and art activities, Art activities, Qigong
- Where
- Indonesia
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Atopic Dermatitis
Efficacy of Topical Coal Tar in Children With Atopic Dermatitis
Rationale/hypothesis: Atopic dermatitis (AD) is an inflammatory skin disease, occurring most frequently in children. Currently, topically applied corticosteroids are used as a standard anti-inflammatory treatment.
- Trial name
- NCT03461302
- Testing
- Topical coal tar, Topical corticosteroids
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Colorectal Neoplasms
Comparison of AMR and ADR Between Endocuff Vision-assisted and Conventional Colonoscopy: a Multicenter Randomized Trial
The aim of this international multicenter study is to compare the adenoma detection rate and adenoma miss rate of conventional and Endocuff Vision-assisted colonoscopy.
- Trial name
- EXCEED (NCT03418948)
- Testing
- CC followed by EC, EC followed by CC, 2x EC
- Where
- 3 sites in Greece, Netherlands
- Volunteers
- 708 people
- Sponsor
- Radboud University Medical Center
Sarcoma, Soft Tissue
Individualizing Pazopanib Therapy by exploRing the Role of Early Metabolic responsE and Drug Exposure as a preDICTor for Treatment Outcome in Patients With STS
This study is a phase IV post registration prospective observational feasibility study in patients with metastatic soft tissue sarcoma.
- Trial name
- PREDICT (NCT01995981)
- Testing
- Pazopanib
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 22 people
- Sponsor
- Radboud University Medical Center
Video-mediated Consultation, Face to Face Consultation
Is the Medium the Message?
Digital communication media like video-interaction (cf. Skype) are increasingly being adopted in institutional environments like hospitals for physician-patient interactions.
- Trial name
- NCT03374865
- Testing
- Facetalk, Face-to-face consultation
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Head and Neck Cancer
Nurse-led Follow-up Care for Head and Neck Cancer Patients
The purpose of this study is to conduct an early evaluation of a nurse-led follow up intervention added to the usual medically oriented follow up care.
- Trial name
- NCT01167179
- Testing
- nurse-led consultation
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- Radboud University Medical Center