Clinical trials: sponsored by Region Skane
Depression
Probiotics to Treat "Inflammatory Depression"
The main aims of this project are to test if: i) Specific probiotic lactobacilli (added to stabilized ongoing treatment) are efficacious in treating depressive symptoms in individuals with low-grade inflammation, defined using…
- Trial name
- NCT03660280
- Testing
- Probiotics
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Region Skane
Chest Pain, Diagnosis
Safety and Efficacy of Hs-cTnT Protocols
Chest pain is a common presenting complaint among patients in the emergency department (ED). A large portion of patients with chest pain undergo lengthy assessment in the ED or are admitted to rule out acute oronary syndrome…
- Trial name
- NCT05484544
- Testing
- High sensitivity troponin T
- Volunteers
- 1,167 people
- Sponsor
- Region Skane
Cancer, Psychological Distress
Acceptance and Commitment Based Group Therapy for Cancer Patients
This study evaluates the preliminary effects of an Acceptance and Commitment (ACT)-based group therapy compared to individual ACT-therapy for adult cancer patients suffering from psychological distress.
- Trial name
- NCT03341364
- Testing
- ACT-based group therapy, ACT individual treatment
- Where
- Sweden
- Sponsor
- Region Skane
Mental Health Impairment, Obesity, Adolescent
Mental Health in Children and Youth Within Pediatric Care
Over the last decades, there has been an increase in the number of children and youth with mental illness, such as anxiety and depression.
- Conditions
- Mental Health Impairment, Obesity, Adolescent, IBD
- Trial name
- PHU (NCT04094324)
- Testing
- Questionnaires
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Atrial Fibrillation, Electrocardiography
CArdioversion of Short Duration Atrial Fibrillation
The study is aimed at testing the hypothesis whether atrial fibrillary rate (AFR), as a measure of atrial electrical remodeling assessed from surface ECG, is predictive of sinus rhythm maintenance after electrical cardioversion.
- Conditions
- Atrial Fibrillation, Electrocardiography, Electrical Remodeling
- Trial name
- CASAF (NCT02112318)
- Where
- 3 sites in Canada, Sweden
- Volunteers
- 32 people
- Sponsor
- Region Skane
Osteoarthritis
RSA Study of Sirius Stem and Exceed Cup
The purpose of this study is to evaluate the efficacy and safety of the Sirius Cemented Stem used in conjunction with the Exceed ABT Cemented Acetabular Cup, either with E1 or Arcom polyethylene, and OptiPac/OptiVac bone cement…
- Trial name
- NCT02307331
- Testing
- Optivac, Optipac, Arcom (Exceed cup)
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Region Skane
Carpal Tunnel Syndrome
Cerebral Changes Following CTS Treated With Guided Plasticity
70 patients with mild to moderate Carpal tunnel Syndrome (CTS) including 24 patients with unilateral CTS were randomized to treatment with ipsilateral cutaneous forearm deafferentation with an anesthetic cream (EMLA®) or placebo…
- Trial name
- NCT06016049
- Testing
- EMLA® adjuvant, Sensory training
- Volunteers
- 70 people
- Sponsor
- Region Skane
Intensive Care, Neonatal, Analgesia
Clonidine for Analgesia to Preterm Infants During Neonatal Intensive Care
A prospective pharmacokinetic (PK), pharmacodynamic (PD) and pharmacogenetic (PG) observation study, including the PK/PD/PG relationship, in clonidine administered for analgesia and sedation to preterm newborn infants receiving…
- Conditions
- Intensive Care, Neonatal, Analgesia, Hypnotics and Sedatives
- Trial name
- NCT04928651
- Testing
- Clonidine
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Rheumatoid Arthritis, Healthy Controls
Subunit Vaccine Against Herpes Zoster in RA Patients Treated With JAK-inhibitors (VACCIMIL-ZOSTER)
Background. A new subunit vaccine against herpes zoster (HZ) has recently been approved for vaccination of adults i in Sweden. This vaccine (Shingrix) elicits a strong cellular and humoral immune response in healthy adults…
- Trial name
- NCT03886038
- Testing
- Shingrix
- Where
- Sweden
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Region Skane
Oropharynx Squamous Cell Carcinoma
Monitoring and Early Response Evaluation Using HPV DNA - A Study on Patients With HPV-positive Throat Cancer (MER-HPV)
The goal of this clinical trial is to determine the value of circulating tumour HPV DNA (human papilloma virus DNA found in the blood) at diagnosis, during treatment, and in the follow-up of patients diagnosed and treated for…
- Trial name
- MER-HPV (NCT05649865)
- Testing
- Blood sample
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Skane
Prostate Cancer (Diagnosis)
Evaluation of Length and Quality of Prostate Biopsies Taken by a New Biopsy Needle
Patient-blinded randomized controlled trial evaluating length and quality of prostate biopsies taken by a novel biopsy needle.
- Trial name
- NCT04880681
- Testing
- Novel needle (18 G, 25 cm with 19 mm sample notch) in a new actuator., Standard Tru Cut biopsy needle (Argon 18G, 25 cm biopsy needle with a 19 mm sample notch) in a standard actuator (Möller Medical Blue RBG-1000-10-1000)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Problem Behavior
Effects of Good Behavior Game in a Swedish Sample
This project seeks to study the impact of Good Behavior Game (GBG), a behavior management program, on classroom environment and problem behavior in K-3 classrooms.
- Trial name
- NCT05794893
- Testing
- Good Behavior Game
- Where
- 5 sites in Sweden
- Volunteers
- 44 people
- Sponsor
- Region Skane
Opioid Abuse
Naloxone Treatment in Skåne County - Effect on Drug-related Mortality and Overdose-related Complications
Death in overdose is the single most common cause of death in people using heroin. In Sweden, the number of drug-related overdose deaths has increased gradually since the early 1990s.
- Trial name
- NCT03570099
- Testing
- Naloxone Nasal Spray, Historical control cohort
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Rheumatoid Arthritis, Systemic Lupus
Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease
The overall objective of this project is to study the influence of modern anti-inflammatory treatments in established inflammatory rheumatic diseases (IRD) on antibody response elicited by pneumococcal vaccination using 13-valent…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus, Sjögren Syndrome, Systemic Vasculitis
- Trial name
- IPS-BOOSTER (NCT03762824)
- Testing
- 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Skane
Achilles Tendon Surgery, Cerebral Palsy
Gastrocsoleus Lengthening in Cerebral Palsy
The goal of this study is to compare passive ankle and knee range of motion (ROM) development after surgery to the gastrocsoleus complex, in children with cerebral palsy (CP).
- Trial name
- NCT05783739
- Volunteers
- 186 people
- Sponsor
- Region Skane
Gambling Disorder, Problem Gambling
Experience of the Nationwide Gambling Self-exclusion Service Spelpaus - Effects and Limitations of a Unique Harm Reduction Instrument for Problem Gambling
Qualitative interview study addressing the effects and limitations of a unique, government-based, nationwide self-exclusion service for the reduction of gambling-related harm.
- Trial name
- NCT05693155
- Testing
- Voluntary self-exclusion from gambling ('Spelpaus')
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Region Skane
Brain Injuries, Traumatic, Biomarkers
Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers
This study will evaluate if traumatic intracranial hemorrhage can be safely ruled out by using a microwave scanner (MD100) in conjunction with a combination of different brain biomarkers analyzed in serum.
- Conditions
- Brain Injuries, Traumatic, Biomarkers, Microwave Imaging
- Trial name
- MBI01 (NCT04666766)
- Testing
- Microwave scanning of the head
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Region Skane
Wrist Arthritis
Clinical and Patient-reported Outcomes After Total Wrist Arthroplasty and Total Wrist Arthrodesis
The wrist is often considered to be the fundament of the hand. Patients with a destroyed wrist joint caused by osteoarthritis or rheumatoid arthritis may suffer from pain and functional disabilities with impaired life quality.
- Trial name
- NCT05693636
- Testing
- Total wrist arthroplasty
- Volunteers
- 51 people
- Sponsor
- Region Skane
Asthma
Blood Leukocyte Profiling in Eosinophilic Type 2 Asthma: Influence of Systemic IL-5 Targeting
The goal of this exploratory and observational prospective study is to study the composition and phenotypes of blood leukocytes collected from asthmatic patients before and after instantiated treatment with the interleukin-5…
- Trial name
- NCT05689931
- Testing
- Mepolizumab, Standard inhaled corticosteroids (ICS) and long-acting beta 2 agonists (LABA)
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Region Skane
COVID-19, Mental Health Disorder
Treatment of Post-covid Syndrome in Patients Treated in Intensive Care
The present study is a pilot randomized controlled trial, which identifies and diagnoses mental health problems in survivors of critical COVID-19 infection at 12 months post-ICU care, and randomize patients to either an…
- Trial name
- NCT05119608
- Testing
- CBT/ACT
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane