Clinical trials: sponsored by Radboud University Medical Center
Pain, Intractable, Central Pain Syndrome
Long-term Effect of Motor Cortex Stimulation in Patients Suffering From Chronic Neuropathic Pain
In order to create insights in the effects of Motor cortex stimulation (MCS) on intractable pain, an open observational study was started in 2003. The aim of this research is to: 1.
- Conditions
- Pain, Intractable, Central Pain Syndrome, Facial Pain
- Trial name
- MCSNL (NCT03189823)
- Testing
- Specify, model 3998, Medtronic Inc., Minneapolis, MN, USA
- Volunteers
- 17 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus
Effect of Gelofusine on GLP1-receptor Imaging
The highly promising and innovative tracer on 111In-DTPA-AHX-Lys40-Exendin 4 has been applied to determine beta cell mass in healthy volunteers and patients with type 1 diabetes.
- Trial name
- GLP1-EX-GELO (NCT02541734)
- Testing
- Gelofusine, 111In-exendin 4 SPECT/CT
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus Type 2
Adipose Tissue Imaging in Type 2 Diabetes
The metabolic function of different white adipose tissue depots in the body and its role in the development of type 2 diabetes (T2D) remains unclear.
- Trial name
- ATI-DM2 (NCT02528695)
- Testing
- 18F-FDG PET/CT, euglycemic clamp, hypoglycemic clamp
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Disturbing Factors, Stress
Disturbing Factors in the Operating Room
Observation of disturbing factors in the operating room and comparison between day and night shift. The investigators have chosen to observe kidney transplantations, since this type of operation has the same priority during day…
- Trial name
- NCT03163537
- Testing
- HealthPatch
- Volunteers
- 45 people
- Sponsor
- Radboud University Medical Center
Delirium
DElirium prediCtIon in the intenSIve Care Unit: Head to Head comparisON of Two Delirium Prediction Models
Currently, two ICU delirium prediction models are available: the PRE-DELIRIC model and the early prediction model (E-PRE-DELRIC).
- Trial name
- DECISION (NCT02518646)
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- Radboud University Medical Center
Dementia
SHARED DECISION MAKING IN LONG-TERM CARE FACILITIES
Shared Decision Making (SDM) is defined as a process where healthcare professionals and patients make decisions together, using the best available evidence.
- Trial name
- NCT02118701
- Testing
- Shared Decision-Making educational training
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Carcinoma, Pancreatic Ductal, Colorectal Neoplasms
Continuous Monitoring on the General Ward
Rationale: Monitoring patients' vital signs is done to detect clinical deterioration. For this, the MEWS, a scoring list comprising seven vital signs measured by nursing staff, is used.
- Conditions
- Carcinoma, Pancreatic Ductal, Colorectal Neoplasms, Arthritis, Hypertension
- Trial name
- NCT02933307
- Testing
- HealthPatch, ViSi Mobile
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Malaria, Plasmodium Falciparum
Safety and Protective Efficacy of BCG Vaccination Against Controlled Human Malaria Infection
The Bacillus Calmette-Guérin (BCG) vaccine, a live attenuated Mycobacterium bovis vaccine, has been used to prevent tuberculosis for almost a century, and it is still the most used vaccine in the world.
- Trial name
- BCG-EHMI (NCT02692963)
- Testing
- BCG vaccination
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Melanoma
Single-step Antigen Loading and TLR Activation of Dendritic Cells in Melanoma Patients
Objectives: This is an exploratory study, consisting of two parts. In part I dose escalation is performed and the primary objective is the safety of different doses of TLR-DC and Trimix DC.
- Trial name
- NCT01530698
- Testing
- autologous dendritic cell vaccine
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Radboud University Medical Center
Melanoma
Toll-like Receptor (TLR) Ligand Matured Dendritic Cell Vaccination in Melanoma Patients
Objectives: This is an exploratory study, consisting of two parts. In part I a dose escalation is performed and the primary objective is the safety of different doses of TLR-dendritic cell (TLR-DC).
- Trial name
- NCT00940004
- Testing
- autologous dendritic cell vaccination
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Mitochondrial Disorders
DINAMITE Study Nutritional State and Effect Diet in Mitochondrial Disease
The m.3243A>G mutation is the most frequent cause of mitochondrial disease in adults, for which currently no therapy is available and treatment is solely supportive.
- Trial name
- DINAMITE (NCT02286856)
- Testing
- diet intervention
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Rectal Tumour
Transanal Endoscopic Microsurgery (TEM) After Radiochemotherapy for Rectal Cancer
In the Netherlands approximately 2300 new patients are diagnosed with rectal cancer each year. Standard treatment for patients with a T2 or T3 rectal cancer consists of preoperative short course of radiotherapy followed by…
- Trial name
- CARTS (NCT01273051)
- Testing
- Capecitabine, radiotherapy, TME resection
- Where
- 13 sites in Netherlands
- Volunteers
- 55 people
- Sponsor
- Radboud University Medical Center
Cardiovascular Diseases
Intervention to Improve Medication Adherence in Cardiovascular Patients
The purpose of this study is to investigate whether a nurse-based intervention, consisting of structural informative consulting and motivational counseling, on top of usual care with or without personalized web-based…
- Trial name
- NCT01449695
- Testing
- Life style counseling, an individualized web portal, individual and group consultations
- Where
- Netherlands
- Volunteers
- 420 people
- Sponsor
- Radboud University Medical Center
Healthy Volunteers
Adrecizumab Phase 1 Trial
This is the first clinical trial with ADRECIZUMAB. The purpose of this clinical trial to identify safety and tolerability of different doses of ADRECIZUMAB in healthy volunteers.
- Trial name
- NCT02991508
- Testing
- Adrecizumab
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Orthodontic Treatment, Fixed Appliances
Effectiveness of Insignia ™ Versus Standard Orthodontic Treatment With Damon Q Brackets
The hypotheses tested in this study are: There is a statistical significant difference, in treatment duration and result of treatment in cases treated using traditional Damon Q brackets or using Insignia.
- Conditions
- Orthodontic Treatment, Fixed Appliances, Insignia, DamonQ Brackets
- Trial name
- NCT01268852
- Testing
- Damon self ligating orthodontic bracket, Insignia self ligating orthodontic bracket
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Radboud University Medical Center
Hypertension
Omics Signature in the Diagnosis of Hypertension
The purpose of this study is to assess the validity and usefulness of omics signatures for improved identification and risk stratification of patients with endocrine hypertension and stratification of patients with primary…
- Trial name
- ENSAT-HT (NCT02772315)
- Testing
- omics
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 4,000 people
- Sponsor
- Radboud University Medical Center
Nausea, Vomiting
Treatment Algorithm for Nausea and Vomiting in the Palliative Phase
Nausea and vomiting are frequently occurring problems in the palliative phase of patients with cancer. Between 20-50% of them regularly suffer from nausea, retching or vomiting.
- Conditions
- Nausea, Vomiting, Cancer
- Trial name
- NCT03017391
- Testing
- metoclopramide, granisetron, Dexamethasone
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
COPD Exacerbation
Platelet Activation and Reactivity in Acute Exacerbations of COPD
Chronic obstructive pulmonary disease (COPD) is known for development of severe cardiovascular co-morbidities. Systemic inflammation during acute exacerbations of COPD (AE-COPD) is thought to play a role in development of…
- Trial name
- NCT03017625
- Testing
- Blood is drawn
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Melanoma
Natural Dendritic Cell Vaccines in Metastatic Melanoma Patients
Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients, and both immunological and clinical responses have…
- Trial name
- NCT01690377
- Testing
- PDC or myDC
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Breast Cancer Patients
Nurse Intervention Project
The use of interventions for cancer-related distress is important to reduce this distress. Distress has a negative impact on quality of life, the recovery during and after treatment and may even adversely affect survival.
- Trial name
- VIP (NCT01091584)
- Testing
- distress thermometer
- Where
- Netherlands
- Volunteers
- 193 people
- Sponsor
- Radboud University Medical Center