Clinical trials: sponsored by Region Skane
Cardiac Amyloidosis, Pacemaker
Increased Pacemaker Lower Rate in ATTR Cardiac Amyloidosis
In cardiac amyloidosis, the heart muscle becomes thick and stiff, making it difficult to pump enough blood with each beat. The heart also often cannot increase its stroke volume, making patients with cardiac amyloidosis more…
- Trial name
- PACE-ATTR (NCT07413081)
- Testing
- Increasing the pacemaker lower rate, Standard setting
- Where
- 9 sites in Denmark, Sweden
- Volunteers
- 34 people
- Sponsor
- Region Skane
Infant, Newborn, Diseases, Colic, Infantile
Acupuncture in Infantile Colic - A Randomised Trial.
About 10 per cent of all new born babies in Sweden have infant colic. This may affect the the whole family and the early connection between the baby and the parents. Although, there are no effective and safe treatment.
- Conditions
- Infant, Newborn, Diseases, Colic, Infantile, Acupuncture
- Trial name
- NCT05894798
- Testing
- Acupuncture
- Sponsor
- Region Skane
Coronary Artery Bypass Graft (CABG), Cardioplegia
Cardioplegic Protection of the Heart
This study seek to compare two different solutions used to protect the heart during cardiac surgery. 40 adult patients planned for coronary artery bypass surgery with cardiopulmonary bypass machine assistance will be included in…
- Conditions
- Coronary Artery Bypass Graft (CABG), Cardioplegia, Cardiopulmonary Bypass, Perioperative Myocardial Injury
- Trial name
- NCT07386990
- Testing
- Modified Buckberg cardioplegic solution, Modified St Thomas´ cardioplegic solution
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Epilepsy, Autism Spectrum Disorder
Biomarkers for Epilepsy Development and the Effect of Physical Exercise in Children With Autism
This study aims to identify novel biomarkers for epilepsy development in children with autism and to evaluate the effects of physical exercise on these biomarkers and clinical outcomes.
- Trial name
- ASD/EP (NCT07373431)
- Testing
- Physical activity program
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Skane
Aged, Circadian Rhythm
Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm
The aim of this project is to evaluate the effect of a dynamic light in order to improve the circadian rhythm, provide a better sleep and well-being, and in the long run an improved recovery.
- Conditions
- Aged, Circadian Rhythm, Cognition, Fatigue
- Trial name
- LIFE (NCT05107947)
- Testing
- Biocentric light
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Ulcerative Colitis, Diet Habit
Micronutrient and Additive Modifications May Optimize Diet To Health
This is a prospective clinical intervention trial where patients with moderately active ulcerative colitis are randomized to either normal healthy diet or a diet with elimination of emulsifying agents within the E 400-group with…
- Conditions
- Ulcerative Colitis, Diet Habit, Microbial Colonization
- Trial name
- Mammoth (NCT05743374)
- Testing
- Normal diet, E400 elimination
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Region Skane
Heart Arrest, Out-Of-Hospital, Hypoxia-Ischemia, Brain
Neuropsychological Outcome After Cardiac Arrest
This study is a sub-study to the large pragmatic Target Temperature Management 2 Trial (TTM2-trial, ClinicalTrials.gov Identifier: NCT02908308), assessing effectiveness of controlled hypothermia after out-of-hospital cardiac…
- Conditions
- Heart Arrest, Out-Of-Hospital, Hypoxia-Ischemia, Brain, Cognition Disorders, Psychological Distress
- Trial name
- NCT03543371
- Testing
- Neuropsychological assessment
- Where
- 8 sites in Denmark, Sweden and 1 more
- Volunteers
- 200 people
- Sponsor
- Region Skane
Psychiatric Diagnosis
Does Implementation of Feedback Informed Therapy (FIT) Improve Access to Psychotherapy in Psychiatry?
This study explores whether the introduction of Feedback-Informed Therapy (FIT) can improve access to psychotherapy within adult psychiatric outpatient care.
- Trial name
- FIT-ACCESS (NCT07280767)
- Testing
- Feedbeack Informed Therapy
- Where
- Sweden
- Volunteers
- 213 people
- Sponsor
- Region Skane
Parkinson Disease
A Trial to Determine the Safety and Tolerability of Transplanted Stem Cell Derived Dopamine Neurons to the Brains of Individuals With Parkinson's Disease
Parkinson's disease (PD) occurs when an area of the brain begins to lose nerve cells that produce a chemical called dopamine. Dopamine is an important chemical, and one of its functions is that it helps to regulate body movement.
- Trial name
- STEM-PD (NCT05635409)
- Testing
- STEM-PD
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 8 people
- Sponsor
- Region Skane
Opioid Overdose
A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose
Opioids are responsible for the greatest drug-related global health burden. Prevention and treatment programs for people with opioid use disorder are widely implemented, but further actions are required to reduce the mortality…
- Trial name
- RESPONDER (NCT07079241)
- Testing
- Naloxone-responder: A volunteer first responder system connected to emergency dispatch service and alerting overdose and first aid educated volunteers with naloxone to suspected opioid overdoses
- Where
- Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Region Skane
Depression, Bipolar, Depression, Unipolar
Pramipexole to Target "Anhedonic Depression"
The heterogeneity of depression suggests that different neurocircuits and pathophysiological mechanisms are involved. Anhedonia - the inability to experience pleasure from, or the lack of motivation to carry out, usually…
- Conditions
- Depression, Bipolar, Depression, Unipolar, Dysthymia, Anhedonia
- Trial name
- PILOT-PRAXOL (NCT04121091)
- Testing
- Pramipexole Pill
- Where
- Sweden
- Volunteers
- 13 people
- Sponsor
- Region Skane
IBS - Irritable Bowel Syndrome
Comparison Between Low FODMAP and SSRD in IBS
The aim of the present study is to compare the efficiency of low FODMAP and SSRD to reduce symptoms in IBS, and to study the mechanisms and consequences of the two diets.
- Trial name
- NCT05192603
- Testing
- low FODMAP or SSRD
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy of L-menthol on Breathlessness in Chronic Obstructive Pulmonary Disease
The purpose of this study is to assess the effect of L-menthol on breathlessness in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- Ment-COPD (NCT05888597)
- Testing
- L-menthol
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Region Skane
Acid Base Imbalance, Osmolality Disturbance
Heart-Lung Machine: Impact of the Priming Solution on Acid-Base Balance, Electrolytes and Outcome on Patients Undergoing Cardiac Surgery
Most cardiac surgery procedures requires the use of heart-lung machine. The heart-lung machine circuit needs to be filled with a fluid before connecting it to the patients circulation.
- Conditions
- Acid Base Imbalance, Osmolality Disturbance, Crystalloid Solutions, Electrolyte Changes
- Trial name
- PRIMEII (NCT07267546)
- Testing
- Ringer's Acetate 80, Plasmalyte, Ringer's Acetate no add
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Acquired Adult Flatfoot Deformity, Flat Foot
Sinus Tarsi Implant as an Adjuvant Procedure to Medial Displacement Calcaneal Osteotomy in the Treatment of Mobile Adult Acquired Flatfoot Deformity
Background: Adult acquired flatfoot deformity (AAFD) is a deformity of the foot which leads to pain and an altered gait pattern. There are several different surgical interventions available for treatment of AAFD.
- Conditions
- Acquired Adult Flatfoot Deformity, Flat Foot, Flexible Flatfoot
- Trial name
- NCT06211504
- Testing
- ProStop, sinus tarsi implant (STI), Conventional surgery
- Where
- 10 sites in Sweden
- Volunteers
- 130 people
- Sponsor
- Region Skane
Glucose, High Blood
Hydration to Optimize Metabolism
This study evaluates hydration (1.5 L of water daily during 1 year) in the lowering of blood glucose concentration in adults with signs of dehydration (elevated levels of the vasopressin marker copeptin and high urine…
- Trial name
- H2O-metabolism (NCT03422848)
- Testing
- Water, general life style advice
- Where
- Sweden
- Volunteers
- 797 people, healthy volunteers welcome
- Sponsor
- Region Skane
Chronic Rhinosinusitis Without Nasal Polyps, Chronic Rhinosinusitis With Nasal Polyps
Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis (CRS).
Chronic rhinosinusitis (CRS) is a disease associated with impaired quality of life and substantial societal costs. Much is still uncertain regarding the underlying etiology of the disease.
- Trial name
- NCT07184684
- Testing
- Sinonasal microbiome transplant procedure.
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Region Skane
Internet Gaming Disorder, Internet Addiction
Family Centered Treatment for Problematic Gaming and Excessive Screen Use
The general increase in screen time as a time-consuming leisure activity among children and youth has been a puzzle to the adult world.
- Trial name
- NCT06098807
- Testing
- Family Centered Treatment for Problematic Gaming and Excessive Screen Use
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Region Skane
Attention Deficit Hyperactivity Disorder, Neurodevelopmental Disorders
Auditory and Visual Noise as Possible Non-pharmacological Treatment of ADHD in School Children
The goal of this study is to compare the influence of visual and auditory white noise on performance in children with attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT06057441
- Testing
- Auditory noise stimulation, Visual noise stimulation
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Region Skane
Kidney Stone
Follow-Up of Ureteral Stones ≤4 mm
The goal of this clinical trial is to evaluate the proportion of ureteral stones ≤4 mm that pass spontaneously within 4 and 8 weeks and assess if pain, blood test (S-creatinine), stone size, stone location and hydronephrosis can…
- Trial name
- NCT07176026
- Where
- 2 sites in Sweden
- Volunteers
- 1,600 people
- Sponsor
- Region Skane