Clinical trials: sponsored by Radboud University Medical Center
Osteoradionecrosis
Efficacy of Hyperbaric Oxygen Therapy in the Treatment of Osteoradionecrosis
The purpose of this study is to determine whether hyperbaric oxygen therapy is effective in the treatment of osteoradionecrosis (late complication of radiation therapy) of the jaw.
- Trial name
- NCT00989820
- Testing
- hyperbaric oxygen
- Where
- 8 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Diabetes Type 2, Heart Failure
RAPIDE: The Feasibility of a Hybrid Care Model
Rationale: During cross-border health emergencies, such as seen with the COVID-19 pandemic, health and care services are rapidly being overwhelmed by high numbers of patients requiring care, leading to stretches in the whole…
- Trial name
- NCT06735404
- Testing
- Hybrid care
- Where
- 4 sites in Italy, Malta and 2 more
- Volunteers
- 180 people
- Sponsor
- Radboud University Medical Center
Ulcerative Colitis (UC), Colorectal Cancer (CRC)
Smart Pill for Measuring Gut Health in Colon Inflammation and Colon Cancer
The goal of this observational pilot study with invasive measurements is to explore whether an ingestible sensor pill can be of use in diagnosis or monitoring of disease in patients with ulcerative colitis or colorectal cancer.
- Trial name
- SPIRIT (NCT07046468)
- Testing
- Ingestion of sensor capsule (twice), Device evaluation questionnaire, Wearing device
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Young Adults, Sensory Processing Sensitivity
Art-based Beauty Appreciation Intervention
This study is a randomized controlled trial with an active control condition evaluating the impact of an art-based beauty appreciation (ABBA) intervention on trait appreciation of beauty as a primary outcome and well-being and…
- Trial name
- ABBA-vention (NCT06788496)
- Testing
- Art-based Beauty Appreciation Intervention Program (Learning to See Beauty), Observation Program (Learning to Observe Life)
- Where
- Netherlands
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Colorectal Polyp, Colonoscopy
Synergistic Effect of G-Eye Balloon for Behind the Folds Visualization With CADe (Discovery System) on Adenoma Detection Rate.
Colonoscopy is the gold standard for colorectal screening. The diagnostic accuracy of colonoscopy highly depends on the quality of inspection of the colon during the procedure.
- Conditions
- Colorectal Polyp, Colonoscopy, Artificial Intelligence, Adenoma
- Trial name
- DiscoveryIII (NCT05220345)
- Testing
- colonoscopy assisted by both balloon-Behind The Folds visualizing and Computer assisted detection (CADe)
- Where
- Netherlands
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Colonic Neoplasms
The Influence of Artificial Intelligence (AI )Assisted Polyp Detection (Discovery System) on Visual Gaze Patterns During Real-time Colonoscopy
In this study, the investigators aim to assess the influence of a computer-aided detection (CADe) system on the visual gaze patterns of endoscopists in order to further understand the effect of AI during real-time colonoscopy.
- Trial name
- REVEAL (NCT05619614)
- Testing
- eye-tracking glasses
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- Radboud University Medical Center
Hemophilia A
Version Testing of EnzySystem Version A for Hemophilia A
Background of the study: To measure blood clotting, blood is taken from a vein. This blood is processed in the laboratory and then tested.
- Trial name
- NCT06273865
- Testing
- Several assays
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hemophilia
He-move-philia, Lifestyle Intervention for Patients With Hemophilia
The main objectives are reduction of body weight, BMI and abdominal circumference. Secondary objectives are reduction of bleeds and units coagulation factor concentrate used, blood-pressure, cholesterol spectrum, glucose and…
- Trial name
- NCT05608863
- Testing
- Lifestyle - group sessions, Lifestyle - individual coaching
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Endometriosis, Adenomyosis
Pain in Endometriosis And the Relation to Lifestyle
The goal of this clinical trial is to investigate the effect of an anti-inflammatory diet and cognitive behavioral therapy (CBT) on pain symptoms, health related quality of life and the effect on inflammatory characteristics in…
- Trial name
- PEARL (NCT06332560)
- Testing
- Anti-inflammatory diet (DI), Cognitive behavioral therapy (CBT)
- Where
- 5 sites in Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Safety and Effectiveness of Intermittent Hypoxia Treatment in Parkinson's Disease
To explore the safety, feasibility and net symptomatic effects of multiple (3x/week, for 4 weeks) intermittent hypoxia treatment sessions in individuals with PD.
- Trial name
- TALISMAN-2 (NCT05948761)
- Testing
- Hypoxia through modified hypoxic generator, Normoxia through hypoxic generator without active elements
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Post ICU Syndrome
MONITOR-IC Post ICU Care Study
OBJECTIVE To evaluate the clinical effectiveness and cost effectiveness of structured, multidisciplinary and personalized post-ICU care versus usual care on physical and psychological functioning, and quality of life (QoL) of ICU…
- Trial name
- MiCare (NCT05066984)
- Testing
- structured, multidisciplinary and personalized post-ICU care
- Where
- 2 sites in Netherlands
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Arrhythmia, Cardiac Implantable Electronic Device
Virtual Reality in Electrophysiological Procedures and Device Implantation: the VR inEP Trial
Each year about 37,000 patients undergo a catheter ablation to treat cardiac arrhythmias or have a cardiac device such as a pacemaker or implantable cardioverter defibrillator implanted in the Netherlands.
- Conditions
- Arrhythmia, Cardiac Implantable Electronic Device, Ablation of Arrhythmias, Electrophysiologic Study
- Trial name
- VR inEP (NCT07105241)
- Testing
- VR therapy, 360 degree education videos
- Volunteers
- 115 people
- Sponsor
- Radboud University Medical Center
Breast Cancer Screening
Digital Breast Tomosynthesis for the Dutch National Breast Cancer Screening Program
Digital breast tomosynthesis (DBT) creates a digital pseudo- three-dimensional image of the breast similar to mammography. This gives the screening radiologist more information about a possible abnormality.
- Trial name
- STREAM (NCT06059300)
- Testing
- Digital Breast Tomosynthesis
- Where
- Netherlands
- Volunteers
- 18,200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson Disease
The Effect of Compensation Strategies on Gait Impairment in Parkinson's Disease
Gait disturbances are disabling and common in Parkinson's disease (PD). Patients use many different, and typically self-developed, strategies to compensate for their walking abnormalities.
- Trial name
- UNITE-PD (NCT06142448)
- Testing
- Cueing app
- Where
- Netherlands
- Volunteers
- 384 people
- Sponsor
- Radboud University Medical Center
Old Age; Atrophy
The Effect of a Combined Personalized Nutritional Intervention and a Personalized Graded Activity Functional Training Program on Physical Performance in Hospitalized Older Patients, Compared to Usual Care
This project aims to improve physical performance in older patients, by offering a personalized combined nutritional intervention with a physical activity training program.
- Trial name
- FITFOOD (NCT05413616)
- Testing
- FITFOOD lifestyle intervention
- Where
- Netherlands
- Volunteers
- 136 people
- Sponsor
- Radboud University Medical Center
Mycobacterium Avium Complex Pulmonary Disease
Pharmacokinetic Study of Minocycline in Patients With Pulmonary Nontuberculous Mycobacterial Disease
Antimycobacterial treatment of M. avium complex pulmonary disease (MAC-PD) has suboptimal cure rates and is challenging due to frequent adverse drug reactions and drug-drug interactions.
- Trial name
- Mino-PK (NCT05861258)
- Testing
- Minocycline
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Artificial Intelligence (AI) in Diagnosis, Artificial Intelligence Supported Image Reviewing
The Impact of Artificial Intelligence on Dentists' Decision-Making Process During Caries Detection
This study aims to evaluate the influence of artificial intelligence (AI) on the decision-making process for intervention after caries lesion detection.
- Trial name
- DECIDE-AI (NCT07027189)
- Testing
- Artificial intelligence in diagnosis
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Patellar Dislocation, Patellar Dislocation, Recurrent
PROMs and Patellar Tracking After MPFL Reconstruction With or Without Tibial Tuberosity Transposition
Patellar dislocations cause pain and functional decline in adolescents, which can be restored by a MPFL reconstruction with or without tibial tuberosity transposition.
- Conditions
- Patellar Dislocation, Patellar Dislocation, Recurrent, Patellofemoral Maltracking
- Trial name
- NCT05547269
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Radboud University Medical Center
Salivary Duct Carcinoma
Phase II Dutasteride in Combination With CAB vs CAB in SDC
Phase 2 clinical trial on the addition of dutasteride to combined androgen blockade (CAB) therapy in recurrent and/or metastatic (R/M) salivary duct carcinoma (SDC) patients.
- Trial name
- DUCT (NCT05513365)
- Testing
- Goserelin 10.8 mg, Bicalutamide 50 mg, Dutasteride 0.5 mg
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Radboud University Medical Center
Stress
Mindful Network Dynamics Regulation Under Stress
This study aims to assess the effectiveness of Mindfulness Based Stress reduction to reduce perceived stress in a highly stressed student population, while concurrently investigating neural mechanisms of the intervention.
- Trial name
- MindRest (NCT05541263)
- Testing
- Mindfulness Based Stress Reduction
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center