Clinical trials: sponsored by Region Skane
C3 Glomerulopathy, Membranoproliferative Glomerulonephritis
Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy
The aim of this cross-over trial is to assess aliskiren, a direct renin inhibitor, as a novel treatment to block complement activation in the kidneys and thereby attenuate renal disease and stabilize or improve kidney function…
- Conditions
- C3 Glomerulopathy, Membranoproliferative Glomerulonephritis, Complement Abnormality, Dense Deposit Disease
- Trial name
- NCT04183101
- Testing
- Aliskiren, Enalapril
- Where
- 4 sites in Sweden
- Volunteers
- 30 people
- Sponsor
- Region Skane
Osteoarthritis Wrist
Effects of a Neuromuscular Exercise Therapy Program for Treatment of Wrist Osteoarthritis: a Randomized Controlled Trial
Individuals with wrist osteoarthritis (OA) can suffer from pain, muscular weakness, and impaired motion of the wrist, which can reduce the quality of life.
- Trial name
- NCT05367817
- Testing
- Neuromuscular exercise therapy, Training program
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Region Skane
Ovarian Cysts, Laparoscopic Gynecologic Surgery
A Randomized Controlled Trial Study Comparing Adnexal Surgery by vNOTES or Laparoscopy
The aim with the study is to compare postoperative pain after vNOTES adnexal surgery versus laparoscopic adnexal surgery. Women aged 18 and above with an indication for adnexal surgery for benign gynecological pathology or…
- Conditions
- Ovarian Cysts, Laparoscopic Gynecologic Surgery, vNOTES
- Trial name
- ADNOLA (NCT06964594)
- Testing
- vNOTES adnexal surgery
- Volunteers
- 200 people
- Sponsor
- Region Skane
Transplant; Failure, Heart
Non-ischaemic Heart Preservation Versus Standard Cold Storage in Human Heart Transplantation
The overall aim of this study is to compare a new state-of-the-art ex-vivo organ preservation method with standard ischemic cold static storage of donor hearts in adult cardiac transplantation.
- Trial name
- NIHP2 (NCT04066127)
- Testing
- Non-ischemic heart preservation (NIHP), Standard ischemic cold static storage (SCS)
- Where
- Sweden
- Volunteers
- 66 people
- Sponsor
- Region Skane
Cardiac Arrest With Successful Resuscitation, Hypoxia, Brain
Stepcare Extended Follow-up Substudy
To provide detailed information on long-term outcomes in relation to potential neuroprotection and improvements in recovery for different targets of sedation, temperature, and pressure management in post out of hospital cardiac…
- Conditions
- Cardiac Arrest With Successful Resuscitation, Hypoxia, Brain, Cognitive Impairment, Caregiver Burden
- Trial name
- NCT06207942
- Testing
- Feed back controlled temperature device, High MAP, Deep sedation
- Where
- 34 sites in Australia, Belgium and 8 more
- Volunteers
- 600 people
- Sponsor
- Region Skane
Ovarian Cancer, Endometrial Cancer
Improved Early Diagnosis in Female Pelvic Cancer With OC Detect
The goal of this observational study is to learn if so called Volatile Organic Compounds (VOCs) in blood can be used for early diagnosis of ovarian cancer.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Breast Cancer, Lymphoma
- Trial name
- NCT06613230
- Where
- 2 sites in Sweden
- Volunteers
- 490 people
- Sponsor
- Region Skane
Physical Activity, Life Style
Increased Physical Activity Through Mindfulness
In a pilot study, 90 physically inactive patients will be opportunistically and consecutively recruited and randomized to three intervention groups: mindfulness training, Physical Activity on Prescription (PAP) or only PAP.
- Conditions
- Physical Activity, Life Style, Mindfulness
- Trial name
- FAR-MIND (NCT02869854)
- Testing
- Mindfulness, PAP
- Where
- Sweden
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Region Skane
Dupuytren Disease of Finger
Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease
This randomized controlled trial will compare the outcome of surgery (fasciectomy) with that of local injection of Collagenase Clostridium Histolyticum in patients with recurrent finger joint contracture after previous treatment…
- Trial name
- NCT03406338
- Testing
- Fasciectomy, Collagenase Clostridium Histolyticum
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
D000784, D020521
CARbon Dioxide Flooding to Reduce Postoperative Neurological Injury Following Surgery for Acute Type A Aortic Dissection
Aortic dissection is a life-threatening condition and a consequence of a tear of the innermost of the three aortic layers- the intima.
- Trial name
- CARTA (NCT04962646)
- Testing
- Carbon dioxide flooding
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Region Skane
Brain Tumor Adult, Awake Surgery
Assessment of Tiredness During Awake Resection of Intracerebral Tumors
Occasional patients with intracranial tumors need to have a planned awakening during surgery to avoid major disability from the tumor resection. During the awake part of the surgery an increasing degree of tiredness is observed.
- Trial name
- NCT06922487
- Testing
- Karolinska Sleepiness Scale, KSS
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Region Skane
Brain Tumor Adult, Processed EEG
Processed EEG for Monitoring of Anesthetic Depth in Intracranial Tumor Surgery
An important feature of neurosurgical anesthesia is early postoperative recovery of consciousness with minimal residual sedation.
- Conditions
- Brain Tumor Adult, Processed EEG, Total Intravenous Anesthesia
- Trial name
- NCT06922500
- Testing
- depth of anesthesia
- Where
- Sweden
- Volunteers
- 126 people
- Sponsor
- Region Skane
Breast Cancer, Quality of Life
ExBRAC - the Pilot Study
The EXBRAC pilot study will investigate the quality of life of patients with breast cancer, and the effect of an intervention with expressive writing.
- Trial name
- ExBRAC-P (NCT06230068)
- Testing
- Expressive writing
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Region Skane
Kidney Stone
Impact of Acute Computed Tomography on Treatment Decisions and Time to Intervention in Renal Colic
This study intend to evaluate the use of acute computed tomography (CT) when acute renal colic, regarding treatment decisions, time to intervention and additional visits to the Emergency Department
- Trial name
- NCT06535711
- Testing
- Acute CT, Deferred CT
- Where
- Sweden
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Region Skane
Atrial Fibrillation, Left Atrial Dilatation
His-pacing and AV-node Ablation vs. Pulmonary Vein Isolation for Atrial Fibrillation
Objective To investigate if conduction system pacing ((CSP) i.e. atrioventricular node ablation + His bundle pacing or Left Bundle Branch pacing) is as good as (or better than) atrial fibrillation ablation with pulmonary vein…
- Trial name
- His-PAAF (NCT04512586)
- Testing
- Conduction System pacing and AV node ablation, Atrial fibrillation ablation by pulmonary vein isolation
- Where
- 4 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Region Skane
Cardiac Arrhythmia, Heart Failure
Ultrasound-guided Venous Access for Pacemaker and Defibrillator Implants
The study will include patients scheduled for transvenous pacemaker- or implantable defibrillator surgery, where venous access is necessary for lead implantation.
- Conditions
- Cardiac Arrhythmia, Heart Failure, AV Block
- Trial name
- TUFF (NCT04867460)
- Testing
- Ultrasound guided venous access
- Where
- Sweden
- Volunteers
- 58 people
- Sponsor
- Region Skane
His Bundle Pacing, Heart Failure, Systolic
His-bundle Pacing vs. Right Ventricular Apical Pacing in Patients With Reduced Ejection Fraction
The study compares standard right ventricle apical pacing with so called His-bundle pacing, for patients with slightly or moderately reduced ejection fraction and atrioventricular block requiring pacemaker therapy.
- Trial name
- HIS-PrEF (NCT04529577)
- Testing
- His-bundle pacing
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Heart Failure, Systolic, Left Bundle Branch Block
Acute Hemodynamic Effects of Pacing the His Bundle in Heart Failure
Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is indicated for patients with low ejection fraction and persistent symptoms of heart failure despite medical therapy and a wide QRS-complex, preferably with…
- Conditions
- Heart Failure, Systolic, Left Bundle Branch Block, Wide QRS Complex
- Trial name
- HEPA-His (NCT04701112)
- Testing
- Temporary His bundle pacing
- Where
- Sweden
- Volunteers
- 2 people
- Sponsor
- Region Skane
Hypertension, High Blood Pressure
Efficient Self-management of Chronic Disease Using Health Information Technology - a Study on Hypertension
Background: Hypertension is an increasing global problem and measures are needed against the emerging hypertensive burden. Management of the risk factor hypertension consists of medical treatment in conjunction with lifestyle…
- Trial name
- PERHIT (NCT03554382)
- Testing
- system to support self-management of hypertension
- Where
- 4 sites in Sweden
- Volunteers
- 971 people
- Sponsor
- Region Skane
Retinopathy of Prematurity (ROP)
To Assess the Effect of Dexamethasone Eye Drops on the Retinopathy of Prematurity Outcome
The purpose is to compare the treatment frequency of preterm infants who developed severe Retinopathy of Prematurity (ROP) during the years 2015-2018 with 2020-2021 in the country, using the statistical method 'difference in…
- Trial name
- NCT06775353
- Testing
- Dexamethasone eyedrop
- Where
- Sweden
- Volunteers
- 2,017 people, healthy volunteers welcome
- Sponsor
- Region Skane
Systemic Vasculitis, Spondylarthropathies
Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases
The purpose of HZ-REUMA study is explore vaccine response and protection against shingles (herpes zoster, HZ) after vaccination with two doses of Shingrix in immunosuppressed patients with inflammatory rheumatic diseases (IRD)…
- Conditions
- Systemic Vasculitis, Spondylarthropathies, Psoriatic Arthritis, Scleroderma
- Trial name
- HZ-REUMA (NCT06763783)
- Testing
- Shingrix, vaccination with 2 doses of Shingrix vaccine
- Where
- Sweden
- Volunteers
- 240 people
- Sponsor
- Region Skane