Clinical trials: sponsored by Region Skane
Preeclampsia, Gut Dysbiosis
Probiotic Supplementation During Pregnancy in Women With High-Risk Pregnancies
Preeclampsia (PE) is a complication during pregnancy characterized by hypertension, organ damage, and inflammation, without an effective treatment. The underlying mechanisms causing the disease also remain partly unknown.
- Trial name
- NCT06700044
- Testing
- GutMagnific
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Skane
Blood Glucose, High
BSE on Blood Glucose
Here we will investigate the effect of sulforaphane, provided as a broccoli sprout extract (BSE) on blood glucose in pre-diabetic individuals without metformin treatment.
- Trial name
- NCT03763240
- Testing
- BSE
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Region Skane
Anxiety Disorders
Stepped vs Stratified Care for Pediatric Anxiety Disorders
The purpose of this trial is to evaluate the feasibility, acceptability, and safety of two care pathways (including internet-delivered cognitive behavioral therapy [CBT] and/or in-person CBT) for children and adolescents with…
- Trial name
- PMAX (NCT06016907)
- Testing
- Internet-delivered cognitive behavioral therapy (ICBT), In-person cognitive behavioral therapy (CBT)
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Region Skane
Progressive Keratoconus
Corneal Crosslinking Treatment Study
Three different protocols for inducing corneal crosslinks in subjets with progressive keratoconus will be evaluated in this randomised clinical study.
- Trial name
- NCT04427956
- Testing
- Corneal crosslinking: CXL (UVA 9mW/cm2), Isotonic riboflavin, Hypotonic riboflavin
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Region Skane
Hip Fractures (ICD-10 72.01-72.2)
Time on Feet After Hip Fracture Event
With simple technology investigators can map how long it takes for a patient with a hip fracture to be helped and encouraged to stand and walk in the days following the injury.
- Trial name
- TOFFEE (NCT06700031)
- Testing
- Inertial measurement unit
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Hypoparathyroidism Postprocedural
Autofluorescence vs Clinical Assessment of Parathyroid Glands During Thyroid Surgery
The purpose of the investigation is to study if the use of Fluobeam®-LX to identify parathyroid glands through autofluorescence during thyroid surgery, may reduce the risk of postoperative hypoparathyroidism, defined as low PTH…
- Trial name
- NCT04509011
- Testing
- Fluobeam® LX
- Where
- 5 sites in Austria, Norway and 2 more
- Volunteers
- 516 people
- Sponsor
- Region Skane
Physical Inactivity, Cerebral Palsy
Effects of Physical Activity on Prescription (PAP) as a Health-enhancing Intervention in People With Disabilities
Physical inactivity is an increasing problem in the general population in society. However, in people with disabilities, inactivity is even more frequently reported.
- Conditions
- Physical Inactivity, Cerebral Palsy, Autism, Autism Spectrum Disorder
- Trial name
- PAP (NCT05867940)
- Testing
- Physical activity on prescription
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Swebcg 91:A RT. Breast Conserving Surgery With or Without Radiotherapy for Breast Cancer Patients
The main goal of the trial was to analyse the value of radiotherapy after breast conserving surgery for patients with breast cancer, and to find groups of patients where the treatment could be omitted.
- Trial name
- NCT06637202
- Testing
- postoperative radiotherapy
- Where
- Sweden
- Volunteers
- 1,187 people
- Sponsor
- Region Skane
Problem Gambling
Mindfulness as an add-on Intervention in Treatment for Problem Gambling in Clinical Settings in Sweden
This study will test the effects of an add-on mindfulness intervention for patients with gambling problems, added to treatment as usual, compared to a waitlist control condition.
- Trial name
- NCT06561139
- Testing
- Mindfulness
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
COVID-19
Aerosoliserat DNase for Treatment of Respiratory Failure in Severe COVID-19
Recent observations have suggested a role of neutrophil extracellular traps (NETs) in the pathophysiology of severe COVID-19. The aim of the study is to assess efficacy and safety of aerosolized DNase I to remove NETs and…
- Trial name
- NCT04541979
- Testing
- aerosolized DNase, NaCl
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Region Skane
Intensive Care, Neonatal, Analgesia
Dexmedetomidine for Analgosedation to Newborn Infants During Neonatal Intensive Care
A prospective pharmacokinetic (PK), pharmacodynamic (PD) and pharmacogenetic (PG) observation study, including the PK/PD/PG relationship, on dexmedetomidine administered for analgesia and sedation to postsurgical and other…
- Conditions
- Intensive Care, Neonatal, Analgesia, Hypnotics and Sedatives
- Trial name
- NCT06482775
- Testing
- dexmedetomidine
- Where
- 2 sites in Sweden
- Sponsor
- Region Skane
Repetitive Head Impact, Selective Head and Neck Cooling
Selective Head-and-neck Cooling on Biomarker Levels and Symptom Rating Following a Boxing Bout
Young, healthy elite boxers ≥ 18 years old are recruited. Prior to, and immediately after a competitive boxing bout over 3x2 or 3x3 minutes, blood samples are drawn.
- Trial name
- NCT06386484
- Testing
- PolarCap System
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Rectal Cancer
Magnetomotoric Ultrasound (MMUS) in Rectal Cancer
Magnetomotoric ultrasound, combines conventional ultrasound with a time-varying magnetic field. The aim is to improve diagnosis of mesolectal lymph nodes.
- Trial name
- MAMORECT (NCT05052086)
- Testing
- Magnetomotoric ultrasound
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Colorectal Cancer, Colorectal Polyp
Epigenetic Regulation of Colorectal Polyps and Cancer
The goal of this study is to learn about the epigenetic and genetic regulation (microRNA/mRNA) of colorectal polyps and their evolvement as polyps and to colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Polyp, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT06206603
- Testing
- Intestinal biopsies, Blood sample
- Where
- Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Region Skane
Multi-antibiotic Resistance
Screening of Multidrug Resistant Bacteria, and the Clinical Implication for the Patient
The goal of this observational study is to evaluate the screening for multidrug resistant bacteria in patients admitted to hospitals in Scania.
- Trial name
- NCT06370299
- Testing
- (exposure of) MDR carriage
- Volunteers
- 10,000 people
- Sponsor
- Region Skane
Neurofibromatosis 1, Child
Treatment of NF1-related Plexiform Neurofibroma With Trametinib
This trial, Treatment of NF1-related plexiform neurofibroma with trametinib; a single arm,open-label study with the goals of volumetric partial remission and pain relief (EudraCT 2018-001846-32, Sponsor protocol number BUS2018-1…
- Conditions
- Neurofibromatosis 1, Child, Neurofibroma, Plexiform
- Trial name
- plexifpc (NCT03741101)
- Testing
- Trametinib
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Region Skane
Adrenal Tumour With Mild Hypercortisolism
Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome
Incidental findings of adrenal tumours,"incidentalomas", occur in 1-5 % in the general population and 10-25 % of these patients will exhibit biochemical mild hypercortisolism.
- Trial name
- AUSC (NCT01246739)
- Testing
- Adrenalectomy
- Where
- 4 sites in Denmark, Norway and 1 more
- Volunteers
- 34 people
- Sponsor
- Region Skane
Septic Shock
Glycosaminoglycans During Septic Shock - a Temporal Study
We have previously shown that the plasma level of glycosaminoglycans (GAG) in septic shock patients are elevated compared to controls.
- Trial name
- GAGS (NCT00814112)
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Region Skane
Professional Burnout
Return to Work After a Workplace-oriented Intervention for Patients on Sick Leave Due to Burnout
The study aims to evaluate the effect on return to work of a workplace intervention with patients being treated for burnout. The intervention intends to reduce job-person mismatch through patient-supervisor communication.The…
- Trial name
- ADA model (NCT01039168)
- Testing
- Workplace dialogue, Care as usual
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Region Skane
Stroke, Atrial Fibrillation
StrokeAlarm Trial 2
This open, multicenter, prospective, singel-arm study will evaluate usability and feasibility of a wearable stroke indication system (Stroke Alarm) in patients with recent TIA, recent minor stroke without persistent arm motor…
- Conditions
- Stroke, Atrial Fibrillation, TIA
- Trial name
- NCT05144932
- Testing
- Stroke Alarm
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane