Clinical trials: sponsored by Region Stockholm
Prostate Cancer (Adenocarcinoma)
Prostate Androgen Response Investigation Using a Stratification BIOmarker; Predicting Prostate Cancer Downstaging by Neoadjuvant Darolutamide With PCAI ImmunoScore
The PARIS-BIO study evaluates whether a novel genomic biomarker, the PCAI ImmunoScore, can predict the response to neoadjuvant treatment with Darolutamide in patients with high-risk localized or locally advanced prostate cancer.
- Trial name
- PARIS-BIO (NCT07617272)
- Testing
- Darolutamide, Radical prostatectomy
- Where
- 2 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Region Stockholm
Major Depressive Disorder
Efficacy and Cost-effectiveness of Internet-delivered CBT for Adolescents With Depression
Adolescent depression is a prevalent and impairing condition that can be effectively treated with Cognitive Behavior Therapy (CBT). However, a majority of adolescents do not have access to CBT.
- Trial name
- IDA (NCT04977856)
- Testing
- Behavioral activation (BA), Regular care within primary or secondary mental health care for children
- Where
- Sweden
- Volunteers
- 219 people
- Sponsor
- Region Stockholm
Metabolic Disease, Mitochondrial Diseases
Genetic Diagnosis in Inborn Errors of Metabolism
Inborn Errors of metabolism comprise a large number of rare conditions with a collective incidence of around 1/2000 newborns. Many disorders are treatable provided that a correct diagnosis can be established in time, and for many…
- Conditions
- Metabolic Disease, Mitochondrial Diseases, Epilepsy in Children, Epilepsy
- Trial name
- NCT06376279
- Testing
- IEM-EP
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Laryngeal Disease
Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery
During apnoeic oxygenation there is a continuous raise in carbon dioxide with subsequent respiratory acidosis. The hypercapnia and respiratory acidosis have several dose-related effects on both the systemic and the pulmonary…
- Trial name
- CAPOX (NCT06316063)
- Testing
- Apnoeic oxygenation with high-flow nasal oxygen, Mechanical ventilation
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Region Stockholm
Postoperative Pulmonary Complications (PPCs)
Postoperative High-flow Nasal Oxygenation After High-risk Surgery in the Frail Adult
High flow nasal oxygen (HFNO) in the immediate postoperative period has been demonstrated to reduce the risk of postoperative pulmonary complications (PPC) after cardiothoracic surgery.
- Trial name
- Hi-POP (NCT07464730)
- Testing
- High Flow Oxygen, Oxygen
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Stockholm
Depression
Behavioral Activation and Emotion-focused Interventions in the Treatment of Depression
The study is a single-case intervention study, evaluating effects of the treatment Behavioral activation and emotion-focused interventions for depression. Research question and hypothesis 1.
- Trial name
- NCT06023732
- Testing
- Behavioral activation and emotion-focused interventions
- Where
- Sweden
- Volunteers
- 7 people
- Sponsor
- Region Stockholm
Endometriosis, Infertility, Female
Innovative Non-Invasive Diagnostics and Personalized Treatment Strategies for Endometriosis Through Advanced Multi-Omics and Ultrasound Integration
Endometriosis is a prevalent gynecological condition affecting approximately 10% of women of reproductive age worldwide. It presents with nonspecific but often severe symptoms, including chronic pelvic pain (in 70% of cases) and…
- Trial name
- ENDO-NOVA (NCT07570225)
- Testing
- Non-invasive diagnosis of endometriosis
- Volunteers
- 365 people
- Sponsor
- Region Stockholm
Knee Osteoarthritis
Investigating the Role of Motivational Interviewing in Swedish Patients Undergoing Knee Arthroplasty
Knee arthroplasty is a successful surgical treatment for end-stage osteoarthritis. Most patients are satisfied with the result, however, 10% of the patients have remained dissatisfied over the last decades despite the advantages…
- Trial name
- NCT05940246
- Testing
- Motivational Interviewing
- Where
- Sweden
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Stroke, Acute Ischemic, Intracerebral Hemorrhage
The Stroke Aetiology and VascuLar Disease in Stroke and TIA Study - A Clinical Study Analysing the Effects on Cardiovascular Health and Disease With an Extended Investigation Into Conditions Causative of Stroke and Concomitant Cardiovascular Disease in Patients Admitted for Acute Stroke or TIA
Annually, about 4000 Swedes suffer a recurrent stroke, and for many, their lives change dramatically. To prevent recurring strokes, knowledge about the individual's risk of recurrence is needed to tailor an effective preventive…
- Conditions
- Stroke, Acute Ischemic, Intracerebral Hemorrhage, TIA, Hypertension
- Trial name
- SALSA (NCT07491744)
- Testing
- Extended assessment
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (Disorder)
Virtual Versus Dye-based Chromoendoscopy in Inflammatory Bowel Disease Surveillance Colonoscopy
People with inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease affecting the colon, have a higher risk of developing colon cancer over time.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (Disorder), Crohns Disease, Colorectal Neoplasms
- Trial name
- NCT07089771
- Testing
- Virtual Chromoendoscopy, Dye-Based Chromoendoscopy
- Where
- Sweden
- Volunteers
- 480 people
- Sponsor
- Region Stockholm
Infarction, Brain
CT-Angiography Versus Angiogram as Ancillary Tests in the Determination of Death by Neurologic Criteria
Diagnostic performance of a novel protocol for computed tomography-angiography, as ancillary test in the determination of complete cerebral infarction, in comparison to four vessel angiography.
- Trial name
- Tadaa (NCT07341490)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Stockholm
Sarcoidosis
Immunological Mechanisms in Sarcoidosis
There is no cure for the inflammatory disease sarcoidosis. Virtually any part of the body can be affected but most often the lungs and lymph nodes.
- Trial name
- NCT06576505
- Testing
- peripheral blood sampling, bronchoscopy, upper airway and faeces sampling
- Where
- Sweden
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Heart Failure
Liberal or Restricted Fluid Intake in Patients With Heart Failure
Heart failure is the most common cause of admission to hospital and is associated with high morbidity and mortality. Treatment options consist of medical- and device treatment and self-care strategies, where fluid restriction has…
- Trial name
- FLUID-HF (NCT05931614)
- Testing
- Free fluid intake
- Where
- Sweden
- Volunteers
- 326 people
- Sponsor
- Region Stockholm
Opioid-Related Disorders, Narcotic-Related Disorders
Safe Prescription of Opioids in Primary Care
Opioid analgesics are commonly prescribed addictive narcotics intended for the treatment of pain. Inappropriate prescription of opioids in quantities and for conditions which lack clinical evidence contributes to the risk of…
- Conditions
- Opioid-Related Disorders, Narcotic-Related Disorders, Addiction
- Trial name
- NCT05577026
- Testing
- Educational intervention and prescription feedback, General information on treatment guidelines
- Where
- Sweden
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Bipolar Disorder, Bipolar Depression
Braining- Aerobic Physical Activity as Add on Treatment in Bipolar Depression
Hypothesis: the hypothesis of the study is that aerobic physical exercise (PE) performed with the method Braining accelerates recovery from bipolar depression as well as improves psychiatric and somatic health in individuals with…
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- NCT05340686
- Testing
- Aerobic Physical Exercise, Relaxing Physical Exercise, Information about physical exercise
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Region Stockholm
Psychiatric Disorder
Braining - Evaluation of Acute Effects of Physical Exercise
"Braining" is a clinical method for physical exercise as adjunctive therapy in psychiatric care. The core components are personnel-led group training sessions and motivating contact with psychiatric staff, as well as measurements…
- Trial name
- NCT06304363
- Testing
- Braining
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Stockholm
Intimate Partner Violence (IPV), People Who Inject Drugs
Intimate Partner Violence Among People Who Inject Drugs - Prevalence, Risk Factors and Experiences
There are around 15,6 million people who inject drugs (PWID) worldwide, of which around 3,5 million are women who inject drugs (WWID) (1). In Sweden, estimates suggest 8000-21000 PWID (2).
- Trial name
- NCT06269952
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Region Stockholm
Superior Canal Dehiscence Syndrome, Autophony
The Diagnostic Accuracy of Ankle Audiometry Performed With the B250 for Superior Canal Dehiscence Syndrome in Patients Affected by Pulsatile Tinnitus and/or Autophony Disorders
The goal of this clinical trial is to learn if the ankle audiometry test performed with the B250 bone conduction transducer can identify patients with superior canal dehiscence syndrome from those without among subjects…
- Conditions
- Superior Canal Dehiscence Syndrome, Autophony, Pulsatile Tinnitus
- Trial name
- AA by B250 (NCT07384091)
- Testing
- Ankle audiometry performed with the B250 transducer
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Stockholm
Brain Neoplasms
Detection of Brain Metastases Using a Novel Gadolinium-Weighted MRI Sequence: A Prospective Comparison
This study will evaluate a new type of MRI sequence designed to improve the visibility of brain metastases after gadolinium contrast injection.
- Trial name
- GDW (NCT07272616)
- Testing
- Novel Gadolinium-Weighted MRI Sequence
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Stockholm
Ulcerative Colitis (UC)
TRIOCOL - The Study of Continued Advanced Medical Therapy or Colectomy in Patients With Ulcerative Colitis
Ulcerative colitis is an inflammatory disease affecting the rectum and colon, most commonly presenting in late adolescence or early adulthood. The primary treatment approach is pharmacological.
- Trial name
- TRIOCOL (NCT07347834)
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Region Stockholm