Clinical trials: sponsored by Radboud University Medical Center
Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)
Nociceptive Processing in Acute Cutaneous Nerve Entrapment Syndrome
Rationale: Chronic abdominal pain is a frequently occurring condition. Although hardly ever considered, the abdominal wall is the primary cause in 10-30% of cases.
- Trial name
- NCT01920880
- Testing
- Quantitative Sensory Testing analysis
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Malaria, Falciparum
Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis
This study will assess the superior protective immunity of the combination of chloroquine and azithromycin prophylaxis under Chemoprophylaxis Sporozoites (CPS) immunization versus a standard chloroquine prophylactic regimen.
- Trial name
- MMV (NCT01783340)
- Testing
- Azithromycin capsules, Immunization with falciparum
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
The ParkCycle Study: Aerobic Exercise in PD
The primary goal of this study is to determine the neuroprotective qualities of long-term, in home, exercise therapy program in human PD patients.
- Trial name
- NCT01562496
- Testing
- Exercise
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 35 people
- Sponsor
- Radboud University Medical Center
Non-Hodgkin Lymphoma
PEARL Study: Improvement of Non-Hodgkin's Lymphoma Care
The main objective of the proposed study is to assess the effectiveness, feasibility and costs of a tailored strategy (developed in accordance with the barriers found and current practice) to improve care for patients with…
- Trial name
- NCT01562509
- Testing
- Implementation tools, Standard intervention
- Where
- Netherlands
- Volunteers
- 418 people
- Sponsor
- Radboud University Medical Center
Pneumonia
Ventilator Associated Pneumonia and Late Complications of Percutaneous Tracheostomy
The purpose of this study is to investigate the incidence of ventilator associated pneumonia and late complications by comparing two different cannulas and two different percutaneous tracheostomy techniques.
- Trial name
- NCT00184925
- Testing
- Tracheostomy, cannula with subglottic drainage
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Pancreatitis, Chronic, Abdominal Pain
Δ9-THC (Namisol®) in Chronic Pancreatitis Patients Suffering From Persistent Abdominal Pain
Abdominal pain resulting from chronic pancreatitis (CP) is often recurrent, intense and long-lasting, and is extremely difficult to treat.
- Conditions
- Pancreatitis, Chronic, Abdominal Pain, Chronic Pain
- Trial name
- NCT01551511
- Testing
- Tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Postsurgical Pain, Abdominal Pain
The Analgesic Efficacy of Δ9-THC (Namisol®) in Patients With Persistent Postsurgical Abdominal Pain
Persistent postsurgical abdominal pain (PPAP) is a very difficult to treat pain. This pain can persist for months or even years and significantly diminishes quality of life.
- Conditions
- Postsurgical Pain, Abdominal Pain, Chronic Pain
- Trial name
- NCT01562483
- Testing
- Tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Radboud University Medical Center
Common Cold
Experimental Human Rhinovirus Infection
Our primary objective is to set up the Human Rhinovirus (HRV)-model in our centre. In addition, to facilitate future clinical trials, we want to determine optimal read-out parameters and read-out time points for experimental HRV…
- Trial name
- EHRVI (NCT01823640)
- Testing
- Human Rhinovirus strain 16 (HRV-16)
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson's Disease
Effectiveness Study of Occupational Therapy in Parkinson's Disease
The purpose of this study is to determine the effectiveness of occupational therapy in Parkinson's disease.
- Trial name
- OTiP (NCT01336127)
- Testing
- Occupational Therapy
- Where
- 10 sites in Netherlands
- Volunteers
- 191 people
- Sponsor
- Radboud University Medical Center
Immunologic Deficiency Syndromes
Effects of Orally Administered Beta-glucan on Leukocyte Function in Humans
The purpose of this study is to test wether orally administered Beta-glucan has systemic effects in humans.
- Trial name
- BG (NCT01727895)
- Testing
- Beta-glucan (Glucan #300®)
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cardiovascular Disease, Ischemic Heart Disease
The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial
Rationale: In patients with a myocardial infarction, occlusion of a coronary artery induces myocardial ischemia and cell death. If untreated, the area of myocardium exposed to this interruption in blood supply, will largely…
- Trial name
- MetCAB (NCT01438723)
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Polycystic Liver Disease
Somatostatin Analogues as a Volume Reducing Treatment of Polycystic Livers (RESOLVE)
The aim of this study is to determine the effect of Lanreotide on polycystic liver and kidneys in patients with autosomal dominant polycystic kidney disease.
- Trial name
- RESOLVE (NCT01354405)
- Testing
- Lanreotide
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Radboud University Medical Center
Behavioural Disturbances, Pain
Delta-THC in Dementia
This is a phase II, randomized, placebo-controlled, double-blind, parallel-group, multicentre study to the efficacy and safety of low dose delta-9-THC in behavioural disturbances and pain in patients with mild to severe dementia…
- Conditions
- Behavioural Disturbances, Pain, Dementia, Alzheimer's Dementia
- Trial name
- NCT01608217
- Testing
- delta-9-tetrahydrocannabinol (delta-THC), Acetaminophen
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
COPD, Cancer
Patient-centred Integrated Palliative Care Pathways in Advanced Cancer and Chronic Disease
Rationale: Palliative care integration in treatment pathways, palliative care networks and institutional collaborations in health services delivery seems a promising approach reducing fragmentation and discontinuity.
- Conditions
- COPD, Cancer, Heart Failure
- Trial name
- InSup-C (NCT02175147)
- Where
- 5 sites in Belgium, Germany and 3 more
- Volunteers
- 576 people
- Sponsor
- Radboud University Medical Center
Reumatoid Arthritis, Cardiovascular Diseases
Interruption of TNFinhibitors and Endothelial Function
Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular events. This increased risk is thought to be driven by inflammation-induced endothelial dysfunction, an initial step in atherogenesis.
- Trial name
- POET-VEF (NCT02130076)
- Volunteers
- 48 people
- Sponsor
- Radboud University Medical Center
Cardiotoxicity, Ischemia
Sunitinib and Atrial Trabeculae Contractility
Rationale: Recently, sunitinib (a tyrosine kinase inhibitor that is used for treatment of metastatic renal carcinoma and gastrointestinal stroma tumors) has been associated with development of heart failure, possibly by…
- Conditions
- Cardiotoxicity, Ischemia, Heart Failure
- Trial name
- SCAR (NCT01246778)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Asthma
Effectiveness of the Pelican Instrument in Medical Care
The objective of this project is to establish the effectiveness of implementation of a self-administered electronic asthma-specific quality of life instrument for childhood asthma in primary care and specialist care.
- Trial name
- PELICANII (NCT01109745)
- Testing
- PELICAN Primary Care, PELICAN Secondary Care
- Where
- 6 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Glomerulonephritis, Membranous
Treatment of Patients With Idiopathic Membranous Nephropathy
Patients with idiopathic membranous nephropathy at risk for renal failure can be identified in an early stage by measuring urinary low molecular weight proteins and urinary immunoglobulin G (IgG).
- Trial name
- NCT00135954
- Testing
- Cyclophosphamide and steroids
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Plasmodium Falciparum Malaria
Experimental Human Malaria Infection After Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
Malaria is one of the major infectious diseases in the world with a tremendous impact on the quality of life significantly contributing to the ongoing poverty in endemic countries.
- Trial name
- EHMI9 (NCT01236612)
- Testing
- Chloroquine prophylaxis, Immunization, Plasmodium falciparum Bloodstage challenge
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Dementia
Delta-THC in Behavioral Disturbances in Dementia
Dementia is a common chronic condition, with predicted increasing prevalence. Nearly all patients with dementia will experience neuropsychiatric symptoms (NPS).
- Trial name
- NCT01302340
- Testing
- Delta-THC
- Where
- 2 sites in Netherlands
- Volunteers
- 22 people
- Sponsor
- Radboud University Medical Center