Clinical trials: sponsored by Region Skane
Chronic Subdural Hematoma
Swedish Trial on Embolization of Middle Meningeal Artery Versus Surgical Evacuation in Chronic Subdural Hematoma
The SWEMMA trial is an open, national, multi-center, prospective, randomized (1:1), superiority trial designed to assess impact on reoperation rates for chronic subdural hematoma with a head-to-head comparison of embolization of…
- Trial name
- SWEMMA (NCT05267184)
- Testing
- Endovascular treatment of the middle meningeal artery, Standard neurosurgical hematoma evacuation
- Where
- 4 sites in Sweden
- Volunteers
- 288 people
- Sponsor
- Region Skane
Heart Arrest
Naloxone for In-Hospital Cardiac Arrest
The goal of this clinical trial is to learn if the drug naloxone in addition to cardiopulmonary resuscitation improves outcomes of in-hospital cardiac arrets.
- Trial name
- naloxone-IHCA (NCT07806565)
- Testing
- naloxone
- Volunteers
- 850 people
- Sponsor
- Region Skane
Surgical Complications
To Evaluate If Preoperative 7 Days Low Calorie Diet Reduces Postoperative Morbidity in Liver Surgery
The rationale for this study is to evaluate whether a standardized, preoperative, short-term Low Calorie Diet (LCD) reduces intraoperative bleeding and postoperative morbidity in liver surgery.
- Trial name
- LowCaLi (NCT07801716)
- Testing
- Low calorie meal replacement plan
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Skin Transplantation, Skin Grafting
Lower Extremity Graft Study (LEGS): A Multicentre Randomised Controlled Trial of Negative Pressure Wound Therapy Versus Conventional Dressings for Split-thickness Skin Grafts After Lower Leg Skin Tumour Excision
The goal of this clinical trial is to compare the effect of negative pressure wound therapy (NPWT) versus traditional dressings on the incidence of transplant infection in adult patients undergoing split-thickness skin grafting…
- Conditions
- Skin Transplantation, Skin Grafting, Split Thickness Skin Graft, Negative-Pressure Wound Therapy
- Trial name
- LEGS (NCT07040683)
- Testing
- Negative Pressure Wound Therapy (NPWT), Traditional Dressing
- Where
- Sweden
- Volunteers
- 232 people
- Sponsor
- Region Skane
Olecranon Fracture
The With Or Without Olecranon K-wires Trial
Fractures of the elbow tip (olecranon) that leave the elbow joint stable but where the fracture ends are separated (Mayo type 2a and 2b) can be treated with pins and a metal wire (tension band wiring, TBW) or metal wiring alone…
- Trial name
- WOW-OK (NCT05657899)
- Testing
- Cerclage fixation, Tension band wiring
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Breast Cancer
System-integrated Point-of-Care Ultrasound in Breast Cancer Screening
To assess the feasibility, safety, and clinical performance of community-based breast cancer screening incorporating clinical breast exam and short-termed trained examiners performing AI-supported breast POCUS for triage in…
- Trial name
- SPRING (NCT07462351)
- Testing
- AI
- Where
- Ethiopia
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- Region Skane
Cardiac Arrest
Biomarkers After Out-of-hospital Cardiac Arrest- a STEPCARE Substudy
A prospective multicenter biomarker study with adult patients treated on intensive care units after out-of-hospital cardiac arrest.
- Trial name
- NCT06471972
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 1,500 people
- Sponsor
- Region Skane
Healthy Volunteers, Inflammatory Bowel Disease (IBD)
Fermented Vegan Optimized Diet in Health and Colitis
The diet is assumed to contribute to many of our present non-communicable diseases. Vegetarian products are instead considered to be health promoting, However, it is not verified that the modern vegetarian and vegan products are…
- Trial name
- FAVORIT (NCT06696222)
- Testing
- Vegetarian yogurt, Vegetarian meat alternative, Ordinary meat diet
- Where
- 2 sites in Sweden
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Region Skane
Cardiac Arrest, Out-Of-Hospital
Late Biomarkers in Adult Survivors After Out-of-hospital Cardiac Arrest
Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by…
- Trial name
- NCT06587763
- Where
- 3 sites in Sweden
- Sponsor
- Region Skane
Bone Marrow Aspiration, Pain
Visual and Auditory Distraction for the Relief of Pain and Anxiety
Bone marrow (BM) examinations are performed in diagnostic workup of malignancies, in particular hematological diseases, and are frequently associated with significant pain, distress, and anxiety.
- Conditions
- Bone Marrow Aspiration, Pain, Anxiety, Hematologic Diseases
- Trial name
- NCT07023692
- Testing
- Distraction with VR (Virtual Reality) headsets
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Region Skane
Asthma
Efficacy of L-menthol on Breathlessness in Asthma
The purpose of this study is to assess the effect of L-menthol on breathlessness and exercise capacity in patients with Asthma.
- Trial name
- Ment-Astma (NCT07500974)
- Testing
- L-menthol
- Where
- 2 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Region Skane
Anorexia Nervosa
Safety, Therapeutic Potential, and Mechanisms of Two Psilocybin Doses, Administered With Psychological Support in Young Adults With Anorexia Nervosa
The goal of this clinical trial is to learn if psilocybin, given with psychological support, is safe and helps treat anorexia nervosa in young adults.
- Trial name
- psiAN (NCT07169747)
- Testing
- Psilocybin
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Meniscus Rupture, Meniscus Injury
Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy
The menisci of the knee joint are structures composed of cartilage and connective tissue, whose primary functions are to stabilize the joint and distribute weight across joint surfaces.
- Conditions
- Meniscus Rupture, Meniscus Injury, Osteoarthritis of Knee
- Trial name
- NCT07079254
- Testing
- Meniscus suture, Partial meniscectomy
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Chronic Coronary Syndrome, Coronary Artery Disease
Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses
Adenosine is a commonly used pharmaceutical stressor at cardiac magnetic resonance examinations to assess suspected chronic coronary syndrome (CCS).
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Ischemic Heart Disease
- Trial name
- HYPER (NCT06578234)
- Testing
- Adenosine
- Where
- Sweden
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Region Skane
Hearing Loss, Hearing Impairment
Follow Up of an Online Hearing Support for First-time Hearing Aid Users
The main questions the research aims to answer are short- and long-term effects on consequences of hearing loss depending on which type of follow-up the participant chooses.
- Conditions
- Hearing Loss, Hearing Impairment, Hearing Disorders
- Trial name
- NCT06468137
- Testing
- Swedish I-ACE, Clinical visit, No follow-up
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Hearing Loss, Hearing Impairment
Effects of an Online Hearing Support for First-time Hearing Aid Users
The goal of this randomised controlled trial is to test a online hearing support for first-time hearing aid users. The main questions it aims to answer are short- and long-term effects on the emotional and social consequences of…
- Conditions
- Hearing Loss, Hearing Impairment, Hearing Disorders, Hearing Disability
- Trial name
- NCT06051968
- Testing
- Online hearing support for first-time hearing aid users, Hearing rehabilitation according to common practice.
- Where
- Sweden
- Volunteers
- 88 people
- Sponsor
- Region Skane
Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
On-treatment Surveillance of Tumor Evolution and Response to Systemic Treatment in Bile Duct and Liver Cancer
The BILLIONSTARS study is a prospective, single arm observational study inviting patients diagnosed with hepatocellular carcinoma (HCC) or cholangiocarcinoma (CCC) who are to be recommended locoregional intervention by surgery…
- Trial name
- BILLIONSTARS (NCT06877637)
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Region Skane
Cancer of Lung, Lung Metastasis
Real-time Motion Management During Prostate and Lung Radiotherapy
The goal of this interventional non-inferiority trial is to assess the accuracy of different real-time motion management radiotherapy techniques.
- Conditions
- Cancer of Lung, Lung Metastasis, Cancer of Prostate
- Trial name
- REMIND (NCT05844761)
- Testing
- Triggered imaging on TrueBeam with margin reduction, Synchrony MLC tracking on fiducials with margin reduction, Synchrony MLC tracking and lung adaptive model with margin reduction
- Where
- Sweden
- Volunteers
- 132 people
- Sponsor
- Region Skane
Latent Tuberculosis, Staphylococcus Aureus
Rifampicin Resistance in S. Aureus During and After Treatment for Latent Tuberculosis
Two commonly used treatments for latent tuberculosis infection are either 4 months rifampicin or 6-9 months isoniazid. The invistigators will study the risk of acquisition of rifampicin resistance in commensal Staphylococcus…
- Trial name
- NCT05073926
- Testing
- No intervention is part of the study protocol
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Oral Anticoagulation
Standalone Thoracoscopic Left Atrial Appendage Closure Versus Medical Therapy in Atrial Fibrillation
Surgical left atrial appendage closure (LAAC) has been associated with reduced rates of stroke in patients with atrial fibrillation (AF) who have undergone cardiac surgery.
- Conditions
- ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Oral Anticoagulation, Thoracotomy
- Trial name
- STELLA-AF (NCT07705282)
- Testing
- Video-assisted thoracoscopic closure of the left atrial appendage using a closure device and discontinuation of treatment if the patient is treated with OAC
- Where
- Sweden
- Volunteers
- 936 people
- Sponsor
- Region Skane