Clinical trials: sponsored by Rennes University Hospital
Pregnancy, Oocyte Donation
What Are the Predictive Factors for Preeclampsia in Oocyte Recipients? - PREROVE
The main goal is to determine which risk factors develop preeclampsia in this specific group of oocyte recipients.
- Trial name
- PREROVE (NCT03668184)
- Testing
- preeclampsia
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Rennes University Hospital
Therapeutic Plasma Exchange
TPE in Rennes Hospital
To assess the indications, tolerance and side effects of therapeutic plasma exchange (TPE) performed at a University Hospital over 8 years
- Trial name
- COMPLASMA (NCT03888417)
- Testing
- Therapeutic plasma exchange (TPE)
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Rennes University Hospital
Spina Bifida or Spinal Dysraphism
Vitamin B9 Supplementation Recommendations in Rennes CHU
The study objective is to assess the knowledge and the follow-up of vitamin B9 supplementation recommendations for women in the periconceptional period to prevent neural tube closure defects.
- Trial name
- QUALI B9 (NCT04195542)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 1,284 people
- Sponsor
- Rennes University Hospital
Peritonitis
Children Peritonitis Ecology at CHU de Rennes - (IIAPEDIA)
The main objectif is assess the germs (species + antibiograms) implicated in children intra-abdominal infections (community acquired or nosocomial ) at CHU de Rennes.
- Trial name
- IIAPEDIA (NCT03668197)
- Testing
- microbiological analysis
- Where
- France
- Volunteers
- 149 people
- Sponsor
- Rennes University Hospital
Mild Head Injury, Anticoagulant
Medico-economic Interest of the Protein S100b in Mild Head Trauma Under Anti-thrombotics
Head trauma is a common injury in emergency department. Investigation to search for complication is guided by the clinical examination and the case history, such as taking anti-thrombotics.
- Conditions
- Mild Head Injury, Anticoagulant, Antiplatelet
- Trial name
- ISTCAT (NCT04305821)
- Testing
- Dosage of S100β protein
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Rennes University Hospital
Acute Respiratory Distress Syndrome, Cardiogenic Shock
Study of Immunity Dysfunction Induced by Extracorporeal Assistance (ECMO / ECLS)
Study of immunosuppression biomarkers in patients with ARDS or cardiogenic shock with ECMO / ECLS, compared to patients with ARDS or cardiogenic shock without ECMO / ECLS
- Trial name
- IMPEC (NCT03262155)
- Testing
- Blood test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Rennes University Hospital
Solid Organ Transplantation
Observational Study Comparing the Efficacy of Ganciclovir as a Function of Blood Exposure to the Drug During a Curative or Preemptive Treatment
This study aims to better define the target range of ganciclovir trough concentrations by investigating the relationship between ganciclovir concentration and the time to undetectable CMV-DNA load, in preemptive and curative…
- Trial name
- GANEX (NCT03088553)
- Testing
- Therapeutic Drug Monitoring
- Where
- France
- Volunteers
- 138 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis, Relapsing-Remitting
Clinical Decision Support System (CADIMS) for MS Diagnostic
1. Background The results obtained in clinical research led to a new paradigm for the treatment of patients affected with multiple sclerosis (MS): "no evidence of disease activity".
- Trial name
- POCADIMS (NCT03205280)
- Where
- 5 sites in France
- Volunteers
- 200 people
- Sponsor
- Rennes University Hospital
Crohn Disease, Anal Suppurations
Analysis of Therapeutic Management Strategies for Anal Suppurations of Crohn's Disease
Determine the optimal therapeutic combination associated with complete clinical and anatomical remission of anal suppurations of Crohn's disease at 12 months.
- Conditions
- Crohn Disease, Anal Suppurations, Drainage Procedure
- Trial name
- 3T-LAP (NCT04192825)
- Testing
- surgical treatment
- Where
- France
- Volunteers
- 440 people
- Sponsor
- Rennes University Hospital
Urinary Retention
Chronic Urinary Retention in Elderly Living in Homes for the Aged : Benefits of Bladder Scan Screening
The goal of this cross-sectional, multicentric and descriptive epidemiological study is to assess the prevalence of chronic urinary retention (CUR) in elderly living in residential care for dependent elderly people in order to…
- Trial name
- RUC EHPAD (NCT03828968)
- Testing
- bladder scan
- Where
- 5 sites in France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Systemic Sclerosis
Systemic Sclerosis and Jak Inhibitors : Emphasis on Macrophages
The Sclero-JAK project aims to assess the impact of a JAK1/2 inhibitor (ruxolitinib) on activation states of monocytes-derived macrophages (MDM) from systemic sclerosis (SSc) patients
- Trial name
- SCLERO JAK (NCT04206644)
- Testing
- biological analysis
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Rennes University Hospital
Non Small-cell Lung Cancer
Trial Involving Subjects Over 70 Years of Age With Non Small-cell Lung Cancer of Stage IV and Comparing a "Classical" Strategy of Treatment Allocation, With an"Optimized" Strategy Allocating the Same Treatments
This is a phase III randomized multicenter study involving subjects over 70 years of age with non small-cell lung cancer of IV and a PS of 0, 1 or 2, who have not previously received chemotherapy.
- Trial name
- ESOGIA (NCT01257139)
- Testing
- Dual-agent therapy or docetaxel alone or best supportive care
- Where
- 45 sites in France
- Volunteers
- 490 people
- Sponsor
- Rennes University Hospital
Alcohol Abuse, Episodic Drinking Behavior
AURAIA Study : Impact Evaluation at 3 Months Follow-up of a Brief Motivational Intervention in Reducing Alcohol Consumption Among Adolescents Aged 16-24 in Pontchaillou Hospital Emergency Department in Rennes, France
The purpose of this study is to evaluate the effectiveness of a Brief Motivational Intervention (BMI), in reducing alcohol consumption among patients with hazardous or harmful drinking admitted in emergency department (ED).
- Trial name
- AURAIA (NCT01435668)
- Testing
- Brief Motivational Intervention (BMI), Simple written advice
- Where
- France
- Volunteers
- 258 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
National Multicenter, Controlled, Single-blind Study With Two Parallel Groups Evaluating the Safety and Efficacy of Sequential Treatment With Mitoxantrone and Interferon Versus Interferon Alone in Patients With Strong Risk of Progression in the Initial Phase of Multiple Sclerosis
The relative effectiveness of current treatments and their different mechanisms of action yield to consider more and more that the multiple sclerosis (MS) therapeutic approach must use multiple molecules, both combined and…
- Trial name
- MITOX-REBIF (NCT02937285)
- Testing
- Interferon beta 1a, Mitoxantrone
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Rennes University Hospital
COPD
Bronchial Obstruction in Dairy Farmers
Chronic Obstructive Pulmonary Disease (COPD) is a major public health problem and is expected to become the 3rd leading cause of death globally by 2020. The main risk factor is tobacco.
- Trial name
- BPCO Airbag (NCT03654469)
- Testing
- questionnaires and electronic mini-spirometry
- Where
- France
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Defining an Immunological Signature Related to Lesion Location in Multiple Sclerosis
The objective of APOLLO is therefore to identify biomarkers associated with the CNS involvement phenotype in early MS patients.
- Trial name
- APOLLO (NCT05326048)
- Testing
- cytof analysis
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Rennes University Hospital
Depression
Apathy in Late Life Depression: New Biomarkers Using Actimetry and Magnetic Resonance Imaging
Old age (> 60 years) is at high risk to develop major depression disorders (MDD). MDD doubles the risk for subsequent cognitive disorders and dementia. Apathy (i.e.
- Trial name
- ACTIDEP (NCT03807167)
- Testing
- Mattis Dementia Rating Scale, Unified Parkinson 's Disease Rating Scale-III, Mini Neuropsychiatric Investigation
- Where
- 6 sites in France
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Atopic Dermatitis
PRAgmatic Trial in Atopic Dermatitis Testing Long-term Control Effectiveness of New Phototherapy Regimen During Winter Coupled With Oral Vitamin D Supplementation vs. Placebo
Spaced phototherapy sessions during winter as add-on therapy in combination with vitamin D supplementation or not, could be beneficial to improve disease LTC in AD patients
- Trial name
- PRADA (NCT02537509)
- Testing
- Cholecalciferol
- Where
- 11 sites in France
- Volunteers
- 111 people
- Sponsor
- Rennes University Hospital
Advanced Non Small Cell Lung Cancer
Nivolumab and Ipilimumab Versus Chimiotherapy in First Line Treatment in PS 2 or Elderly in Advanced NSCLC Patients
Lung cancer is the most common cancer in the world and the leading cause of cancer-related deaths in Western countries. Unfortunately, at the time of diagnosis, the majority of patients already have metastatic disease and a…
- Trial name
- eNERGY (NCT03351361)
- Testing
- Nivolumab + Ipilimumab, Chemotherapy
- Where
- 30 sites in France
- Volunteers
- 217 people
- Sponsor
- Rennes University Hospital
Aortic Valve Stenosis
Randomized Study for the Optimal Treatment of Symptomatic Patients With Low Gradient Severe Aortic Valve Stenosis and Preserved Left Ventricular Ejection Fraction
According to current European Recommendations on valvular heart disease (VHD), "classical" severe aortic stenosis (AS) is defined by an aortic valve area (AVA) ≤1 cm2 and indexed AVA ≤0.6 cm2/m2, a mean aortic pressure gradient…
- Trial name
- ROTAS (NCT03667365)
- Testing
- aortic valve replacement, strict clinical surveillance
- Where
- 18 sites in Belgium, France
- Volunteers
- 52 people
- Sponsor
- Rennes University Hospital