Clinical trials: sponsored by Region Skane
Continuous Renal Replacement Therapy (CRRT), Magnesium
Magnesium Kinetics During Citrate-Anticoagulated CRRT
The goal of this observational study is to assess how continuous renal replacement therapy (CRRT), a type of dialysis used in critically ill patients, affects magnesium levels in adults treated in intensive care units (ICUs).
- Trial name
- NCT07906340
- Testing
- Serial blood and dialysis circuit fluid sampling
- Volunteers
- 35 people
- Sponsor
- Region Skane
Health Behaviors, Risk Factors
Targeted Health Dialogues in Primary Care
The County Council of Region Skåne, Sweden, has recently initiated Targeted Health Dialogues in primary care. The prevention program includes health dialogues provided by specially trained personnel, collection of clinical and…
- Conditions
- Health Behaviors, Risk Factors, Cardiovascular Diseases, Cancer
- Trial name
- NCT04912739
- Testing
- Targeted health dialogues
- Where
- Sweden
- Volunteers
- 18,000 people
- Sponsor
- Region Skane
Asphyxia Neonatorum, Fetal Hypoxia
Sustained Cord Circulation at Emergency Cesarean Section
The goal of this clinical trial is to evaluate if sustained cord circulation during resuscitation improves outcomes for term neonates born by emergency Cesarean section.
- Trial name
- SUCCECS (NCT06540222)
- Testing
- Sustained cord (≥ 180 seconds) resuscitation, Routine (< 60 seconds) cord clamping
- Where
- 12 sites in Sweden
- Volunteers
- 2,200 people
- Sponsor
- Region Skane
Anal Fistula, Rectal Fistula
Mechanical Bowel Preparation Prior To Sphincter-Sparing Surgery For Complex Anal Fistulae
The goal of this clinical trial is to learn whether bowel preparation with Plenvu before surgery improves healing of complex anal fistula in adults aged 18 to 64 years with a fistula of cryptoglandular origin or associated with…
- Conditions
- Anal Fistula, Rectal Fistula, Crohn Disease
- Trial name
- PLEN-SPARE (NCT07897539)
- Testing
- Mechanical bowel preparation
- Where
- Sweden
- Volunteers
- 116 people
- Sponsor
- Region Skane
Faecal Incontinence With Faecal Urgency, Rectal Cancer
Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer Surgery
This study aims to assess and evaluate the clinical efficacy of an intensified form of Percutaneous tibial nerve stimulation (PTNS) compared to standard conservative treatment for low anterior resection syndrome (LARS).
- Conditions
- Faecal Incontinence With Faecal Urgency, Rectal Cancer, Radiotherapy Side Effects, Low Anterior Resection Syndrome (LARS>20)
- Trial name
- HiPLARS (NCT07862673)
- Testing
- Percutaneous Tibial Nerve Stimulation
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Epilepsy, Sleep
Prospective Longitudinal Study of Sleep, Brain Activity, and Plasma Analyses in Patients Undergoing Epilepsy Surgery
The goal of this observational study is to understand how sleep and brain activity change after epilepsy surgery in adults with drug-resistant epilepsy.
- Conditions
- Epilepsy, Sleep, Drug Resistant Epilepsy, Epilepsy Sleep
- Trial name
- NCT07885826
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Graves Disease, Graves Disease (Basedow's Disease)
Prophylactic Treatment of Graves Ophthalmopathy (GO) in Newly Diagnosed Graves' Disease (GD) With Atorvastatin (ATORGO)
Graves' disease is an autoimmune condition that causes an overactive thyroid. Some people with Graves' disease develop thyroid eye disease, also called Graves' orbitopathy, which can cause swelling around the eyes, eye…
- Conditions
- Graves Disease, Graves Disease (Basedow's Disease), Graves Orbitopathy, Graves Ophthalmopathy
- Trial name
- ATORGO (NCT07883356)
- Testing
- Atorvastatin
- Where
- 7 sites in Sweden
- Volunteers
- 554 people
- Sponsor
- Region Skane
Colorectal Cancer, Colorectal Adenoma
Protein Signature Based Screening of Colorectal Adenomas and Cancer
Colorectal cancer is a common cancer, that in general develops over a long time period (approximately 10-15 years) from precancerous polyps. The disease is in many cases asymptomatic.
- Trial name
- NCT07881549
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Region Skane
Endometriosis
Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial.
Endometriosis is a chronic condition affecting approximately 10% of women. It is frequently associated with persistent or recurrent pelvic and abdominal pain.
- Trial name
- ENDPAIN (NCT07881562)
- Testing
- Esketamine
- Volunteers
- 1,000 people
- Sponsor
- Region Skane
Skin Cancer
Implementation of Teledermoscopy and Artificial Intelligence
The study has 2 parts. Part 1 will investigate the effects of introducing teledermoscopy in clinical practice, more specifically the change in referral patterns, the risk of undetected skin cancers and the effect on diagnostic…
- Trial name
- NCT05033678
- Testing
- Diagnostic algorithms
- Where
- Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Region Skane
Fall Injury, Hip Fractures
Fall, Fracture and Frailty
This project aims to improve the global outcome for an aging individual after a traumatic fall, through identifying conditions contributing to a fall and promoting recovery and rehabilitation.
- Conditions
- Fall Injury, Hip Fractures, Risk Reduction, Osteoporosis, Osteopenia
- Trial name
- FFF (NCT05712252)
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane
Skin Ageing, Skin
Skin Type Determination Using Image Artificial Intelligence
Skin color, how easily a person burns or tans in the sun (skin phototype), and the amount of chronic sun damage in the skin are important factors in skin health.
- Trial name
- SPAI (NCT07765303)
- Testing
- Skin imaging and skin characteristic assessment
- Where
- 13 sites in Australia, Brazil and 9 more
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Region Skane
Pelvic Floor Dysfunction, Perineal Laceration
Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial
The goal of this clinical trial is to determine whether using a soft perineal protection device (BabySlide®) in addition to standard manual perineal support during vaginal delivery can reduce the risk of perineal trauma in…
- Conditions
- Pelvic Floor Dysfunction, Perineal Laceration, Wound Dehiscence, Anal Incontinence
- Trial name
- PeriPROTECT (NCT07862660)
- Testing
- Perineal protection device, BabySlide, Standard manual perineal support
- Where
- Sweden
- Volunteers
- 4,226 people
- Sponsor
- Region Skane
Myocardial Infarction, Chest Pain
AI-based Decision Support in Acute Chest Pain
The AIDE-CP1 trial will test whether a decision support tool based on artificial intelligence (AI) can improve care for patients who come to an emergency department with chest pain.
- Trial name
- AIDE-CP1 (NCT07864038)
- Testing
- AIDE-CP available
- Volunteers
- 4,500 people
- Sponsor
- Region Skane
Septic Shock
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
The objective of this trial is to assess the beneficial and harmful effects of a restrictive strategy for administration of non-resuscitation fluids in adult patients with septic shock.
- Trial name
- REDUSE (NCT06140147)
- Testing
- Protocolised reduction of non-resuscitation fluids, Usual care
- Where
- 22 sites in Finland, Sweden and 1 more
- Volunteers
- 1,850 people
- Sponsor
- Region Skane
Gender Dysphoria, Adult
GLOW: Gender-Affirming Care and Mental Health: A Longitudinal Study On Quality of Life, Work Life, and Healthcare Outcomes
Gender-Affirming Care and Mental Health (GLOW) investigates the psychological, medical, and social factors that influence the outcomes of gender-affirming care, as well as its impact on mental health, work capacity, and quality…
- Trial name
- GLOW (NCT07480590)
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Region Skane
Latent Tuberculosis, Persistent Infection
New Strategies for Assessment of the Persistence of Viable Bacilli in Latent and Active Tuberculosis
Current diagnostic tools such as interferon gamma release assay (IGRA) and purified protein derivative (PPD) can not distinguish patients with latent tuberculosis infection (LTBI) and persistence of live mycobacteria.
- Conditions
- Latent Tuberculosis, Persistent Infection, Mycobacterium Tuberculosis
- Trial name
- TB-LIVE (NCT05621343)
- Where
- Sweden
- Volunteers
- 89 people
- Sponsor
- Region Skane
Head and Neck Cancer (H&N), Free Tissue Flaps
Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical Assessment for Flap Perfusion in Head and Neck Reconstruction (VISION Trial)
This is a prospective multicentre randomised controlled trial evaluating whether intraoperative indocyanine green (ICG) fluorescence angiography improves outcomes in head and neck free flap reconstruction compared with standard…
- Conditions
- Head and Neck Cancer (H&N), Free Tissue Flaps, Free Flap, Free Flap Evaluation
- Trial name
- VISION (NCT07635420)
- Testing
- Indocyanine Green, Standard clinical perfusion assessment
- Where
- Sweden
- Volunteers
- 244 people
- Sponsor
- Region Skane
Mental Disorder, Mental Health Issue
A Comparison of Two Ultra-brief Interventions in Primary Care for Patients With Anxiety, Depression, and Stress.
This pilot randomized controlled trial evaluated the feasibility of a Swedish translation of an Acceptance and Commitment Therapy protocol targeting repetitive negative thinking (RNT-ACT) compared with therapist-supported…
- Conditions
- Mental Disorder, Mental Health Issue, Mental Depression, Anxiety
- Trial name
- RNTACTSweden (NCT05946382)
- Testing
- RNT-ACT Protocol, iCBT Treatment
- Where
- Sweden
- Volunteers
- 13 people
- Sponsor
- Region Skane
Hypertension
Sustainable Hypertension Management in Primary Health Care in Sweden
New sustainable models of patient-focused and team-based care for patients with hypertension should be developed to achieve health improvements and cost-efficiency.
- Trial name
- SHIP-CARE (NCT06580613)
- Testing
- New model of Hypertension Management, Control
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Region Skane